KEGG   Pan troglodytes (chimpanzee): 469986
Entry
469986            CDS       T01005                                 
Symbol
GNAS
Name
(RefSeq) guanine nucleotide-binding protein G(s) subunit alpha isoform X4
  KO
K04632  guanine nucleotide-binding protein G(s) subunit alpha
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr01522  Endocrine resistance
ptr04015  Rap1 signaling pathway
ptr04020  Calcium signaling pathway
ptr04024  cAMP signaling pathway
ptr04072  Phospholipase D signaling pathway
ptr04081  Hormone signaling
ptr04082  Neuroactive ligand signaling
ptr04261  Adrenergic signaling in cardiomyocytes
ptr04270  Vascular smooth muscle contraction
ptr04540  Gap junction
ptr04611  Platelet activation
ptr04713  Circadian entrainment
ptr04714  Thermogenesis
ptr04724  Glutamatergic synapse
ptr04726  Serotonergic synapse
ptr04728  Dopaminergic synapse
ptr04730  Long-term depression
ptr04750  Inflammatory mediator regulation of TRP channels
ptr04911  Insulin secretion
ptr04912  GnRH signaling pathway
ptr04913  Ovarian steroidogenesis
ptr04915  Estrogen signaling pathway
ptr04916  Melanogenesis
ptr04918  Thyroid hormone synthesis
ptr04921  Oxytocin signaling pathway
ptr04922  Glucagon signaling pathway
ptr04923  Regulation of lipolysis in adipocytes
ptr04924  Renin secretion
ptr04925  Aldosterone synthesis and secretion
ptr04926  Relaxin signaling pathway
ptr04927  Cortisol synthesis and secretion
ptr04928  Parathyroid hormone synthesis, secretion and action
ptr04934  Cushing syndrome
ptr04935  Growth hormone synthesis, secretion and action
ptr04961  Endocrine and other factor-regulated calcium reabsorption
ptr04962  Vasopressin-regulated water reabsorption
ptr04970  Salivary secretion
ptr04971  Gastric acid secretion
ptr04972  Pancreatic secretion
ptr04976  Bile secretion
ptr05012  Parkinson disease
ptr05030  Cocaine addiction
ptr05031  Amphetamine addiction
ptr05032  Morphine addiction
ptr05034  Alcoholism
ptr05142  Chagas disease
ptr05146  Amoebiasis
ptr05163  Human cytomegalovirus infection
ptr05165  Human papillomavirus infection
ptr05200  Pathways in cancer
ptr05207  Chemical carcinogenesis - receptor activation
ptr05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    469986 (GNAS)
   04020 Calcium signaling pathway
    469986 (GNAS)
   04072 Phospholipase D signaling pathway
    469986 (GNAS)
   04024 cAMP signaling pathway
    469986 (GNAS)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    469986 (GNAS)
   04081 Hormone signaling
    469986 (GNAS)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    469986 (GNAS)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    469986 (GNAS)
  09152 Endocrine system
   04911 Insulin secretion
    469986 (GNAS)
   04922 Glucagon signaling pathway
    469986 (GNAS)
   04923 Regulation of lipolysis in adipocytes
    469986 (GNAS)
   04912 GnRH signaling pathway
    469986 (GNAS)
   04913 Ovarian steroidogenesis
    469986 (GNAS)
   04915 Estrogen signaling pathway
    469986 (GNAS)
   04921 Oxytocin signaling pathway
    469986 (GNAS)
   04926 Relaxin signaling pathway
    469986 (GNAS)
   04935 Growth hormone synthesis, secretion and action
    469986 (GNAS)
   04918 Thyroid hormone synthesis
    469986 (GNAS)
   04928 Parathyroid hormone synthesis, secretion and action
    469986 (GNAS)
   04916 Melanogenesis
    469986 (GNAS)
   04924 Renin secretion
    469986 (GNAS)
   04925 Aldosterone synthesis and secretion
    469986 (GNAS)
   04927 Cortisol synthesis and secretion
    469986 (GNAS)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    469986 (GNAS)
   04270 Vascular smooth muscle contraction
    469986 (GNAS)
  09154 Digestive system
   04970 Salivary secretion
    469986 (GNAS)
   04971 Gastric acid secretion
    469986 (GNAS)
   04972 Pancreatic secretion
