Panthera uncia (snow leopard): 125928720 Help Entry 125928720         CDS       T08832                                  Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism puc  Panthera uncia (snow leopard) Pathway puc04010   MAPK signaling pathway puc04014   Ras signaling pathway puc04015   Rap1 signaling pathway puc04022   cGMP-PKG signaling pathway puc04066   HIF-1 signaling pathway puc04068   FoxO signaling pathway puc04072   Phospholipase D signaling pathway puc04081   Hormone signaling puc04150   mTOR signaling pathway puc04151   PI3K-Akt signaling pathway puc04152   AMPK signaling pathway puc04211   Longevity regulating pathway puc04213   Longevity regulating pathway - multiple species puc04520   Adherens junction puc04910   Insulin signaling pathway puc04913   Ovarian steroidogenesis puc04923   Regulation of lipolysis in adipocytes puc04930   Type II diabetes mellitus puc04931   Insulin resistance puc04932   Non-alcoholic fatty liver disease puc04960   Aldosterone-regulated sodium reabsorption puc05010   Alzheimer disease puc05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:puc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     125928720    04014 Ras signaling pathway     125928720    04015 Rap1 signaling pathway     125928720    04066 HIF-1 signaling pathway     125928720    04068 FoxO signaling pathway     125928720    04072 Phospholipase D signaling pathway     125928720    04022 cGMP-PKG signaling pathway     125928720    04151 PI3K-Akt signaling pathway     125928720    04152 AMPK signaling pathway     125928720    04150 mTOR signaling pathway     125928720   09133 Signaling molecules and interaction    04081 Hormone signaling     125928720  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     125928720  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     125928720    04923 Regulation of lipolysis in adipocytes     125928720    04913 Ovarian steroidogenesis     125928720   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     125928720   09149 Aging    04211 Longevity regulating pathway     125928720    04213 Longevity regulating pathway - multiple species     125928720  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     125928720   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     125928720   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     125928720    04932 Non-alcoholic fatty liver disease     125928720    04931 Insulin resistance     125928720  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:puc01001]     125928720   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:puc04090]     125928720 Enzymes [BR:puc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      125928720 Protein kinases [BR:puc01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    125928720 CD molecules [BR:puc04090]  Proteins   125928720 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Recep_L_domain Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  125928720 NCBI-ProteinID:  XP_049495356 LinkDB All DBs Position A2:5890756..5945094 Genome browser AA seq 1160 aa AA seqDB search PAVFPLPPVCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCP PPYYHFQDWRCVNFSFCRDLHNKCKNSRRQGCHQYVIHNNRCIPECPSGYTMNSSNLMCT PCLGPCPKVCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIE EISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTIT QGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSY DKILLKWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSND PKSQNHPGWLMRGLKPWTQYAVFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPI SVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPF ESEGSQKHNQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKR RALADAGNVTAAVPTVPGFPNTSSSVPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIEL QACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIV LYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYF YVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSA SDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNES ASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSLRPEA ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR DIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN EQVLKFVMDGGYLDQPDNCPERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVS FFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDHIPYT HMNGGKKNGRILTLPRSNPS NT seq 3483 nt NT seq  +upstreamnt  +downstreamnt ccagctgtttttcctctccctccagtttgtccgaccatctgcaagtcgcacggctgcacg gccgacggcctctgctgccacagcgagtgtctgggcaactgctccgagcccgacgacccc accaagtgcgtggcctgtcgcaacttctacctggacggcaggtgcgtggagacctgcccg cccccctactaccacttccaagactggcgctgcgtgaacttcagcttctgccgggacctg cacaataaatgcaagaactcccggagacagggttgccaccagtatgtcattcacaacaac aggtgcatccctgagtgcccctcggggtacacgatgaattccagcaacctgatgtgcact ccctgcctgggcccctgtcccaaggtctgccacatcctggaaggcgagaagaccatcgac tcggtgacatctgcccaggagctccgaggctgcaccgtcgtcaacggaagcctaatcatc aacattcgagggggcaacaacctggcagctgagctggaggccaacctcggactcattgaa gaaatttctgggtacctgaagatccgaaggtcctatgctcttgtgtcactttcctttttc cggaagttacggctgattcggggagagaccttggaaatcgggaactactctttctatgcc ttggacaaccagaacctgaggcagctatgggactggagcaaacacaacctcaccatcact caggggaaactcttcttccactataatcccaaactctgcttgtcggaaattcacaagatg gaggaggtttcaggaaccaaggggcgccaggagcggaacgacattgccctgaagaccaat ggggaccaggcgtcttgtgaaaatgaactacttaaattttcttacattcggacatcttac gacaagatcttgctaaaatgggagccgtactggccccctgacttccgagacctcctgggc ttcatgctcttctacaaagaggccccttatcagaatgtgaccgagttcgacgggcaggac gcgtgtggctccaacagctggacggtggtggacattgacccgcctctgaggtccaatgac cccaagtcgcagaaccacccagggtggctgatgcggggtctcaagccctggacccagtat gctgtctttgtcaagaccttggtcaccttttctgatgagcgccgcacgtatggggccaag agtgacatcatctatgtccagaccgatgccaccaacccttccgtccccctggatcctatc tcggtttcgaattcctcctctcagatcattctgaagtggaagcctccctcggaccccaat ggcaacatcacgcactacctggtgttctgggagaggcaggcggaggacagtgagctgtat gagttggattattgcctcaaagggttgaagctgccttcccggacctggtccccgccgttc gagtccgagggctcccagaagcacaatcagagtgagtacgaggagtccgctggcgaatgc tgctcgtgtcccaagaccgactctcagatcctgaaggagctggaggagtcctctttcagg aagacgttcgaggattacctgcacaatgtggttttcgtgcccaggccgtcgcggaagcgc agggccctcgccgacgctgggaacgtgacggccgccgtgcccacggtgcctggtttcccc aacacttccagcagcgtgcccacgagcccggaagagcacaagcccttcgagaaggtggtg aacaaagagtctctggtcatctccggcctgcgtcacttcaccggctaccgcatcgagctg caggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcctacgtcagcgcc aggaccatgcccgaagccaaggcagacgacattgttggccctgtgacccatgaaatcttc gagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaatggattgatcgtg ctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctctgtgtctcccgt agacactttgctctggagcggggctgcaggctgcgagggctgccgccggggaattacagt gtgcgagttcgggccacctccctggcgggcaacggctcctggacagaagccacttatttc tatgtgacagactatttagatgtcccatcgaacattgcaaaaattatcatcgggcctctc atctttgtctttctcttcagtgttgtgattggaagtatttatctattcctgagaaagagg cagccggatgggccactggggccgctgtatgcttcttcaaaccctgagtacctcagtgcc agtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtgcctcgggagaag atcactctcctgcgcgagctggggcagggctccttcggcatggtgtacgagggcaatgcc agggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgagtcc gccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatgaagggcttcacc tgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccgacgctggtggtg atggagctgatggttcacggagacctgaagagctacctccgctccctgcggccggaggct gagaataaccctggccgccctccccctactctgcaagagatgattcagatggcggcggag atcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgggatctcgcagct cgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttcggaatgaccaga gacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcggtgg atggcaccggaatccctgaaggacggggtcttcaccacttcttctgacatgtggtccttt ggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaaggcctgtctaat gaacaggtgttgaaatttgtcatggacggaggatatttggaccaacctgacaactgtccg gagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaagatgcggcccacc ttcctggagatcgttgacctgctcaaggacgacctgcaccccagctttccggaagtctcc ttcttccacagcgaggagaacaaggcacctgagagtgaggagttggaaatggagtttgag gacatggagagtgtccccctggatcgggcctcacactcacagagggaagaggccgggggc cgggatggagtgtcctcgctgggcctcaagcggaactacgaggaccacatcccctacacc cacatgaacgggggcaagaaaaatggacggattctgaccctgccgaggtcgaatccttcc taa

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