KEGG   Pongo pygmaeus (Bornean orangutan): 129029200
Entry
129029200         CDS       T10128                                 
Symbol
ROCK2
Name
(RefSeq) rho-associated protein kinase 2
  KO
K17388  Rho-associated protein kinase 2 [EC:2.7.11.39]
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg04022  cGMP-PKG signaling pathway
ppyg04024  cAMP signaling pathway
ppyg04062  Chemokine signaling pathway
ppyg04071  Sphingolipid signaling pathway
ppyg04270  Vascular smooth muscle contraction
ppyg04310  Wnt signaling pathway
ppyg04360  Axon guidance
ppyg04510  Focal adhesion
ppyg04520  Adherens junction
ppyg04530  Tight junction
ppyg04611  Platelet activation
ppyg04670  Leukocyte transendothelial migration
ppyg04810  Regulation of actin cytoskeleton
ppyg04921  Oxytocin signaling pathway
ppyg05132  Salmonella infection
ppyg05135  Yersinia infection
ppyg05163  Human cytomegalovirus infection
ppyg05200  Pathways in cancer
ppyg05205  Proteoglycans in cancer
ppyg05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    129029200 (ROCK2)
   04071 Sphingolipid signaling pathway
    129029200 (ROCK2)
   04024 cAMP signaling pathway
    129029200 (ROCK2)
   04022 cGMP-PKG signaling pathway
    129029200 (ROCK2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129029200 (ROCK2)
   04520 Adherens junction
    129029200 (ROCK2)
   04530 Tight junction
    129029200 (ROCK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129029200 (ROCK2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129029200 (ROCK2)
   04670 Leukocyte transendothelial migration
    129029200 (ROCK2)
   04062 Chemokine signaling pathway
    129029200 (ROCK2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    129029200 (ROCK2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129029200 (ROCK2)
  09158 Development and regeneration
   04360 Axon guidance
    129029200 (ROCK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129029200 (ROCK2)
   05205 Proteoglycans in cancer
    129029200 (ROCK2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    129029200 (ROCK2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129029200 (ROCK2)
   05135 Yersinia infection
    129029200 (ROCK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129029200 (ROCK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppyg01001]
    129029200 (ROCK2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ppyg03036]
    129029200 (ROCK2)
Enzymes [BR:ppyg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     129029200 (ROCK2)
Protein kinases [BR:ppyg01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   129029200 (ROCK2)
Chromosome and associated proteins [BR:ppyg03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    129029200 (ROCK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Pkinase_C APH Irp3-like_C
Other DBs
NCBI-GeneID: 129029200
NCBI-ProteinID: XP_054330369
LinkDB
Position
12:122709592..122873934
AA seq 1388 aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSLSCRENDSIQSRKNEESQEIQKKLYTLEEHLSNEIQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR
DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKNGKI
LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK
QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG
DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
QLAPNKPS
NT seq 4167 nt   +upstreamnt  +downstreamnt
atgagccggcccccgccgacggggaaaatgcccggcgcccccgagaccgcgccgggggac
ggggcaggcgcgagccgccagaggaagctggaggcgctgatccgagaccctcgctccccc
atcaacgtggagagcttgctggatggcttaaattccttggtccttgatttagattttcct
gctttgaggaaaaacaagaacatagataatttcttaaatagatatgagaaaattgtgaaa
aaaatcagaggtctacagatgaaggcagaagactatgatgttgtaaaagttattggaaga
ggtgcttttggtgaagtgcagttggttcgtcataaggcatcgcagaaggtttatgctatg
aagcttcttagtaagtttgagatgataaaaagatcagattctgcctttttttgggaagaa
agagatattatggcctttgccaatagcccctgggtggttcagcttttttatgcctttcaa