    469986 (GNAS)
   04976 Bile secretion
    469986 (GNAS)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    469986 (GNAS)
   04961 Endocrine and other factor-regulated calcium reabsorption
    469986 (GNAS)
  09156 Nervous system
   04724 Glutamatergic synapse
    469986 (GNAS)
   04728 Dopaminergic synapse
    469986 (GNAS)
   04726 Serotonergic synapse
    469986 (GNAS)
   04730 Long-term depression
    469986 (GNAS)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    469986 (GNAS)
  09159 Environmental adaptation
   04713 Circadian entrainment
    469986 (GNAS)
   04714 Thermogenesis
    469986 (GNAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    469986 (GNAS)
   05207 Chemical carcinogenesis - receptor activation
    469986 (GNAS)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    469986 (GNAS)
   05165 Human papillomavirus infection
    469986 (GNAS)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    469986 (GNAS)
   05142 Chagas disease
    469986 (GNAS)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    469986 (GNAS)
  09165 Substance dependence
   05030 Cocaine addiction
    469986 (GNAS)
   05031 Amphetamine addiction
    469986 (GNAS)
   05032 Morphine addiction
    469986 (GNAS)
   05034 Alcoholism
    469986 (GNAS)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    469986 (GNAS)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    469986 (GNAS)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    469986 (GNAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ptr04147]
    469986 (GNAS)
   04031 GTP-binding proteins [BR:ptr04031]
    469986 (GNAS)
Exosome [BR:ptr04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   469986 (GNAS)
  Exosomal proteins of other body fluids (saliva and urine)
   469986 (GNAS)
  Exosomal proteins of colorectal cancer cells
   469986 (GNAS)
  Exosomal proteins of bladder cancer cells
   469986 (GNAS)
GTP-binding proteins [BR:ptr04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    469986 (GNAS)
SSDB
Motif
Pfam: G-alpha Arf Gtr1_RagA GTP_EFTU Roc
Other DBs
NCBI-GeneID: 469986
NCBI-ProteinID: XP_009435758
Ensembl: ENSPTRG00000032488
VGNC: 57986
LinkDB
Position
21:65136150..65206823
AA seq 362 aa
MEDAVQILLVFMDSGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKV
QDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKA
LWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKF
QVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNL
FKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDP
RVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYE
LL
NT seq 1089 nt   +upstreamnt  +downstreamnt
atggaggacgccgtccagattctccttgttttcatggattcaggtgctggagaatctggt
aaaagcaccattgtgaagcagatgaggatcctgcatgttaatgggtttaatggagagggc
ggcgaagaggacccgcaggctgcaaggagcaacagcgatggtgagaaggcaaccaaagtg
caggacatcaaaaacaacctgaaagaggcgattgaaaccattgtggccgccatgagcaac
ctggtgccccccgtggagctggccaaccccgagaaccagttcagagtggactacattctg
agtgtgatgaacgtgcctgactttgacttccctcccgaattctatgagcatgccaaggct
ctgtgggaggatgaaggagtgcgtgcctgctatgaacgctccaacgagtaccagctgatt
gactgtgcccagtacttcctggacaagatcgacgtgatcaagcaggctgactacgtgccg
agcgatcaggacctgcttcgctgccgtgtcctgacttctggaatctttgagaccaagttc
caggtggacaaagtcaacttccacatgtttgacgtgggtggccagcgcgatgaacgccgc
aagtggatccagtgcttcaacgatgtgactgccatcatcttcgtggtggccagcagcagc
tacaacatggtcatccgggaggacaaccagaccaaccgcctgcaggaggctctgaacctc
ttcaagagcatctggaacaacagatggctgcgcaccatctctgtgattctgttcctcaac
aagcaagatctgctcgctgagaaagtccttgctgggaaatcgaagattgaggactacttt
ccagaatttgctcgctacactactcctgaggatgctactcccgagcccggagaggaccca
cgcgtgacccgggccaagtacttcattcgagatgagtttctgaggatcagcactgccagt
ggagatgggcgtcactactgctaccctcatttcacctgcgctgtggacactgagaacatc
cgccgtgtgttcaacgactgccgtgacatcattcagcgcatgcaccttcgtcagtacgag
ctgctctaa

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