Panthera uncia (snow leopard): 125911117 Help Entry 125911117         CDS       T08832                                  Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism puc  Panthera uncia (snow leopard) Pathway puc04022   cGMP-PKG signaling pathway puc04068   FoxO signaling pathway puc04081   Hormone signaling puc04140   Autophagy - animal puc04150   mTOR signaling pathway puc04151   PI3K-Akt signaling pathway puc04152   AMPK signaling pathway puc04211   Longevity regulating pathway puc04213   Longevity regulating pathway - multiple species puc04722   Neurotrophin signaling pathway puc04910   Insulin signaling pathway puc04920   Adipocytokine signaling pathway puc04923   Regulation of lipolysis in adipocytes puc04930   Type II diabetes mellitus puc04931   Insulin resistance puc04932   Non-alcoholic fatty liver disease puc04935   Growth hormone synthesis, secretion and action puc04960   Aldosterone-regulated sodium reabsorption puc05010   Alzheimer disease puc05206   MicroRNAs in cancer puc05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:puc00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     125911117    04022 cGMP-PKG signaling pathway     125911117    04151 PI3K-Akt signaling pathway     125911117    04152 AMPK signaling pathway     125911117    04150 mTOR signaling pathway     125911117   09133 Signaling molecules and interaction    04081 Hormone signaling     125911117  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     125911117  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     125911117    04923 Regulation of lipolysis in adipocytes     125911117    04920 Adipocytokine signaling pathway     125911117    04935 Growth hormone synthesis, secretion and action     125911117   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     125911117   09156 Nervous system    04722 Neurotrophin signaling pathway     125911117   09149 Aging    04211 Longevity regulating pathway     125911117    04213 Longevity regulating pathway - multiple species     125911117  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     125911117   09164 Neurodegenerative disease    05010 Alzheimer disease     125911117   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     125911117   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     125911117    04932 Non-alcoholic fatty liver disease     125911117    04931 Insulin resistance     125911117 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  125911117 NCBI-ProteinID:  XP_049470746 LinkDB All DBs Position C1 Genome browser AA seq 1348 aa AA seqDB search MHLRSFPAAAAARRLGSRRIRAALAPDALPPPPGHETPVNSGRGHLLGAAAESPFGCPSP ARAAAWCLESGVLPPPALFACAGPRRGASAPHPVVFQRLPLLGGGGGGGGGGGSMASPPE TEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPL ESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKSHHDGAAA PGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLC LTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVA QNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTE SITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLH PPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFI SSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPNGHYILP RGGNGHRYVAGAGLGTSPALAGDEGASAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVA SIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEVHRGHHRPDTSSLHTDDG YMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSC SPDIGGGPSSSGSGAAPSGSSYGKLWTNGVGSHHPHALPHPKLPVESGGGKLLSCTGDYI NMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEDSARHQHLRLSS SSGRLLYAATAEDSSSSTSSDSLGGGYCGVRPDSGLPHIHHQVLQPHLPRKVDTAAQTNS RLARPTRLSLGDPKASTLPRVREQQPQPPLLHPPEPKSPGEYVNIEFGGDQPGYLSGPVA SRGSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQEGAGVQPGRVGPTPPGAAS VCRPTRAVPSSRGHYMTMQMGCPGQSYVDTSPVAPISYADMRTGLVVEEASLPGATAAAP SSSSGASASPTAPQKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQG CRRRHSSETFSSTPSATRAGNTVPFGGGAAGGGSGGGNGSAEEVKRHSSASFENVWLRPG ELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQPPPPLPPHQPLGSS EGSSTRRSSEDLSAYASISFQKQPEDLQ NT seq 4047 nt NT seq  +upstreamnt  +downstreamnt atgcatcttcgctccttcccggccgcggcggctgcgaggagacttggctctcggaggatc