KEGG   PATHWAY: pvw03070
Entry
pvw03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas vanderleydeniana
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
pvw03070  Bacterial secretion system
pvw03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas vanderleydeniana [GN:pvw]
Gene
HU752_003470  TolC family outer membrane protein [KO:K12340]
HU752_016465  TolC family protein [KO:K12340]
HU752_024745  sctF; type III secretion system needle filament subunit SctF [KO:K03221]
HU752_015535  sctC; type III secretion system outer membrane ring subunit SctC [KO:K03219]
HU752_015625  sctW; type III secretion system gatekeeper subunit SctW [KO:K04058]
HU752_015510  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
HU752_015590  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
HU752_015585  sctS; type III secretion system export apparatus subunit SctS [KO:K03227]
HU752_015580  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
HU752_015575  sctU; type III secretion system export apparatus subunit SctU [KO:K03229]
HU752_015620  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
HU752_024835  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
HU752_015610  FliI/YscN family ATPase [KO:K03224] [EC:7.4.2.8]
HU752_015595  FliM/FliN family flagellar motor switch protein [KO:K03225]
HU752_024810  FliM/FliN family flagellar motor switch protein [KO:K03225]
HU752_015520  sctL; type III secretion system stator protein SctL [KO:K03223]
HU752_003085  gspD; type II secretion system secretin GspD [KO:K02453]
HU752_018255  gspD; type II secretion system secretin GspD [KO:K02453]
HU752_030220  general secretion pathway protein GspD [KO:K02453]
HU752_003080  protein XcpP [KO:K02452]
HU752_018285  general secretion pathway protein GspC [KO:K02452]
HU752_003095  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
HU752_018245  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
HU752_030190  type II secretion system F family protein [KO:K02455]
HU752_003100  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
HU752_018275  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
HU752_030160  type II secretion system GspH family protein [KO:K02456]
HU752_030165  type II secretion system GspH family protein [KO:K02456]
HU752_030180  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
HU752_003105  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
HU752_018290  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
HU752_003110  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
HU752_018280  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
HU752_003115  gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459]
HU752_018295  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
HU752_003120  general secretion pathway protein GspK [KO:K02460]
HU752_018270  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
HU752_003125  general secretion pathway protein GspL [KO:K02461]
HU752_018265  type II secretion system protein GspL [KO:K02461]
HU752_003130  type II secretion system protein M [KO:K02462]
HU752_018260  type II secretion system protein M [KO:K02462]
HU752_031170  tadA; Flp pilus assembly complex ATPase component TadA [KO:K02454] [EC:7.4.2.8]
HU752_003090  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
HU752_018250  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
HU752_030195  GspE/PulE family protein [KO:K02454] [EC:7.4.2.8]
HU752_006255  secD; protein translocase subunit SecD [KO:K03072]
HU752_006260  secF; protein translocase subunit SecF [KO:K03074]
HU752_029455  secE; preprotein translocase subunit SecE [KO:K03073]
HU752_028690  secG; preprotein translocase subunit SecG [KO:K03075]
HU752_029290  secY; preprotein translocase subunit SecY [KO:K03076]
HU752_006250  yajC; preprotein translocase subunit YajC [KO:K03210]
HU752_001035  yidC; membrane protein insertase YidC [KO:K03217]
HU752_008185  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
HU752_030800  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
HU752_002695  secB; protein-export chaperone SecB [KO:K03071]
HU752_006540  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
HU752_002910  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
HU752_002905  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
HU752_002900  tatC; twin-arginine translocase subunit TatC [KO:K03118]
HU752_000360  type VI secretion system tip protein VgrG [KO:K11904]
HU752_004095  hypothetical protein [KO:K11904]
HU752_009305  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
HU752_010525  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
HU752_011850  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
HU752_000335  type VI secretion system tube protein Hcp [KO:K11903]
HU752_011795  Hcp family type VI secretion system effector [KO:K11903]
HU752_000310  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
HU752_011810  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
HU752_000295  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
HU752_011890  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
HU752_000300  DotU family type VI secretion system protein [KO:K11892]
HU752_011800  icmH; type IVB secretion system protein IcmH/DotU [KO:K11892]
HU752_000355  tssH; type VI secretion system ATPase TssH [KO:K11907]
HU752_000280  serine/threonine-protein kinase [KO:K11912] [EC:2.7.11.1]
HU752_000315  tagH; type VI secretion system-associated FHA domain protein TagH [KO:K11913]
HU752_000285  serine/threonine-protein phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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