gatgataggtatctgtacatggtaatggagtacatgcctggtggagaccttgtaaacctt
atgagtaattatgatgtgcctgaaaaatgggccaaattttacactgctgaagttgttctt
gctctggatgcaatacactccatgggtttaatacacagagatgtgaagcctgacaacatg
ctcttggataaacatggacatctaaaattagcagattttggcacgtgtatgaagatggat
gaaacaggcatggtacattgtgatacagcagttggaacaccggattatatatcacctgag
gttctgaaatcacaagggggtgatggttactatgggcgagaatgtgattggtggtctgta
ggtgttttcctttatgagatgctggtgggggatactccattttatgcggattcacttgta
ggaacatatagcaaaattatggatcataagaattcactgtgtttccctgaagatgcagaa
atttccaaacatgcaaagaatctcatctgtgctttcttaacagatagggaggtacgactt
gggagaaatggggtggaagaaatcagacagcatcctttctttaagaatgatcagtggcat
tgggataacataagagaaacggcagctcctgtagtacctgaactcagcagtgacatagac
agcagcaatttcgatgacattgaagatgacaaaggagatgtagaaaccttcccaattcct
aaagcttttgttggaaatcagctgcctttcataggatttacctactatagagaaaatttg
ctattaagtgactctctatcttgtagagaaaatgattcaatacaatcaaggaaaaatgaa
gaaagtcaagagattcagaaaaaactgtatacattagaagaacatcttagcaatgagata
caagccaaagaggaactggaacagaagtgcaaatctgttaatactcgcctagaaaaaaca
gcaaaggagctagaagaggagattaccttacggaaaagtgtggaatcagcattaagacag
ttagaaagagaaaaggcgcttcttcagcacaaaaatgcagaatatcagaggaaagctgat
catgaagcagacaaaaaacgaaatttggaaaatgatgttaacagcttaaaagatcaactt
gaagatttgaaaaaaagaaatcaaaactctcaaatatccactgagaaagtgaatcaactc
cagagacaactggatgaaaccaatgctttactgcgaacagaatctgatactgcagcccgg
ttaaggaaaacccaggcagaaagttcaaaacagattcagcagctggaatctaacaataga
gatctacaagataaaaactgcctgctggagaccgccaagttaaaacttgaaaaggaattt
atcaatcttcagtcagctctagaatctgaaaggagggatcgaacccatggatcagagata
attaatgatttacaaggtagaatatctggcctagaagaagatttaaagaacggcaaaatc
ttattagcaaaagtagaactggagaagagacaactacaggagagatttactgatttggaa
aaggaaaaaagcaacatggaaatagatatgacataccaactaaaagttatacagcagagc
ctagaacaagaagaagctgaacataaggccacaaaggcacgactagcagataaaaataag
atctatgagtccatcgaagaagccaaatcagaagccatgaaagaaatggagaagaagctc
ttggaggaaagaactttaaaacagaaagtggagaacctattgctagaagctgagaaaaga
tgttctctattagactgtgacctcaaacagtcacagcagaaaataaatgagctccttaaa
cagaaagatgtgctaaatgaggatgttagaaacctgacattaaaaatagagcaagaaact
cagaagcgctgccttacacaaaatgacctgaagatgcaaacacaacaggttaacacacta
aaaatgtcagaaaagcagttaaagcaagaaaataaccatctcatggaaatgaaaatgaac
ttggaaaaacaaaatgctgaacttcgaaaagaacgtcaggatgcagatgggcaaatgaaa
gagctccaggatcagctcgaagcagaacagtatttctcaaccctttataaaacacaagtt
agggagcttaaagaagaatgtgaagaaaagaccaaacttggtaaagaattgcagcagaag
aaacaggagttacaggatgaacgggactccttggctgcccaactggagatcaccttgacc
aaagcagattctgagcaactggctcgttcaattgctgaagaacaatattctgatttggaa
aaagagaagatcatgaaagagctggagatcaaagagatgatggctagacacaaacaggaa
cttaccgaaaaagatgctacaattgcttctcttgaagaaactaataggacactaactagt
gatgttgccaatcttgcaaatgagaaagaagaattaaataacaaattgaaagatgttcaa
gagcaactgtcaagattgaaagatgaagaaataagcgcagcagctattaaagcacagttt
gagaaacagctattaacagaaagaacactcaaaactcaagctgtgaataagttggctgag
atcatgaatcgaaaagaacctgtcaagcgtggtaatgacacagatgtgcggagaaaagag
aaggagaataggaagctacatatggagcttaaatctgaacgtgagaaattgacccagcag
atgatcaagtatcagaaagaactgaatgaaatgcaggcacaaatagctgaagagagccag
attcgaattgaactgcagatgacattggacagtaaagacagtgacattgagcagctgcgg
tcacaactccaagccttgcatattggtctggatagttccagtataggcagtggaccaggg
gatgctgaggcagatgatgggtttccagaatcaagattagaaggatggctttcattgcct
gtacgaaacaacactaagaaatttggatgggttaaaaagtatgtgattgtaagcagtaag
aagattcttttctatgacagtgaacaagataaagaacaatccaatccttacatggtttta
gatatagacaagttatttcatgtccgaccagttacacagacagatgtatatagagcagat
gctaaagaaattccaaggatattccagattctgtatgccaatgaaggagaaagtaagaag
gaacaagaatttccagtggagccagttggagaaaaatctaattatatttgccacaaggga
catgagtttattcctactctttatcatttcccaaccaactgtgaggcttgtatgaagccc
ctgtggcacatgtttaagcctcctcctgctttggagtgccgccgttgccatattaagtgt
cataaagatcacatggacaaaaaggaggagattatagcaccttgcaaagtatattatgat
atttcaacggcaaagaatctattattactagcaaattctacagaagagcagcagaagtgg
gttagtcggttggtgaaaaagatacctaaaaagcccccagctccagacccttttgcacga
tcatctcctagaacttcaatgaagatacagcaaaaccagtctattagacggccaagtcga
cagcttgccccaaacaaacctagctaa

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