Panthera tigris altaica (Amur tiger): 102952137 Help Entry 102952137         CDS       T02988                                  Symbol PLCG1 Name (RefSeq) phospholipase C gamma 1   KO K01116   phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg00562   Inositol phosphate metabolism ptg01100   Metabolic pathways ptg01521   EGFR tyrosine kinase inhibitor resistance ptg04012   ErbB signaling pathway ptg04014   Ras signaling pathway ptg04015   Rap1 signaling pathway ptg04020   Calcium signaling pathway ptg04062   Chemokine signaling pathway ptg04064   NF-kappa B signaling pathway ptg04066   HIF-1 signaling pathway ptg04070   Phosphatidylinositol signaling system ptg04072   Phospholipase D signaling pathway ptg04360   Axon guidance ptg04370   VEGF signaling pathway ptg04613   Neutrophil extracellular trap formation ptg04650   Natural killer cell mediated cytotoxicity ptg04658   Th1 and Th2 cell differentiation ptg04659   Th17 cell differentiation ptg04660   T cell receptor signaling pathway ptg04664   Fc epsilon RI signaling pathway ptg04666   Fc gamma R-mediated phagocytosis ptg04670   Leukocyte transendothelial migration ptg04722   Neurotrophin signaling pathway ptg04750   Inflammatory mediator regulation of TRP channels ptg04919   Thyroid hormone signaling pathway ptg04933   AGE-RAGE signaling pathway in diabetic complications ptg04935   Growth hormone synthesis, secretion and action ptg05012   Parkinson disease ptg05022   Pathways of neurodegeneration - multiple diseases ptg05135   Yersinia infection ptg05167   Kaposi sarcoma-associated herpesvirus infection ptg05170   Human immunodeficiency virus 1 infection ptg05171   Coronavirus disease - COVID-19 ptg05200   Pathways in cancer ptg05205   Proteoglycans in cancer ptg05206   MicroRNAs in cancer ptg05214   Glioma ptg05223   Non-small cell lung cancer ptg05225   Hepatocellular carcinoma ptg05231   Choline metabolism in cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ptg05417   Lipid and atherosclerosis Module ptg_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:ptg00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102952137 (PLCG1)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102952137 (PLCG1)    04014 Ras signaling pathway     102952137 (PLCG1)    04015 Rap1 signaling pathway     102952137 (PLCG1)    04370 VEGF signaling pathway     102952137 (PLCG1)    04064 NF-kappa B signaling pathway     102952137 (PLCG1)    04066 HIF-1 signaling pathway     102952137 (PLCG1)    04020 Calcium signaling pathway     102952137 (PLCG1)    04070 Phosphatidylinositol signaling system     102952137 (PLCG1)    04072 Phospholipase D signaling pathway     102952137 (PLCG1)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102952137 (PLCG1)    04650 Natural killer cell mediated cytotoxicity     102952137 (PLCG1)    04660 T cell receptor signaling pathway     102952137 (PLCG1)    04658 Th1 and Th2 cell differentiation     102952137 (PLCG1)    04659 Th17 cell differentiation     102952137 (PLCG1)    04664 Fc epsilon RI signaling pathway     102952137 (PLCG1)    04666 Fc gamma R-mediated phagocytosis     102952137 (PLCG1)    04670 Leukocyte transendothelial migration     102952137 (PLCG1)    04062 Chemokine signaling pathway     102952137 (PLCG1)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102952137 (PLCG1)    04919 Thyroid hormone signaling pathway     102952137 (PLCG1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102952137 (PLCG1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102952137 (PLCG1)   09158 Development and regeneration    04360 Axon guidance     102952137 (PLCG1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102952137 (PLCG1)    05206 MicroRNAs in cancer     102952137 (PLCG1)    05205 Proteoglycans in cancer     102952137 (PLCG1)    05231 Choline metabolism in cancer     102952137 (PLCG1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102952137 (PLCG1)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102952137 (PLCG1)    05214 Glioma     102952137 (PLCG1)    05223 Non-small cell lung cancer     102952137 (PLCG1)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102952137 (PLCG1)    05171 Coronavirus disease - COVID-19     102952137 (PLCG1)    05167 Kaposi sarcoma-associated herpesvirus infection     102952137 (PLCG1)   09171 Infectious disease: bacterial    05135 Yersinia infection     102952137 (PLCG1)   09164 Neurodegenerative disease    05012 Parkinson disease     102952137 (PLCG1)    05022 Pathways of neurodegeneration - multiple diseases     102952137 (PLCG1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102952137 (PLCG1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102952137 (PLCG1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102952137 (PLCG1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ptg04131]     102952137 (PLCG1) Enzymes [BR:ptg01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102952137 (PLCG1) Membrane trafficking [BR:ptg04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102952137 (PLCG1)  Endocytosis   Macropinocytosis    Phospholipase