KEGG   Prionailurus viverrinus (fishing cat): 125150373
Entry
125150373         CDS       T09889                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pviv  Prionailurus viverrinus (fishing cat)
Pathway
pviv01521  EGFR tyrosine kinase inhibitor resistance
pviv01522  Endocrine resistance
pviv01524  Platinum drug resistance
pviv04012  ErbB signaling pathway
pviv04014  Ras signaling pathway
pviv04015  Rap1 signaling pathway
pviv04024  cAMP signaling pathway
pviv04062  Chemokine signaling pathway
pviv04066  HIF-1 signaling pathway
pviv04068  FoxO signaling pathway
pviv04070  Phosphatidylinositol signaling system
pviv04071  Sphingolipid signaling pathway
pviv04072  Phospholipase D signaling pathway
pviv04081  Hormone signaling
pviv04140  Autophagy - animal
pviv04150  mTOR signaling pathway
pviv04151  PI3K-Akt signaling pathway
pviv04152  AMPK signaling pathway
pviv04210  Apoptosis
pviv04211  Longevity regulating pathway
pviv04213  Longevity regulating pathway - multiple species
pviv04218  Cellular senescence
pviv04360  Axon guidance
pviv04370  VEGF signaling pathway
pviv04380  Osteoclast differentiation
pviv04510  Focal adhesion
pviv04550  Signaling pathways regulating pluripotency of stem cells
pviv04611  Platelet activation
pviv04613  Neutrophil extracellular trap formation
pviv04620  Toll-like receptor signaling pathway
pviv04625  C-type lectin receptor signaling pathway
pviv04630  JAK-STAT signaling pathway
pviv04650  Natural killer cell mediated cytotoxicity
pviv04660  T cell receptor signaling pathway
pviv04662  B cell receptor signaling pathway
pviv04664  Fc epsilon RI signaling pathway
pviv04666  Fc gamma R-mediated phagocytosis
pviv04668  TNF signaling pathway
pviv04670  Leukocyte transendothelial migration
pviv04722  Neurotrophin signaling pathway
pviv04725  Cholinergic synapse
pviv04750  Inflammatory mediator regulation of TRP channels
pviv04810  Regulation of actin cytoskeleton
pviv04910  Insulin signaling pathway
pviv04914  Progesterone-mediated oocyte maturation
pviv04915  Estrogen signaling pathway
pviv04917  Prolactin signaling pathway
pviv04919  Thyroid hormone signaling pathway
pviv04923  Regulation of lipolysis in adipocytes
pviv04926  Relaxin signaling pathway
pviv04929  GnRH secretion
pviv04930  Type II diabetes mellitus
pviv04931  Insulin resistance
pviv04932  Non-alcoholic fatty liver disease
pviv04933  AGE-RAGE signaling pathway in diabetic complications
pviv04935  Growth hormone synthesis, secretion and action
pviv04960  Aldosterone-regulated sodium reabsorption
pviv04973  Carbohydrate digestion and absorption
pviv05010  Alzheimer disease
pviv05017  Spinocerebellar ataxia
pviv05020  Prion disease
pviv05100  Bacterial invasion of epithelial cells
pviv05135  Yersinia infection
pviv05142  Chagas disease
pviv05146  Amoebiasis
pviv05160  Hepatitis C
pviv05161  Hepatitis B
pviv05162  Measles
pviv05163  Human cytomegalovirus infection
pviv05164  Influenza A
pviv05165  Human papillomavirus infection
pviv05166  Human T-cell leukemia virus 1 infection
pviv05167  Kaposi sarcoma-associated herpesvirus infection
pviv05168  Herpes simplex virus 1 infection
pviv05169  Epstein-Barr virus infection
pviv05170  Human immunodeficiency virus 1 infection
pviv05171  Coronavirus disease - COVID-19
pviv05200  Pathways in cancer
pviv05203  Viral carcinogenesis
pviv05205  Proteoglycans in cancer
pviv05206  MicroRNAs in cancer
pviv05207  Chemical carcinogenesis - receptor activation
pviv05208  Chemical carcinogenesis - reactive oxygen species
pviv05210  Colorectal cancer
pviv05211  Renal cell carcinoma
pviv05212  Pancreatic cancer
pviv05213  Endometrial cancer
pviv05214  Glioma
pviv05215  Prostate cancer
pviv05218  Melanoma
pviv05220  Chronic myeloid leukemia
pviv05221  Acute myeloid leukemia
pviv05222  Small cell lung cancer
pviv05223  Non-small cell lung cancer
pviv05224  Breast cancer
pviv05225  Hepatocellular carcinoma
pviv05226  Gastric cancer
pviv05230  Central carbon metabolism in cancer
pviv05231  Choline metabolism in cancer
pviv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pviv05415  Diabetic cardiomyopathy
pviv05417  Lipid and atherosclerosis
pviv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pviv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125150373 (PIK3R2)
   04014 Ras signaling pathway
    125150373 (PIK3R2)
   04015 Rap1 signaling pathway
    125150373 (PIK3R2)
   04370 VEGF signaling pathway
    125150373 (PIK3R2)
   04630 JAK-STAT signaling pathway
    125150373 (PIK3R2)
   04668 TNF signaling pathway
    125150373 (PIK3R2)
   04066 HIF-1 signaling pathway
    125150373 (PIK3R2)
   04068 FoxO signaling pathway
    125150373 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    125150373 (PIK3R2)
   04072 Phospholipase D signaling pathway
    125150373 (PIK3R2)
   04071 Sphingolipid signaling pathway
    125150373 (PIK3R2)
   04024 cAMP signaling pathway
    125150373 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    125150373 (PIK3R2)
   04152 AMPK signaling pathway
    125150373 (PIK3R2)
   04150 mTOR signaling pathway
    125150373 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    125150373 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    125150373 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    125150373 (PIK3R2)
   04218 Cellular senescence
    125150373 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125150373 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    125150373 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125150373 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125150373 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    125150373 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    125150373 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    125150373 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    125150373 (PIK3R2)
   04660 T cell receptor signaling pathway
