Phodopus roborovskii (desert hamster): 127220248 Help Entry 127220248         CDS       T08852                                  Symbol Irs2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism prob  Phodopus roborovskii (desert hamster) Pathway prob04022   cGMP-PKG signaling pathway prob04068   FoxO signaling pathway prob04081   Hormone signaling prob04140   Autophagy - animal prob04152   AMPK signaling pathway prob04211   Longevity regulating pathway prob04213   Longevity regulating pathway - multiple species prob04910   Insulin signaling pathway prob04920   Adipocytokine signaling pathway prob04923   Regulation of lipolysis in adipocytes prob04930   Type II diabetes mellitus prob04931   Insulin resistance prob04932   Non-alcoholic fatty liver disease prob04935   Growth hormone synthesis, secretion and action prob05010   Alzheimer disease prob05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:prob00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     127220248 (Irs2)    04022 cGMP-PKG signaling pathway     127220248 (Irs2)    04152 AMPK signaling pathway     127220248 (Irs2)   09133 Signaling molecules and interaction    04081 Hormone signaling     127220248 (Irs2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     127220248 (Irs2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     127220248 (Irs2)    04923 Regulation of lipolysis in adipocytes     127220248 (Irs2)    04920 Adipocytokine signaling pathway     127220248 (Irs2)    04935 Growth hormone synthesis, secretion and action     127220248 (Irs2)   09149 Aging    04211 Longevity regulating pathway     127220248 (Irs2)    04213 Longevity regulating pathway - multiple species     127220248 (Irs2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     127220248 (Irs2)   09164 Neurodegenerative disease    05010 Alzheimer disease     127220248 (Irs2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     127220248 (Irs2)    04932 Non-alcoholic fatty liver disease     127220248 (Irs2)    04931 Insulin resistance     127220248 (Irs2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Mcp5_PH Motif Other DBs NCBI-GeneID:  127220248 NCBI-ProteinID:  XP_051037934 LinkDB All DBs Position Unknown AA seq 1335 aa AA seqDB search MASAPLPGPPAPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA AAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVISLDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRSGDGGSGTAATGGSCSASLPGVLGGSAGAAGCD DNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQ LMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFR PRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCISCRV RTASEGDGGAAAGAGAAGSRPMSVAGSPLSPGPVRVPLSRSHTLSGGCGGRPSKVTLAPA GGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGPHPHLPHPLHHPQGQRP SSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGY MSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMR ATFSCSSGRLCPSYPASSPKVAYHPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAAL RSGGPSSCKSDDYMPMSPTSVSAPKQIMQPRSAAAAAAAAAAALPPSGTAVPAPPSGAGR TFPVNGGSYKANSPAESSPEDSGYMRMWYGSKLSMENTDPKLLPNGDYLNMSPSEAGTAG TPPDFSAALRGSGEGLKGVPGHCYSSLPRSYKASYCSGDNDQYVLMSSPVGRILEEERLE PQTIPGNSQLAGTFGAAGGGHTQPHHSAVPSSMRPSGGTGRPEGFLGQRCRAVRPTRLSL EGLQTLPSMQEYPLPAEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPA SSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGTHSGDTVGSMDGLLSPEASSPYP PLPPRPSASPSSLQQPPAPGELYRLPPASAATSQGPAAGSSKSSEPGDNGDYTEMAFGVA ATPPQPIAAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADP QGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSGILGGSDEPPT SPGQAQPSPVVPPAPQARPWNPGQPGALIGCPGGSSSPMRRETSAGFQNGLNYIAIDVRD DQGSLSLTQPQHPQPGDKSSWGRTRSLGGLLSTVGSTGSSGVCGGPGTGALPSASTYASI DFLSHHLKEATVVKE NT seq 4008 nt NT seq  +upstreamnt  +downstreamnt atggccagcgcgccccttcctgggccccccgcgccggcgggtggggacggcccgaacctc aataacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcggccccggcacgggcggcgacgaggca gccgcggctggggggtcgccgccgcagccgccgcggctggagtactacgagagcgagaag