Pan troglodytes (chimpanzee): 457846 Help Entry 457846            CDS       T01005                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X22   KO K04962   ryanodine receptor 2 Organism ptr  Pan troglodytes (chimpanzee) Pathway ptr04020   Calcium signaling pathway ptr04024   cAMP signaling pathway ptr04260   Cardiac muscle contraction ptr04261   Adrenergic signaling in cardiomyocytes ptr04371   Apelin signaling pathway ptr04713   Circadian entrainment ptr04911   Insulin secretion ptr04921   Oxytocin signaling pathway ptr04972   Pancreatic secretion ptr05020   Prion disease ptr05022   Pathways of neurodegeneration - multiple diseases ptr05410   Hypertrophic cardiomyopathy ptr05412   Arrhythmogenic right ventricular cardiomyopathy ptr05414   Dilated cardiomyopathy ptr05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ptr00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     457846 (RYR2)    04020 Calcium signaling pathway     457846 (RYR2)    04024 cAMP signaling pathway     457846 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     457846 (RYR2)    04921 Oxytocin signaling pathway     457846 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     457846 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     457846 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     457846 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     457846 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     457846 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     457846 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     457846 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     457846 (RYR2)    05414 Dilated cardiomyopathy     457846 (RYR2)    05415 Diabetic cardiomyopathy     457846 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ptr04040]     457846 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ptr04990]     457846 (RYR2) Ion channels [BR:ptr04040]  Voltage-gated cation channels   Ryanodine receptor    457846 (RYR2) Domain-containing proteins not elsewhere classified [BR:ptr04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    457846 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  457846 NCBI-ProteinID:  XP_016797063 Ensembl:  ENSPTRG00000002149 VGNC:  6990 LinkDB All DBs Position 1:complement(11341682..12130593) Genome browser AA seq 4953 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGTAQGGGHRTLLYGHAILLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDK NLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWL TYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRG LDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEE GMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKK WYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHL WSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVV SFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLG PTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNK RQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQL TSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRL VPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHARAEVCSGTGERFRIFRAEKT YAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYG RSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVG RMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRI DGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKND LEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRT KPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQY DTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDA ASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKS EHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIP EENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKY MPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGL STSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGT TEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDA KLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFV AKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIR DQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSK KSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSV EDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVME VMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPA MRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPV EGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKI AEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGK GEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLD RVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAP LFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLV FDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALS QKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITI PEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRW PIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTL SRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIL KFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEH FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGV LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTME NLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRI LTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERA ALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHG PENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQ LLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLL IRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIT DTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNICAPGDQELIALAK NRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERVLD IANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYE KSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEED FLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTIS ASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDL NAFERQNKAEGLGMVTEEGSASHFESHRLRTGEKVLQDDEFTCDLFRFLQLLCEGHNSDF QNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAK QVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDL QKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKE YDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDI GFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISE SSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNGR SANKEESEKERPEEQGPRMAFFSILTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKM TVKDMVTAFFSSYWSIFMTLLHFVASVFRGFSRIICSLLLGGSLVEGAKKIKVAELLANM PDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLI PHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAK EDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAIN FILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPTLRI LAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSL SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14862 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaagacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcaccgcaaccatccacaaagaacaacagaagctatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttccaattccaagaatgtgccccca gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggcgctgcaggag atgctggctaacaccgtggagaaatcagaagggactgctcaaggtggtggtcatcgaaca ctcctctacggacatgccatattgctgcgccattcctatagtggcatgtatctgtgctgc ctgtccacctcccggtcttcaactgataagctggcttttgatgttggcttgcaagaggac accacaggggaggcttgttggtggaccatacaccctgcctctaagcagcgatcagaagga gaaaaagtacgagttggagatgacctcatcttagttagcgtgtcctctgaaaggtacttg