    125150373 (PIK3R2)
   04662 B cell receptor signaling pathway
    125150373 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    125150373 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    125150373 (PIK3R2)
   04670 Leukocyte transendothelial migration
    125150373 (PIK3R2)
   04062 Chemokine signaling pathway
    125150373 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125150373 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    125150373 (PIK3R2)
   04929 GnRH secretion
    125150373 (PIK3R2)
   04915 Estrogen signaling pathway
    125150373 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    125150373 (PIK3R2)
   04917 Prolactin signaling pathway
    125150373 (PIK3R2)
   04926 Relaxin signaling pathway
    125150373 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    125150373 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    125150373 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125150373 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    125150373 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    125150373 (PIK3R2)
   04722 Neurotrophin signaling pathway
    125150373 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125150373 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    125150373 (PIK3R2)
   04380 Osteoclast differentiation
    125150373 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    125150373 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    125150373 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125150373 (PIK3R2)
   05206 MicroRNAs in cancer
    125150373 (PIK3R2)
   05205 Proteoglycans in cancer
    125150373 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    125150373 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    125150373 (PIK3R2)
   05203 Viral carcinogenesis
    125150373 (PIK3R2)
   05230 Central carbon metabolism in cancer
    125150373 (PIK3R2)
   05231 Choline metabolism in cancer
    125150373 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125150373 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125150373 (PIK3R2)
   05212 Pancreatic cancer
    125150373 (PIK3R2)
   05225 Hepatocellular carcinoma
    125150373 (PIK3R2)
   05226 Gastric cancer
    125150373 (PIK3R2)
   05214 Glioma
    125150373 (PIK3R2)
   05221 Acute myeloid leukemia
    125150373 (PIK3R2)
   05220 Chronic myeloid leukemia
    125150373 (PIK3R2)
   05218 Melanoma
    125150373 (PIK3R2)
   05211 Renal cell carcinoma
    125150373 (PIK3R2)
   05215 Prostate cancer
    125150373 (PIK3R2)
   05213 Endometrial cancer
    125150373 (PIK3R2)
   05224 Breast cancer
    125150373 (PIK3R2)
   05222 Small cell lung cancer
    125150373 (PIK3R2)
   05223 Non-small cell lung cancer
    125150373 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125150373 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    125150373 (PIK3R2)
   05161 Hepatitis B
    125150373 (PIK3R2)
   05160 Hepatitis C
    125150373 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    125150373 (PIK3R2)
   05164 Influenza A
    125150373 (PIK3R2)
   05162 Measles
    125150373 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    125150373 (PIK3R2)
   05163 Human cytomegalovirus infection
    125150373 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125150373 (PIK3R2)
   05169 Epstein-Barr virus infection
    125150373 (PIK3R2)
   05165 Human papillomavirus infection
    125150373 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    125150373 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    125150373 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125150373 (PIK3R2)
   05142 Chagas disease
    125150373 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125150373 (PIK3R2)
   05017 Spinocerebellar ataxia
    125150373 (PIK3R2)
   05020 Prion disease
    125150373 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125150373 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    125150373 (PIK3R2)
   05415 Diabetic cardiomyopathy
    125150373 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125150373 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    125150373 (PIK3R2)
   04931 Insulin resistance
    125150373 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    125150373 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125150373 (PIK3R2)
   01524 Platinum drug resistance
    125150373 (PIK3R2)
   01522 Endocrine resistance
    125150373 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pviv04131]
    125150373 (PIK3R2)
Membrane trafficking [BR:pviv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    125150373 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 125150373
NCBI-ProteinID: XP_047686179
LinkDB
Position
A2:12820282..12833119
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPEPPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPATR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgagcagccctgcaggtg
ctgggcgtggccgagggcaacgagcgctgcccacagagcgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagagcagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagccgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctggtggagaagttgcttcaggaacatctggaagagcaggaggtcgcgcccccagcgctg
ccacccaaaccccccaaggccaagccagcccccgcaggcctagccaatggggggagcccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccgctcaccttctgctccgttgtggacctcatc
acccactaccgccacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacgcaagagaagtgtagc
aaggagtatctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gagcaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagaccgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaggctgaggaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctccgtggtggtggac
ggcgacaccaagcactgtgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgcgggcccccgggcccggg
cccccgccggccacccgctga

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