Pan troglodytes (chimpanzee): 463081 Help Entry 463081            CDS       T01005                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism ptr  Pan troglodytes (chimpanzee) Pathway ptr04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ptr00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     463081 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:ptr03036]     463081 (SYNE1) Chromosome and associated proteins [BR:ptr03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     463081 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SR_desmoplakin_3 SYNE3 Motif Other DBs NCBI-GeneID:  463081 NCBI-ProteinID:  XP_016812214 Ensembl:  ENSPTRG00000018717 VGNC:  13035 LinkDB All DBs Position 5:complement(164083533..164602238) Genome browser AA seq 8832 aa AA seqDB search MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT TKIQGNAKKALLKWVQYIAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNAGTDGQ EDDEILPGIPSFANSVQNFKREDRLIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD HTRLQRQIADVHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQITQAQQGEGGLPDRGHEE LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQ QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER GEAIANSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLNELQTTSE ISIMDHHVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL QDAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSSRDEIEGWS NNCVPQMAENISNLDNRLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD LQFIEADLRQKLEHAKEITEVAKGTLKDFMAQSTQVEKFINDITTWFTKVEESLMNCAQT ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDRKVLEAKLHDLQNIL DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL QSMWSWVKAIQDRLACVESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYGERKNQLEQWMESVD QKVEYPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEEFSALLKTWAQQLTLLEGKNTDE EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDDVRQFSGWMDSMEANLN ESERQHAELRDKITMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF NNVVNKLRLMEQKFQQVDEWLKTAEDKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS LSSYSDWYGSTHKNFKNVATKIDKVDTAMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER AVKYLEESEAERLRKEIHDHVEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET SSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT KDSYSAICSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQRLVQAQNLTQGWE EIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESTELHTQLAKYQNILEQSP EYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPQQFNVIVALAKDKFYKVQEAILAR KEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK ARHQIQSWQEELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQEMLQLAGNGLDVESAEENLK RHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKMASLELRSQRMSRDSGAQV ELLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ QALSMLQDGAAPTSGGEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIR QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQL IEGAHREIEDKPVATSNIQQLQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG RSPESQMAEHQSFLQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTV LAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTA LSPPKEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL RRLKGSLLELQRALHDKQLNMQQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQ SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL DSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQ AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLTLK SQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVV ESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ LNQLGERWLSNTNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTV PQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQW TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHE YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE DLIKAKEKEVEKIEQNGLALIQNKKEDVSGIVMSTLRELGQTWANLDHMVGQLKILLKSV LDQWSNHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQ KFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYS KQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGE QLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL AFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDL TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR WDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQ LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNPSLSLAQPLRSE RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE LDTSYKGYMKLLGECSGSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLL QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS QQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSD SSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFH PMLRYTNGPPPL NT seq 26499 nt NT seq  +upstreamnt  +downstreamnt atggcaacctccagaggggcctcccggtgtcctcgggatatcgccaatgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgaactttcacaaaatggatcaactctcat ctggccaagcggaaacctccaatggtggtggacgatctttttgaagacatgaaagatggt gttaaactgcttgcccttctggaggtcctgtctgggcagaaactgccttgtgaacaagga cgccggatgaagcgaatccatgctgtggctaacattggcacggcactcaagttcctcgaa ggaagaaagtccatgcacagaggatcaccgattaaattagtcaacattaactccaccgat atagctgatggccgaccctcaatagttcttggattgatgtggaccattattctatatttc cagattgaagagttgaccagcaacctgccccagctccagtctttgtccagcagcgcatcc tccgtggacagcatagttagctctgagactcccagcccaccaagtaaacggaaggtgacc accaagatccaaggaaatgctaagaaggctttattaaagtgggttcagtacatagctggc aagcagactggaatagaagtaaaagattttgggaagagttggagaagcggggttgccttt cattcagttattcatgccattcgacccgaattggtggacttggagacagtgaaaggcaga tccaaccgagaaaatttggaggatgctttcactatcgctgaaacagaactggggatccca agactgctagatcctgaagatgttgatgtggataaaccagatgagaagtctattatgacc tatgtagcccagtttctgaaacattatcctgacatccacaatgcaggcactgatgggcaa gaggatgatgaaatacttccaggtatcccatcttttgcaaattctgtacaaaattttaag agagaagacaggctaatttttaaggaaatgaaagtttggatagaacaatttgagagagac ttgacaagagcacagatggtggaatcaaatttacaggataaatatcagtcatttaagcac ttcagagttcaatatgaaatgaagaggaaacagattgaacatttaatacaaccattacac agagacggtaaattgtcacttgaccaagcattggtaaaacaatcttgggatagagtgacc tccaggctctttgactggcatatacagctggataaatctcttcctgcacctctgggcacc ataggtgcctggctgtacagagcggaggtggccctgagagaggaaataaccattcaacag gtccacgaggaaacagcaaacacgatacaacggaaacttgagcaacataaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccggaccaggtctgttaac gggattccagtgccacctgatcaattagaggacatggccgagaggtttcattttgtttcc tccacatcagagctacacctaatgaaaatggaatttttagaattaaagtaccgtctgctc