KEGG   Panthera uncia (snow leopard): 125936595
Entry
125936595         CDS       T08832                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc00562  Inositol phosphate metabolism
puc01100  Metabolic pathways
puc01521  EGFR tyrosine kinase inhibitor resistance
puc04012  ErbB signaling pathway
puc04014  Ras signaling pathway
puc04015  Rap1 signaling pathway
puc04020  Calcium signaling pathway
puc04062  Chemokine signaling pathway
puc04064  NF-kappa B signaling pathway
puc04066  HIF-1 signaling pathway
puc04070  Phosphatidylinositol signaling system
puc04072  Phospholipase D signaling pathway
puc04360  Axon guidance
puc04370  VEGF signaling pathway
puc04517  IgSF CAM signaling
puc04613  Neutrophil extracellular trap formation
puc04650  Natural killer cell mediated cytotoxicity
puc04658  Th1 and Th2 cell differentiation
puc04659  Th17 cell differentiation
puc04660  T cell receptor signaling pathway
puc04664  Fc epsilon RI signaling pathway
puc04666  Fc gamma R-mediated phagocytosis
puc04670  Leukocyte transendothelial migration
puc04722  Neurotrophin signaling pathway
puc04750  Inflammatory mediator regulation of TRP channels
puc04919  Thyroid hormone signaling pathway
puc04933  AGE-RAGE signaling pathway in diabetic complications
puc04935  Growth hormone synthesis, secretion and action
puc05012  Parkinson disease
puc05022  Pathways of neurodegeneration - multiple diseases
puc05135  Yersinia infection
puc05167  Kaposi sarcoma-associated herpesvirus infection
puc05170  Human immunodeficiency virus 1 infection
puc05171  Coronavirus disease - COVID-19
puc05200  Pathways in cancer
puc05205  Proteoglycans in cancer
puc05206  MicroRNAs in cancer
puc05214  Glioma
puc05223  Non-small cell lung cancer
puc05225  Hepatocellular carcinoma
puc05231  Choline metabolism in cancer
puc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
puc05417  Lipid and atherosclerosis
Module
puc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:puc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125936595
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125936595
   04014 Ras signaling pathway
    125936595
   04015 Rap1 signaling pathway
    125936595
   04370 VEGF signaling pathway
    125936595
   04064 NF-kappa B signaling pathway
    125936595
   04066 HIF-1 signaling pathway
    125936595
   04020 Calcium signaling pathway
    125936595
   04070 Phosphatidylinositol signaling system
    125936595
   04072 Phospholipase D signaling pathway
    125936595
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    125936595
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    125936595
   04650 Natural killer cell mediated cytotoxicity
    125936595
   04660 T cell receptor signaling pathway
    125936595
   04658 Th1 and Th2 cell differentiation
    125936595
   04659 Th17 cell differentiation
    125936595
   04664 Fc epsilon RI signaling pathway
    125936595
   04666 Fc gamma R-mediated phagocytosis
    125936595
   04670 Leukocyte transendothelial migration
    125936595
   04062 Chemokine signaling pathway
    125936595
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    125936595
   04919 Thyroid hormone signaling pathway
    125936595
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    125936595
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125936595
  09158 Development and regeneration
   04360 Axon guidance
    125936595
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125936595
   05206 MicroRNAs in cancer
    125936595
   05205 Proteoglycans in cancer
    125936595
   05231 Choline metabolism in cancer
    125936595
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125936595
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    125936595
   05214 Glioma
    125936595
   05223 Non-small cell lung cancer
    125936595
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    125936595
   05171 Coronavirus disease - COVID-19
    125936595
   05167 Kaposi sarcoma-associated herpesvirus infection
    125936595
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    125936595
  09164 Neurodegenerative disease
   05012 Parkinson disease
    125936595
   05022 Pathways of neurodegeneration - multiple diseases
    125936595
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125936595
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    125936595
