Phodopus roborovskii (desert hamster): 127216563
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Entry
127216563 CDS
T08852
Symbol
Map2k2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
prob
Phodopus roborovskii (desert hamster)
Pathway
prob01521
EGFR tyrosine kinase inhibitor resistance
prob01522
Endocrine resistance
prob04010
MAPK signaling pathway
prob04012
ErbB signaling pathway
prob04014
Ras signaling pathway
prob04015
Rap1 signaling pathway
prob04022
cGMP-PKG signaling pathway
prob04024
cAMP signaling pathway
prob04066
HIF-1 signaling pathway
prob04068
FoxO signaling pathway
prob04071
Sphingolipid signaling pathway
prob04072
Phospholipase D signaling pathway
prob04140
Autophagy - animal
prob04148
Efferocytosis
prob04150
mTOR signaling pathway
prob04151
PI3K-Akt signaling pathway
prob04210
Apoptosis
prob04218
Cellular senescence
prob04270
Vascular smooth muscle contraction
prob04370
VEGF signaling pathway
prob04371
Apelin signaling pathway
prob04540
Gap junction
prob04550
Signaling pathways regulating pluripotency of stem cells
prob04613
Neutrophil extracellular trap formation
prob04620
Toll-like receptor signaling pathway
prob04650
Natural killer cell mediated cytotoxicity
prob04660
T cell receptor signaling pathway
prob04662
B cell receptor signaling pathway
prob04664
Fc epsilon RI signaling pathway
prob04720
Long-term potentiation
prob04722
Neurotrophin signaling pathway
prob04730
Long-term depression
prob04810
Regulation of actin cytoskeleton
prob04910
Insulin signaling pathway
prob04912
GnRH signaling pathway
prob04915
Estrogen signaling pathway
prob04916
Melanogenesis
prob04917
Prolactin signaling pathway
prob04919
Thyroid hormone signaling pathway
prob04921
Oxytocin signaling pathway
prob04926
Relaxin signaling pathway
prob04929
GnRH secretion
prob04934
Cushing syndrome
prob04935
Growth hormone synthesis, secretion and action
prob05010
Alzheimer disease
prob05022
Pathways of neurodegeneration - multiple diseases
prob05132
Salmonella infection
prob05135
Yersinia infection
prob05160
Hepatitis C
prob05161
Hepatitis B
prob05163
Human cytomegalovirus infection
prob05164
Influenza A
prob05165
Human papillomavirus infection
prob05166
Human T-cell leukemia virus 1 infection
prob05167
Kaposi sarcoma-associated herpesvirus infection
prob05170
Human immunodeficiency virus 1 infection
prob05200
Pathways in cancer
prob05205
Proteoglycans in cancer
prob05206
MicroRNAs in cancer
prob05207
Chemical carcinogenesis - receptor activation
prob05208
Chemical carcinogenesis - reactive oxygen species
prob05210
Colorectal cancer
prob05211
Renal cell carcinoma
prob05213
Endometrial cancer
prob05214
Glioma
prob05215
Prostate cancer
prob05216
Thyroid cancer
prob05218
Melanoma
prob05219
Bladder cancer
prob05220
Chronic myeloid leukemia
prob05221
Acute myeloid leukemia
prob05223
Non-small cell lung cancer
prob05224
Breast cancer
prob05225
Hepatocellular carcinoma
prob05226
Gastric cancer
prob05230
Central carbon metabolism in cancer
prob05231
Choline metabolism in cancer
prob05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
prob00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
127216563 (Map2k2)
04012 ErbB signaling pathway
127216563 (Map2k2)
04014 Ras signaling pathway
127216563 (Map2k2)
04015 Rap1 signaling pathway
127216563 (Map2k2)
04370 VEGF signaling pathway
127216563 (Map2k2)
04371 Apelin signaling pathway
127216563 (Map2k2)
04066 HIF-1 signaling pathway
127216563 (Map2k2)
04068 FoxO signaling pathway
127216563 (Map2k2)
04072 Phospholipase D signaling pathway
127216563 (Map2k2)
04071 Sphingolipid signaling pathway
127216563 (Map2k2)
04024 cAMP signaling pathway
127216563 (Map2k2)
04022 cGMP-PKG signaling pathway
127216563 (Map2k2)
04151 PI3K-Akt signaling pathway
127216563 (Map2k2)
04150 mTOR signaling pathway
127216563 (Map2k2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
127216563 (Map2k2)
04148 Efferocytosis
127216563 (Map2k2)
09143 Cell growth and death
04210 Apoptosis
127216563 (Map2k2)
04218 Cellular senescence
127216563 (Map2k2)
09144 Cellular community - eukaryotes
04540 Gap junction
127216563 (Map2k2)
04550 Signaling pathways regulating pluripotency of stem cells
127216563 (Map2k2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
127216563 (Map2k2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
127216563 (Map2k2)
04620 Toll-like receptor signaling pathway
127216563 (Map2k2)
04650 Natural killer cell mediated cytotoxicity
127216563 (Map2k2)
04660 T cell receptor signaling pathway
127216563 (Map2k2)
04662 B cell receptor signaling pathway
127216563 (Map2k2)
04664 Fc epsilon RI signaling pathway
127216563 (Map2k2)
09152 Endocrine system