tcactgctggttcttgcagagtcaaagctgaagtcttggatcattaagtacgggaggaga gagtcagtggagcagcttctacaaaactacgtgtcttttatagaaaatagcaagttcttt gaacaatatgaggtgacataccagatcttgaaacagacagctgagatgtatgtcaaagca gatggttcagtggaagaagctgagaatgtgatgaaattcatgaatgaaaccaccgctcag tggaggaatctctcagtagaagtgaggagtgtgaggagcatgctggaagaagtgatctct aactgggatcgctatggcaatacagtggctagtctgcaagcctggctagaggatgctgaa aaaatgctcaatcaatcagaaaatgccaaaaaggatttttttcgaaatttacctcattgg attcagcagcatactgccatgaacgacgctggcaattttctaattgaaacctgtgatgag atggtttcccgtgacctgaagcagcaattactgttgctaaatgggcggtggagggagttg tttatggaagtcaagcaatatgctcaagctgatgagatggacagaatgaagaaggaatac acagactgtgttgttaccctgtctgcttttgcaacggaagcccataagaaactttctgaa cccttagaagtctcttttatgaatgtcaagctattaattcaagacttggaggatattgag cagagggtgcctgtgatggatgcccaatacaagataattacaaagacagcacacctcatt accaaagaaagcccccaagaagaaggaaaagaaatgtttgcgaccatgtcaaagctcaaa gagcagctaaccaaggtcaaagaatgttactccccactcctttatgagtctcagcagctg ttgattccgttggaggaattagaaaagcagatgacgtccttttatgactcacttgggaaa atcaatgaaattatcaccgttcttgagcgtgaggcacaatcgagtgctctttttaaacaa aaacatcaggaactgttagcttgtcaagaaaactgtaagaaaaccttgacacttattgag aaaggcagtcaaagtgttcaaaagtttgtgaccttgagcaacgtgttaaagcattttgat cacacgaggctacaaagacagattgcagatgttcatgttgcttttcagagtatggtaaag aaaactggagactggaagaagcacgtggaaaccaacagtcgcttgatgaagaagtttgag gagtctcgagcagagttggagaaggtactacggattgctcaggaaggcctggaggaaaag ggggatccggaggagctcctgcggagacacactgagtttttcagtcagctggatcagagg gtgctcaatgctttcctgaaagcttgtgatgaactcaccgacatccttccagagcaggag cagcaggggctgcaggaagctgttcgaaagctccacaaacaatggaaggatcttcaagga gaagccccttatcatttgcttcatctgaagattgatgtggagaagaataggttcttagcc tctgtagaagaatgcagaactgagctggatcgagagaccaagctgatgccccaggaaggc agtgaaaagataattaaagagcacagggttttcttcagtgacaaaggtcctcatcatctc tgtgagaaaaggttacagctcattgaggaactctgtgtgaaactcccagtgcgggaccca gtaagggacacacctggaacctgtcacgtgactctcaaagagctcagagctgccattgac agcacctacaggaagctcatggaagacccagacaagtggaaggactacactagcagattc tctgagttctcatcttggatatctacaaatgagacacaattaaaggggatcaagggtgag gccatcgatactgccaaccacggagaggttaaacgtgccgttgaagagatcagaaatggt gttaccaaaaggggtgagaccctcagctggctgaaatccaggctgaaagttttgacagaa gtttcttctgagaatgaagcccaaaagcagggagatgagctggcaaaattatccagctct ttcaaggctcttgtgacgctgctgtcagaggttgaaaagatgctaagcaattttggggac tgtgtccagtacaaagaaatagtcaaaaattctctcgaagaattaatttctggctctaaa gaagtccaggaacaagctgagaagatcttggatactgaaaatctgtttgaagcacagcag ttacttcttcatcaccagcaaaagacaaagcggatctcagcaaagaagagagatgtgcag cagcagatcacgcaggcgcagcagggagaaggggggctgcctgaccgaggccacgaggag ctgcggaagctggagagcaccctggatggcctggagcgcagccgggagaggcaggaacgc cgcatccaggtcacattaagaaaatgggagcgatttgaaacaaacaaagaaacagtagta agatacctttttcaaacaggttccagtcatgaacgcttcttgagttttagcagtttggaa agtttatcttcagaactggaacaaacaaaggagttttctaaacggacagaaagtattgca gtccaggctgagaaccttgtaaaggaagcttcagagataccgcttgggccccaaaataag cagctgcttcaacagcaggccaagtcaatcaaagaacaagtcaaaaaattagaagacacg cttgaagaagatattaaaaccatggaaatggtgaaaaccaagtgggatcattttggcagt aattttgagactctgtccgtctggataactgagaaagaaaaagaactcaatgccttggaa acttcgtcatctgccatggacatgcaaatcagccaaattaaggtcacaattcaggaaata 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gagagcaaaaagggcgaattgcagagtctgcagggtcacttagcaaagttgggttctctg ggccgtgctgaggacctccacctcctgcagggaaaggctgaggactgcttccagctgttt