KEGG   Pan troglodytes (chimpanzee): 460858
Entry
460858            CDS       T01005                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr00562  Inositol phosphate metabolism
ptr01100  Metabolic pathways
ptr01521  EGFR tyrosine kinase inhibitor resistance
ptr01522  Endocrine resistance
ptr01524  Platinum drug resistance
ptr04012  ErbB signaling pathway
ptr04014  Ras signaling pathway
ptr04015  Rap1 signaling pathway
ptr04024  cAMP signaling pathway
ptr04062  Chemokine signaling pathway
ptr04066  HIF-1 signaling pathway
ptr04068  FoxO signaling pathway
ptr04070  Phosphatidylinositol signaling system
ptr04071  Sphingolipid signaling pathway
ptr04072  Phospholipase D signaling pathway
ptr04081  Hormone signaling
ptr04140  Autophagy - animal
ptr04150  mTOR signaling pathway
ptr04151  PI3K-Akt signaling pathway
ptr04152  AMPK signaling pathway
ptr04210  Apoptosis
ptr04211  Longevity regulating pathway
ptr04213  Longevity regulating pathway - multiple species
ptr04218  Cellular senescence
ptr04360  Axon guidance
ptr04370  VEGF signaling pathway
ptr04380  Osteoclast differentiation
ptr04510  Focal adhesion
ptr04517  IgSF CAM signaling
ptr04518  Integrin signaling
ptr04550  Signaling pathways regulating pluripotency of stem cells
ptr04611  Platelet activation
ptr04613  Neutrophil extracellular trap formation
ptr04620  Toll-like receptor signaling pathway
ptr04625  C-type lectin receptor signaling pathway
ptr04630  JAK-STAT signaling pathway
ptr04650  Natural killer cell mediated cytotoxicity
ptr04660  T cell receptor signaling pathway
ptr04662  B cell receptor signaling pathway
ptr04664  Fc epsilon RI signaling pathway
ptr04666  Fc gamma R-mediated phagocytosis
ptr04668  TNF signaling pathway
ptr04670  Leukocyte transendothelial migration
ptr04722  Neurotrophin signaling pathway
ptr04725  Cholinergic synapse
ptr04750  Inflammatory mediator regulation of TRP channels
ptr04810  Regulation of actin cytoskeleton
ptr04910  Insulin signaling pathway
ptr04914  Progesterone-mediated oocyte maturation
ptr04915  Estrogen signaling pathway
ptr04917  Prolactin signaling pathway
ptr04919  Thyroid hormone signaling pathway
ptr04923  Regulation of lipolysis in adipocytes
ptr04926  Relaxin signaling pathway
ptr04929  GnRH secretion
ptr04930  Type II diabetes mellitus
ptr04931  Insulin resistance
ptr04932  Non-alcoholic fatty liver disease
ptr04933  AGE-RAGE signaling pathway in diabetic complications
ptr04935  Growth hormone synthesis, secretion and action
ptr04960  Aldosterone-regulated sodium reabsorption
ptr04973  Carbohydrate digestion and absorption
ptr05010  Alzheimer disease
ptr05017  Spinocerebellar ataxia
ptr05020  Prion disease
ptr05100  Bacterial invasion of epithelial cells
ptr05132  Salmonella infection
ptr05135  Yersinia infection
ptr05142  Chagas disease
ptr05146  Amoebiasis
ptr05160  Hepatitis C
ptr05161  Hepatitis B
ptr05162  Measles
ptr05163  Human cytomegalovirus infection
ptr05164  Influenza A
ptr05165  Human papillomavirus infection
ptr05166  Human T-cell leukemia virus 1 infection
ptr05167  Kaposi sarcoma-associated herpesvirus infection
ptr05168  Herpes simplex virus 1 infection
ptr05169  Epstein-Barr virus infection
ptr05170  Human immunodeficiency virus 1 infection
ptr05171  Coronavirus disease - COVID-19
ptr05200  Pathways in cancer
ptr05203  Viral carcinogenesis
ptr05205  Proteoglycans in cancer
ptr05206  MicroRNAs in cancer
ptr05207  Chemical carcinogenesis - receptor activation
ptr05208  Chemical carcinogenesis - reactive oxygen species
ptr05210  Colorectal cancer
ptr05211  Renal cell carcinoma
ptr05212  Pancreatic cancer
ptr05213  Endometrial cancer
ptr05214  Glioma
ptr05215  Prostate cancer
ptr05218  Melanoma
ptr05220  Chronic myeloid leukemia
ptr05221  Acute myeloid leukemia
ptr05222  Small cell lung cancer
ptr05223  Non-small cell lung cancer
ptr05224  Breast cancer
ptr05225  Hepatocellular carcinoma
ptr05226  Gastric cancer
ptr05230  Central carbon metabolism in cancer
ptr05231  Choline metabolism in cancer
ptr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ptr05415  Diabetic cardiomyopathy
ptr05417  Lipid and atherosclerosis
ptr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    460858 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    460858 (PIK3CA)
   04014 Ras signaling pathway
    460858 (PIK3CA)
   04015 Rap1 signaling pathway
    460858 (PIK3CA)
   04370 VEGF signaling pathway
    460858 (PIK3CA)
   04630 JAK-STAT signaling pathway
    460858 (PIK3CA)
   04668 TNF signaling pathway
    460858 (PIK3CA)
   04066 HIF-1 signaling pathway
    460858 (PIK3CA)
   04068 FoxO signaling pathway
    460858 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    460858 (PIK3CA)
   04072 Phospholipase D signaling pathway
    460858 (PIK3CA)
   04071 Sphingolipid signaling pathway
    460858 (PIK3CA)
   04024 cAMP signaling pathway
    460858 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    460858 (PIK3CA)
   04152 AMPK signaling pathway
    460858 (PIK3CA)
   04150 mTOR signaling pathway
    460858 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    460858 (PIK3CA)
   04517 IgSF CAM signaling
    460858 (PIK3CA)
   04518 Integrin signaling
    460858 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    460858 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    460858 (PIK3CA)
   04218 Cellular senescence