aagtggaggagcaaggcgggcgcgccgaagcgagtgatctcgctcgactgctgcctgaac atcaacaagcgcgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggcggcggagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacttggtcagcgagggtcgctccggcgatggaggctcgggcaccgcggccaccggcggg tcctgcagcgcctctcttcctggcgtcctgggcggctcggcaggtgccgctggctgcgat gacaactacgggctcgtgacgcccgccacggcagtctaccgcgaggtgtggcaggtgaac ctgaagcccaagggcctgggccagagcaaaaacctgaccggtgtataccgcctttgcctg tctgcgcgcaccatcggcttcgtgaagctcaattgcgaacagccgtctgtgacgctgcag cttatgaacatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgc tcggccgtcaccggccccggcgagctgtggatgcaagccgacgactcggtagtggcgcag aacatccacgagactatcctggaggccatgaaggcacttaaggagctctttgagttccgg cctcgaagcaagagtcagtcgtccgggtcgtctgccacgcatcccatcagtgtgccgggc gcgcgccgccaccatcacctggtcaacctgccccctagccagaccggcctggtgcgccgc tcacgcacggacagccttgcggccaccccgccagcagccaaatgcatctcgtgtcgggtg cgtacagccagtgagggcgacggcggcgcagcagctggggctggggcagcgggaagcagg cctatgtcggtggccgggagccccctgagtcccgggccggtgcgcgtgcccctgagccgc tcgcacacactgagcggcggctgcggaggccgcccgagcaaagtgacgctggcgccggca gggggcgccctgcaacacagccgctccatgtccatgccggtggcgcactcgccgcctgca gccaccagccctggcagcctgtcctccagcagtggacacggctcgggctcctacccgctg ccccccggcccccacccgcatctgcctcatccgctacaccacccccaaggtcagcgtcca tccagtggtagtgcctcagcctccggctcccccagtgacccaggtttcatgtcacttgac gagtatggctccagccctggtgacctgagagccttcagtagccacaggagcaacacgccc gagtcaatcgcggagacccctccagccagggacggcagtgggggtgagctctatgggtac atgagcatggatagacccctgagccactgtggccgcccttaccgtagggtctctggggac ggggcccaggacctggacaggggactgaggaagaggacttattccctgaccacgcctgcc cgacagcggccagtaccccagccttcctctgcctccctggatgagtatactctcatgcgg gccaccttctcttgcagttcaggacgcctctgcccatcttaccccgcgtcctctcctaaa gtggcctaccacccttacccagaggactatggagacattgagattggctctcacaagagt tctagcagtaacttgggggcagatgatggctacatgcccatgacccctggggcggccctc aggagtggtggccccagtagctgcaaaagtgatgattatatgcccatgagccccaccagt gtgtctgctcccaagcagatcatgcagccgaggtcagcggcggcggcggcggcggcggcg gcggcagccttgcccccttcgggaacagcagtgccagcacccccttcaggggcaggcagg accttcccagtgaatggaggcagctacaaagctaattccccagctgagagctccccagag gatagcgggtacatgcgaatgtggtatggctccaagctgtccatggagaacacagaccca aagctcctccctaacggggactacctcaacatgtcccccagtgaggctggcaccgcgggc acgccacctgacttctcagcagccttgcgtggaagtggcgagggcctcaaaggtgtccct ggtcactgctacagctctttgcctcgctcttacaaggcttcctattgcagtggggacaac gaccagtatgtgctcatgagctcccctgtgggccgaatcttggaagaggagaggctagaa ccccagaccattcctgggaactcccagttggctggcacctttggggcagctgggggtggc catacccaacctcatcactcagcagtaccttcctccatgaggccaagtggcggcactggc cgccctgagggcttcctgggccagcgctgtcgggcagtacgacctacacgcttgtccttg gagggactgcagacccttcctagcatgcaagagtaccctctacctgcagagcccaagagt cctggcgagtacatcaacattgactttggtgaggcaggtacccgcctgtccccgcctgcc ccgccactgctggcatcagctgcttcatcctcttcgctgctttcggccagtagtcctgct tcttccctgggttcaggtaccccaggcaccagcagtgacagccggcagcgctccccgctc tctgactatatgaacttagacttcagttctcccaagtctcctaagcctggcacccatagt ggggacacagtgggctccatggatggccttctctctccagaggcctcatccccataccca ccgctacccccacgtccttctgcctccccctcttccctgcagcagccacctgccccagga gagctataccgcctgcctccagcatcagctgccacttcccagggacccgctgctggctcc tcaaagtcctcggagcctggggataatggtgactataccgagatggcctttggtgtggct gctaccccgccacaacctattgcggcacccccaaagccagaaggtgcccgagtgacaagt cccacatccggcttaaagcggctaagtctcatggatcaggtgtctggggtggaggccttt cttcaagtcagccagccccctgatccccaccggggtgccaaagtcatccgcgcagatcca cagggggggcgacgtcgccacagttcagagaccttctcctccactaccacagtcacccca gtgtccccctccttcgcccacaattccaagcgccacaattcggcctctgtggaaaacgtc tctctcaggaaaagtagtgaaggcagtggcatcctgggaggaagtgatgagccacccaca tccccgggacaagcgcagccctcaccggttgtgccaccagcgccacaggctaggccatgg aacccaggtcagcctggagctttgattggctgtccgggaggcagcagctctcccatgcgc agagagacctccgcgggtttccagaacggcctcaactacatcgccattgatgtgagggat gatcaagggtccttatcgctgactcagcctcagcatccacagccaggagacaagagctct tggggccggacccgtagccttgggggcctcctcagcaccgtcggaagtactggcagcagc ggagtgtgtgggggcccaggcactggagccttgccctctgccagcacctatgccagcatc gacttcttgtcccatcacttgaaggaagccacagttgtgaaagaatga

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