Pan troglodytes (chimpanzee): 454268
Help
Entry
454268 CDS
T01005
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr00562
Inositol phosphate metabolism
ptr01100
Metabolic pathways
ptr01521
EGFR tyrosine kinase inhibitor resistance
ptr04012
ErbB signaling pathway
ptr04014
Ras signaling pathway
ptr04020
Calcium signaling pathway
ptr04062
Chemokine signaling pathway
ptr04064
NF-kappa B signaling pathway
ptr04066
HIF-1 signaling pathway
ptr04070
Phosphatidylinositol signaling system
ptr04072
Phospholipase D signaling pathway
ptr04360
Axon guidance
ptr04370
VEGF signaling pathway
ptr04380
Osteoclast differentiation
ptr04611
Platelet activation
ptr04613
Neutrophil extracellular trap formation
ptr04625
C-type lectin receptor signaling pathway
ptr04650
Natural killer cell mediated cytotoxicity
ptr04662
B cell receptor signaling pathway
ptr04664
Fc epsilon RI signaling pathway
ptr04666
Fc gamma R-mediated phagocytosis
ptr04670
Leukocyte transendothelial migration
ptr04722
Neurotrophin signaling pathway
ptr04750
Inflammatory mediator regulation of TRP channels
ptr04919
Thyroid hormone signaling pathway
ptr04933
AGE-RAGE signaling pathway in diabetic complications
ptr04935
Growth hormone synthesis, secretion and action
ptr05167
Kaposi sarcoma-associated herpesvirus infection
ptr05169
Epstein-Barr virus infection
ptr05170
Human immunodeficiency virus 1 infection
ptr05171
Coronavirus disease - COVID-19
ptr05200
Pathways in cancer
ptr05205
Proteoglycans in cancer
ptr05206
MicroRNAs in cancer
ptr05214
Glioma
ptr05223
Non-small cell lung cancer
ptr05225
Hepatocellular carcinoma
Module
ptr_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
454268 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
454268 (PLCG2)
04014 Ras signaling pathway
454268 (PLCG2)
04370 VEGF signaling pathway
454268 (PLCG2)
04064 NF-kappa B signaling pathway
454268 (PLCG2)
04066 HIF-1 signaling pathway
454268 (PLCG2)
04020 Calcium signaling pathway
454268 (PLCG2)
04070 Phosphatidylinositol signaling system
454268 (PLCG2)
04072 Phospholipase D signaling pathway
454268 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
454268 (PLCG2)
04613 Neutrophil extracellular trap formation
454268 (PLCG2)
04625 C-type lectin receptor signaling pathway
454268 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
454268 (PLCG2)
04662 B cell receptor signaling pathway
454268 (PLCG2)
04664 Fc epsilon RI signaling pathway
454268 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
454268 (PLCG2)
04670 Leukocyte transendothelial migration
454268 (PLCG2)
04062 Chemokine signaling pathway
454268 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
454268 (PLCG2)
04919 Thyroid hormone signaling pathway
454268 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
454268 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
454268 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
454268 (PLCG2)
04380 Osteoclast differentiation
454268 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
454268 (PLCG2)
05206 MicroRNAs in cancer
454268 (PLCG2)
05205 Proteoglycans in cancer
454268 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
454268 (PLCG2)
05214 Glioma
454268 (PLCG2)
05223 Non-small cell lung cancer
454268 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
454268 (PLCG2)
05171 Coronavirus disease - COVID-19
454268 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
454268 (PLCG2)
05169 Epstein-Barr virus infection
454268 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
454268 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
454268 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ptr04131
]
454268 (PLCG2)
Enzymes [BR:
ptr01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
454268 (PLCG2)
Membrane trafficking [BR:
ptr04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
454268 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
454268 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
SH3_9
PH
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
454268
NCBI-ProteinID:
XP_001148089
Ensembl:
ENSPTRG00000008395
VGNC:
8991
UniProt:
A0A2I3SHP7
LinkDB
All DBs
Position
18:79941837..80120163
Genome browser
AA seq
1265 aa
AA seq
DB search
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcgg
agaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagttcgtcctcagcacgctcagcttggcggctgactctaaagaggatgcagtt
aactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcg
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatc
aagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgctgacgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacatggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggat
ataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagaca
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgtggagaggcagaggacatgctg
atgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctat
gccatcacgttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgacgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcatcagacagaagcccgttgacctcctgaagtacaatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacgccagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagat
atgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag
DBGET
integrated database retrieval system