    460858 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    460858 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    460858 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    460858 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    460858 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    460858 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    460858 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    460858 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    460858 (PIK3CA)
   04660 T cell receptor signaling pathway
    460858 (PIK3CA)
   04662 B cell receptor signaling pathway
    460858 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    460858 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    460858 (PIK3CA)
   04670 Leukocyte transendothelial migration
    460858 (PIK3CA)
   04062 Chemokine signaling pathway
    460858 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    460858 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    460858 (PIK3CA)
   04929 GnRH secretion
    460858 (PIK3CA)
   04915 Estrogen signaling pathway
    460858 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    460858 (PIK3CA)
   04917 Prolactin signaling pathway
    460858 (PIK3CA)
   04926 Relaxin signaling pathway
    460858 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    460858 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    460858 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    460858 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    460858 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    460858 (PIK3CA)
   04722 Neurotrophin signaling pathway
    460858 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    460858 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    460858 (PIK3CA)
   04380 Osteoclast differentiation
    460858 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    460858 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    460858 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    460858 (PIK3CA)
   05206 MicroRNAs in cancer
    460858 (PIK3CA)
   05205 Proteoglycans in cancer
    460858 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    460858 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    460858 (PIK3CA)
   05203 Viral carcinogenesis
    460858 (PIK3CA)
   05230 Central carbon metabolism in cancer
    460858 (PIK3CA)
   05231 Choline metabolism in cancer
    460858 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    460858 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    460858 (PIK3CA)
   05212 Pancreatic cancer
    460858 (PIK3CA)
   05225 Hepatocellular carcinoma
    460858 (PIK3CA)
   05226 Gastric cancer
    460858 (PIK3CA)
   05214 Glioma
    460858 (PIK3CA)
   05221 Acute myeloid leukemia
    460858 (PIK3CA)
   05220 Chronic myeloid leukemia
    460858 (PIK3CA)
   05218 Melanoma
    460858 (PIK3CA)
   05211 Renal cell carcinoma
    460858 (PIK3CA)
   05215 Prostate cancer
    460858 (PIK3CA)
   05213 Endometrial cancer
    460858 (PIK3CA)
   05224 Breast cancer
    460858 (PIK3CA)
   05222 Small cell lung cancer
    460858 (PIK3CA)
   05223 Non-small cell lung cancer
    460858 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    460858 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    460858 (PIK3CA)
   05161 Hepatitis B
    460858 (PIK3CA)
   05160 Hepatitis C
    460858 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    460858 (PIK3CA)
   05164 Influenza A
    460858 (PIK3CA)
   05162 Measles
    460858 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    460858 (PIK3CA)
   05163 Human cytomegalovirus infection
    460858 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    460858 (PIK3CA)
   05169 Epstein-Barr virus infection
    460858 (PIK3CA)
   05165 Human papillomavirus infection
    460858 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    460858 (PIK3CA)
   05135 Yersinia infection
    460858 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    460858 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    460858 (PIK3CA)
   05142 Chagas disease
    460858 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    460858 (PIK3CA)
   05017 Spinocerebellar ataxia
    460858 (PIK3CA)
   05020 Prion disease
    460858 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    460858 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    460858 (PIK3CA)
   05415 Diabetic cardiomyopathy
    460858 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    460858 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    460858 (PIK3CA)
   04931 Insulin resistance
    460858 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    460858 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    460858 (PIK3CA)
   01524 Platinum drug resistance
    460858 (PIK3CA)
   01522 Endocrine resistance
    460858 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptr04131]
    460858 (PIK3CA)
Enzymes [BR:ptr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     460858 (PIK3CA)
Membrane trafficking [BR:ptr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    460858 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 460858
NCBI-ProteinID: XP_024211590
Ensembl: ENSPTRG00000015642
VGNC: 7083
UniProt: K7BQ68
LinkDB
Position
2:182330292..182418850
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaagaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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