cacttgtcttatggcaacggcagcttacacgtggatgccgctttccagcagactctctgg agcgtggccccaatcagctcaggaagtgaggcagcccaagggtatctcattggtggtgat gtcctcaggttgctgcatggacacatggacgagtgtctcactgtcccttcaggagaacat ggtgaagagcagcggagaactgttcattatgaaggtggcgctgtgtctgttcatgcacgt tccctttggagactagagacgctaagagttgcgtggagtggaagccacataaggtgggga cagccattccgactacgccatgtcacaacaggaaaatacttgagtctcatggaagacaaa aaccttctactcatggacaaagagaaagctgatgtaaaatcaacagcatttaccttccgg tcttccaaggaaaaattggatgtaggggtgagaaaagaagtcgacggcatgggaacatct gaaataaaatacggtgactcagtatgctatatacaacatgtagacacaggcctatggctt acttaccagtctgtggacgtgaaatccgtgagaatgggatctatacaacgtaaggctatt atgcatcatgaaggccacatggatgatggcataagtttatcgagatcccagcatgaagaa tcacgcacagcacgagttatccggagcacagtcttccttttcaatagatttataaggggc cttgatgctctcagcaagaaagcgaaggcttccacagtcgatttgcctatagagtccgta agtctaagtctgcaggatctcattggctacttccaccccccagatgagcatttagagcat gaagacaaacagaacagactacgagccctgaagaatcggcaaaatctcttccaggaagag ggaatgatcaacctcgtgctagagtgcatagaccgtttgcacgtctacagcagtgcagca cactttgctgatgttgctgggcgagaagcaggagagtcttggaaatccattctgaattct ctgtatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgctcaattttcc ggctccctcgactggttgatcagcagattggaaagactggaagcttcttcgggcattctg gaagttttacactgtgttttagtagaaagtccagaagctctaaatattattaaagaagga catattaaatctattatctcacttttagacaaacatggaagaaatcacaaggttctggat gttttgtgctcactctgtgtttgccacggggttgctgtccgttctaaccagcatctcatc tgtgacaatctcttaccaggaagagacttgttattgcagacacgtcttgtgaaccatgtc agcagcatgagacccaatatttttctgggcgtcagtgaaggttctgctcagtataagaaa tggtactatgaattgatggtggaccacacagagccctttgtgacagctgaagcgactcac ctgcgagtgggctgggcttccactgaagggtattctccctaccctggagggggcgaagag tggggtggaaatggtgttggagatgatctcttctcctatggatttgatggccttcatctc tggtcaggttgtattgctcgtactgtaagctcaccaaaccaacatctgttaagaactgat gatgtcatcagttgctgtttagatctgagtgccccaagcatctcgttccgaattaatgga caacctgttcaaggaatgtttgagaatttcaacatcgatggcctcttctttccagtcgtt agtttctctgcaggaataaaagtacgctttctccttggagggcgacatggagaattcaaa tttcttcctccacctgggtatgctccttgttatgaagctgttctgccaaaagaaaagttg aaagtggaacacagccgagagtacaagcaagaaagaacttacacacgcgacctgctgggc cccacagtttccctgacgcaagctgccttcacacccatccctgtggataccagccagatc gtgttgcctcctcatctagaaagaataagagaaaaactggcagagaatatccatgaactc tgggttatgaataaaattgagcttggctggcagtatggtccggttagagatgacaacaag agacaacacccatgcctggtggagttctgcaagctgcctgaacaggagcgcaattacaac ttacaaatgtcgcttgagaccctgaagactttgttggcattaggatgtcatgtgggtata tcagatgaacatgctgaagacaaggtgaaaaaaatgaagctacccaagaattaccagctg acaagtggatacaagcctgcccctatggacctgagctttatcaaactcaccccatcgcaa gaagcaatggtggacaagttggcagaaaatgcgcataatgtgtgggcgcgggatcgaatc cggcagggctggacttatggcatccaacaggacgtaaagaacagaagaaatcctcgcctt gttccctacactcttctggatgaccgaaccaagaaatccaacaaggacagcctccgcgag gctgtgcgcacgctgctggggtacggctacaacttggaagcaccagatcaagatcatgcc agagccgaagtgtgcagcggcactggggaaaggttccgaatcttccgtgccgagaagacc tatgcagtgaaggccggacggtggtattttgaatttgagacggtcactgctggagacatg agggttggttggagtcggcctggttgtcagccggatcaggagcttggctcagatgaacgt gcctttgcctttgatggcttcaaggcccagcggtggcatcagggcaatgaacactatggg cgctcttggcaagcaggcgatgtcgtggggtgtatggttgacatgaacgaacacaccatg atgttcacactgaatggtgaaatccttcttgatgattcaggctcagaactggctttcaag gactttgatgttggcgatggattcatacctgtgtgtagccttggagtggctcaagtgggt aggatgaactttggaaaggatgtcagcaccttgaaatatttcaccatctgtggcttacaa gagggctatgaaccatttgctgttaatacaaacagggatattaccatgtggctgagcaag aggcttcctcagtttcttcaagttccatcaaaccatgaacatatagaggtgaccagaata gacggcaccatagacagttccccatgtttaaaggtcactcagaagtcttttggttctcag aacagcaacactgatatcatgttttatcgcctgagcatgccgatcgagtgcgcggaggtc ttctccaagacggtggctggagggctccctggggctggccttttcgggcccaagaatgac ttggaagattatgatgctgattctgactttgaggttctgatgaagacagctcatggccat ctagtgcccgatcgtgttgacaaagacaaagaagctactaaaccagagtttaacaaccac aaagattatgcccaggaaaagccctctcgtctgaaacaaagatttttgcttagaagaaca