Panthera uncia (snow leopard): 125921018 Help Entry 125921018         CDS       T08832                                  Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism puc  Panthera uncia (snow leopard) Pathway puc00230   Purine metabolism puc01100   Metabolic pathways puc01522   Endocrine resistance puc04015   Rap1 signaling pathway puc04022   cGMP-PKG signaling pathway puc04024   cAMP signaling pathway puc04062   Chemokine signaling pathway puc04072   Phospholipase D signaling pathway puc04081   Hormone signaling puc04082   Neuroactive ligand signaling puc04114   Oocyte meiosis puc04211   Longevity regulating pathway puc04213   Longevity regulating pathway - multiple species puc04261   Adrenergic signaling in cardiomyocytes puc04270   Vascular smooth muscle contraction puc04371   Apelin signaling pathway puc04540   Gap junction puc04611   Platelet activation puc04713   Circadian entrainment puc04714   Thermogenesis puc04723   Retrograde endocannabinoid signaling puc04724   Glutamatergic synapse puc04725   Cholinergic synapse puc04726   Serotonergic synapse puc04727   GABAergic synapse puc04728   Dopaminergic synapse puc04750   Inflammatory mediator regulation of TRP channels puc04911   Insulin secretion puc04912   GnRH signaling pathway puc04913   Ovarian steroidogenesis puc04914   Progesterone-mediated oocyte maturation puc04915   Estrogen signaling pathway puc04916   Melanogenesis puc04918   Thyroid hormone synthesis puc04921   Oxytocin signaling pathway puc04923   Regulation of lipolysis in adipocytes puc04924   Renin secretion puc04925   Aldosterone synthesis and secretion puc04926   Relaxin signaling pathway puc04927   Cortisol synthesis and secretion puc04928   Parathyroid hormone synthesis, secretion and action puc04934   Cushing syndrome puc04935   Growth hormone synthesis, secretion and action puc04970   Salivary secretion puc04971   Gastric acid secretion puc04972   Pancreatic secretion puc04976   Bile secretion puc05012   Parkinson disease puc05030   Cocaine addiction puc05031   Amphetamine addiction puc05032   Morphine addiction puc05034   Alcoholism puc05163   Human cytomegalovirus infection puc05166   Human T-cell leukemia virus 1 infection puc05200   Pathways in cancer puc05207   Chemical carcinogenesis - receptor activation puc05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:puc00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     125921018  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     125921018    04371 Apelin signaling pathway     125921018    04072 Phospholipase D signaling pathway     125921018    04024 cAMP signaling pathway     125921018    04022 cGMP-PKG signaling pathway     125921018   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     125921018    04081 Hormone signaling     125921018  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     125921018   09144 Cellular community - eukaryotes    04540 Gap junction     125921018  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     125921018    04062 Chemokine signaling pathway     125921018   09152 Endocrine system    04911 Insulin secretion     125921018    04923 Regulation of lipolysis in adipocytes     125921018    04912 GnRH signaling pathway     125921018    04913 Ovarian steroidogenesis     125921018    04915 Estrogen signaling pathway     125921018    04914 Progesterone-mediated oocyte maturation     125921018    04921 Oxytocin signaling pathway     125921018    04926 Relaxin signaling pathway     125921018    04935 Growth hormone synthesis, secretion and action     125921018    04918 Thyroid hormone synthesis     125921018    04928 Parathyroid hormone synthesis, secretion and action     125921018    