Pongo pygmaeus (Bornean orangutan): 129011530 Help Entry 129011530         CDS       T10128                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism ppyg  Pongo pygmaeus (Bornean orangutan) Pathway ppyg04022   cGMP-PKG signaling pathway ppyg04068   FoxO signaling pathway ppyg04081   Hormone signaling ppyg04140   Autophagy - animal ppyg04152   AMPK signaling pathway ppyg04211   Longevity regulating pathway ppyg04213   Longevity regulating pathway - multiple species ppyg04910   Insulin signaling pathway ppyg04920   Adipocytokine signaling pathway ppyg04923   Regulation of lipolysis in adipocytes ppyg04930   Type II diabetes mellitus ppyg04931   Insulin resistance ppyg04932   Non-alcoholic fatty liver disease ppyg04935   Growth hormone synthesis, secretion and action ppyg05010   Alzheimer disease ppyg05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:ppyg00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     129011530 (IRS2)    04022 cGMP-PKG signaling pathway     129011530 (IRS2)    04152 AMPK signaling pathway     129011530 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     129011530 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     129011530 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     129011530 (IRS2)    04923 Regulation of lipolysis in adipocytes     129011530 (IRS2)    04920 Adipocytokine signaling pathway     129011530 (IRS2)    04935 Growth hormone synthesis, secretion and action     129011530 (IRS2)   09149 Aging    04211 Longevity regulating pathway     129011530 (IRS2)    04213 Longevity regulating pathway - multiple species     129011530 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     129011530 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     129011530 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     129011530 (IRS2)    04932 Non-alcoholic fatty liver disease     129011530 (IRS2)    04931 Insulin resistance     129011530 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Mcp5_PH Motif Other DBs NCBI-GeneID:  129011530 NCBI-ProteinID:  XP_054302557 LinkDB All DBs Position 14:complement(119738651..119769722) Genome browser AA seq 1348 aa AA seqDB search MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLISEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGEFYG YMTMDRPLSHCGRPYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLM RATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAA LAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAAVAVTPAGPAGPAPTSAASR TFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTG TPPDFFSAALHAGGEPLRGVPGCCYSSLPRSYKASYTCGGDSDQYVLMSSPVGRILEEER LEPQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGSLGGGRPDGFLGQRGRAVRPTRLS LEGLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGAHLSPPAPPLLASAASSSSLLSASSP ASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEVSSLY PPLPPRPSASPSSSLQPPPPPPPPGELYRLPPASAAATAQGPGAASSSSSDTGDNGDYTE MAFGVAATPPQPIAAPPKPEAARVTSPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAK VIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGP GGSDEPPTSPRQLQPALPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGL NYIAIDVREEPGLPPQPQPQPQPPLPQPGDKSSWGRTRSLGGLISAVGVGSSGGGCGGPG PGALPPANTYASIDFLSHHLKEATIVKE NT seq 4047 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgcggcacgggccgcccgggccggcgagcggagacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg acggcgggcggggggtcggctccgcagccgccgcggctcgagtactacgagagcgagaaa aagtggcggagcaaggcaggcgcgccgaaacgggtgatcgcgctcgactgctgcttgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggccgccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctgatcagcgagggccgcgcggccgccggagacgcgccccccgccgccgcacccgcc