KEGG   Panthera tigris altaica (Amur tiger): 102969936
Entry
102969936         CDS       T02988                                 
Symbol
TPH1
Name
(RefSeq) tryptophan hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00380  Tryptophan metabolism
ptg00790  Folate biosynthesis
ptg01100  Metabolic pathways
ptg04726  Serotonergic synapse
Module
ptg_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    102969936 (TPH1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    102969936 (TPH1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    102969936 (TPH1)
Enzymes [BR:ptg01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     102969936 (TPH1)
SSDB
Motif
Pfam: Biopterin_H ACT TH_ACT ACT_4 zf-C2HE GmrSD_N
Other DBs
NCBI-GeneID: 102969936
NCBI-ProteinID: XP_007098492
UniProt: A0A8C9KKT2
LinkDB
Position
Un
AA seq 444 aa
MIEDNKENKDHSLERGRATLIFSLKNEVGGLIKALKIFQEKHVSLLHIESRKSKRRNSEF
EIFIDCDINREQLNDIFHLLKSYTNVLSVNPPDNFTVKEDSMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHSLSGHAKVKPFDPKITC
KQECRITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSKQLSI
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgattgaagacaataaggaaaataaagaccattccctagaaagaggaagggcaactctc
attttttccttgaagaatgaagttggtggactaataaaagcactgaaaatcttccaggag
aaacatgtgagcctgttacatattgagtcccgaaaatcaaagagaagaaactcagaattt
gagatctttattgactgtgatatcaacagagaacaattgaatgatatttttcatctgttg
aagtcctacactaacgttctctctgtgaatccaccagataattttactgtgaaagaagac
agtatggaaactgttccttggtttccaaaaaagatttctgacctggatcattgtgccaac
agagttctgatgtatggatctgaactggatgcagaccatcctggcttcaaagacaatgtc
taccgtaaaagacgaaagtattttgcagacttggctatgaactataaacatggagacccc
attcccaaggttgaattcactgaagaggagattaagacctggggaaccgtgttccgagag
ctgaacaaactttacccaacccatgcctgcagagagtatctcaaaaacttacctttgctt
tctaaatattgtggataccgggaagataatatcccacaattggaagatgtctcaaacttt
ttaaaagagcgcacaggtttttccatccgtcctgtggctggttacttatcaccaagagat
ttcttatcaggtttagcctttcgagtttttcactgcacacagtatgtgagacacagttca
gaccctctctataccccagagccagatacctgccatgaactcttaggtcatgtccccctg
ttggctgaacctagttttgctcaattctcccaagaaattggcctggcttctcttggagct
tcagaggaggctgttcaaaaactggcaacgtgctactttttcactgtggagtttggtctc
tgtaaacaagatgggcagttgcgagtctttggtgctggattactttcttcgatcagtgaa
cttaaacattcactttctggacatgccaaagtaaagccctttgatcccaagattacctgc
aaacaggagtgtcgcatcacaacttttcaggatgtctactttgtatctgaaagctttgaa
gatgcaaaagagaagatgagagaatttaccaaaacaattaagcgtccgtttggagtaaag
tataatccatatacacggagtattcagatcctgaaagacaccaagagcataaccagtgcc
atgaatgaactgcagcatgatcttgatgttgtcagtgatgcccttgcgaaggtcagcaag
cagctgagcatctga

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