gaggaggccagccaggttgtggagaggcggcagcttgccctgtcccatttggcagaattc ctccagagccatgcctctctgtccggcattctccgccagctgaggcaaacagtggaagca accaacagtatgaataagaacgagtctgatttgatagaaaaggacctcaatgatgctctt caagatgctaaagcattagaatctgctgccgtcagtctggatggcattctttccaaagcc caataccatctgaaaatcgggagctctgagcaaaggacttcctgcagagccacggctgat cagctctgtggagaggtagagaggatccagaaccttctgggaaccaagcagagtgaggca gatgccctggcagtgttgaaaaaagcattccaagaccagaaagaggagcttctgaaaagc attgaggacattgaagaaaggactgacaaagagcgattgaaagaacctacccgccaagct cttcagcagaggttaagagtgtttaatcagctagaagatgaattgaattctcacgagcat gaactatgttggttgaaagacaaagccaagcaaattgcccagaaagatgtagcttttgca cctgaagttgacagggagataaaccgcttagaggtcacctgggatgataccaaaagacta attcatgaaaatcagggtcagtgctgtggacttattgacttaatgagagaatatcagaac ctgaaatcagctgtatctaaagtcttagaaaatgccagcagtgtgattgtaaccagaact accataaaagatcaggaggatcttaaatgggctttttccaagcatgaaactgccaagaac 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aagattgacaaagtagatacagcaatgatggggaagaaattgaagacgttggaggttttg ctaaaagacatggagaaaggtcacagtttgctaaaatcggcccgggagaaaggagagagg gctgttaaatacttggaggaaagcgaggcagagaggttaagaaaggagattcatgatcac gtggagcagttgaaggaactgaccagcactgtccggaaagaacacatgacgctggaaaaa ggtcttcatttagcaaaggaattctcagataaatgcaaagcactgacacagtggatagca gaataccaggaaatcctacatgttcctgaagaacccaaaatggaattatatgagaaaaaa gctcagttatctaaatacaagtcacttcaacaaacggtgctgtcccatgaaccatcagta aagtcagtgagagagaagggtgaagctcttttggaactggtgcaggatgtcactttaaag gacaaaatagatcaacttcaaagtgattaccaggacctgtgcagcataggaaaggagcat gtcttcagtctggaggcgaaagtcaaagaccatgaagactacaacagtgagctccaagag gtcgaaaagtggctgctgcagatgtccggcagactggtggcacctgacctcctggagaca agcagcctggagacaatcacccagcaattggcccaccacaaggcaatgatggaagaaatt gctggttttgaagaccgtttgaacaatcttcaaatgaaaggtgatactttgattggccaa tgtgcagaccacctgcaagcgaaacttaaacaaaacgtgcatgctcatctgcagggcaca aaggacagctactcagcgatctgcagcacagctcagagggtgtaccagagtttggaacac gaacttcagaagcacgtcagccgacaagataccctgcagcagtgccaggcctggctttct gcagtccagccggacttagagccaagtcctcaaccacctcttagtagggcagaagccgtt aagcaggtcaaacacttcagagctttgcaagagcaggcaaggacctacctagatctcctt tgctccatgtgtgacctgtcaaatgcttcagtgaaaaccacagcaaaagacattcaacaa acagagcaaacgattgaacaaaggctcgtccaggcccagaacttaactcagggttgggaa gagatcaagcacctgaagtctgagctctggatttacctgcaagatgctgatcagcaactg cagaacatgaagaggaggcactctgagctagagctgaacattgcacagaacatggtttca caagttaaggattttgttaagaaactacagagcaaacaggcatccgtgaacaccataata gaaaaggtgaataagttaacaaagaaggaggaatcacctgaacacaaggaaataaatcat ttaaatgatcagtggctcgatttgtgccgtcagtctaacaacctgtgcttgcaaagggaa gaggatcttcagagaacaagagattaccatgactgtatgaatgtcgttgaagtgttccta gaaaaatttactacagaatgggataacttggccagatctgatgcagagagtacagctgtc cacctggaagctttgaaaaagttagcattggcattgcaggagagaaagtatgctattgaa gatctgaaagatcaaaagcagaaaatgatagagcatctgaatttagatgacaaggagtta gtcaaagaacagacgagtcatttagagcaacgttggtttcagcttgaggacctcattaaa aggaaaatccaagtgtcagtcaccaacttggaggagttaaatgtggtgcagtccagattt caggagctaatggagtgggcagaagagcaacaacccaacatcgccgaggcccttaagcag 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acactgacttctccagaagttggacgtctcagtctcaaggagcagctctctcatcggcag catttgttgtctgagatggagtcactgaagccgaaggtgcaagcagtgcagctctgccag agtgccctccggatccccgaggatgtggttgccagcttacctctctgtcatgctgctctg cggctgcaggaagaggccagccggctgcagcacaccgccatccagcagtgtaacatcatg