gcgtcctgcagcgcctccctgcccggcgccctgggcggctctgccggcgccgccggggcc gaggacagctacgggctggtggcgcccgccacggccgcctaccgtgaggtgtggcaggtg aacctgaagcccaagggtctgggccagagcaagaacctgacgggcgtgtaccgtctgtgc ctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctg cagctcatgaacatccgccgctgcggccactcggacagctttttcttcatcgaggtgggc cgctcggccgtcacaggccccggcgagctgtggatgcaggcggacgactcggtggtggcg cagaacatccatgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttc cggccgcgcagcaagagccagtcgtcggggtcgtcggccacgcaccccatcagcgtcccc ggcgcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgc cgctcgcgcaccgacagcctggccgccaccccgccggcggccaagtgcagctcgtgccgg gtgcgtaccgccagcgagggcgatggcggcgcggcggcgggggcggcggccgcgggcgcc aggccggtgtcggtggccgggagccccctgagccccgggccggtgcgcgcgcccctgagc cgctcgcacaccctgagcggcggctgcggcggccgcgggagcaaggtggcgctgctgccg gcagggggcgcgttgcagcacagccgctccatgtccatgcccgtggcgcactcgccgccc gccgccaccagccccggttccctgtcgtccagcagcggccacggctcgggctcctacccg ccgccgcccggcccgcacccgcccctgccgcatccgctgcaccacggccccggccagcgg ccctccagcggcagcgcctccgcctcgggctcccccagcgaccccggcttcatgtccctg gacgagtacggttccagcccaggcgacctgcgcgccttctgcagtcaccgaagcaacacg cccgagtccatcgcggagacgcccccggcccgagacggcggcggcggtgagttctacggg tacatgaccatggacaggcccctgagccactgtggccgcccctaccgccgggtctcgggg gacgcggcccaggacctggaccgagggctgcgcaagaggacctactccctgaccacgccg gcccggcagcggccggtgccccagccctcctctgcctcgctggatgagtacaccctgatg cgggccaccttctcgggcagcgcgggccgcctctgcccgtcctgccccgcgtcgtctccc aaggtggcttaccacccctacccggaggactacggagacatcgagatcggctcccacagg agctccagcagcaacctgggcgcagacgacggctacatgcccatgacgcccggcgcggcc ctcgcgggcagtgggagcggcagctgcaggagcgacgactacatgcccatgagccccgcc agcgtgtccgcccccaagcagatcttgcagcccagggccgccgctgccgccgccgccgcc gccgtcgccgtgacccctgcggggcctgcgggaccagcgcccacctctgcggcgagcagg acattcccggcgagtgggggcggctacaaggccagctcgcccgccgagagctcccccgag gacagtgggtacatgcgcatgtggtgcggctccaagctgtccatggagcatgcagatggc aagctgctgcccaacggggactacctcaacgtgtcccccagcgacgcggtcaccacgggc accccgcccgacttcttctccgcagccctgcacgccggcggggagccgctcaggggcgtt cctggctgctgctacagctccttgcctcgctcctacaaggcctcctacacctgcggcggg gacagcgaccagtacgtgctcatgagctcccccgtggggcgcatcctggaggaggagcgg ctggagcctcaggccacgccagggcccagccaggcggccagcgccttcggggccggcccc acgcagccccctcaccccgtagtgccttcgcccgtgcggcctagcggcagcctaggcggc ggccgcccggacggcttcttgggccagcgcggccgggcggtgaggcccacgcgcctgtcc ctggaggggctgcccagcctgcccagcatgcacgagtacccactgccaccggagcccaag agccccggcgagtacatcaacatcgacttcggcgagcccggggcccacctgtcgccgccc gcgcctcccctgctggcgtcggcggcctcgtcctcctcgctcttgtccgccagcagcccg gcctcgtcgctgggctcaggcaccccgggcaccagcagcgacagccggcagcgctctccg ctctccgactacatgaacctcgacttcagctcccccaagtctcctaagccgggcgccccg agcggccaccccgtgggctccttggacggcctcctgtcccccgaggtctcctccctgtat ccgccgctgcccccgcgtccgtccgcgtccccgtcgtcgtccctgcagccgccgccaccg ccgccgcccccgggggagctgtaccgcctgccccccgcctcggccgccgccaccgcccag ggcccgggcgccgcctcatcgtcgtcctcggacaccggggacaatggtgactacaccgag atggcttttggtgtggccgccaccccgccgcaaccaatcgcggcccccccgaagccagaa gctgcccgcgtgaccagcccgacgtcgggcgtgaagaggctgagcctcatggagcaggtg tcaggggtcgaggccttcctgcaggccagccagcccccggacccccaccgcggcgccaag gtcatccgcgcagacccgcaggggggccgacgccgccacagttccgagaccttctcctcc accacgacggtcacccccgtgtccccgtccttcgcccacaaccccaagcgccacaactcg gcctccgtggaaaatgtctctctcaggaaaagcagcgagggcggcgtgggtgtcggcccc ggagggagcgacgagccgcccacctccccccgacagttgcagccggcgctcccggcgccc cctttggcaccacagggccggccgtggaccccgggtcagcccgggggcttggtcggttgt cctgggagcggtggatcgccaatgcgcagagagacctctgctggcttccagaatggtctc aactacatcgccatcgacgtaagggaggagcccgggctgccaccccagccgcagccgcag ccgcagccgccgcttcctcagccgggagacaagagctcctggggtcggacccgaagcctc gggggtctcatcagcgctgtgggcgtcggcagcagcggcggcgggtgtggggggccgggt cccggtgccctgccccctgccaacacctacgccagcattgacttcttgtcccaccacttg aaggaggccaccattgtgaaagagtga

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