aagccagattacagcacaagccattctgcaagactcaccgaagatgtccttgctgatgat cgggatgactatgatttcttgatgcaaacgtccacgtactattactcagtgagaatcttt cctggacaagaacctgctaatgtctgggtgggctggattacatcagatttccatcagtat gacacaggctttgacttggacagagttcgcacagtaacagttactctaggagatgaaaaa ggaaaagtgcatgaaagcatcaaacgcagcaactgctatatggtatgtgcgggtgagagc atgagccccgggcaaggacgcaacaataatggactggagattggctgtgtggtggatgct gccagcgggctgctcacattcattgccaatggcaaggaactgagcacatactatcaggtg gaaccgagtacaaaattatttcctgcggtttttgcacaagctacaagtcccaatgttttc cagtttgagttgggaagaataaagaatgtgatgcctctctcggcgggattattcaagagt gaacacaagaaccccgtgccgcagtgccccccgcgcctccacgtgcagttcctgtcacac gtcctgtggagcagaatgcccaaccagtttttgaaggtagatgtgtctcgaataagtgaa cgccaaggctggttggtgcagtgtttggatcctctgcagttcatgtctcttcatatccct gaggaaaacagatctgttgacatcttagagttgacagagcaggaggaattgctgaaattt cactatcacaccctccggctctactcagccgtctgtgctcttgggaaccaccgggtggcc catgccctgtgcagccatgtggatgaacctcagctcctctatgccattgagaacaagtac atgcctggtttgctgcgtgctggctactatgacctgctgattgacatccacctgagctcc tatgccactgccagactcatgatgaacaacgagtacattgtccccatgacggaggagacg aagagcatcaccctgttccctgatgagaacaaaaagcacggccttccagggatcggcctc agcacctccctcaggccacggatgcagttttcctcccccagttttgtaagcattagtaat gaatgttaccagtacagtccagagttcccactggacatcctcaagtccaaaaccatacag atgctgacagaagctgttaaagagggcagtcttcatgcccgggacccagttggagggact actgaattcctctttgtacctctcatcaagcttttctatacgctgctgatcatgggcatc tttcacaacgaggacttgaagcacatcttgcagttgattgagcccagtgtgtttaaagaa gctgccactccggaggaggagagtgacacgctggagaaagagctcagtgtggacgatgca aagctgcaaggagctggtgaggaagaagccaaggggggcaagcggcccaaggaaggcctg ctccaaatgaaactgccagagccagttaaattgcagatgtgcctactgcttcagtacctc tgtgactgccaggtccggcaccggatagaagccattgtagccttttcagatgattttgtg gctaagctccaagacaatcaacgtttccgatacaacgaagtcatgcaagccttaaacatg tcagctgcactcacagccaggaaaacaaaggaatttagatcaccacctcaagaacagatc aatatgcttctcaattttaaggatgacaaaagtgaatgtccatgtccagaagaaattcgt gaccaactattggatttccatgaagatttgatgacacattgtggaattgagctggatgaa gatgggtctctggatggaaacagtgatttaacaatcagagggcgtctgctatccctggta gaaaaggtgacatatctgaagaagaagcaagcagaaaaaccagttgagagtgactccaaa aagtcctccactctgcagcagctgatctctgagaccatggtccgatgggctcaggagtct gtcattgaagaccccgagctggtgagggccatgtttgtgttgctccatcggcagtatgac ggcattgggggtcttgttcgggccctgccaaagacctacacgataaatggtgtgtccgtg gaggacaccatcaacctgctggcatcccttggtcagattcggtccctgctgagtgtgaga atgggcaaagaagaagagaagcttatgattcgtggattaggggatattatgaataacaaa gtgttttaccagcaccctaatcttatgagggcactggggatgcacgagactgtgatggag gtcatggtgaacgtccttggaggtggagagtccaaggaaatcacctttcccaagatggtg gccaactgttgccgttttctctgttacttctgtcgtataagtaggcagaatcaaaaagct atgtttgatcatctcagttatttactggaaaacagcagtgttggtcttgcctccccagct atgagaggttcaacaccactggatgtggctgcagcttcggtgatggataataatgaacta gcattagctctgcgtgagccggatctagaaaaggtagttcgttatttggctggttgtgga ctgcaaagttgccagatgctggtgtctaagggctatccagacattgggtggaacccagtt gaaggagagagatatcttgactttctcagatttgctgtcttctgtaatggggagagtgtg gaggaaaatgcaaatgttgtggtgagattgctcattcggaggcctgagtgttttggtcct gctttgagaggagaaggtgggaatgggcttcttgcagcaatggaagaagccatcaaaatc gccgaggatccttcccgagatggtccctcaccaaatagcggatccagtaaaacacttgat acagaggaggaggaagatgacactatccacatggggaacgcgatcatgaccttctattca gctttgattgacctcttgggacgctgtgctcctgagatgcatttgattcatgctgggaag ggagaagccatcagaattaggtccattttgagatccctaattcccctgggagatttggtg ggcgttatcagcatcgcttttcagatgccaacaatagccaaagatgggaatgtggtggaa cctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttattccttgac agggtctatggaattgaggttcaagacttcctcctccatcttcttgaggttggctttctg ccagatctccgggcagctgcttctttagatacggcagctttgagtgctacagacatggcc ttggccctcaatcggtacctttgcacagccgtcttgccattgttaacaagatgtgctcct ctctttgctggcacagagcaccacgcttctctcattgactcattacttcatactgtgtat agactttctaagggctgttcacttaccaaagctcagcgggattccatagaagtttgttta ctctctatttgtggacaactgagaccttctatgatgcagcacttactcagaagattagta