KEGG   Pan paniscus (bonobo): 100994315
Entry
100994315         CDS       T02283                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04081  Hormone signaling
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04517  IgSF CAM signaling
pps04518  Integrin signaling
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagosome formation
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05415  Diabetic cardiomyopathy
pps05417  Lipid and atherosclerosis
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100994315 (PIK3R1)
   04014 Ras signaling pathway
    100994315 (PIK3R1)
   04015 Rap1 signaling pathway
    100994315 (PIK3R1)
   04370 VEGF signaling pathway
    100994315 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100994315 (PIK3R1)
   04668 TNF signaling pathway
    100994315 (PIK3R1)
   04066 HIF-1 signaling pathway
    100994315 (PIK3R1)
   04068 FoxO signaling pathway
    100994315 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100994315 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100994315 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100994315 (PIK3R1)
   04024 cAMP signaling pathway
    100994315 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100994315 (PIK3R1)
   04152 AMPK signaling pathway
    100994315 (PIK3R1)
   04150 mTOR signaling pathway
    100994315 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100994315 (PIK3R1)
   04517 IgSF CAM signaling
    100994315 (PIK3R1)
   04518 Integrin signaling
    100994315 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100994315 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    100994315 (PIK3R1)
   04218 Cellular senescence
    100994315 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100994315 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100994315 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100994315 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100994315 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    100994315 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100994315 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    100994315 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100994315 (PIK3R1)
   04660 T cell receptor signaling pathway
    100994315 (PIK3R1)
   04662 B cell receptor signaling pathway
    100994315 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100994315 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    100994315 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100994315 (PIK3R1)
   04062 Chemokine signaling pathway
    100994315 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100994315 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    100994315 (PIK3R1)
   04929 GnRH secretion
    100994315 (PIK3R1)
   04915 Estrogen signaling pathway
    100994315 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    100994315 (PIK3R1)
   04917 Prolactin signaling pathway
    100994315 (PIK3R1)
   04926 Relaxin signaling pathway
    100994315 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100994315 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100994315 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100994315 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100994315 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100994315 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100994315 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100994315 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100994315 (PIK3R1)
   04380 Osteoclast differentiation
    100994315 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100994315 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100994315 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100994315 (PIK3R1)
   05206 MicroRNAs in cancer
    100994315 (PIK3R1)
   05205 Proteoglycans in cancer
    100994315 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    100994315 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100994315 (PIK3R1)
   05203 Viral carcinogenesis
    100994315 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100994315 (PIK3R1)
   05231 Choline metabolism in cancer
    100994315 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100994315 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100994315 (PIK3R1)
   05212 Pancreatic cancer
    100994315 (PIK3R1)
   05225 Hepatocellular carcinoma
    100994315 (PIK3R1)
   05226 Gastric cancer
    100994315 (PIK3R1)
   05214 Glioma
    100994315 (PIK3R1)
   05221 Acute myeloid leukemia
    100994315 (PIK3R1)
   05220 Chronic myeloid leukemia
    100994315 (PIK3R1)
   05218 Melanoma
    100994315 (PIK3R1)
   05211 Renal cell carcinoma
    100994315 (PIK3R1)
   05215 Prostate cancer
    100994315 (PIK3R1)
   05213 Endometrial cancer
    100994315 (PIK3R1)
   05224 Breast cancer
    100994315 (PIK3R1)
   05222 Small cell lung cancer
    100994315 (PIK3R1)
   05223 Non-small cell lung cancer
    100994315 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100994315 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100994315 (PIK3R1)
   05161 Hepatitis B
    100994315 (PIK3R1)
   05160 Hepatitis C
    100994315 (PIK3R1)
   05171 Coronavirus disease
    100994315 (PIK3R1)
   05164 Influenza A
    100994315 (PIK3R1)
   05162 Measles
    100994315 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    100994315 (PIK3R1)
   05163 Human cytomegalovirus infection
    100994315 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100994315 (PIK3R1)
   05169 Epstein-Barr virus infection
    100994315 (PIK3R1)
   05165 Human papillomavirus infection
    100994315 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100994315 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100994315 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100994315 (PIK3R1)
   05142 Chagas disease
    100994315 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100994315 (PIK3R1)
   05017 Spinocerebellar ataxia
    100994315 (PIK3R1)
   05020 Prion disease
    100994315 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100994315 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    100994315 (PIK3R1)
   05415 Diabetic cardiomyopathy
    100994315 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100994315 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100994315 (PIK3R1)
   04931 Insulin resistance
    100994315 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100994315 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100994315 (PIK3R1)
   01524 Platinum drug resistance
    100994315 (PIK3R1)
   01522 Endocrine resistance
    100994315 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100994315 (PIK3R1)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100994315 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 CEP135_TSGA10_CC Laminin_I SH3_9 ODF2_C DicA_C Exonuc_VII_L
Other DBs
NCBI-GeneID: 100994315
NCBI-ProteinID: XP_003806841
Ensembl: ENSPPAG00000042049
UniProt: A0A2R9CKR4
LinkDB
Position
4:complement(45620454..45705861)
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacaccctccgtggacttggaaatgatcgatgtgcac
gttttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctccagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgcacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacatggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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