caggaggctgtggtgcagtatgaacaatatgagcaagaaatgaaacatctccagcaactg atagaaggagctcacagagagattgaggataaacctgttgccaccagtaacatacagcag ctgcaggctcagatttctcggcatgaggagctggcgcagaaaattaagggctaccaggag cagatcgcttctttgaattccaagtgcaagatgctgacgatgaaagccaagcacgccacc atgctgctgacggtgaccgaggtcgaggggctggcggaagggacagaggacctggatggg gagctcctccccacgccttcggcccacccctctgtggtcatgatgactgcaggtcgctgt cacactttgctgtcaccggtcactgaggagtctggggaggagggaaccaacagtgagatt tcctctccacctgcctgtcgctccccttcacctgtggctaatacagatgcttctgttaac caggacattgcatattaccaagccttgtctgctgagaggttgcagacagatgctgcaaaa attcaccccagcacatccgcatcccaggagttctatgaaccgggattggagccatccgct actgccaaactgggtgatttgcagcgttcttgggaaaccttaaagaatgtgatcagtgag aagcagcgcacactctatgaagctttggaacgccagcagaagtaccaggactccctccag tccatctctacgaagatggaggctattgagctgaaactcagtgagagcccagagcctggc aggagtccagaaagccagatggctgaacatcagtctttcctccaggcattgatggatgag attctcatgctccaggatgaaatcaatgagctccagtcctctctcgcagaggagctggta tccgagtcttgtgaggccgaccccgcggagcagctggccttgcagtccacgctcactgtc ttagccgagcgaatgtccaccatcaggatgaaagcctcggggaaacggcagcttttggag gagaagttgaatgatcagctggaggaacaaaggcaggaacaggccctgcagaggtatcgc tgtgaagccgatgagctggacagctggctcttgagtaccaaggccactctggacactgcg ctgagtccacccaaggagcccatggacatggaggcccagcttgtggactgccagaatatg ctggtggaaatagagcagaaggtggtggctttatcagaactgtcagtccacaatgagaac ctgctgctggagggcaaagctcacaccaaggacgaggccgagcagctggctggaaagctg agaaggctcaaggggagcctgctggagctgcagagagccctgcatgataagcagctcaac atgcagcagggaacagcacaggagaaggaggagagcgatgttgacctaacagccacgcag agccccggcgtccaggaatggctggcccaagctcgcaccacatggacccagcagcggcag agcagtctccagcaacaaaaagagttagaacaggaattagccgagcagaagagtctcctt cgctcagtagccagtcgtggagaggagattctaattcaacattcggcggcagagacttct ggtgatgctggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggagaaa tcatctgctgaagaccagatgagaatgaaatgggaaagcctacatcaagaatttagtacc aagcagaaactactacagaatgttctggaacaggaacaagagcaagtgctttatagcagg ccaaatcgactcttgtctggtgtgccactgtacaaaggggacgtgccaacccaagataaa tctgcagttacatctttgctggatggactgaaccaagccttcgaggaggtttcatcccag agtggaggggcaaagaggcagagtatacacttggagcagaagttgtatgatggagtctca gccacctctacttggttggatgacgttgaagaacgtttatttgttgccacagcactttta ccagaagaaacagagacttgtctcttcaaccaagagattcttgccaaagacattaaggaa atgtctgaagaaatggataagaacaaaaacttgttttcccaagcttttccagagaatggt gataatcgagatgttattgaagatactttgggttgtcttttgggcaggttatctttgcta gactcagtagtgaatcaacgatgtcatcagatgaaagaaagacttcagcaaatactaaat ttccagaatgatctgaaagtgctgtttacatcactggctgacaacaaatacatcattctg caaaaactggcaaatgtgtttgaacagcccgtagcagaacaaatagaggcaatacaacag gctgaagatggactcaaagaattcgatgcaggaatcattgaattaaagaggcgtggtgac aagctacaggtcgagcagccgtccatgcaagaactctccaagctccaggacatgtatgat gagctgatgatgaccattggctcccggaggagtggtctgaatcagaaccttacactcaag agtcagtatgagagggccctacaagatctggctgacctgctagaaactggtcaggagaag atggcaggagaccagaaaatcatcgtgtcttccaaagaggaaatccagcaactacttgac aaacataaggaatactttcagggcctggaatctcatatgatcttgactgaaacactcttc agaaagataatcagctttgcagtccaaaaggaaacccagttccatacagagctgatggct caggcttctgctgtactgaaacgggctcacaagaggggtgtggagctggagtacattcta gagacgtggtcccatctggatgaggaccagcaggagctcagcagacagctggaggtggtg gaaagcagcatcccaagcgtgggtctggtggaggagaacgaggacaggcttattgaccgc ataacactctaccagcatttaaaatctagccttaatgaataccagcccaaattatatcaa gtattagatgatgggaaacgacttctgatatccatcagctgctcagatctagaaagccaa