cgggctgcactagcgccggacgcactgcctccccccccagggcatgaaacgcccgtaaac tccggccggggccacctccttggcgcagccgctgagtcccccttcggctgcccctccccg gcgcgggcggcggcgtggtgtttggagtcgggggttctgccgcctccagccctgtttgca tgtgcggggccgcggcgaggagcctccgccccccacccggttgtttttcagcgcctccct ctcctcggcggcggcggcggcggcggcggtggcggcggcagcatggcgagccctccggag accgaaggcttctcggacgtgcgcaaggtgggctacctgcgcaaacccaagagcatgcac aagcgcttcttcgtgctgcgggcggccagcgaggcggggggcccggcgcgcctcgagtac tacgagaacgagaagaagtggcggcacaagtcgagcgcccccaaacgctcgatccccctg gagagctgcttcaacatcaacaagcgggcggactccaagaacaagcacctggtggccctc tacacccgggacgagcactttgccatcgcggcggacagcgaggcggagcaggacagctgg taccaggccctcctgcagctgcacaaccgggccaagagccaccacgacggggccgcggcc cccggggcaggaggcggcgggggcagctgcagtggcagctcgggcctcggcgaggctggg gaggacttgagctacggggatgtgcccccaggacctgcgttcaaggaggtctggcaggtg atcctgaaacccaagggcctgggtcagacaaagaacctgattggcatctaccgcctctgc ctgaccagcaagaccatcagcttcgtgaagctgaactcggaggcggcggccgtggtgctg cagctgatgaacatcagacgctgcggccactccgagaacttcttcttcatcgaagtgggc cgttccgcagtgacgggacctggggagttctggatgcaggtggatgactctgtggtggcc cagaacatgcacgagacaatcctggaggccatgcgggccatgagcgacgagttccgtcct cgaagtaagagccagtcctcctccaactgctccaaccccatcagcgtccccctgcgcagg caccacctcaacaacccgccacccagccaggtggggctgacccgccgctctcgcaccgag agcatcaccgccacctctccggccagcatggtgggcgggaagcagggctccttccgcgtg cgcgcgtccagcgacggcgagggcaccatgtcccgcccggcctcggtggacggcagcccc gtgagtccgagcaccaacaggacgcacgcgcaccggcatcgcggcagctcccggctgcac ccgcctctcaaccacagccgctccatccccatgccttcgtcccgctgctcgccttctgcc accagcccggtcagtctgtcgtccagcagcaccagtggccacggctccacctcggactgc ctcttcccccggcgctctagtgcttctgtgtccggttcccccagcgatggcggtttcatc tcctcggatgagtacggctccagtccttgcgatttccgaagttccttccgcagtgtcacc ccggattccctgggccacaccccaccggcccgcggggaggaggagctgagcaactacatc tgcatgggaggcaaaggctcctccaccctcaccgcccccaatggtcactacattttgcct cggggtggcaatggtcaccgctacgtcgccggggccggcctgggcaccagcccagccctg gccggggatgaaggagctagtgcagccgatctggataatcggttccgaaagcggactcac tcggccggcacgtcccctaccatttcccaccagaagaccccatcgcagtcctcggtggct tccattgaggagtacacggagatgatgcctgcctacccgccaggaggtggcagcggaggc cgcctgcccggctaccggcactccgccttcgtgcccacccactcctaccccgaggagggt ctggaggtgcaccggggccaccaccgcccagacacctcctctctccacactgatgatggc tacatgcccatgtccccaggagtggccccagtgcccagcagccgcaagggcagcggggac tacatgcccatgagccccaagagcgtgtctgcgccacagcagatcatcaaccccatcagg cgccatccccagagggtggaccccaatggctacatgatgatgtcccctagcggcagctgc tctcctgacatcggaggtgggcccagcagcagcggcagtggcgccgccccctctgggagc agctacgggaagctgtggaccaacggggtcgggagccaccaccctcacgctctgccacat cccaaactccccgtagagagtggtggcggcaagctcttgtcttgtaccggtgactacata aacatgtcgccggtgggggactccaataccagcagcccctccgactgctactacggcccg gaggacccccagcacaagccagtcctctcctactactcgttgccaaggtcctttaagcac acccagcgccccggggagctggaggacagtgcccggcaccagcacctccgcctttcctcc agctctggtcgccttctctatgccgccactgcagaagactcctcctcctctaccagcagc gacagcctgggcggcgggtactgtggggtcaggcccgattctggcctcccgcacatccac catcaggtcctgcagccccatctgcctcgaaaggtggacacggctgcccagaccaacagc cgcctggctcggcccacgaggctgtccctgggggatcccaaggccagcaccttacctcgg gtccgagagcagcagccacagcccccgctgctgcaccctccggagcccaagagcccaggg gaatatgtgaatattgagtttgggggggatcagccgggctacttatctggtcccgtggct tcccgcggctcgccttctgtcaggtgcccatcccagctccagccagcccccagagaggaa gagactggcactgaagagtacatgaacatggacctggggccgggcaggagggccacctgg caggagggtgccggggtccagccaggcagagtgggccccacacctcctggggcggccagc gtgtgcaggcccacccgggccgtgcccagcagccgcggtcactacatgaccatgcagatg ggctgtcccggtcagagctatgtggacacctcaccagttgcccccatcagctatgctgac atgcggacaggcctcgttgtggaggaggcgagccttccgggggccacggccgccgctccc tcctcatcctcgggggcctcggcttcccccactgcgcctcaaaaagcaggggagctggtg gcccgctcttccctgctggggggcccgcagggacccggaggcatgagcgccttcaccagg gtgaacctcagccccaaccggaaccagagtgccaaagtgatccgtgcggacccgcaaggg tgccggaggcggcacagctctgagaccttctcctcgacacccagtgccacccgggcgggc aacacggtgcccttcggagggggcgctgcaggagggggcagcggtggtggcaacggcagc gccgaggaggtgaaacgccacagttctgcttccttcgagaacgtgtggctgaggcctggg gagctcgggggagcccccaaggagccggcccaagtgtgcggggccgccgggggtttggag aacggtcttaactacatagacctggatttggtcaaggacttcaaacagcgccctcaggag cgcccccctcaaccacagccgcccccgcccctgccccctcatcagcctctgggcagcagc gagggcagctccacccgccgctccagcgaggatttaagcgcctatgccagcatcagtttc cagaagcagccagaggacctccagtag

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