Pan troglodytes (chimpanzee): 745893
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Entry
745893 CDS
T01005
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr05012
Parkinson disease
ptr05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
745893 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
745893 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ptr01001
]
745893 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ptr04131
]
745893 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ptr04147
]
745893 (LRRK2)
Enzymes [BR:
ptr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
745893 (LRRK2)
Protein kinases [BR:
ptr01001
]
Serine/threonine kinases: TKL group
LRRK family
745893 (LRRK2)
Membrane trafficking [BR:
ptr04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
745893 (LRRK2)
Exosome [BR:
ptr04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
745893 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_14
LRR_9
WDR55
LRR_13
Arf
Beta-prop_EML_2
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
Ank_2
nSTAND3
LRR_NXF1-5
T2SSE
AAA_22
ABC_tran
AAA_7
Beta-prop_BBS7
GTP_EFTU
G-alpha
PduV-EutP
Kdo
NACHT
AAA_16
LRR_6
Septin
TrwB_AAD_bind
cobW
MMR_HSR1
WD40_Prp19
TniB
MobB
TsaE
ResIII
AAA_29
FtsK_SpoIIIE
SRPRB
AAA_23
WD40_WDHD1_1st
ARM_LIN_2nd
SRP54
Motif
Other DBs
NCBI-GeneID:
745893
NCBI-ProteinID:
XP_001168494
Ensembl:
ENSPTRG00000004828
VGNC:
13210
UniProt:
H2Q5Q4
A0A6D2W2J3
LinkDB
All DBs
Position
10:complement(55506926..55650374)
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
DIHKLVLAPLNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISRICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDPGMQSATVGIDVKDWPIQI
RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILIGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTLPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNLTVECMVATHH
NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCELIDCVHLLREVTVKE
NKESKHKMSYSGRVKTLCLQKNTALWVGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
AQLGSLKNVMLVLGYNRKSTEGTQEQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
MRGTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggaaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcctatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaaatctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcagtgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttgctgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtctcagaggagcaactgactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtgcttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaagaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aattttttcaatatcctggtattaaatgaagtccatgagtttgtggtgaaagctgtgcag
cagtacccagagaacgcagcattgcagatctcagcgctcagctgtttggccctcctcact
gagactattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagataaattgttttggctggaagcctgttacaaagcattaacgtggcat
agaaagaacaagcacgtgcaggaggccgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgcttatgcattcttcatcaaaggaagttttccaggcatctgcgaat
gcattgtcaactctcttagaacaaaatgttaatttcagaaaaatactgttatcaaaagga
atacacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacttccctggatataatg
gcagcagtggtccccaaaatactaacagttatgaaacgtcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgcctggcatgccagaagaatcc
agggaggatacagaatttcatcataagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcacctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctattgtacattttcctgatgcattagagatgtta
tccctggaaggtgctatggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatacttgattacaaagaagaatgtgttc
ataggaactggacatctgctggcaaaaattctggtttccagcttataccgatttaaggat
gttgctgaaatacagactaaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcatttgacttagtaatattccatcaaatgtct
tccaatatcatggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgattacttaaaaaatgtgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattgggagcagatgccaatcaagcaaaggag
ggatcttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttactgaatagtggatctcgtgaacaagatgtacgaaaagcgctgacgataagcattggg
aaaggtgacagccagatcatcagcttgcttttaaggaggctggccctggatgtggccaac
aatagcatttgccttggaggattttgtataggaaaagttgaaccttcttggctcggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgctgtggaagaaggaacagcctcaggcagc
gatggaaatttttctgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtgtttgctcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaggaaatctaattcaattagtgtaggagaattttaccgagatgcc
gtattacagcgttgctcaccaaatttgcaaagacattccaattccttggggcccattttt
gatcatgaagatttactgaagcgaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgagttgtatt
gctaatcttgatgtctctcgaaatgacattggaccctcagtggttttagatcctacagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttttgtacctgag
aacctcactgatgtggtagagaaactggagcagctcattttagaaggaaataaaatatca
cggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaagaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttctatgacaatcctaaaatta
tctcagaacaaattttcctgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaacgatattcagtacctaccaggtcctgcacactggaaatctttg
aacttaagggaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaa
gcatatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggag
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcgattaaaaaaggctgtgccttataaccgaatgaaacttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatca
gatcctggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agagacaaaagaaagagagatctcgtcctaaatgtgtgggattttgcaggtcgtgaggaa
ttctatagtactcatccccattttatgacgcagcgagcattgtaccttgctgtctatgac
ctcagcaagggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcattggcacacatttggatgtttctgatgagaag
caacgcaaagcctgcataagtaaaatcaccaaggaactcctgaataagcgagggttccct
gccatacgagattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaacgagagccttaatttcaagatccgagatcagcttgttgttgga
cagctgattccagactgctatgtagaacttgaaaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcccgtaattgaccggaaacgattattacaactagtgagagaaaat
cagctgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtactttgtggaaccc
aagtggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggaattatttcgcgtagagatgtggaaaaatttctttcaaagaaaaggaaa
tttccaaagaactacatgtcacagtattttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttt
ccaatgggattttggtcaagattaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatttactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcatccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggcgaa
gaacatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcacccttccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagttggaatttgaacaagct
ccagagtttctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacatacatcactcaggctgttaagacaagag
cttgtggtgctttgccacctccaccaccccagtttgatatctttgctggcagctgggatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacagcacaggatcgcactccatgtagctgat
ggtttgagatacctccactcagccatgattatataccgagacctgaaaccccacaatgtg
ctgcttttcaccctgtatcccaatgctgccatcattgcaaagattgctgactacggcatt
gctcagtactgctgtagaatggggataaaaacatcagagggcacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattagaaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaaattaattaaacagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacgcattttattacctaaaaacttaactgttgaatgcatggttgctacacatcac
aacagcaggaatgcaagcatttggctgggctgtgggcacaccgacagaggacagctctca
tttcttgacttaaatactgaaggatacacttctgaggaagttgctgatagtagaatattg
tgcttagccttggtgcatcttcctgttgaaaaggaaagctggattgtgtctgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattctgtcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaagttagcaatttttgaagataagactgtt
aagcttaaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccacaaattcaacggaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctaatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttttcttatgcagctttcagtgattccaacatcataacagtggtggtagac
actgctctctatattgctaagcaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgtgaactaatagactgcgtgcaccttttaagggaggtaacggtaaaagaa
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaaaccctctgccttcag
aagaacactgctctttgggtaggaactggaggaggccatattttactcctggatctttca
actcgtcgacttatacgtgtaatttacaacttttgtaattcggtcagagtcatgatgaca
gcacagctaggaagccttaaaaatgtcatgctggtattgggctacaaccggaaaagtact
gaaggtacacaagagcagaaagagatacaatcttgcttgaccgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagaggaacatctgttgaataa
DBGET
integrated database retrieval system
