Panthera tigris altaica (Amur tiger): 102972446 Help Entry 102972446         CDS       T02988                                  Symbol PTEN Name (RefSeq) phosphatase and tensin homolog   KO K01110   phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg00562   Inositol phosphate metabolism ptg01100   Metabolic pathways ptg01521   EGFR tyrosine kinase inhibitor resistance ptg04068   FoxO signaling pathway ptg04070   Phosphatidylinositol signaling system ptg04071   Sphingolipid signaling pathway ptg04115   p53 signaling pathway ptg04140   Autophagy - animal ptg04150   mTOR signaling pathway ptg04151   PI3K-Akt signaling pathway ptg04218   Cellular senescence ptg04510   Focal adhesion ptg04931   Insulin resistance ptg05165   Human papillomavirus infection ptg05166   Human T-cell leukemia virus 1 infection ptg05200   Pathways in cancer ptg05206   MicroRNAs in cancer ptg05208   Chemical carcinogenesis - reactive oxygen species ptg05213   Endometrial cancer ptg05214   Glioma ptg05215   Prostate cancer ptg05218   Melanoma ptg05222   Small cell lung cancer ptg05224   Breast cancer ptg05225   Hepatocellular carcinoma ptg05230   Central carbon metabolism in cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ptg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ptg00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102972446 (PTEN)  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     102972446 (PTEN)    04070 Phosphatidylinositol signaling system     102972446 (PTEN)    04071 Sphingolipid signaling pathway     102972446 (PTEN)    04151 PI3K-Akt signaling pathway     102972446 (PTEN)    04150 mTOR signaling pathway     102972446 (PTEN)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102972446 (PTEN)   09143 Cell growth and death    04115 p53 signaling pathway     102972446 (PTEN)    04218 Cellular senescence     102972446 (PTEN)   09144 Cellular community - eukaryotes    04510 Focal adhesion     102972446 (PTEN)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102972446 (PTEN)    05206 MicroRNAs in cancer     102972446 (PTEN)    05208 Chemical carcinogenesis - reactive oxygen species     102972446 (PTEN)    05230 Central carbon metabolism in cancer     102972446 (PTEN)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102972446 (PTEN)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102972446 (PTEN)    05214 Glioma     102972446 (PTEN)    05218 Melanoma     102972446 (PTEN)    05215 Prostate cancer     102972446 (PTEN)    05213 Endometrial cancer     102972446 (PTEN)    05224 Breast cancer     102972446 (PTEN)    05222 Small cell lung cancer     102972446 (PTEN)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102972446 (PTEN)    05165 Human papillomavirus infection     102972446 (PTEN)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102972446 (PTEN)   09167 Endocrine and metabolic disease    04931 Insulin resistance     102972446 (PTEN)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102972446 (PTEN)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ptg01009]     102972446 (PTEN) Enzymes [BR:ptg01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.3  Phosphoric-monoester hydrolases     3.1.3.16  protein-serine/threonine phosphatase      102972446 (PTEN)     3.1.3.48  protein-tyrosine-phosphatase      102972446 (PTEN)     3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase      102972446 (PTEN) Protein phosphatases and associated proteins [BR:ptg01009]  Protein tyrosine phosphatases (PTPs)   Class I PTPs (Dual specificity phosphatases)    Phosphatase and Tensin homologs (PTEN)     102972446 (PTEN) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PTEN_C2 Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256 Motif Other DBs NCBI-GeneID:  102972446 NCBI-ProteinID:  XP_007079321 UniProt:  A0A8C9KJD9 LinkDB All DBs Position Un AA seq 403 aa AA seqDB search MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV NT seq 1212 nt NT seq  +upstreamnt  +downstreamnt atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaggaggatgga ttcgacttagacttgacctatatttatccaaacattattgctatggggtttcctgcagaa agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag cataaaaaccattacaagatatacaatctgtgtgctgaaagacattatgataccgccaaa tttaactgcagagttgcacagtatccttttgaagaccataacccaccgcagctggaactt atcaaacccttttgtgaagatcttgaccaatggctcagtgaagatgacaatcatgttgca gcaattcactgtaaagctggaaagggacgaactggtgtaatgatttgtgcatatttattg catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc agagacaaaaagggagtaactattcccagtcagaggcgctatgtttattattatagctac ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagctc aaggtgaagatctattcctccaattcgggacccacacgacgggaagacaagttcatgtac ttcgagttccctcagccgctgcctgtgtgtggtgacatcaaagtagagttcttccacaaa cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatt gatagtatttgcagtatagagcgtgcagataatgacaaggaatatctagtactcacttta acaaaaaatgatctcgacaaagcaaataaagacaaggccaaccgctacttttctccaaat tttaaggtgaagctgtacttcacaaaaacagtagaggagccatcaaatccagaggctagc agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt acaaaagtctga

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