KEGG   Pan troglodytes (chimpanzee): 100614256
Entry
100614256         CDS       T01005                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr01521  EGFR tyrosine kinase inhibitor resistance
ptr01522  Endocrine resistance
ptr04010  MAPK signaling pathway
ptr04012  ErbB signaling pathway
ptr04068  FoxO signaling pathway
ptr04270  Vascular smooth muscle contraction
ptr04650  Natural killer cell mediated cytotoxicity
ptr04720  Long-term potentiation
ptr04726  Serotonergic synapse
ptr04730  Long-term depression
ptr04810  Regulation of actin cytoskeleton
ptr04910  Insulin signaling pathway
ptr04914  Progesterone-mediated oocyte maturation
ptr04928  Parathyroid hormone synthesis, secretion and action
ptr05010  Alzheimer disease
ptr05022  Pathways of neurodegeneration - multiple diseases
ptr05034  Alcoholism
ptr05160  Hepatitis C
ptr05161  Hepatitis B
ptr05200  Pathways in cancer
ptr05205  Proteoglycans in cancer
ptr05208  Chemical carcinogenesis - reactive oxygen species
ptr05210  Colorectal cancer
ptr05211  Renal cell carcinoma
ptr05212  Pancreatic cancer
ptr05213  Endometrial cancer
ptr05214  Glioma
ptr05215  Prostate cancer
ptr05218  Melanoma
ptr05219  Bladder cancer
ptr05220  Chronic myeloid leukemia
ptr05221  Acute myeloid leukemia
ptr05223  Non-small cell lung cancer
ptr05224  Breast cancer
ptr05225  Hepatocellular carcinoma
ptr05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100614256 (ARAF)
   04012 ErbB signaling pathway
    100614256 (ARAF)
   04068 FoxO signaling pathway
    100614256 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100614256 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100614256 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100614256 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100614256 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100614256 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100614256 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100614256 (ARAF)
   04720 Long-term potentiation
    100614256 (ARAF)
   04730 Long-term depression
    100614256 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100614256 (ARAF)
   05205 Proteoglycans in cancer
    100614256 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100614256 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100614256 (ARAF)
   05212 Pancreatic cancer
    100614256 (ARAF)
   05225 Hepatocellular carcinoma
    100614256 (ARAF)
   05226 Gastric cancer
    100614256 (ARAF)
   05214 Glioma
    100614256 (ARAF)
   05221 Acute myeloid leukemia
    100614256 (ARAF)
   05220 Chronic myeloid leukemia
    100614256 (ARAF)
   05218 Melanoma
    100614256 (ARAF)
   05211 Renal cell carcinoma
    100614256 (ARAF)
   05219 Bladder cancer
    100614256 (ARAF)
   05215 Prostate cancer
    100614256 (ARAF)
   05213 Endometrial cancer
    100614256 (ARAF)
   05224 Breast cancer
    100614256 (ARAF)
   05223 Non-small cell lung cancer
    100614256 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100614256 (ARAF)
   05160 Hepatitis C
    100614256 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100614256 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100614256 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100614256 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100614256 (ARAF)
   01522 Endocrine resistance
    100614256 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ptr01001]
    100614256 (ARAF)
Enzymes [BR:ptr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100614256 (ARAF)
Protein kinases [BR:ptr01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100614256 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100614256
NCBI-ProteinID: XP_016798738
Ensembl: ENSPTRG00000021846
LinkDB
Position
X:47998292..48009020
AA seq 611 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSLSPGSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLT
GQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq 1836 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcctttcccctggcagcccccgcacccagcactgtgacccggag
cacttccccttccctgccccagccaatgcccccctacagcgcatccgctccacgtccact
cccaacgtccatatggtcagcaccacggcccccatggactccaacctcatccagctcact
ggccagagtttcagcactgatgctgccggtagtagaggaggtagtgatggaaccccccgg
gggagccccagcccagccagcgtgtcctcggggaggaagtccccacattccaagtcacca
gcagagcagcgcgagcggaagtccttggccgatgacaagaagaaagtgaagaacctgggg
taccgggactcaggctattactgggaggtaccacccagtgaggtgcagctgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtg
aaggtgctcaaggtgtcccagcccacagctgagcaggcccaggctttcaagaatgagatg
caggtgctcaggaagacgagacatgtcaacatcttgctgtttatgggcttcatgacccgg
ccgggatttgccatcatcacacagtggtgtgagggctccagcctctaccatcacctgcat
gtggccgacacacgcttcgacatggtccagctcatcgacgtggcccggcagactgcccag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctacatgaggggctcacggtgaagatcggtgactttggcttggccacagtgaagact
cgatggagcggggcccagcccttggagcagccctcaggatctgtgctgtggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcagacgtctatgcctac
ggggttgtgctctacgagcttatgactggctcactgccttacagccacattggctgccgt
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgggag
gagcggcccctcttcccccagatcctggccacaattgagctgctgcaacggtcactcccc
aagattgagcggagtgcctcggaaccctccttgcaccgcacccaggccgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag

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