04916 Melanogenesis     125921018    04924 Renin secretion     125921018    04925 Aldosterone synthesis and secretion     125921018    04927 Cortisol synthesis and secretion     125921018   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     125921018    04270 Vascular smooth muscle contraction     125921018   09154 Digestive system    04970 Salivary secretion     125921018    04971 Gastric acid secretion     125921018    04972 Pancreatic secretion     125921018    04976 Bile secretion     125921018   09156 Nervous system    04724 Glutamatergic synapse     125921018    04727 GABAergic synapse     125921018    04725 Cholinergic synapse     125921018    04728 Dopaminergic synapse     125921018    04726 Serotonergic synapse     125921018    04723 Retrograde endocannabinoid signaling     125921018   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     125921018   09149 Aging    04211 Longevity regulating pathway     125921018    04213 Longevity regulating pathway - multiple species     125921018   09159 Environmental adaptation    04713 Circadian entrainment     125921018    04714 Thermogenesis     125921018  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125921018    05207 Chemical carcinogenesis - receptor activation     125921018   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     125921018    05163 Human cytomegalovirus infection     125921018   09164 Neurodegenerative disease    05012 Parkinson disease     125921018   09165 Substance dependence    05030 Cocaine addiction     125921018    05031 Amphetamine addiction     125921018    05032 Morphine addiction     125921018    05034 Alcoholism     125921018   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     125921018   09167 Endocrine and metabolic disease    04934 Cushing syndrome     125921018   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     125921018 Enzymes [BR:puc01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      125921018 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  125921018 NCBI-ProteinID:  XP_049484250 LinkDB All DBs Position C2:complement(67476870..67625652) Genome browser AA seq 1263 aa AA seqDB search MSGSKSVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPHAPGGSTRSCTKKPGGA VTPQQQQQQRLANRWRNDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQ RRGAAGGGSTRAPPGGGGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRAADELEAGAG AVEGDEGSGDGSSLAGSGAGPGSVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLN QSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHM GLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLS ALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQAR LHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGF TSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCV EMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAG GKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAK MNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDE FLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFV QITIVPHSVFMLSFYLTCFLLLTLVVFVSVIYSCVKLFPAPLQTLSRKIVRSKTNSTLVG VFTITLVFLSAFVNMFMCNSKDLFGCLADEHNISTSQVNACHVVESAVNYSLGDERGFCS SPRPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELTYVLIVEVPRVTLFDNA DLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLW KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDS TYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI WGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGP PLS NT seq 3792 nt NT seq  +upstreamnt  +downstreamnt atgtccggctccaaaagcgtaagccccccgggctacgcggcgcagacagcggcggcgccg gcgtcccggggaggcccggaacatcgctcggcgtggggggaggccgattcccgcgccaat ggctacccccacgcccccgggggttcgacccgcagctgcaccaagaaacccgggggggcg