ctaaatcaacttggagagcgctggctaagtaacaccaataaagtgtctaaggaacttcac agactggaaacaatattgaaacactggaccagatatcaaagtgaatctgcagatctaatt cactggttacaatctgcaaaagaccggctagaattttggactcagcaatctgtgacagtc ccacaagagctggaaatggtccgtgatcatctaaatgctttcctggagttttctaaagaa gtggatgcccagtcttccctgaaatcatctgttctgagtactggaaatcagctccttcga ctaaaaaaggtggacacagccacgctgcgctctgagctgtcgcgcattgatagccagtgg actgacctgctaaccaatatcccagctgtccaggagaagctccaccagctccagatggat aaactgccttcccgccatgccatttctgaagtcatgagttggatttctctaatggaaaat gttattcagaaggatgaagataatattaaaaattccataggttacaaggcaattcatgaa taccttcagaaatataagggttttaagatagacattaactgtaaacagctgacggtggat tttgtgaaccagtccgtgctacaaatcagcagtcaggatgtggaaagtaagcgtagtgat aagactgattttgctgagcaacttggagcaatgaataaaagttggcaaattctgcaaggt ctagtaactgagaagatccagctgttggaaggcttattggaatcttggtcagaatatgaa aataatgtacaatgtctgaaaacatggtttgaaacccaggaaaagagactaaaacaacag catcgaattggagatcaggcttctgttcaaaatgcactgaaagactgtcaggatctggaa gatttgattaaagcaaaagaaaaagaagtagagaaaattgagcagaatggacttgctttg attcagaacaagaaagaagacgtctctggcattgtcatgagcacactgcgagagctcggc caaacctgggcaaatttagatcacatggttggacaattaaagatactgctgaaatcagtg cttgaccaatggagtaatcacaaagtggcctttgacaagataaacagttacctcatggag gccagatactctctttcccgattccgtctgctgactggctccttagaagctgtgcaagtt caggtggacaatcttcagaatctccaagatgatcttgaaaaacaggaaaggagcttacag aaatttggctctatcaccaaccaattattaaaagagtgtcacccacctgtgacagaaacg cttaccaatacactgaaagaagtcaacatgaggtggaataacttgctggaagagattgct gagcagctacactccagcaaggccctacttcagctttggcaaagatacaaggactactcc aaacagtgtgcttcgacagttcagcagcaggaggatcgaaccaatgagctgttgaaggca gccacaaacaaggacatcgccgatgatgaggttgccacatggattcaagattgcaacgac ctcctcaaaggactgggcacagttaaagattccctctttgttctccatgagctgggagag caactgaagcaacaagtggatgcttccgcagcatccgctattcaatcggatcaactctct ttgagtcaacacttgtgtgccctggagcaggctctctgcaaacagcagacttcgttacag gctggagttcttgattatgaaacctttgccaagagtttagaagctttggaggcctggata gtggaagctgaagaaatactacaagggcaggaccctagccactcatctgacctctccaca atccaggaaaggatggaagaacttaagggacagatgttaaaattcagcagcatggctcca gatttagaccgtctaaatgagcttggatataggttacccttgaatgataaggaaatcaaa aggatgcagaatctgaaccgccattggtctctgatctcctctcagactacagaaagattc agcaagttgcagtcatttttgctacaacatcagactttcttggaaaaatgtgaaacatgg atggaattcctagttcagacagaacaaaagttagcagtagagatttcaggaaattatcag caccttttggaacagcagagagcacacgagttgtttcaagccgagatgttcagtcgtcag cagattttgcactcaatcattattgatgggcaacgtcttctagaacaaggtcaagttgat gacagggatgaattcaacctgaaattgacactcctcagtaatcaatggcagggagtgatt cgcagggcccagcagaggcgggggatcattgacagccagattcgccagtggcagcgctat agggagatggcagaaaagcttcgtaaatggttggttgaagtgtcctacctccccatgagt ggtctcggaagtgttcctataccactgcaacaagcaaggaccctctttgatgaagtgcag ttcaaagaaaaagtgtttctgcggcaacaaggcagctacatcctgactgtggaggctggc aagcaactccttctctcagcggacagtggcgctgaggccgccttgcaggccgaactcgct gaaatccaagagaaatggaaatcagccagcatgcggctggaagaacagaagaaaaaacta gccttcttgttgaaagactgggaaaaatgtgagaaaggaatagcagattccctggagaaa ctacgaactttcaaaaagaagctttcgcagtctctcccggatcaccatgaagagctccat gcagaacaaatgcgttgcaaggaattagaaaatgcagttgggagctggacagatgacttg acccagttgagcctgctgaaggacaccctctctgcctatatcagtgctgatgatatctcc attcttaatgaacgcgtagagcttctgcaaaggcagtgggaagaactatgccaccagctc tccttaaggcggcagcaaataggtgaaagattgaatgaatgggcagtcttcagtgaaaag aacaaggaactctgtgagtggttgactcaaatggaaagcaaagtttctcagaatggagac