Pteropus vampyrus (large flying fox): 105300232 Help Entry 105300232         CDS       T07815                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp04020   Calcium signaling pathway pvp04371   Apelin signaling pathway pvp04713   Circadian entrainment pvp04730   Long-term depression pvp04921   Oxytocin signaling pathway pvp05017   Spinocerebellar ataxia pvp05020   Prion disease pvp05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105300232 (RYR1)    04020 Calcium signaling pathway     105300232 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105300232 (RYR1)   09156 Nervous system    04730 Long-term depression     105300232 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     105300232 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     105300232 (RYR1)    05020 Prion disease     105300232 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     105300232 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pvp01009]     105300232 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pvp04147]     105300232 (RYR1)    04040 Ion channels [BR:pvp04040]     105300232 (RYR1) Protein phosphatases and associated proteins [BR:pvp01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      105300232 (RYR1) Exosome [BR:pvp04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    105300232 (RYR1) Ion channels [BR:pvp04040]  Voltage-gated cation channels   Ryanodine receptor    105300232 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR SPRY RR_TM4-6 MIR Ins145_P3_rec RyR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  105300232 NCBI-ProteinID:  XP_011370642 UniProt:  A0A6P3R377 LinkDB All DBs Position Unknown AA seq 4402 aa AA seqDB search MGDGGEGEDEVQFLRTDDDVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQSSQG GGHRTLLYGHAILLRHAHSGMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASK QRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPISSGCEEGYVT GGHVLRLFHGHMDECLTISSADSDDQRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLR WGQPLRIRHVTTGRYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDMAPKRDVEGMG PPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKRKAMLHQEGHMDDALSLTRCQQ EESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIGYFEPP SEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESW KEIVNLLYELLASLIRGNRTNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL NIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQT NLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPY PGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARLVTSPGQHLLAPEDVVSCCLDLNVPSI SFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAV LPRERLHLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLA ENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKNWLYS PKPAKVLPFSGVSYHPLGLVESQSRWDRVRIFRAEKSYVVQSGRWYFEFEAVTTGEMRVG WARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFT LNGEILMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGF EPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVARMDGTVDTPPCLRLSHRTWGSQNSL VEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPAEDEARAAEPDTDYENLRRSAGRWG ETEGGKEGTAKEGLPGATSQAGVEAQPVRAENEKDATTEKNKKRGFLFKAKKAAMMTQTP ATPALPRLPREVVPADDRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQHDMN FDLSKVRAVTVTMGDEQGNIHSSLKCSNCYMVWGGDFVSSGQQGRISHTDLVIGCLVDLA TGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSE RKNSAPQCPPRLEVQMLMPISWSRMPNRFLQVETQRAGERLGWAVQCQEPLIMMALHIPE ENRCMDILELSERLNLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHL PGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPSGKSADNGPRRHGL PGVGVTTSLRPPHHFSPPCFVVALPVAGVAEAPARLSPSIPLEALRDKALRMLGEAVRDG GQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEEEEE EEEEDEEEKEEDEEEEAQEKEDEEKEEEETAEGDKEESLEEGLLQMKLPESVKLQMCHLL EYFCDQELQHRVESLAAFAERYVDKLQGNQRDRYHLLMKAFTMSAAETARRTREFRSPPQ EQINMLVHFKDGEEVEDCPLPEEMQQDLLEFHQDLLAHCGIQLEGEEEEPEEEATLGSRL MSLLEKVRLVKKKEKSPEEELPAEESKPESLQELVSHTVVRWAQEDFVQSPELVRAMFSL LHRQYDGLGELLRALPRAYTISPSSMEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIG NIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRIS RQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLA GCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPEC FGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRRDRRREHFGEEPPEENRVHLGHAIM SFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDG ALVQPKMSASFVPDHKASMVLFLDRVYGIENQEFLLHVLDVGFLPDMRAAASLDTATFST TEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVI EDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWAN FGITSEEELHLTRKLFWGIFDSLAHKKYDSELYRMAMPCLCAIAGALPPDYVDASYSSKA EKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDE DLKTHPMLRPYKTFSEKVTKPWGPMLGVQNETFKFGSSGMMTPICPPPPDAVVSSGRVEK SPHEQEIKFFAKILLPLIKQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSPSFILSC LLPSGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLG KVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIY SLGTTRNSYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLP NSVEEMCPDIPMLERLMADIRGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEMPP PALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPEL LHSHFIPTIGRLCKRAGKVVAEEEQLRLEAKAEAEEGEILVRDEFSVLCRDLYALYPLLI RYVDNNRAHWLTEPDPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTAD NKSKMAKSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKT RYALKDTDEEVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQE VSAVLYHLEQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYK ATWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDE DFLYMAYADIMAKSCHLEEGAENSEAEEEAEVSFEEKEMEKQRLLYQQARLHNRGAAEMV LQMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTC SVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDF QNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAK QVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDL QKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQD YVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPAREI GFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISE TNRAQWEMPQVRKPAAENGEKEDVPEPPPEPPKKTAPPPPPPKKEEAGGGGLEFWGELEV QRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDLAGAGSG GGSGWGSGVGEEAEDDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKV PLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWNRLVLNTPSFPSNYWDKFVKRKVLD KHGDIFGRERIAELLGMDLATLEITAHNERKPAPPPGLLTWLMSIDVKYQIWKFGVIFTD NLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGG GIGDEIEDPAGDEYELYRVVFDITFFFFVIIILLAIIQGLIIDAFGELRDQQEQVKEDME TKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDKTEYTGQESYVWKMYQ ERCWDFFPAGDCFRKQYEDQLS NT seq 13209 nt NT seq  +upstreamnt  +downstreamnt atgggagacggaggagagggtgaggacgaggtccagttcctgaggacggacgacgacgtg gtcctgcaatgcagcgccaccgtgctcaaggaacagctcaaactctgcctggcagccgag ggctttggcaaccgcctctgcttcctggagcccaccagcaatgcccagtcgtcccagggt gggggacacaggacactcctgtatggccatgccatcctgctccggcacgcacacagcggc atgtacctgagctgcctcaccacctcccgctccatgactgacaaactggccttcgatgtg ggactgcaggaggatgcaacaggagaggcctgttggtggacaatgcacccagcctccaaa cagaggtctgaaggagaaaaggtccgcgtcggggatgacctcattctcgttagtgtctcc tctgagcgctacctgcacctgtcaacggccagcggggagctccaggttgacgcctccttc atgcagacactgtggaacatgaaccccatctcctctggctgcgaagagggttacgtgact ggaggccatgtcctccgcctctttcacggacacatggatgagtgtctgactatctcctcc gctgacagtgatgaccagcgcagactcgtccattacgaggggggagctgtgtgcacccac gctcgctccctctggagactggagcctctgagaatcagctggagtgggagccacctgcgc tggggccagccgcttcgcatccggcatgtcaccacagggcggtacctggcgctcaccgag gaccagggcctggtggtggttgacgccagcaaggcccacaccaaggccacctccttctgt ttccgcatctccaaggaaaagctggatatggcccccaagcgggatgtagaaggcatgggc ccccccgagatcaagtatggagagtcactgtgcttcgtgcagcatgtagcctcaggcctg tggctcacctatgctgccccggaccccaaggccctgcggctcggcgtgctcaagaggaag gccatgctgcaccaggaaggccacatggatgatgcgctgtctctgacccgctgccagcag gaggagtcccaggctgcccgcatgatccacagcactgccggcctgtacaaccagttcatc aaaggcctggacagcttcagcgggaagccacggggctcagggccgccggctggcacagcg ctgcccatcgagggcgtcatcctgagcctgcaagacctcatcggctacttcgagccgccc tccgaggagctgcagcacgaggagaagcagagcaaactgcgcagcttgcgcaaccgccag agcctcttccaggaggaggggatgctctccctggtcctgaattgcatcgaccgcctaaat gtctacaccacagctgcccactttgctgagtttgccggggaggaggcagccgagtcctgg aaagagattgtgaacctgctctatgaactcctggcttctctgatccgtggcaatcgtacc aactgtgccctcttctccaccaacttggattggttggtcagcaagctggataggctggag gcctcatctgggatcctagaagtgctatactgtgtcctgattgagagtcctgaggtcctg aacatcatccaagagaaccacatcaagtcaatcatctcactcctggacaaacatgggagg aaccacaaggtgctggatgtgctgtgttccctgtgtgtgtgtaatggcgtggccgtgcgc tccaaccaagatctcattactgagaacttactgcctggccgtgagcttctgctccagaca aacctcatcaactatgtcaccagcatccgccctaacatctttgtgggccgagcagagggc actacgcagtacagcaaatggtactttgaggtgatggtggatgaagtggctccattcctg acagctcaggccacccacctacgggtgggctgggccctcactgagggctacagcccctac