gtgaccccgcagcagcagcagcagcagcgcctggctaatcgttggcgcaacgacgacgac gacgatcctcctctgagtggtgacgaccctctggccgggggcttcggcttcagcttccgc tccaaatctgcttggcaggagcgcggcggcgacgactgcggtcgcggcagccgccggcag cggcggggcgcggccggcgggggcagcacccgggcgccccctgggggcggcggtggcggc tcggccgcggctgcggccgcagcgggcgggaccgaggtgcgccctcgctcggtggagctg ggcctggaggagcggcgaggcaagggccgcgcggcggacgagctggaggccggtgccggt gccgtcgagggcgacgaagggtcaggggatggcagcagcttggccggctcaggcgcgggg cccggctcagtgctgtcgctgggcgcctgctgcctggcgctgctgcagatattccgctcc aagaagttcccgtcggacaaactggagcggctgtaccagcgttacttcttccgtctgaac cagagcagcctcactatgcttatggctgtgctggtgctcgtgtgcctcgtcatgttggcc ttccacgcggcgcggcccccgctccagctgccctacctggcagtgctggcggcagcggtg ggtgtcatccttgtcatggctgtgctctgtaaccgcgccgccttccaccaggaccacatg ggcctggcctgctacgcgctcatcgccgtggtgctggctgtccaggtggtgggcctgctg ctgccccagccgcgcagcgcctcggagggcatctggtggaccgtgttcttcatctacacc atctacacgttgctgcctgtgcgcatgcgggccgcggtactcagtggggtgctgctgtct gccctccacctggccatcgccctgcgcaccaacgcccaggaccagttcctgctcaagcag cttgtctccaatgtcctcattttctcctgcaccaacatcgtgggtgtctgcacccactac ccggctgaggtctctcagagacaggccttccaggaaacccgggagtgcatccaggcacgg ctccactcacaacgggagaatcagcaacaggagcggctcctactgtctgtcctgccccgt catgttgccatggagatgaaagcagacatcaatgccaagcaggaggatatgatgttccat aagatttacatccagaaacatgacaacgtgagcatcctgtttgctgacatcgagggcttc accagcctggcgtcccagtgcactgcccaggagctagtcatgaccctcaacgagctcttc gcccgcttcgacaagctggctgcggagaatcactgtttacgtattaagatcctgggggat tgttattactgtgtctctgggctgcctgaagcgagggctgaccacgctcactgctgcgtg gagatgggcatggacatgattgaggccatctcgttggtccgggaggtgactggggtgaac gtgaacatgcgcgtgggaattcacagcgggcgagtacactgcggtgtccttggtctcagg aagtggcagttcgacgtctggtctaatgacgtcacgctggccaaccacatggaagctgga ggcaaggcagggcgcatccacatcaccaaggccacgctcaactacctgaatggtgactat gaggtggagccaggctgtgggggcgagcgcaacgcctacctcaaggagcacagcattgag accttcctcatcctgcgctgcacccagaagcggaaagaagaaaaggccatgatcgccaag atgaatcgccagagaaccaactccattgggcacaacccgccccactggggggctgagcgt cccttctacaaccacctagggggcaaccaggtgtccaaggagatgaagcggatgggcttt gaagaccccaaggacaagaacgcccaggaaagtgcaaaccctgaggatgaagtggacgaa tttctgggccgtgccattgacgccaggagcatcgacaggctgcggtctgagcatgtccgc aagttcctcttgaccttcagggagcctgacttagagaagaagtactccaagcaggtggat gaccgattcggtgcctatgtggcatgtgcctcgcttgtcttcctcttcatctgctttgtc cagatcaccatcgtgccccactccgtgttcatgttgagtttctacctgacctgtttcctg ctgctgaccttggtggtgtttgtgtccgtgatttattcctgcgtgaagctcttcccggcc ccgctgcagaccctttccaggaagatcgtgcggtccaagacgaacagcaccctggtcgga gtgttcaccatcaccctggtgttcctgtcggcttttgtcaacatgttcatgtgtaactcc aaggacctgttcggctgcctggcggatgagcacaacatcagcaccagccaggtcaacgcg tgccatgtggtggagtcggcagtcaactacagcctgggtgacgagcggggcttctgcagc agcccccggcccaactgcaacttccccgagtacttcacctacagtgtgctgctcagcctg ctggcctgctccgtgttcctgcagatcagctgcattgggaagctggtgctcatgctggcc attgagctcacatacgtgctcattgttgaggtgccccgcgtcacgctctttgacaacgcc gacctgctggtcaccgccaatgccatagacttcagcaacaacgggacctcccagtgccct gaacatgcgaccaaggtggcgctgaaggtggtgacgcccatcatcatctcagtcttcgtg ctggccctatacctgcatgcccagcaagtggagtccaccgcccgcctggacttcctctgg aaactgcaggccacagaggaaaaggaggagatggaggagctgcaggcctacaaccggcgg ctgctgcacaacatcctgcccaaggatgtggccgcccacttcctggcccgtgagcgacgc aatgatgagctctactaccagtcgtgtgagtgtgtggccgtcatgttcgcctccatcgcc aacttctctgaattctacgtggagctggaggccaacaatgagggtgttgagtgcctgcga ctactcaatgagatcatcgccgactttgacgagatcatcagtgaggatcggttcaggcag ctggaaaagatcaagaccattggcagcacctacatggctgcctcaggcctcaatgactct acatatgacaaggtgggcaagacccacatcaaagccctggctgactttgccatgaagctc atggaccaaatgaagtacatcaatgagcactccttcaacaacttccagatgaagatcggg ctcaatattggccccgtggtggctggggtgatcggggctcgcaagcctcagtacgacatc tggggcaatacggtgaacgtggccagccgcatggacagcaccggtgtgcctgaccgcatc caggtcaccacagacatgtaccaggtgctggctgccaacacataccagctggagtgcagg ggtgtggtcaaggtcaagggcaaaggagagatgatgacctacttcctcaacggtgggccc ccgctcagttag

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