attctcattgaagaaatgatagagaagctcaagaaggattatcaagaggaaattgctatt gcccaagagaacaaaatacagctccaacaaatgggagaacgacttgctaaagccagccat gaaagcaaagcatctgagattgaatacaagctgggaaaggtcaacgaccggtggcagcat ctcctggacctcattgcagccagggtgaagaagctgaaggagaccctggtagccgtgcag cagcttgataagaacatgagcagcctgaggacctggctcgctcacatcgagtcagagctg gccaagccaatagtctacgattcctgtaactcggaagaaatacagagaaagcttaatgag cagcaggagcttcagagagacatagagaagcacagtacaggtgttgcatctgtcctcaac ctgtgtgaagtcctgctgcacgactgtgacgcctgtgccactgatgccgagtgtgactct atacagcaggctacgagaaacctggaccggcggtggagaaacatttgtgctatgtccatg gaaaggaggctgaaaatcgaagagacgtggcgattgtggcagaaatttctggatgactat tcacgttttgaagattggctgaagtcttcagaaaggacagctgcttttcccagctcttct ggggtgatctatacagttgccaaggaagaactaaagaaatttgaggctttccagcgacag gtccacgagtgcctgacgcagctggaactgatcaacaagcagtaccgccgcctggccagg gagaaccgcactgattcagcgtgtagcctcaaacagatggttcacgaaggcaaccagaga tgggacaacctgcaaaagcgtgtcacctccatcttgcgcagactcaagcattttattggc cagcgtgaggagtttgagactgcgcgggacagcattctggtctggctcacagagatggat ctgcagctcactaatattgaacatttttctgagtgtgatgttcaagctaaaataaagcaa ctcaaggccttccagcaggaaatttcactgaaccacaataagattgagcagataattgcc caaggagaacagctgatagaaaagagtgagcccttggatgcagcgatcatcgaggaggaa ctagatgagctccgacggtactgccaggaggtcttcgggcgtgtggaaagataccataag aaactgatccgcctgcctctcccagacgatgagcatgacctctcagacagagagctggag ctggaagactctgcagctctgtcagacctgcactggcacgaccgctctgcagacagcctg ctttctccacagccttcctccaacccctccctctcgctcgctcagcccctccggagcgag cggtcaggacgagacaccccggctagtgtggactccatccccctggagtgggatcacgac tatgacctcagtcgggacctggagtctgcaatgtccagagctctgccctctgaggatgaa gagggtcaggatgacaaagatttctacctccggggagctgttggcttatcagatgtaatg atccccgaaagccctgaggcctatgtaaaactcacagaaaatgcaatcaaaaatacctcc ggggaccacagtgccctagagtcacagatccgacaactgggcaaagccctggatgatagc cgctttcagatacagcaaaccgaaaatatcattcgcagcaaaactcccacggggccggag ctagacaccagctacaaaggctacatgaaactgctgggcgaatgcagtggcagtatagac tccgtgaagagactggagcacaaactgaaggaggaagaggagagccttcctggctttgtt aacctgcatagtaccgaaacccaaacggctggtgtgattgaccgatgggagcttctccag gcccaggcattgagcaaggagttgaggatgaagcagaacctccagaagtggcagcagttt aactcagacttgaacagcatctgggcctggctgggggacacggaggaggagttggaacag ctccagcgtctggaactcagcactgacatccagaccattgagctccagatcaaaaagctc aaggagctccagaaagctgtggaccaccgcaaagccatcatcctctccatcaatctctgc agccctgagttcacccaggctgacagcaaggagagccgggacctgcaggatcgcttgtcg cagatgaatgggcgctgggaccgagtgtgctctctgctggaggagtggcggggcctgctg caggatgccctgatgcagtgccagggtttccatgaaatgagccatggtttgcttcttatg ctggagaacattgacagaaggaaaaatgaaattgtccctattgattctaaccttgatgca gagatacttcaggaccatcataaacagcttatgcaaataaagcatgagctgttggaatcc caactcagagtagcctctttgcaagacatgtcttgccaactactggtgaatgctgaagga acagactgtttagaagccaaagaaaaagtccatgttattggaaatcggctcaaacttctc ttgaaggaggtcagtcgtcatatcaaggaactggagaagttattagacgtgtcaagtagt cagcaggatttgtcttcctggtcttctgctgatgaactggacacctcagggtctgtgagt cccacatcaggaaggagcaccccaaacagacagaaaacgccacgaggcaagtgtagtctc tcacagcctggaccctctgtcagcagtccacatagcaggtccacaaaaggtggctccgat tcctccctttctgagccagggccaggtcggtccggccgcggcttcctgttcagagtcctc cgagcagctcttccccttcagcttctcctgctcctcctcatcgggcttgcctgccttgta ccaatgtcagaggaagactacagctgtgccctctccaacaactttgcccggtcattccac cccatgctcagatacacaaatggccctcctccactctga

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