ccagggggcggcgaaggctggggcggcaacggggttggcgacgatctctattcctacgga tttgatgggctgcatctctggacaggacatgtggcacggctggtgacttctccagggcag cacctcttggcccctgaggatgtggtcagctgctgcctggacctcaacgttccatccatc tccttccgcatcaatggctgtcctgtgcagggtgtctttgaggccttcaaccttgatggg ctcttcttccctgttgtcagcttctcagccggtgtcaaggtgcggttcctccttggtggc cgccacggtgaattcaagttccttcccccgcctggctacgccccatgccatgaggctgta ctccctcgagagcgactccacctggaacccatcaaggagtaccggcgggaggggccaagg gggccgcacctggtgggccccagccgctgcctctcacacaccgactttgtgccctgccct gtggacactgtccagattgtcctgcctccccatctggagcgtattcgggagaagctggca gagaacattcatgaactctgggcactgactcgcatcgagcaaggctggacctatggcccg gttcgggatgacaataagaggctgcacccatgtcttgtgaacttccacagcctaccagag ccggagaggaattacaacctgcagatgtcaggggagacgctcaaaaactggctctattcc cccaagccggccaaggtccttcccttctctggtgtctcctaccatcctcttggtctggtg gagagccagtctcgctgggaccgggtgcgcatcttccgggcagagaaatcctatgtggtg cagagcggccgctggtacttcgagttcgaggcggtcaccacaggagagatgcgagtgggc tgggcaaggcccgagctgcggcctgatgtggagctgggagctgatgagctggcctatgtc ttcaacgggcaccgtggccagcgctggcacttgggcagtgaaccatttgggcgcccctgg cagtcgggtgatgtcgtgggctgcatgatcgacctcacagagaacaccattatcttcacc ctcaatggcgagatcctcatgtccgattcgggctccgaaacagccttccgggaaatcgag attggggatggcttcctgcccgtgtgcagcttgggacctggccaggtgggtcacctgaat ctgggtcaggacgtgagctccctgcggttctttgccatctgcggtctccaggaaggcttt gagccattcgctatcaacatgcagcgcccggtcaccacctggttcagcaaaagccttccc cagtttgaggctgtgccccttgagcacccccactatgaggtggcccgtatggacggcact gtggacactcccccctgcctgcgcctgagccaccgcacctggggctcccagaatagcctg gtggagatgctcttcctccggctgagccttccagtccagttccaccagcacttccgctgc actgcaggggccaccccgctggcgtcccccggcctgcagcccccggccgaggacgaggcc cgggcagcggaaccggacaccgactacgaaaacctgcgccgctcggctgggcgctggggc gagaccgaagggggcaaagagggaactgccaaggaggggctgcccggggccacctcccag gctggggtagaggcccaacctgtcagggcagagaatgagaaggatgccaccacagagaag aacaagaagagagggttcttattcaaggccaagaaggccgccatgatgactcagacgcca gccacccccgctctgccccgactccctcgtgaggtggtgcccgccgatgaccgtgatgac cctgagatcatcctcaacaccaccacgtactattactccgtgagggtctttgctggtcag gagcccagctgcgtgtgggtgggctgggtcacccccgattaccatcagcacgacatgaac ttcgacctcagcaaggtccgggcagtgacggtgacaatgggggacgaacaaggcaacatc cacagcagcctcaagtgcagcaactgctacatggtgtggggcggggacttcgtgagctct gggcagcagggccggatcagccacacggaccttgtcattggctgcctggtggacttggcc actggcctaatgacctttacagccaatggcaaggagagcaacacctttttccaggtggaa cccaacacgaagctctttcctgccgtctttgtcctgcccacgcaccagaacgtcatccag tttgagctggggaagcagaagaacatcatgccactctcggccgccatgtttctgagcgaa cgcaagaactcagctccacagtgcccgccgcggctcgaggtgcagatgctgatgcccatc tcttggagccgcatgcccaaccgcttcctgcaggtggagacacagcgagccggcgagcgg ctgggctgggccgtgcagtgccaggagccgctgatcatgatggcactgcacatccctgag gagaaccggtgcatggacatcctggagctgtccgagcgcctgaacctgcagcggttccat tcccacaccctccgcctctatcgcgctgtgtgcgccttgggcaacaaccgcgtggcgcat gctctgtgcagccacgtggaccaggcgcagctgctgcacgccctggaggacgcgcacctg cctggcccgctgcgtgctggctactacgacctcctcatcagcatccacctcgaaagtgcc tgccgcagccgccgctctatgctctccgagtacatcgtgcccctcacgccagagacccgc