Pongo pygmaeus (Bornean orangutan): 129020822 Help Entry 129020822         CDS       T10128                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism ppyg  Pongo pygmaeus (Bornean orangutan) Pathway ppyg04010   MAPK signaling pathway ppyg04014   Ras signaling pathway ppyg04015   Rap1 signaling pathway ppyg04022   cGMP-PKG signaling pathway ppyg04066   HIF-1 signaling pathway ppyg04068   FoxO signaling pathway ppyg04072   Phospholipase D signaling pathway ppyg04081   Hormone signaling ppyg04150   mTOR signaling pathway ppyg04151   PI3K-Akt signaling pathway ppyg04152   AMPK signaling pathway ppyg04211   Longevity regulating pathway ppyg04213   Longevity regulating pathway - multiple species ppyg04520   Adherens junction ppyg04910   Insulin signaling pathway ppyg04913   Ovarian steroidogenesis ppyg04923   Regulation of lipolysis in adipocytes ppyg04930   Type II diabetes mellitus ppyg04931   Insulin resistance ppyg04932   Non-alcoholic fatty liver disease ppyg04960   Aldosterone-regulated sodium reabsorption ppyg05010   Alzheimer disease ppyg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ppyg00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     129020822 (INSR)    04014 Ras signaling pathway     129020822 (INSR)    04015 Rap1 signaling pathway     129020822 (INSR)    04066 HIF-1 signaling pathway     129020822 (INSR)    04068 FoxO signaling pathway     129020822 (INSR)    04072 Phospholipase D signaling pathway     129020822 (INSR)    04022 cGMP-PKG signaling pathway     129020822 (INSR)    04151 PI3K-Akt signaling pathway     129020822 (INSR)    04152 AMPK signaling pathway     129020822 (INSR)    04150 mTOR signaling pathway     129020822 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     129020822 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     129020822 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     129020822 (INSR)    04923 Regulation of lipolysis in adipocytes     129020822 (INSR)    04913 Ovarian steroidogenesis     129020822 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     129020822 (INSR)   09149 Aging    04211 Longevity regulating pathway     129020822 (INSR)    04213 Longevity regulating pathway - multiple species     129020822 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     129020822 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     129020822 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     129020822 (INSR)    04932 Non-alcoholic fatty liver disease     129020822 (INSR)    04931 Insulin resistance     129020822 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ppyg01001]     129020822 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:ppyg04090]     129020822 (INSR) Enzymes [BR:ppyg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      129020822 (INSR) Protein kinases [BR:ppyg01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    129020822 (INSR) CD molecules [BR:ppyg04090]  Proteins   129020822 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  129020822 NCBI-ProteinID:  XP_054321634 LinkDB All DBs Position 20:complement(7102673..7283905) Genome browser AA seq 1382 aa AA seqDB search MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTAAVPTVAAF PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV SRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcaccgggggccggcggggggcggcggccgcgccgctgctggtggcggtggccgcg ctgctattgggcgccgcgggccacctgtacccaggagaggtgtgtcccggcatggatatc cggaacaacctcactaggttgcatgagctggagaattgctctgtcatcgaaggacacttg cagatactcttgatgttcaaaacgaggcccgaagatttccgagacctcagtttccccaaa ctcataatgatcactgattacttgctgctcttccgggtctatgggctcgagagcctgaag gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactacgcgctg