Pongo pygmaeus (Bornean orangutan): 129031768 Help Entry 129031768         CDS       T10128                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism ppyg  Pongo pygmaeus (Bornean orangutan) Pathway ppyg04022   cGMP-PKG signaling pathway ppyg04068   FoxO signaling pathway ppyg04081   Hormone signaling ppyg04140   Autophagy - animal ppyg04150   mTOR signaling pathway ppyg04151   PI3K-Akt signaling pathway ppyg04152   AMPK signaling pathway ppyg04211   Longevity regulating pathway ppyg04213   Longevity regulating pathway - multiple species ppyg04722   Neurotrophin signaling pathway ppyg04910   Insulin signaling pathway ppyg04920   Adipocytokine signaling pathway ppyg04923   Regulation of lipolysis in adipocytes ppyg04930   Type II diabetes mellitus ppyg04931   Insulin resistance ppyg04932   Non-alcoholic fatty liver disease ppyg04935   Growth hormone synthesis, secretion and action ppyg04960   Aldosterone-regulated sodium reabsorption ppyg05010   Alzheimer disease ppyg05206   MicroRNAs in cancer ppyg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ppyg00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     129031768 (IRS1)    04022 cGMP-PKG signaling pathway     129031768 (IRS1)    04151 PI3K-Akt signaling pathway     129031768 (IRS1)    04152 AMPK signaling pathway     129031768 (IRS1)    04150 mTOR signaling pathway     129031768 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     129031768 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     129031768 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     129031768 (IRS1)    04923 Regulation of lipolysis in adipocytes     129031768 (IRS1)    04920 Adipocytokine signaling pathway     129031768 (IRS1)    04935 Growth hormone synthesis, secretion and action     129031768 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     129031768 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     129031768 (IRS1)   09149 Aging    04211 Longevity regulating pathway     129031768 (IRS1)    04213 Longevity regulating pathway - multiple species     129031768 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     129031768 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     129031768 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     129031768 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     129031768 (IRS1)    04932 Non-alcoholic fatty liver disease     129031768 (IRS1)    04931 Insulin resistance     129031768 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  129031768 NCBI-ProteinID:  XP_054334423 LinkDB All DBs Position 11:complement(127336494..127406345) Genome browser AA seq 1244 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSTRLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GQYVLSRGGNGHRYTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVES SSGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPENPQHKPVLSYYSLPRSFKHTQHPGEP EEGARHQHLRLSTSSGRLLYAATVDDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH LPRKVDTAAQTNSRLARPTLLSLGDPKASTLPRAREQQQQQQQQPLLHPPEPKSPGEYVN IEFGSDQPGYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGWRAAWQEST GVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTG IAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLS PNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDV KRHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQRPQECTPE PQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ NT seq 3735 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgctgccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgagacgagcactttgccatcgcggcggacagcgag gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac cacgacggagctgctgccctcggtgcgggaggtggtgggggcagctgcagtggcagctcc ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagccgccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggagaacttc ttcttcatcgaggtgggccgttctgccgtgacgggtcccggggagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc cgccgatcgcgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcactatgtcccgcccagcc tcggtagacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg ggcagcacccggctgcaccccccgctcaaccacagccgttccatccccatgccggcttcc cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc agcgatggcggtttcatctcctcagatgagtatggctccagtccctgtgattttcggagt tccttccgcagcgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggtggcaaggggccctccaccctgaccgcccccaac ggtcaatacgttttgtctcggggtggcaatggccaccgctacaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc ccagacagctccaccctccacactgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagcagccgaaagggcagtggagactatatgcccatgagtcccaagagcgtg tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc agcagcagcagcagcagcaatgctgtcccttccgggagcagctatggaaagctgtggaca aacggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagc agcagtggtaagctcttaccttgtacaggtgactacatgaacatgtcaccagtgggggac tccaacaccagcagcccctccgactgctactacggccctgagaacccccagcacaagcca gtcctctcctactactcattgccaagatcctttaagcacacccagcaccctggggagccg gaggagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctat gctgcaacagtggatgattcttcctcctccaccagcagtgacagcctgggtgggggatac tgcggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccat ctgcctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgttg ctgtccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcag cagcagcagcagcccctgctgcaccctccagagcccaaaagcccaggggaatatgtcaat attgaatttgggagtgatcagcctggctacttgtctggcccggtggcttcccgcagctca ccttctgtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcact gaggagtacatgaagatggacctggggccgggctggagggcagcctggcaggagagcact ggggtcgagatgggcagactgggccccgcacctcctggggctgctagcatttgcaggcct acccgggcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgt cagagctacgtggacacctcgccagctgcccctgtaagctatgctgacatgcggacaggc attgctgcagaggaggtgagcctgccgagggccaccatggctgctgcctcctcatcctca gcagcctctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtcc ctgctggggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagt cctaaccgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggagg catagctccgagaccttctcctcaacacccagtgccactcgggtgggcaacacagtgccc tttggagcaggggcagcagtagggggcggtggcggtagcagcagcagcagcgaggatgtg aaacgccacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttggggga gcccccaaggagccagcccaactgtgtggggctgctgggggtttggagaatggtcttaac tacatagacctggatttggtcaaggacttcaaacagcgccctcaggagtgcacccctgaa ccgcagcctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctcc acccgccgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagcca gaggaccgtcagtag

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