Pongo pygmaeus (Bornean orangutan): 129020970 Help Entry 129020970         CDS       T10128                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism ppyg  Pongo pygmaeus (Bornean orangutan) Pathway ppyg04062   Chemokine signaling pathway ppyg04151   PI3K-Akt signaling pathway ppyg04217   Necroptosis ppyg04550   Signaling pathways regulating pluripotency of stem cells ppyg04630   JAK-STAT signaling pathway ppyg04658   Th1 and Th2 cell differentiation ppyg04659   Th17 cell differentiation ppyg05161   Hepatitis B ppyg05162   Measles ppyg05166   Human T-cell leukemia virus 1 infection ppyg05169   Epstein-Barr virus infection ppyg05200   Pathways in cancer ppyg05203   Viral carcinogenesis ppyg05223   Non-small cell lung cancer ppyg05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:ppyg00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     129020970 (JAK3)    04151 PI3K-Akt signaling pathway     129020970 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     129020970 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     129020970 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     129020970 (JAK3)    04659 Th17 cell differentiation     129020970 (JAK3)    04062 Chemokine signaling pathway     129020970 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     129020970 (JAK3)    05203 Viral carcinogenesis     129020970 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     129020970 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     129020970 (JAK3)    05161 Hepatitis B     129020970 (JAK3)    05162 Measles     129020970 (JAK3)    05169 Epstein-Barr virus infection     129020970 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     129020970 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ppyg01001]     129020970 (JAK3) Enzymes [BR:ppyg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      129020970 (JAK3) Protein kinases [BR:ppyg01001]  Non-receptor tyrosine kinases   JAK family [OT]    129020970 (JAK3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl FERM_C_FAK1 Kinase-like ABC1 Kdo SH2 LRR_RI_capping Haspin_kinase Motif Other DBs NCBI-GeneID:  129020970 NCBI-ProteinID:  XP_054321966 LinkDB All DBs Position 20:complement(18259959..18282953) Genome browser AA seq 1124 aa AA seqDB search MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQSQR LGELLKTISYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM DLERLDPAGAAETFHVGLPGALGGQDGLGLLRVAGDSGISWTQGEQEVLQPFCDFPEIVD ISIKQAPRVGPAGEHRLVTLTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSHPGSYVLRRSPQDFDSFLLTVCVQTP LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS GVTMPISALDPAKKLQFYEDQQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP SPQDRPSFSTLGPQLDMLWSGSRGCETHAFTAHPEGKPHSLSFL NT seq 3375 nt NT seq  +upstreamnt  +downstreamnt atggcacctccaagtgaagagacgcccctgatccctcagcgttcatgcagcctcttgtcc acggaggctggtgccctgcatgtgctgctgcccgctcggggccccgggcccccccagcgc ctatctttctcctttggggaccacttggctgaggacctgtgcgtgcaggctgccaaggcc agcggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc tggttccccccgagccacatcttttcagtggaggatgccagcacccaagtcctgctctac aggattcgcttttacttccccaattggtttgggctggagaagtgccaccgctttgggcta