tttgatgttccattattaaatgaacacgcaaagatgcctcttaaactgctgacaaatcat tatgaaagatgctggaaatattactgcctgcctggagggtggggaaactttggtgctgcc tcagaagaagaacttcatttatcaagaaagttgttctggggcatttttgatgccctgtct caaaagaaatatgaacaagaacttttcaaactggcactgccttgcctgagtgcagttgcg ggagctttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtca tcaatggattctgaagggaactttaacccacaacctgttgatacctcaaatattacaatt cctgagaagttggaatacttcattaacaaatatgcagaacactcccatgacaaatggtca atggacaagttggcaaatggatggatttatggagaaatatattcagactcttctaaggtt cagccattaatgaagccatataagctattgtctgaaaaggaaaaagaaatttaccgctgg ccaatcaaagaatctttaaaaactatgctggcttggggctggagaattgaaagaactcgg gagggagacagcatggccctttacaaccggactcgtcgtatttctcagacaagccaggtt tctgtagacgctgcccatggttacagtccccgggccattgacatgagcaatgttacgctc tctagagacctgcatgctatggcagaaatgatggctgaaaactaccataatatatgggca aagaaaaagaaaatggagttggagtccaaaggaggaggaaaccatcctctgctggtgccc tatgatacactgacagccaaagagaaagccaaggatagagaaaaagcacaggacatcctc aagttcttgcagatcaatggatatgctgtatccagaggatttaaggacctggaactggac acgccttctattgagaaacgatttgcctatagtttcctccaacaactcattcgctatgtg gatgaagcccatcagtatatcctggagtttgatggtggcagcagaggcaaaggagaacat ttcccttatgaacaagaaatcaagttctttgcaaaagtcgttcttcctttaattgatcag tatttcaaaaaccatcgtttatacttcttatctgcagcaagcagacctctctgctctgga ggacatgcttccaacaaagagaaagaaatggtgactagcctattctgcaaacttggagtt cttgtcaggcataggatttcactatttggcaatgatgcaacatcaattgtcaactgtctt catattttgggtcagactttggatgcaaggacagtgatgaagactggcctggagagtgtt aaaagtgcactcagagcttttctggacaacgctgcagaggatctggagaagaccatggaa aacctcaagcagggccagttcactcacacccgaaaccagcccaaaggggttactcagatt atcaattacaccacagtggccctgctgccaatgctgtcttcattatttgaacatattggc cagcatcagttcggagaagacctaatattggaagatgtccaggtgtcttgttatagaatt ctgactagcttatatgctttgggaaccagcaagagtatttacgtggagaggcaacgttct gcattaggagaatgtctagctgcctttgctggtgctttccctgtagcatttttggaaact catctggacaaacataatatttactccatctacaataccaagtcttcacgagaaagagca gctctcagtttgccaactaatgtggaagatgtttgtccaaacataccgtctttggagaaa ctcatggaagaaatcgtggaattagccgagtccggcattcgctacactcaaatgccacat gtcatggaagtcatactgcccatgctttgcagctacatgtctcgttggtgggagcatgga cctgagaacaatccagaacgggccgagatgtgctgcacggccctgaactcagagcacatg aacacacttctagggaacatattgaaaatcatatataataacttggggattgatgaagga gcctggatgaagaggctagcagtgttttcccagcctataataaataaagtgaaacctcag ctcttgaaaactcatttcttgccattaatggagaaactcaagaaaaaggcagctacggtg gtgtctgaggaagaccacctgaaagccgaggccaggggggacatgtcggaggctgaactc ctcatcctagatgagttcaccacactggccagagatctctatgccttctaccctctcttg attagatttgtggactataacagggcaaagtggctaaaggagcctaacccagaagcagag gagctcttccgcatggtggctgaagtgtttatctactggtcgaagtcccataatttcaaa agagaagagcagaacttcgttgtacagaatgaaatcaacaatatgtctttccttattact gataccaagtcaaagatgtcaaaggcagctgtttctgatcaggaaaggaagaaaatgaag cgcaaaggagatcggtattccacgcagacctctctgattgtagcagctctgaagcggtta ctgcccattgggttgaacatctgtgcccctggggaccaggagctcattgctctggccaaa aatcgatttagcctgaaagatactgaggatgaagtacgagatataatccgcagcaatatt catttacaaggcaagttggaggatcctgctattagatggcaaatggctctttacaaagac ttaccaaacaggactgatgatacctcagatccagagaagacggtagaaagagtattggat atagcaaatgtgctttttcatcttgaacaggtggagcatcctcagagatctaaaaaggct gtatggcataaactactctctaagcagaggaaaagggctgttgtagcctgcttccggatg gcccccttatataatctgccaaggcatcgggctgtcaatctctttcttcagggatatgaa aagtcttggattgaaacagaagaacattactttgaagataaactgatagaagatttagca aaacctggggctgaacctccagaagaagatgaaggcactaagagagttgatcctctacat cagctgatccttctgtttagtcggacagctttaacagagaaatgcaaactggaggaagat tttttatatatggcctatgcagatattatggcaaagagttgtcatgatgaggaagatgac gatggtgaagaggaagtgaagagttttgaagaaaaagaaatggaaaaacaaaagcttcta taccagcaagcccgactccacgatcgtggcgcggctgagatggtgctacagacaatcagt gccagcaaaggtgaaactggaccaatggtagcagctactctgaaacttggaattgctatt ttaaatggtgggaactccacagtacagcagaaaatgcttgactacctcaaggagaaaaag gatgtgggcttctttcagagcctggccggcctgatgcagtcatgtagtgtccttgaccta