gccatcacactcttcccatctggaaaaagcgcagataatggtccccgccgccacggcctg cctggcgttggcgtcaccacctcgctgcggcctccacaccatttctcacccccctgtttc gtggttgccctgccagttgctggggtggcagaagcccctgcccgcctcagtcccagcatc cctctggaggccctgcgggacaaagcactgagaatgctgggggaggcggtgcgagatggc ggacagcacgcacgcgaccctgttggggggtctgtggagttccagtttgtgcccgtgctc aagcttgtgtccaccctgctggtgatgggtatctttggtgatgaggatgtgaaacagata ttgaagatgattgagcctgaagtattcactgaggaagaggaggaggaagaggaagaggag gaggaagaggaagatgaagaggagaaggaggaggatgaggaggaggaggcacaggagaag gaagatgaagaaaaggaggaagaggagacagcagaaggggacaaagaagaaagcttggag gaaggtctgctccagatgaaattgccagagtctgtgaaattacagatgtgccacctactg gagtatttctgtgaccaagagctgcagcaccgcgtggagtccctggcagcctttgcagag cgctatgtggacaagcttcagggcaaccagcgggaccgctaccacctcctcatgaaagcc ttcaccatgtctgcagctgagactgcccgacgtacccgagagttccgctcgccaccccag gagcagatcaacatgctagtgcacttcaaagatggcgaggaagtggaagattgtcctctt cctgaagagatgcaacaggatttgcttgaatttcatcaagacctgctggctcactgtgga attcagctggagggggaggaggaggaaccagaggaagaggccaccctgggcagccgccta atgagcctgttggagaaagtgcgactggtgaagaagaaggaaaagagccctgaggaggag ctgcctgctgaggagagcaaacccgagtcgctgcaggaattggtgtcccacacagtggtg cgctgggcccaggaggactttgtgcagagccccgagctggtacgggccatgtttagcctc ctgcaccggcagtatgacgggcttggggagctgctgcgtgccctgccccgggcgtacacc atctcgccatcctccatggaggacaccatgagtctgcttgagtgcctcggccagatccgc tcgctgctcatcgtgcagatgggcccccaggaggagaacctcatgatccagagcatcggg aacatcatgaacaacaaagtcttttaccagcacccgaacctgatgcgggcactgggcatg cacgagacagtcatggaggtcatggtgaacgtcctcgggggtggtgaatccaaggagatc cgcttccccaagatggtgacgagctgctgccgcttcctctgctacttctgtcgcatcagc cggcagaaccagcgctccatgttcgaccacctgagctacctgctggagaacagtggcatc ggcctgggcatgcagggctccacacccctggacgtggcagctgcctctgtcattgacaac aacgagctggctttggcattgcaggagcaggacctggagaaggtggtatcctacctggcg ggctgtggccttcagagctgccccatgctcctggccaaagggtacccggatatcggctgg aacccctgcggcggtgagcgctacctggacttcctgcgcttcgctgtctttgtcaacggc gagagcgtggaggagaacgccaacgtggtggtgcggctgctcatccgcaagcctgagtgc ttcgggccggccctgcgcggcgagggcggctcggggctgctggctgccatcgaggaggcc atccgcatctccgaggaccctgcgcgggatggcccaggcgtccgcagggaccggcggcgg gaacacttcggggaggagccccctgaggaaaaccgggtgcacctggggcacgctatcatg tccttctacgctgccttgatcgacctgcttggacgctgtgcaccagagatgcatttaatc caagccggcaaaggtgaggccctgcggatccgtgccatcctgcgctccttagtgcccctg gacgaccttgtaggcatcatcagcctcccgctgcagatccccacactgggcaaagatggg gctctggtacagccaaagatgtcggcatcctttgtgccggaccacaaggcatccatggtg ctcttcctggaccgtgtgtatggcatcgagaaccaggaattcttgctgcatgtgctggat gtggggttcctgccggacatgagggcagccgcctcgctggacacggccaccttcagcacc accgagatggcgctggcgcttaaccgctacctgtgcctggcggtgctgccgctcatcacc aaatgtgctccactctttgcgggaaccgagcaccgcgccatcatggtggactccatgctt cacacggtgtaccgcctgtcccgcggccgctcgctcaccaaggcacagcgcgacgtcatc gaggattgcctcatggcgctctgcaggtacatccggccgtccatgctacagcacctgctg cggcgcctggtgtttgacgtgcccatccttaacgagttcgccaagatgccgctcaagctc ctcaccaaccactatgagcgctgttggaaatattactgcttgcccacgggctgggccaac tttggcatcacttcagaggaagagctgcacctcacgaggaaactcttctggggcatcttt