cgcaaggatttggccagcgctatccttgacctgccagtcctggagcacctctttgcccag caccgcagtgacctggtgagtgggcgcctccccgtgggcctcagtctcaaagagcagggt gagtgtctcagcctggccgtgctggacctggcccggatggcgcgagagcagtcccagcgg ctgggagagctgctgaagactatcagctacaaggcctgcctacccccaagcctgcgcgac ctgatccagggcctgagcttcgtgacgcggaggcgtattcggaggacggtgcgcagggcc ctgcgccgcgtggccgcctgccaggcagaccggcactcgctcatggccaagtacatcatg gacctggagcggctggatccagccggggccgccgagaccttccacgtgggcctccctggg gcccttggtggccaggacgggctagggctgctccgcgtggctggggacagcggcatctcc tggacccagggagaacaggaggtcctccagcccttctgcgactttccagaaatcgtagac attagcatcaagcaggccccgcgcgttggcccggccggggagcaccgcctggtcactctt accaggacagacaaccagattttggaggccgagttcccagggctgcccgaggctctgtcg ttcgtggcgctcgtggacggctacttccggctgaccacggactcccagcacttcttctgc aaggaggtggcaccgccgaggctgctggaggaagtggccgagcagtgccacggccccatc actctggactttgccatcaacaagcttaagactgggggctcacatcctggctcctatgtt ctccgccgcagcccccaggactttgacagcttcctcctcactgtctgtgtccagaccccc cttggtcctgattataagggctgcctcatccggcgcagccccacaggaaccttccttctg gttggcctcagccgaccccacagcagtcttcgagagctcctggcaacatgctgggatggg gggctgcacgtagatggggtggcagtgaccctcacctcctgctgtatccccagacccaaa gaaaagtccaacctgatcgtggtccagagaggtcacagcccacccacatcatccttggtt cagccccaatcccaataccagctgagtcagatgacatttcacaagatccctgctgacagc ctggagtggcatgagaacctgggccatgggtccttcaccaagatttaccggggctgtcgc catgaggtggtggatggggaggcccgaaagacagaggtgctgctgaaggtgatggatgct aagcacaagaactgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtcg taccggcatctcgtgctgctccacggcgtgtgcatggctggagacagcaccatggtgcag gaatttgtacacctgggggcgatagacatgtatcttcgaaaacgtggccacctggtgcca gccagctggaagctgcaggtggtcaaacagctggcctacgccctcaactatctggaggac aaaggcctcccccatggcaatgtctctgcccggaaggtgctcctggctcgggagggggct gatgggagcccgcccttcatcaagctgagtgaccctggggtcagccccgctgtgttaagc ctggagatgctcactgacaggatcccctgggtggcccccgagtgtctccgggaggcccag acacttagcttggaagctgacaagtggggcttcggcgccacggtctgggaagtgtttagt ggcgtcaccatgcccatcagcgccctggatcctgctaagaaactccaattttatgaggac cagcagcagctgccggcccccaagtggacagagctggccctgctgattcaacagtgcatg gcctatgagccagtccagaggccctccttccgagccgtcattcgtgacctaaatagcctc atctcttcagactatgagctcctctcagaccccacacctggagccctggcacctcgtgat gggctgtggaatggtgcccagctctatgcctgccaagaccccacgatctttgaggagaga cacctcaagtacatctcacagctgggcaagggcaactttggcagcgtggagctgtgccgc tatgacccgctaggtgacaatacaggtgccctggtggccgtgaaacagctgcagcacagc gggccagaccagcagagggactttcagcgggagattcagatcctcaaagcactgcacagt gatttcattgtcaagtatcgtggtgtcagctacggcccgggccgccagagcctgcggctg gtcatggagtacctgcccagcggctgcttgcgcgacttcctgcagcggcaccgtgcgcgc ctcgatgccagccgcctccttctctattcctcacagatctgcaagggcatggagtaccta ggctcccgccgctgcgtgcaccgcgacctggccgcccgaaacatcctcgtggagagcgag gcacacgtcaagatcgctgacttcggcctagctaagctgctgccgcttgacaaagactac tacgtcgtccgcgagccgggccagagccccattttctggtatgcccccgaatccctctcg gacaatatcttctctcgccagtcagacgtctggagctttggggtcgtcctgtacgagctc ttcacctactgcgacaaaagctgcagtccctcggccgagttcctgcggatgatgggatgt gagcgggatgtccccgccctctgccgcctcctggaactgctggaggagggccagaggctg ccggcgcctcctgcctgccctgcagaggttcacgagctcatgaagctgtgctgggcccct agcccacaggaccggccatcattcagcaccctgggcccccagctggacatgctgtggagc ggaagccgggggtgtgagactcatgccttcactgctcacccagagggcaaaccccactcc ctgtcctttttatag

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