gtcatcttcgagatggttcacctaaaggaactcggcctctacaacctgatgaacatcacc cggggttctgtccgcatcgagaagaacaatgagctctgttacttggccactatcgactgg tcccgtatcctggattccgtggaggataattacatcgtattgaacaaagatgacaatgag gagtgtggagacatctgtccgggtactgcaaagggcaagaccaactgccccgccactgtc atcaatgggcagtttgtcgaacggtgttggactcatagtcactgccagaaagtttgcccg accatctgtaagtcacacggctgcaccgccgaaggcctctgttgccacagcgagtgcctg ggcaactgttctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggc tgccaccagtacgtcattcacaacaacaagtgcatccctgagtgtccctccgggtacacg atgaattccagcaacttgctgtgcaccccatgcctgggtccctgtcccaaggtgtgccac ctcctagaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggatgc accgtcatcaacgggagtctgatcatcaacattcgaggaggcaacaatctggcagctgag ctagaagccaacctcggcctcattgaagaaatttcagggtatctaaaaatccgccgatcc tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg gaaatcgggaactactccttctatgccttggacaaccagaacctaaggcagctctgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag agaaacgacattgccctgaagaccaatggggaccaggcatcctgtgaaaatgagttactt aaattttcttacattcggacatcttttgacaagatcttgctgagatgggagccgtactgg ccccccgacttccgagacctcttggggttcatgctgttctacaaagaggccccttatcag aatgtgacggagttcgacgggcaggatgcgtgtggttccaacagctggacggtggtagac attgacccacccctgaggtccaacgaccccaaatcacagaaccacccaggatggctgatg cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg gatgaacgccggacctatggggccaagagtgacatcatttatgtccagacagatgccacc aacccctctgtgcccctggatccaatctcagtgtctaactcatcatcccagattattttg aagtggaaacccccctccgaccccaatggcaacatcacccactacctggttttctgggag aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaagggctgaagctg ccctcgaggacctggtctccaccattcgagtctgaagattctcagaagcacaaccagagt gagtatgaggattcggccggcgaatgctgctcctgtccaaagacagactctcagatcctg aaggagctggaggagtcctcgtttaggaagacgtttgaggattacctgcacaacgtggtt tttgtccccagaaaaacctcttcaggcactggtgccgaggaccctaggccatctcggaaa cgcaggtcccttggcgatgttgggaatgtgacagcggctgtgcccacggtggcagctttc cccaacacttcctcaaccagcgtgcccacgagtccggaggagcacaggccctttgagaag gtggtaaacaaggagtcgctggtcatctctggcttgcgacacttcacaggctatcgcatc gagctgcaggcttgcaaccaagacacccctgaggaacggtgcagtgtggcagcctacgtc agtgccaggaccatgcctgaagccaaggctgatgacatcgtcggccctgtgacgcacgaa atctttgagaacaacgttgtccacttgatgtggcaggagccgaaggagcccaatggtctg atcgtgctgtatgaagtgagttatcggcgatatggcgatgaggagctgcatctctgcgtc tcccgcaagcacttcgctctggaacggggctgcaggctgcgtgggctgtcgccggggaac tacagcgtgcgagtccgggccacctcccttgcgggcaacggctcctggacggaacccacc tatttctacgtgacagactatttagatgtcccgtcaaatattgcaaaaattatcatcggc cccctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattcctgaga aagaggcagccagatgggccgctgggaccgctttacgcttcttcaaaccctgagtatctc agtgccagtgatgtgtttccatgctctgtgtacgtgccggacgagtgggaggtgcctcga gagaagataaccctccttcgagagctggggcagggctccttcggcatggtatatgagggc aacgccagggacatcatcaagggtgaggcagagacccgtgtggcggtgaagacggtcaac gagtcagccagtctccgagagcggattgaattcctcaatgaggcctcggtcatgaagggc ttcacctgccatcacgtggtgcgcctcctgggagtggtgtccaagggccagcccacgctg gtggtgatggagctgatggctcatggagacctgaagagctacctccgttctctgcggcca gaggctgagaataatcctggccgccctccgcctaccctgcaagagatgattcagatggcg gcagagattgctgacgggatggcctacctgaacgccaagaagtttgtgcatcgggacctg gcagcgagaaactgcatggtcgcccatgattttactgtcaaaattggagactttggaatg accagagacatctatgaaacggattactaccggaaagggggtaagggtctgctccctgta cggtggatggcgccggagtccctgaaggatggggtctttaccacttcttctgacatgtgg tcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctg tctaatgaacaggtgttgaaatttgtcatggatggagggtatctggatcaacccgacaac tgtccagagagagtcactgacctcatgcgcatgtgctggcaattcaaccccaagatgagg ccaaccttcctggagattgtcaacctgctcaaggacgacctgcaccccagctttccggag gtgtcgttcttccacagcgaggagaacaaggctcccgagagtgaggagctggagatggag tttgaggacatggagaatgtgcccctggaccgttcctcgcactgtcagagggaggaggcg gggggccgggatggagggtcctcgctaggtttcaagcggagctacgaggaacacatccct tacacacacatgaacggaggcaagaaaaacgggcggattctgaccttgcctcggtccaat ccttcctaa

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