gactcactggcccacaagaagtatgactcagagctgtaccgcatggctatgccatgtcta tgcgccatcgcaggggccctgcccccagactacgtagacgcctcatactcatcgaaggct gagaaaaaggccacggtggatgctgaaggcaactttgatcctcgacctgtggagaccctc aacgtgatcattccagagaagctggactccttcattaacaagtttgcggagtacacacat gagaagtgggccttcgacaagatccagaacaactggtcctacggggagaacatagatgag gacctgaagacccaccccatgctgaggccctacaagaccttctcagagaaggtgaccaag ccctggggcccaatgttgggggtccaaaatgaaaccttcaaattcgggagttcagggatg atgacccctatttgccctcccccaccagacgctgtggtcagcagtggacgagtggaaaag tccccgcatgaacaagagattaaattctttgccaagatcctgctccctctgatcaagcag tacttcaccaaccactgcctgtatttcctgtccacacctgccaaagtgctgggcagtggt ggccacgcctccaacaaggagaaggaaatgatcaccagcccttccttcatcttgtcctgt cttcttccctcagggacggatgccccagctgtggtcaactgtcttcacatcctggcacgc tccctggatgccaggacggtgatgaagtcaggccctgagattgtgaaggctggccttcgt tccttctttgagagtgcctcagaggacatcgagaagatggtggagaacctgcggctaggc aaagtgtcacaggcacgcacgcaagtgaagggtgtgggccagaacctcacctacaccacc gtggccctgctgcctgtcctcaccaccctcttccagcacatcgcccagcaccagtttgga gatgatgtcatcttggatgacgtccaggtctcgtgctaccgaacgctgtgcagtatctac tctctaggaacgaccaggaactcttatgtggaaaagctgcggccagcgcttggggagtgc ctggcccgcctggcagcggccatgccggtcgcgttcctggagcctcagctgaatgagtac aacgcctgctcggtgtacaccaccaagtctccccgggagcgggccatcctagggctcccc aacagcgtggaagagatgtgtcccgacatcccaatgctggagcggctcatggcagacatc agggggctggccgagtcgggggcccgctacacggagatgccacatgtcatcgagatcact ctgcccatgctgtgcagctatctgccccgctggtgggagcgcggacctgagatgccccca cccgccctgcccgctggggcccccccgccctgcacagctgtcacctctgaccacctcaac tccctgctggggaacatcctgcgaatcatcgtcaacaacctgggcatcgatgaggcctcg tggatgaagcggctcgctgtgtttgcccagcctattgtgagccgggcccggcccgagctc ctgcactcacacttcatcccgaccatcgggcggctgtgcaagcgggcggggaaggtggtg gccgaggaggagcagctgcgcctggaggctaaggcggaagctgaggagggggagatcctg gtgcgggatgagttctctgtgctctgccgggacctgtacgctctctatccactgctcatc cgctacgtggacaacaacagggcccactggctgacagagcctgaccccagtgccgaggag ctgttcaggatggtgggcgagatcttcatctactggtccaagtcccacaactttaagcgt gaggagcagaacttcgtggtccagaatgagatcaacaacatgtcgtttctgactgcagac aacaagagcaaaatggccaagtcaggtggctcagaccaggaacgcacgaagaagaagcgc cgaggggaccggtactctgtgcagacgtcgctgattgtggccacactcaagaagatgctg cccattggcctgaacatgtgtgcacccactgaccaggacctcatcacgctggccaagact cgctatgccctgaaagacacagatgaggaagtccgggaatttttgcaaaacaaccttcac cttcagggaaaggttgaaggctccccttctctgcgctggcagatggccctgtaccggggc ctaccgggccgcgaggaggacgccgacgacccggagaagatcgtgcgcagagtccaggag gtgtctgcggtgctctaccatctggagcagatcgagcacccttacaagtctaagaaggct gtgtggcacaagctcttgtccaagcagcgccgaagggcggtcgttgcctgtttccgcatg acccccctgtacaacctgcccacgcaccgggcatgtaacatgttcctggagagctacaag gccacatggatcctgactgaagaccacagttttgaggaccgcatgatagatgacctttca aaagcaggggagcaggaggaggaagaggaagaggtggaggagaagaagccagaccccctg caccagctcgtcctgcacttcagccgcacagccttgactgaaaagagcaaactggatgag gatttcctgtatatggcatatgcggatatcatggcaaagagctgccacctggaggaggga gcggagaacagtgaagctgaagaagaggctgaggtttctttcgaggagaaagagatggag aagcagaggctcctgtaccagcaggcgcggctgcacaaccggggggctgcagagatggtg