aatgcatttgagcgacaaaacaaagctgaaggtcttgggatggtgacagaggaaggatca gcctctcactttgaaagtcacagactgcggactggagaaaaggttctgcaggacgatgag ttcacctgtgacctcttccgattcctgcaactactctgtgagggacacaactcagatttt cagaattatctgagaactcagactggcaataatacaactgtcaacataattatctccact gtagactacctactgagagttcaggaatcaattagtgacttttattggtattactctggg aaagatgttattgatgaacaaggacaacggaatttctccaaagctatccaagtggcaaaa caagtctttaacactcttacagagtatattcagggtccttgcactgggaatcaacagagt ttggcacacagcaggctgtgggatgctgtggtcggctttcttcatgtgtttgcccatatg cagatgaagctgtcgcaggattccagtcaaattgagctattaaaagaattaatggatctg cagaaggatatggtggtcatgttgctgtccatgttagaaggtaatgttgttaatggaacg attggcaaacagatggtggatatgcttgtggaatcttccaacaatgtggagatgattctc aaattttttgacatgttcttaaaactaaaggatttgacgtcgtctgatacttttaaagaa tatgaccccgatggcaagggagtcatctccaagagggacttccacaaagcgatggagagc cataagcactacacgcagtcagaaacggaatttcttctgtcttgtgcggagacggatgag aatgaaaccctcgactacgaagagttcgtcaaacgcttccacgaacctgcgaaggacatc ggcttcaatgtcgccgtccttctgacaaacctctccgagcacatgcccaacgatacccga cttcagacttttctggaattagcagagagcgtcctgaattatttccagccctttctgggc cgcatcgaaatcatgggaagcgccaaacgcatcgagagagtctattttgaaatcagtgag tccagccgaacccagtgggagaagccccaggtcaaggagtccaaaagacagttcatattt gacgtggtcaacgaaggaggagagaaagagaagatggaactcttcgtgaacttctgcgag gacaccatctttgaaatgcagctggcggctcagatctcggagtcggacttgaacgggagg tcagcgaacaaggaagaaagcgagaaggagaggccggaagagcagggcccgaggatggcg ttcttctccatcctgacggtcaagtcggccctgtttgcgctcaggtacaatatcttgacc cttatgcgaatgctcagtctgaagagcctgaagaagcagatgaaaaaagtaaaaaagatg accgtgaaggacatggtcacggccttcttttcgtcctactggagtattttcatgaccctc ttgcacttcgtggccagcgttttcagaggcttttcccgcatcatttgcagcctgctgctt gggggaagcctcgtcgaaggtgctaaaaagatcaaagttgcagaactgttagccaacatg ccagaccccactcaggatgaggttagaggagatggggaggagggagagaggaaacccctg gaagccgccctgccctccgaggatctgaccgacttaaaggagctgacagaggaaagtgac cttctttcggacatctttggcctggatctgaagagagaaggaggacagtacaaactgatt cctcataatccaaatgctgggctcagtgacctcatgagcaacccagtccccatgcctgag gtgcaggaaaaatttcaggaacagaaggcaaaagaagaagaaaaggaagaaaaagaagaa accaaatctgaacctgaaaaagccgagggagaagatggagaaaaagaagagaaagccaag gaagacaagggcaaacaaaagttgaggcagcttcacacacacagatacggagaaccagaa gtgccagagtcagcattctggaagaaaatcatagcatatcaacagaaacttctaaactat tttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgctatcaat ttcatcttgctcttctataaggtctccacttcttctgtggttgaaggaaaggagctcccc acgagaagttcaagtgaaaatgccaaagtgaccagcctggacagcagctcccatagaatc atcgcagttcactatgtactagaggagagcagcggctacatggagcccacgttgcgtatc ttagctattctgcacacggtcatttctttcttctgcatcattggatactactgcttgaaa gtcccattggttatttttaagcgagaaaaggaagtggcacggaaattggaatttgatggg ctttatattacagaacagccttcagaagatgatattaaaggccagtgggatagactcgta atcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatg gataagtatggagagttctacggccgagacagaatcagtgaattacttggcatggacaag gcagctctggacttcagtgatgccagagaaaagaagaagccaaagaaagacagctcctta tcagctgtactgaactccattgatgtgaagtatcagatgtggaaactaggagtcgttttc actgacaattccttcctctacctagcctggtatatgactatgtctgttcttggacactat aacaactttttttttgccgctcaccttctcgacattgctatgggattcaagacattaaga accatcttgtcctcagtaactcacaatggcaaacagctcgtattaaccgttggcttatta gctgttgttgtatacctatacactgtggtggcattcaattttttccgaaaattctacaat aaaagtgaagatggtgatacgccagatatgaaatgtgacgatatgctaacatgctatatg ttccacatgtatgttggagttcgtgctggaggagggatcggggatgaaatcgaagaccca gcaggcgatgaatatgagatctatcgaatcatctttgacatcactttcttcttctttgtt attgtcattctcttggccataatacaaggtctaattatcgatgcttttggagaactaaga gaccaacaggaacaagtcaaagaagacatggagaccaaatgcttcatctgtgggataggc aatgattacttcgacacagtgccacatggctttgaaacccacactttacaggagcacaac ttggctaattacttgttttttctgatgtatcttataaacaaagatgaaacagaacacaca ggacaggaatcttatgtctggaagatgtatcaagaaaggtgttgggaatttttcccagca ggggattgcttccggaaacagtatgaagaccagctaaattaa

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