KEGG   Panthera uncia (snow leopard): 125918032
Entry
125918032         CDS       T08832                                 
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc01521  EGFR tyrosine kinase inhibitor resistance
puc01522  Endocrine resistance
puc04010  MAPK signaling pathway
puc04012  ErbB signaling pathway
puc04014  Ras signaling pathway
puc04015  Rap1 signaling pathway
puc04022  cGMP-PKG signaling pathway
puc04024  cAMP signaling pathway
puc04066  HIF-1 signaling pathway
puc04068  FoxO signaling pathway
puc04071  Sphingolipid signaling pathway
puc04072  Phospholipase D signaling pathway
puc04140  Autophagy - animal
puc04148  Efferocytosis
puc04150  mTOR signaling pathway
puc04151  PI3K-Akt signaling pathway
puc04210  Apoptosis
puc04218  Cellular senescence
puc04270  Vascular smooth muscle contraction
puc04370  VEGF signaling pathway
puc04371  Apelin signaling pathway
puc04517  IgSF CAM signaling
puc04540  Gap junction
puc04550  Signaling pathways regulating pluripotency of stem cells
puc04613  Neutrophil extracellular trap formation
puc04620  Toll-like receptor signaling pathway
puc04650  Natural killer cell mediated cytotoxicity
puc04660  T cell receptor signaling pathway
puc04662  B cell receptor signaling pathway
puc04664  Fc epsilon RI signaling pathway
puc04720  Long-term potentiation
puc04722  Neurotrophin signaling pathway
puc04730  Long-term depression
puc04810  Regulation of actin cytoskeleton
puc04910  Insulin signaling pathway
puc04912  GnRH signaling pathway
puc04915  Estrogen signaling pathway
puc04916  Melanogenesis
puc04917  Prolactin signaling pathway
puc04919  Thyroid hormone signaling pathway
puc04921  Oxytocin signaling pathway
puc04926  Relaxin signaling pathway
puc04929  GnRH secretion
puc04934  Cushing syndrome
puc04935  Growth hormone synthesis, secretion and action
puc05010  Alzheimer disease
puc05022  Pathways of neurodegeneration - multiple diseases
puc05132  Salmonella infection
puc05135  Yersinia infection
puc05160  Hepatitis C
puc05161  Hepatitis B
puc05163  Human cytomegalovirus infection
puc05164  Influenza A
puc05165  Human papillomavirus infection
puc05166  Human T-cell leukemia virus 1 infection
puc05167  Kaposi sarcoma-associated herpesvirus infection
puc05170  Human immunodeficiency virus 1 infection
puc05200  Pathways in cancer
puc05205  Proteoglycans in cancer
puc05206  MicroRNAs in cancer
puc05207  Chemical carcinogenesis - receptor activation
puc05208  Chemical carcinogenesis - reactive oxygen species
puc05210  Colorectal cancer
puc05211  Renal cell carcinoma
puc05213  Endometrial cancer
puc05214  Glioma
puc05215  Prostate cancer
puc05216  Thyroid cancer
puc05218  Melanoma
puc05219  Bladder cancer
puc05220  Chronic myeloid leukemia
puc05221  Acute myeloid leukemia
puc05223  Non-small cell lung cancer
puc05224  Breast cancer
puc05225  Hepatocellular carcinoma
puc05226  Gastric cancer
puc05230  Central carbon metabolism in cancer
puc05231  Choline metabolism in cancer
puc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:puc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    125918032
   04012 ErbB signaling pathway
    125918032
   04014 Ras signaling pathway
    125918032
   04015 Rap1 signaling pathway
    125918032
   04370 VEGF signaling pathway
    125918032
   04371 Apelin signaling pathway
    125918032
   04066 HIF-1 signaling pathway
    125918032
   04068 FoxO signaling pathway
    125918032
   04072 Phospholipase D signaling pathway
    125918032
   04071 Sphingolipid signaling pathway
    125918032
   04024 cAMP signaling pathway
    125918032
   04022 cGMP-PKG signaling pathway
    125918032
   04151 PI3K-Akt signaling pathway
    125918032
   04150 mTOR signaling pathway
    125918032
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    125918032
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125918032
   04148 Efferocytosis
    125918032
  09143 Cell growth and death
   04210 Apoptosis
    125918032
   04218 Cellular senescence
    125918032
  09144 Cellular community - eukaryotes
   04540 Gap junction
    125918032
   04550 Signaling pathways regulating pluripotency of stem cells
    125918032
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125918032
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    125918032
   04620 Toll-like receptor signaling pathway
    125918032
   04650 Natural killer cell mediated cytotoxicity
    125918032
   04660 T cell receptor signaling pathway
    125918032
   04662 B cell receptor signaling pathway
    125918032
   04664 Fc epsilon RI signaling pathway
    125918032
  09152 Endocrine system
   04910 Insulin signaling pathway
    125918032
