Entry Name Glucosinolate metabolism - Paraburkholderia terrae
Description Glucosinolates are biologically active secondary metabolites found in Brassicaceae (mustard family) and related families.These compounds are genetically variable within plant species and used as natural pesticides, such as against insect herbivores. All glucosinolates share a common structure consisting of a beta-thioglucose moiety, a sulfonated oxime moiety, and a variable aglycone side chain derived from an alpha-amino acid. Genes encoding glucosinolate biosynthetic enzymes have been identified in Arabidopsis thaliana by genetic polymorphisms and loss-of-function mutations. This map shows examples of side chain elongation in methionine-derived glucosinolates and the core pathway for biosynthesis of glucosinolates from amino acids.
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map Other DBs Organism Paraburkholderia terrae [GN:
pter ]
Gene Compound C01069 Benzyl-desulfoglucosinolate
C01180 4-Methylthio-2-oxobutanoic acid
C02937 Indole-3-acetaldehyde oxime
C03719 Phenylacetothiohydroximate
C08422 4-Hydroxyglucobrassicin
C08423 4-Methoxyglucobrassicin
C16516 Indolylmethylthiohydroximate
C16517 Indolylmethyl-desulfoglucosinolate
C17210 2-(2'-Methylthio)ethylmalic acid
C17211 2-Oxo-5-methylthiopentanoic acid
C17212 3-(2'-Methylthio)ethylmalic acid
C17214 2-(3'-Methylthio)propylmalic acid
C17215 3-(3'-Methylthio)propylmalic acid
C17216 2-Oxo-6-methylthiohexanoic acid
C17241 4-Methylthiobutanaldoxime
C17243 4-Methylthiobutylthiohydroximate
C17244 3-Methylthiopropyl-desulfoglucosinolate
C17245 5-Methylthiopentanaldoxime
C17248 4-Methylthiobutyl-desulfoglucosinolate
C21620 S-[(E)-N-Hydroxy(indol-3-yl)acetimidoyl]-L-glutathione
C21622 S-[(Z)-N-Hydroxy(phenyl)acetimidoyl]-L-glutathione
C21663 (E)-1-(L-Cysteinylglycine-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethane-1-imine
C21667 (Z)-1-(L-Cysteinylglycine-S-yl)-N-hydroxy-2-phenylethane-1-imine
C22630 N-(Sulfonatooxy)alkanimidothioate
C22640 Phenyl-N-(sulfonatooxy)methanimidothioate
C22641 N-(Sulfonatooxy)prop-2-enimidothioate
C22643 2-(Thiiran-2-yl)acetonitrile
C23230 5-Methylthiopentylthiohydroximate
C23234 S-Glutathione-thiohydroximate
C23235 (E)-1-(Glutathione-S-yl)-omega-(methylthio)butylhydroximate
C23236 (E)-1-(Glutathione-S-yl)-omega-(methylthio)pentylhydroximate
C23237 (E)-1-(L-Cysteinylglycine-S-yl)-N-hydroxy-omega-(methylsulfanyl)butan-1-imine
C23238 (E)-1-(L-Cysteinylglycine-S-yl)-N-hydroxy-omega-(methylsulfanyl)pentan-1-imine
C23239 S-Cysteinylglycine-thiohydroximate
C23241 Indolyl-N-(sulfonatooxy)methanimidothioate
Reference Authors Wittstock U, Halkier BA
Title Glucosinolate research in the Arabidopsis era.
Journal Reference Authors Windsor AJ, Reichelt M, Figuth A, Svatos A, Kroymann J, Kliebenstein DJ, Gershenzon J, Mitchell-Olds T
Title Geographic and evolutionary diversification of glucosinolates among near relatives of Arabidopsis thaliana (Brassicaceae).
Journal Reference Authors Textor S, Bartram S, Kroymann J, Falk KL, Hick A, Pickett JA, Gershenzon J
Title Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle.
Journal Reference Authors Piotrowski M, Schemenewitz A, Lopukhina A, Muller A, Janowitz T, Weiler EW, Oecking C
Title Desulfoglucosinolate sulfotransferases from Arabidopsis thaliana catalyze the final step in the biosynthesis of the glucosinolate core structure.
Journal Reference Authors Mikkelsen MD, Halkier BA
Title Metabolic engineering of valine- and isoleucine-derived glucosinolates in Arabidopsis expressing CYP79D2 from Cassava.
Journal Reference Authors Chen S, Andreasson E.
Title Update on glucosinolate metabolism and transport.
Journal Reference Authors Zang YX, Kim HU, Kim JA, Lim MH, Jin M, Lee SC, Kwon SJ, Lee SI, Hong JK, Park TH, Mun JH, Seol YJ, Hong SB, Park BS
Title Genome-wide identification of glucosinolate synthesis genes in Brassica rapa.
Journal Reference Authors Sonderby IE, Geu-Flores F, Halkier BA.
Title Biosynthesis of glucosinolates--gene discovery and beyond.
Journal Reference Authors Pfalz M, Mikkelsen MD, Bednarek P, Olsen CE, Halkier BA, Kroymann J
Title Metabolic engineering in Nicotiana benthamiana reveals key enzyme functions in Arabidopsis indole glucosinolate modification.
Journal Reference Authors Hansen BG, Kerwin RE, Ober JA, Lambrix VM, Mitchell-Olds T, Gershenzon J, Halkier BA, Kliebenstein DJ.
Title A novel 2-oxoacid-dependent dioxygenase involved in the formation of the goiterogenic 2-hydroxybut-3-enyl glucosinolate and generalist insect resistance in Arabidopsis,
Journal Reference Authors Burow M, Losansky A, Muller R, Plock A, Kliebenstein DJ, Wittstock U.
Title The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis.
Journal Reference Authors Kuchernig JC, Backenkohler A, Lubbecke M, Burow M, Wittstock U.
Title A thiocyanate-forming protein generates multiple products upon allylglucosinolate breakdown in Thlaspi arvense.
Journal Reference Authors Watanabe H, Usami R, Kishino S, Osada K, Aoki Y, Morisaka H, Takahashi M, Izumi Y, Bamba T, Aoki W, Suganuma H, Ogawa J.
Title Enzyme systems involved in glucosinolate metabolism in Companilactobacillus farciminis KB1089.
Journal Reference Authors van den Bosch TJM, Tan K, Joachimiak A, Welte CU
Title Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria.
Journal Related pter00400 Phenylalanine, tyrosine and tryptophan biosynthesis
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