ctccagatgatcagtgcctgcaaaggagagactggcgccatggtgtcctccaccctgaag ctgggcatctccatcttaaatgggggcaatgctgatgtgcagcagaaaatgttggattat ctgaaggacaagaaggaagttggcttcttccagagtatccaggcgctgatgcagacatgc agcgtcctggatctcaatgcattcgagagacagaacaaggcagaggggctgggcatggtg aacgaggatggaactgtcatcaaccgccagaacggagagaaggtcatggcagatgacgaa ttcacccaagacctgttccgattcctgcaattgctctgcgaggggcataataatgatttc caaaactacctacggacacagacggggaacacgaccactattaacatcatcatctgtaca gtggactaccttctgcggctgcaggagtccatcagcgacttctactggtattactccggc aaggatgtcattgaggagcaaggcaagaggaacttttctaaggccatgtcggtagctaaa caggtgttcaacagcctcaccgagtacatccagggcccctgcaccgggaaccagcagagc ctggcgcacagccgcctctgggacgccgtggtgggattcctgcacgtatttgcccacatg atgatgaagctcgctcaggactcgagccagatcgagctgttgaaggagctgctggatcta cagaaggacatggtggtgatgttgctgtcactactggaagggaacgtggtgaacggcatg attgcccggcagatggtagacatgctggtggaatcttcatccaacgttgagatgatcctc aagttcttcgacatgttcctgaaactcaaggacatagtgggctcggaggccttccaggac tacgtcactgatccccgtggcctcatctccaagaaggacttccagaaggccatggacagc cagaagcagttcactggtccagaaatccagttcctgctttcgtgctccgaggcggatgag aatgagatgatcaactgtgaggagttcgccaaccgcttccaggagccagcccgcgaaatc ggctttaacgtggcggtactgctgaccaatctgtcggagcacgtgccccacgacccgcgc ctgcgcaacttcctagagctggcggagagcatcctcgagtacttccggccctacctgggt cgcatcgagatcatgggcgcctctcgccgcattgagcgcatctactttgagatctcggag accaaccgcgcccaatgggagatgccgcaggtcagaaagcctgctgccgagaatggggag aaggaagatgttcccgagcccccgccagagccccccaagaagacagcacctcctccacct cctccaaagaaggaggaagccggaggtgggggcctggaattttggggagagctggaagtg cagagggtgaagttcttgaactacctctcccggaatttttacaccctgcgattccttgcc ctcttcctggcatttgccatcaacttcatcttgctgttttataaggtctcagactctcca ccaggggaggatgacatggagggctcagcagctggggatctggcaggcgctgggtctggc ggcggctctggctggggctcaggggttggtgaggaagcggaagacgacgaggatgagaac atggtgtactacttcctggaggagagcacaggctacatggagcctgccttgcgttgctta agcctgctgcatacactggtggcctttctctgcatcattggctacaactgcctcaaggta cccctggtgatcttcaagcgggagaaggagctggcccggaagctggagtttgacggcctc tatatcaccgagcagcctgaggacgatgacgtgaaggggcagtggaaccgactggtgctc aatacaccgtcgttccccagcaactattgggacaagtttgtcaagcggaaggtcctggac aagcacggggacatctttgggcgggagcggatcgccgagctgctgggcatggatctggcc acgctggagatcacagcccacaacgagcgcaagccagctccaccgcccgggctgcttacc tggctcatgtccatcgacgtcaagtaccagatttggaagttcggggtcatcttcacagac aatctggtgatgaccgtgggcctcctggcggtggtggtctacctgtacactgtggtggcc ttcaacttcttccgcaagttctacaacaaaagcgaggatgaggatgagcctgacatgaaa tgtgatgacatgatgacgtgttacctgtttcacatgtacgtgggtgtccgagctggtggg ggcattggggacgagattgaggacccggcaggtgatgaatatgagctgtaccgggtggtc ttcgacatcaccttcttcttctttgtcatcatcatcctgctggccatcatccagggtctg atcattgatgcttttggcgagctccgagaccaacaagagcaagtgaaggaagatatggag accaagtgcttcatctgcggcattggcagtgattactttgacaccacaccacatgggttc gagacccacacgctagaagagcacaacctggccaattacatgtttttcctgatgtacctg ataaacaaggacaagacagaatacactggtcaggagtcctatgtttggaagatgtaccaa gagagatgctgggacttcttcccggctggtgactgtttccgcaagcagtacgaggaccag ctcagttga

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