C     102952137 (PLCG1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 SH3_1 C2 PH EF-hand_PLCG1 SH3_9 SH3_2 GDPD EF-hand_6 PH_9 EF-hand_7 Motif Other DBs NCBI-GeneID:  102952137 NCBI-ProteinID:  XP_007077781 LinkDB All DBs Position Un AA seq 1179 aa AA seqDB search MEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRI SAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPF LEASALRAVERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPY FFLDEFVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEA YARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAY EEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDE EEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFV GDYTLSFWRNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMR LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKI KHCRVQQEGQTVVLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYG ALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGD YGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNN RLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALE LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDE AFDPFDKSSLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVV DNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKAGYRAVPL KNNYSEDLELASLLIKIEVFPAKQENGDVSPFSSMSLRERGSDASGQLFHGRGREGSFEA RYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL NT seq 3540 nt NT seq  +upstreamnt  +downstreamnt atggagttccgcctgaagaccctgagcctgcaagctacatctgaggatgaagtgaacatg tggatcaaggggttaacttggctgatggaagatacattgcaggcagccacacctctgcag attgaaaggtggctgaggaagcagttctattcggtggatcggaatcgtgaggatcgtata tcagccaaggacctgaagaacatgctgtcccaggtcaactaccgggtccccaacatgcgc ttcctccgagagcgtctgacggacctggagcagcgcagcagtgacatcacctatgggcag tttgctcagctgtaccgcagcctcatgtacagcgcccagaagacgatggacctccccttc ttggaagccagtgccctgagggcggtggagcggccggagctctgtcgcgtgtcccttcct gagttccagcagttcctccttgagtaccagggggagctgtgggccgtcgaccggcttcag gtgcaagaatttatgctcagctttctccgagaccccttgcgagagattgaagagccgtac ttcttcctggatgagtttgtcaccttcctgttctccaaagagaacagtgtgtggaactca cagctggatgcagtgtgcccagaaaccatgaacaaccccctctcccactactggatctcc tcctcccacaacacatacctgaccggggaccagttctccagcgagtcctccctggaagcc tacgctcgctgcctgcggatgggctgtcgctgcattgagttggactgctgggatggccca gatgggatgccagtcatttaccatggacacacccttaccaccaagatcaagttctcagac gtcctgcacactatcaaggagcacgcctttgtggcctcagagtacccggtcatcctgtcc attgaggaccattgcagcattgcccagcagaggaacatggcacagtacttcaagaaggtg cttggggacacactccttaccaagcctgtggacatcgctgccgatggactcccctcaccc aaccagctcaagaggaagatccttatcaagcacaagaagctggcagagggcagtgcctat gaagaggtgcctacatcagtgatgtactccgagaacgatatcagcaactccatcaagaat ggcatcctctacctggaggaccctgtgaaccacgagtggtatccccactacttcgtcctg accagcagcaaaatctactactctgaggagacgagcagtgaccagggcaacgaggatgag gaggagcccaaggaggccagtggcagcacagagctgcactccagtgagaaatggttccac gggaagctcggggcaggacgggatgggcggcacatcgctgagcgcctgcttaccgagtac tgcattgagaccggggcccctgatggctccttcctcgtgcgagagagcgagaccttcgtg ggcgactataccctctctttctggcggaatgggaaagtccagcactgccggatccactct cggcaggacgctggggcccccaagttcttcttgacagacaacctggtctttgactcactc tatgacctcatcacacactaccagcaggtgcccctacgctgcaacgaatttgagatgcgc ctctcagagccagtcccgcagaccaatgcccacgagagcaaagagtggtaccatgccagc ctgaccagagctcaggctgagcacatgctgatgcgcgtcccccgggatggggccttcctg gtgaggaaacggaatgagcccaactcctacgccatctccttccgggctgagggcaagatc aagcattgccgcgtccagcaggagggccagacggtggtcctgggcaactccgagttcgac agcctcgtggacctcatcagctactatgagaagcacccactgtaccgcaagatgaagctg cgctatcccatcaacgaggaggcgctggagaagatcggcacagctgagccagactacggg gccctgtatgagggccgcaacccaggcttctatgtggaggcgaatcctatgccaactttc aagtgtgcagtcaaagcactctttgactacaaggcccagagagaggatgagctgactttc actaagagcgccatcatccagaacgtggagaagcaagaaggtggctggtggcggggggac tatggtgggaagaagcagctgtggttcccgtcaaactacgtggaagagatggtcagcccc gcagccctggagcctgagagggagcacttggacgagaacagccccttgggggatttgctc cggggggtcttggatgtgccagcttgtcagattgccatccgtcccgagggcaagaacaac cggctgttcgtcttctccatcagtatggcttccgtggcgcactggtccctggatgtcgct gctgactcacaagaggagctgcaggactgggtgaagaagatccgagaagtggcccagacg gcagacgccaggctcacggagggcaagatgatggagcggaggaagaagatcgccctggag ctctccgagctggttgtctactgtcggcctgttcccttcgatgaagagaagattggcaca gaacgtgcctgctaccgggacatgtcatccttcccggaaaccaaggctgagaaatacgtg aacaaggccaaaggcaagaagtttctccagtacaaccggctgcagctctcccgcatctac cccaagggccagcggctggactcttccaattacgaccccttgcccatgtggatctgtggc agtcagctcgtggctctcaacttccagaccccagacaagcctatgcagatgaaccaggcc ctcttcatggccggtggccactgtggctacgtgctgcagccgagcaccatgcgggatgag gcctttgatccctttgacaagagcagcctccgaggcctggagccatatgccatctgcatt gaggtgctgggggcccggcacctgccgaagaatggccgaggcatcgtgtgtccttttgtg gagattgaggtggccggagcagagtatgacagcatcaaacagaagacagaatttgtggtg gacaacggactgaaccctgtttggcccgccaagcccttccacttccagatcagtaacccg gaattcgccttcctgcgctttgtggtgtatgaggaggacatgttcagtgaccagaacttc ctggctcaggccaccttcccagtgaagggcttgaaggcaggatacagagccgtgcctttg aagaacaactacagtgaggacctggagctggcctccctgctcatcaagatcgaagttttc cctgccaagcaggagaacggtgacgtcagtcccttcagtagtatgtctctgcgggagcgg ggctccgatgcctcgggccagctgttccatggccggggccgggaaggttcctttgaagcc cgctaccagcagccgtttgaggactttcgtatctcccaagagcatctggcagaccatttt gacagtcgggaacggagggccccacgaaggactcgggtcaacggggacaaccgcctctag

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