KEGG   Pan paniscus (bonobo): 100990187
Entry
100990187         CDS       T02283                                 
Name
(RefSeq) LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00140  Steroid hormone biosynthesis
pps01100  Metabolic pathways
pps04913  Ovarian steroidogenesis
pps04925  Aldosterone synthesis and secretion
pps04927  Cortisol synthesis and secretion
pps04934  Cushing syndrome
Module
pps_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
pps_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
pps_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pps_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100990187
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100990187
   04925 Aldosterone synthesis and secretion
    100990187
   04927 Cortisol synthesis and secretion
    100990187
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100990187
Enzymes [BR:pps01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100990187
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100990187
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR
Other DBs
NCBI-GeneID: 100990187
NCBI-ProteinID: XP_008950472
Ensembl: ENSPPAG00000028516
LinkDB
Position
1:112051786..112064715
AA seq 458 aa
MTGWSCLVTGAGGFLGQRIICLLVEETELKEIRALDRAFRPGLREEFSKLQNKSKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRQSIMNVSVKGRVLLLEACVQATVPVF
IYTSTLQLAGPNSYKEIIENAHEEDFLENTWSAPYPYSKKLAEKAVLAANGWTLKNGDTL
YTCALRPMYIYGEGSPFLTTNIIEALNNNGILSSVSKFSTADPVYVGNVAWAHILALRAL
REPKKAPSVLGQFYYISDDTPHQSYDNLNYILSKEFGLCLDSRXSLLLSLMYWIGVLLEI
VSLLLRPICTYQPPFDCHTVTLSNSMFTFSYKKAQRDLAYKPLYSWEEAKQKTMEWVDSL
VDRHKENLKSKTQCFKDDRDVHVGIVRRCHQAPSSWLHTECDKGISPGPAASLSHNAQLI
VFLVSSKPAHSLTQPEAFCPNHIPEDRQCDLLFPNLSG
NT seq 1377 nt   +upstreamnt  +downstreamnt
atgacaggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcctgttagtggaggagacagagctgaaggagatcagggccttggacagggccttcaga
ccaggattgagggaggaattttctaaactccagaacaagagcaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtcatcatc
cacaccgcctgtatcattgatgtcttcggagtcactcacagacagtctatcatgaatgtc
agtgtgaaaggtagggtactcctgttggaggcctgtgtccaagctactgtgccagtcttc
atctacaccagtaccctacagttagctgggcccaactcctacaaggaaatcattgagaat
gcccatgaagaagactttctggaaaacacatggtctgctccatatccatacagcaaaaag
cttgctgagaaggctgtgctggcagctaatgggtggactctgaaaaatggtgataccttg
tacacttgtgccttaagacccatgtatatctatggggaaggaagcccatttcttactacc
aatataattgaggccctgaacaacaatgggatcctgtcgagtgtcagcaagttctccaca
gccgacccagtctatgttggcaatgtggcctgggcccatattctggccttgagggccctg
cgggagcccaagaaagccccaagtgtcctaggacagttctactacatctcagatgacacg
cctcaccaaagctatgataaccttaattacatcctgagcaaagagttcggcctctgcctt
gattccagatgaagtcttcttttatccctgatgtactggattggcgtcctgctggaaata
gtgagcctcctgctcaggccaatttgcacctatcaaccgcccttcgactgccacacagtg
acattgtcaaatagcatgttcaccttctcttacaagaaggctcagcgagatctggcatat
aagccactttacagctgggaggaagccaagcagaaaaccatggagtgggtagattccctt
gtggaccggcacaaggagaacctgaagtccaagactcagtgctttaaggatgacagagat
gtgcatgtgggtattgttaggagatgtcatcaagctccatcctcctggcttcatacagaa
tgtgacaagggcataagcccaggtcctgctgcctccctttcacacaatgcccaacttatt
gtcttcctcgtgtcatcaaaacctgcccattccctgacccaaccagaagctttctgtcct
aatcatataccagaggacagacaatgtgatttgctttttccaaatctcagtggctga

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