   04929 GnRH secretion
    125918032
   04912 GnRH signaling pathway
    125918032
   04915 Estrogen signaling pathway
    125918032
   04917 Prolactin signaling pathway
    125918032
   04921 Oxytocin signaling pathway
    125918032
   04926 Relaxin signaling pathway
    125918032
   04935 Growth hormone synthesis, secretion and action
    125918032
   04919 Thyroid hormone signaling pathway
    125918032
   04916 Melanogenesis
    125918032
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    125918032
  09156 Nervous system
   04720 Long-term potentiation
    125918032
   04730 Long-term depression
    125918032
   04722 Neurotrophin signaling pathway
    125918032
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125918032
   05206 MicroRNAs in cancer
    125918032
   05205 Proteoglycans in cancer
    125918032
   05207 Chemical carcinogenesis - receptor activation
    125918032
   05208 Chemical carcinogenesis - reactive oxygen species
    125918032
   05230 Central carbon metabolism in cancer
    125918032
   05231 Choline metabolism in cancer
    125918032
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125918032
  09162 Cancer: specific types
   05210 Colorectal cancer
    125918032
   05225 Hepatocellular carcinoma
    125918032
   05226 Gastric cancer
    125918032
   05214 Glioma
    125918032
   05216 Thyroid cancer
    125918032
   05221 Acute myeloid leukemia
    125918032
   05220 Chronic myeloid leukemia
    125918032
   05218 Melanoma
    125918032
   05211 Renal cell carcinoma
    125918032
   05219 Bladder cancer
    125918032
   05215 Prostate cancer
    125918032
   05213 Endometrial cancer
    125918032
   05224 Breast cancer
    125918032
   05223 Non-small cell lung cancer
    125918032
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125918032
   05170 Human immunodeficiency virus 1 infection
    125918032
   05161 Hepatitis B
    125918032
   05160 Hepatitis C
    125918032
   05164 Influenza A
    125918032
   05163 Human cytomegalovirus infection
    125918032
   05167 Kaposi sarcoma-associated herpesvirus infection
    125918032
   05165 Human papillomavirus infection
    125918032
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125918032
   05135 Yersinia infection
    125918032
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125918032
   05022 Pathways of neurodegeneration - multiple diseases
    125918032
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    125918032
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125918032
   01522 Endocrine resistance
    125918032
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:puc01001]
    125918032
Enzymes [BR:puc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     125918032
Protein kinases [BR:puc01001]
 Serine/threonine kinases: STE group
  STE7 family
   125918032
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 125918032
NCBI-ProteinID: XP_049480051
LinkDB
Position
Unknown
AA seq 382 aa
MFLASPCPWGLCRANLVDLQKKLAELELDEQQKKRLEAFLTQKAKVGELKDDDFERISEL
GAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHGCNSPYIVGFYGAFY
SDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPS
NILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLV
ELSIGRYPIPPPDAKELEATFGRPMVDGAEGEPHSISPRPRPPGRPVSGHGTDSRPAMAI
FELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADLKTLTNHTFIKRSEVEEVD
FAGWLCKTLRLNQPSTPTHTAV
NT seq 1149 nt   +upstreamnt  +downstreamnt
atgttcttggctagcccttgcccttggggtctttgcagagcaaacttggtggacctccag
aagaagctagcagagcttgaactcgacgagcagcagaagaagcgtctagaagccttcctc
acccagaaggccaaggtcggagagctcaaggacgatgacttcgaaaggatctcggaactg
ggggccgggaacggcggggtggtcaccaaggtccaacacagaccctccggcctcatcatg
gcgagaaagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgag
ctgcaggtgctgcacgggtgtaactccccgtacatcgtgggcttctacggggccttctac
agcgacggcgagatcagcatctgcatggagcacatggacggcggttctctggaccaggtg
ttgaaagaagccaagagaattcccgaggagatcctggggaaggtcagcatcgcggttctc
cggggtttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccgtcc
aacatcctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcgggcag
ctcatcgactccatggccaactccttcgtgggaactcggtcctacatgtctccggagcgg
ttgcagggcacgcactactcggtgcagtcggacatctggagcatgggcctgtccctggtg
gagctgtccatcggaaggtaccccatccccccgccggacgccaaggagctggaggccacg
ttcggccggcccatggttgacggggcagaaggagagcctcacagcatctcgccacggccc
agaccgcctggacgccccgtcagtggccacgggacggacagccggccggccatggccatc
ttcgagctgctggactacattgtgaatgagccacctcccaagctgcccagcggtgtcttc
acccaggacttccaggagtttgtaaataaatgcctcattaagaacccagcggagcgagcc
gacctgaagacgctcacgaaccacacgttcatcaagcggtccgaggtggaagaagtggac
ttcgccggctggttgtgtaaaacgctgcggctgaaccagcccagcacgcccacacacacc
gccgtgtga

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