KEGG   Pan paniscus (bonobo): 100987989
Entry
100987989         CDS       T02283                                 
Symbol
AKR1C4
Name
(RefSeq) aldo-keto reductase family 1 member C4
  KO
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00120  Primary bile acid biosynthesis
pps00140  Steroid hormone biosynthesis
pps01100  Metabolic pathways
pps05208  Chemical carcinogenesis - reactive oxygen species
Module
pps_M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
pps_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    100987989 (AKR1C4)
   00140 Steroid hormone biosynthesis
    100987989 (AKR1C4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    100987989 (AKR1C4)
Enzymes [BR:pps01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     100987989 (AKR1C4)
    1.1.1.225  chlordecone reductase
     100987989 (AKR1C4)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     100987989 (AKR1C4)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 100987989
NCBI-ProteinID: XP_008951353
Ensembl: ENSPPAG00000032322
UniProt: A0A2R9AMJ4
LinkDB
Position
8:17757499..17783289
AA seq 323 aa
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIANGSVKREDIFYASKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALQPGETPLPKDENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHELWVDPKSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggatcccaaatatcagcgtgtggagctaaatgatggtcacttcatgcccgtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtggaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcaaatggcagtgtgaagagagaagacatattc
tacgcttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctccagccaggtgagacgccactaccaaaagatgaaaatggaaaagtaatattcgac
acagtggatctctgtgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgttctggttgcccacagtgctctggga
acccaacgacatgaactatgggtggacccaaagtccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaaacacaaacgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaat
gtccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggtctaaac
agaaattatcgatatgttgtcatggatttccttatggaccaccctgattatccattttca
gatgaatattag

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