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125936595
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:puc04131]
    125936595
Enzymes [BR:puc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     125936595
Membrane trafficking [BR:puc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    125936595
 Endocytosis
  Macropinocytosis
   Phospholipase C
    125936595
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG PH SH3_1 C2 EF_HAND_1_PLCG SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 125936595
NCBI-ProteinID: XP_049506736
LinkDB
Position
A3
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRTDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
VERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVVLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKAGYRAVPLKNNYSEDL
ELASLLIRIEVFPAKQENGDVSPFSSMSLRERGSDASGQLFHGRGREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggatcctgctttccga
acagaccagtcacactgctttgtcatactgtatgggatggagttccgcctgaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaaggggttaacttggctg
atggaagatacattgcaggcagccacacctctgcagattgaaaggtggctgaggaagcag
ttctattcggtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctatgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggcg
gtggagcggccggagctctgtcgcgtgtcccttcctgagttccagcagttcctccttgag
taccagggggagctgtgggccgtcgaccggcttcaggtgcaagaatttatgctcagcttt
ctccgagaccccttgcgagagattgaagagccgtacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcagtgtgcccagaa
accatgaacaaccccctctcccactactggatctcctcctcccacaacacatacctgacc
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcagacgtcctgcacactatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtccattgaggaccattgcagcattgcc
cagcagaggaacatggcacagtacttcaagaaggtgcttggggacacactccttaccaag
cctgtggacatcgctgccgatggactcccctcacccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggcagagggcagtgcctatgaagaggtgcctacatcagtgatg
tactccgagaacgatatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgagtggtatccccactacttcgtcctgaccagcagcaaaatctactactct
gaggagacgagcagtgaccagggcaacgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccagtgagaaatggttccacgggaagctcggggcaggacgggat
gggcggcacatcgctgagcgcctgcttaccgagtactgcattgagaccggggcccctgat
ggctccttcctcgtgcgagagagcgagaccttcgtgggcgactataccctctctttctgg
cggaatgggaaagtccagcactgccggatccactctcggcaggacgctggggcccccaag
ttcttcttgacagacaacctggtctttgactcgctctatgacctcatcacacactaccag
caggtgcccctacgctgcaacgaatttgagatgcgcctctcagagccagtcccgcagacc
aatgcccacgagagcaaagagtggtaccatgccagcctgaccagagctcaggctgagcac
atgctgatgcgcgtcccccgggatggggctttcctggtgaggaaacggaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcattgccgcgtccagcaggag
ggccagacggtggtcctgggcaactccgagttcgacagcctcgtggacctcatcagctac
tatgagaagcacccactgtaccgcaagatgaagctgcgctatcccatcaacgaggaggcg
ctggagaagatcggcacagctgagccagactacggggccctgtatgagggccgcaaccca
ggcttctatgtggaggcgaatcctatgccaactttcaagtgtgcagtcaaagcactcttt
gactacaaggcccagagagaggatgagctgactttcactaagagcgccatcatccagaac
gtggagaagcaagaaggtggctggtggcggggggactatggtgggaagaagcagctgtgg
ttcccgtcaaactacgtggaagagatggtcagccccgcagccctggagcctgagagggag
cacttggacgagaacagccccttgggggatttgctccggggggtcttggatgtgccagct
tgtcagattgccatccgtcccgagggcaagaacaaccggctgttcgtcttctccatcagt
atggcttccgtggcgcactggtccctggatgtcgctgctgactcacaagaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagacgccaggctcacggagggc
aagatgatggagcggaggaagaagatcgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttt
ctccagtacaaccggctgcagctctcccgcatctaccccaagggccagcggctggactct
tccaattacgaccccttgcccatgtggatctgtggcagtcagctcgtggctctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggccggtggccactgt
ggctacgtgctgcagccgagcaccatgcgggatgaggcctttgatccctttgacaagagc
agcctccgaggcctggagccatatgccatctgcattgaggtgctgggggcccggcacctg
ccgaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggccggagcagag
tatgacagcatcaaacagaagacagaatttgtggtggacaacggactgaaccctgtttgg
cccgccaagcccttccacttccagatcagtaacccggaattcgccttcctgcgctttgtg
gtgtatgaggaggacatgttcagtgaccagaacttcctggctcaggccaccttcccagtg
aagggcttgaaggcaggatacagagccgtgcctttgaagaacaactacagtgaggacctg
gagctggcctccctgctcatcaggatcgaagttttccctgccaagcaggagaatggtgat
gtcagtcccttcagtagtatgtctctgcgggagcggggctccgatgcctcgggccagctg
ttccatggccggggccgggaaggttcctttgaagcccgctaccagcagccgtttgaggac
tttcgtatctcccaagagcatctggcagaccattttgacagtcgggaacggagggcccca
cgaaggactcgggtcaacggggacaaccgcctctag

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