04910 Insulin signaling pathway
127216563 (Map2k2)
04929 GnRH secretion
127216563 (Map2k2)
04912 GnRH signaling pathway
127216563 (Map2k2)
04915 Estrogen signaling pathway
127216563 (Map2k2)
04917 Prolactin signaling pathway
127216563 (Map2k2)
04921 Oxytocin signaling pathway
127216563 (Map2k2)
04926 Relaxin signaling pathway
127216563 (Map2k2)
04935 Growth hormone synthesis, secretion and action
127216563 (Map2k2)
04919 Thyroid hormone signaling pathway
127216563 (Map2k2)
04916 Melanogenesis
127216563 (Map2k2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
127216563 (Map2k2)
09156 Nervous system
04720 Long-term potentiation
127216563 (Map2k2)
04730 Long-term depression
127216563 (Map2k2)
04722 Neurotrophin signaling pathway
127216563 (Map2k2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
127216563 (Map2k2)
05206 MicroRNAs in cancer
127216563 (Map2k2)
05205 Proteoglycans in cancer
127216563 (Map2k2)
05207 Chemical carcinogenesis - receptor activation
127216563 (Map2k2)
05208 Chemical carcinogenesis - reactive oxygen species
127216563 (Map2k2)
05230 Central carbon metabolism in cancer
127216563 (Map2k2)
05231 Choline metabolism in cancer
127216563 (Map2k2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
127216563 (Map2k2)
09162 Cancer: specific types
05210 Colorectal cancer
127216563 (Map2k2)
05225 Hepatocellular carcinoma
127216563 (Map2k2)
05226 Gastric cancer
127216563 (Map2k2)
05214 Glioma
127216563 (Map2k2)
05216 Thyroid cancer
127216563 (Map2k2)
05221 Acute myeloid leukemia
127216563 (Map2k2)
05220 Chronic myeloid leukemia
127216563 (Map2k2)
05218 Melanoma
127216563 (Map2k2)
05211 Renal cell carcinoma
127216563 (Map2k2)
05219 Bladder cancer
127216563 (Map2k2)
05215 Prostate cancer
127216563 (Map2k2)
05213 Endometrial cancer
127216563 (Map2k2)
05224 Breast cancer
127216563 (Map2k2)
05223 Non-small cell lung cancer
127216563 (Map2k2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
127216563 (Map2k2)
05170 Human immunodeficiency virus 1 infection
127216563 (Map2k2)
05161 Hepatitis B
127216563 (Map2k2)
05160 Hepatitis C
127216563 (Map2k2)
05164 Influenza A
127216563 (Map2k2)
05163 Human cytomegalovirus infection
127216563 (Map2k2)
05167 Kaposi sarcoma-associated herpesvirus infection
127216563 (Map2k2)
05165 Human papillomavirus infection
127216563 (Map2k2)
09171 Infectious disease: bacterial
05132 Salmonella infection
127216563 (Map2k2)
05135 Yersinia infection
127216563 (Map2k2)
09164 Neurodegenerative disease
05010 Alzheimer disease
127216563 (Map2k2)
05022 Pathways of neurodegeneration - multiple diseases
127216563 (Map2k2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
127216563 (Map2k2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
127216563 (Map2k2)
01522 Endocrine resistance
127216563 (Map2k2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
prob01001
]
127216563 (Map2k2)
Enzymes [BR:
prob01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
127216563 (Map2k2)
Protein kinases [BR:
prob01001
]
Serine/threonine kinases: STE group
STE7 family
127216563 (Map2k2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
127216563
NCBI-ProteinID:
XP_051033254
UniProt:
A0AAU9YV87
LinkDB
All DBs
Position
Unknown
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKAQHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEGEEVDFAGWLCRILRLKQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggctcggaggaagccggtgctaccggcgctcaccatcaatcctgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaggcgaacctggtggacctgcagaagaag
ctagaggagctagacctggatgagcagcagaggaagcgtctggaggccttccttacccag
aaggccaaggttggggaactcaaggatgatgactttgagcggatctcagagctgggagct
ggcaatggtggtgtggtcactaaggcccagcacaggccgtcaggcctcatcatggccaga
aagctgatccatctggagatcaaaccagccgtacgcaaccagatcatccgggagctacag
gtgctgcatgaatgcaactcgccctacattgtgggcttctacggagccttctacagtgat
ggcgagatcagcatctgcatggagcacatggatggtggctcactggaccaggtactgaag
gaggccaagcggatccctgaggacatcttggggaaggtcagcattgcggtgctccgaggc
ctggcatacctccgtgagaagcaccagatcatgcacagagatgtgaagccctccaacatc
cttgtgaactctcgtggtgagatcaagctgtgtgacttcggggtgagcggccaactgatt
gactccatggctaattcgtttgttggaacacgctcctacatgtctccagagcggctacag
ggcacgcattactctgtgcagtcagacatctggagcatgggactgtcactggtggagctg
gccatcgggaggtaccccatccccccacctgatgccaaggaactagaggccagctttggg
cggcctgtagtcgatggcgcagacggagagccccatagtgtctcgccgcggcccaggccg
cctggacgccccatcagcggtcatgggatggacagccgacctgccatggccatctttgaa
ctgctggactacatcgtaaatgagccacctcccaagctgcccagtggtgtattcagctcg
gacttccaggagtttgtgaataaatgcctcattaaaaacccagcagagcgagcagatctg
aagatgctgatgaaccacgccttcatcaagcgctccgagggggaggaggtggacttcgca
ggctggctgtgccgaatcctgcggctgaagcagcccagcacacccacgcgcactgcagtc
tga
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