Pleurodeles waltl (Iberian ribbed newt): 138283084
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Entry
138283084 CDS
T10800
Symbol
CPLANE1
Name
(RefSeq) ciliogenesis and planar polarity effector 1 isoform X1
KO
K22859
protein JBTS17
Organism
pwl Pleurodeles waltl (Iberian ribbed newt)
Brite
KEGG Orthology (KO) [BR:
pwl00001
]
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
03037 Cilium and associated proteins [BR:
pwl03037
]
138283084 (CPLANE1)
Cilium and associated proteins [BR:
pwl03037
]
Primary cilia and associated proteins
Ciliogenesis and planar polarity effectors (CPLANE) complex
138283084 (CPLANE1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Joubert
WD40_WDHD1_1st
KilA-N
Motif
Other DBs
NCBI-GeneID:
138283084
NCBI-ProteinID:
XP_069077332
LinkDB
All DBs
Position
1_1:complement(219022297..221014625)
Genome browser
AA seq
3317 aa
AA seq
DB search
MEVKLEVLISRSIRRKKPCSRFCWLGQEKESVFLLDDNSFSEINLVSGRIKKKVARLQPL
LKNKNVAVLGTSRNGAWLAGVLTSGEIFIWNKDQDVVKTIPLTEELSNELAASEERCRRL
YLFVSEDGRRLLLATTLGSVFVWESIDIKNFPSSWKGPLSSGRWSRIDPDASTVLPDTDN
KETAVHAIFIRNQTLGDCCLCSFAFYIEDRLMLVFLLLRWHENAYQYISSLPYDVHWSHQ
ECSLSSLVPSCTPVKSKGALITAFAGDGLVLAATINQKDPEATQVLFVNIVNFVTISGSL
KGCSSKNHMIPTKFIRSYWVGDMSWTHDSLFLACILKRGALVLLTRLGDLLSLVTTGCSV
EFGPAEFIPLHPLITYRSSDAALQTADGNSSLGSTASEKDMLRQRFSVTTHPRSPYLIVS
DGYMVTALRFINNYSPSSFMKSLLLDSAQSLEAMRQLHLPSKHHKGKRPKLRSLSSLKAS
ILKAHGSQNSTFSMIPRFLQGEEEMLELRLADLQVCEEDSEDEVLPKDGFTSLSFKHDSS
GKSVDHGRLEFASMFDTIHATDATDEMDDEGNVFSKLNCIQKNLMTAWSLGISFGTIEEK
DVLLNSTIGFLTHLINVLQFLKRPPSTKDKFSRTTARNSSWVHFVFKLFQQCLIVLQWDV
PHRQGFRHIIKLTSEVVKLMTVCPQDQPFSRTLLEAFSLLKMVSYYLNIIYTPQCNRISA
SVGKDLSVELDSLFLPLCQNLSESKVKDFFFMDVLCSLPPRTSTFEHSPDKRLTFLWRLL
YQHALRFQAQLCLHVSRNDSQLKEKINDEESIIAVVLCHIQATLQSSGDTLEKAVRLEPV
TGEEHFLLGSYKESVQIWKRALQENTAPEGKRTCFLQMRYFLAMLYCHLYYNNLSEAQGL
CDHLTRELLSRSRLPFDQLECNSESPRADDLGLLRGVHVKAALTVVQSMARFMASYFTNQ
PLYVLPPHNVNILPPLHIRQEKCPRVVPLQHCTVANAVRDQNLSSVWTVEYALDLLLIGG
LIPEAAWFALQLGDWKMSVSIGLAYNLSCQITEDRTWLNSVEMQLPPKLTPAHTFQEKLQ
SFLGRPGSSEIIKAEGRGYKQFTDPIEDEDTDALFSSVQEMLKAAVMAEADILSETFLLL
IEAAKDLSKGLSGLVPEKLYLPAPPLYCPQPASVSEGDYGDQVLASEKDYRQKLSGVLQR
ILLLLRAARCSIPSAQWYIKKLKWARKVMQKIRAKSFLPPLSQLPESLLNYSRTNSTFFK
TGPDGDKLDDVSCKIIGSFRELCALCWMLHVREKLSDGCRRYQISRDNMEKQQDFEKTVP
FDSSVVEQCLNALEWAYRMLPFSAFLNIEELVQDIILSLIGELPPVQKVAEILVKAFPSS
EAVRVSLRDKYHSLQQRLRHCMVKGPKGEEMMSLVMHNFHKVRIKTLKRVVRNIGPIEMN
IWEPEEENPDNEVQLYDRFSMGTSLSRSTLTEFGKPQVYSDADTGDTLSEALMTEEPIPR
MEMSVTEDLRYNNDTLYRKKDISAKSKTDQKEPKETTLLPSVGTWEFERDDDEYIAFLDL
FMSYLLERDLINYTDPCIPFLTSFSEHLREFELNSLLFDVHTTLKRRQGRSKHCNVFRAG
YSYTASAEAGAQPVNSVQPCDEKENALRRLPSNPTSLIFLPASKPSLIQYFNEGNNATLG
KKGLFGLNLRTALQEDHQEESSACPKEPHQSTETPVVVNTFKIIHFESVLPSEELLTELK
TKFGGVSRLLEWMIRWSEKQLLCGSSKEELIRENSTIIRVKTSAAAILTSLWLLEERHCA
GCRDKNTNFRIPDAENIKAPVFQSMERQTMQRESSVDTGYRGSTGTPIDALEENLYEDVC
ESDPESSSIHDHKDELEEVQDIQQKVLDIPSTSEDDFEDDFDPVSPSISVNIRPVQRLTE
NSVETYEIPYRESESEKLEEKKTHHDSTCASEQPGGPPLVCADMKVSTPSDRGSPAPASS
YGPSFPTLPDLHAENVQSHAAIYTSPLDTHNSDHRTQPQNTSEAVRQMFQDEMFRLLQLQ
QINFMSLMQIVGSSFASLPQVQQLLQQSQPINLQEGQTSANVRGLVTEGLLTTPAEDRHH
MISVPPVQQPHTMKSGGERATNSSNSLPSPDESSKENQQDHTELKREESRPSKSRMLLAT
CNMLDSVNGKASIDTQNVIPLVTTPQNLSAAKSFPLLHLSPERSFKPEENDTFQSFARPP
QNPREAWVTIETIKNRKDSETPEYSSGVVQPHVNQQVKHFKQKEKQKKKSAVCVKTETPK
NVHVNPYMLNSNRATLPQNLKHAVAPSLESKVSSQGAFRNQAGFPLLHMQVNPVPLFPHI
IRPNNAGLIIPPHDISRKDIQVPQQIPKLTLLHASIPLENKVISQVLPFQPPRLIPLQHI
IAYKQSIQNKSEQLFEEHVAGSIKLLKANIEPFEGRDVQKERKGRVRRRLEKQHKQEHVE
RPPYKQDNTETKLEKQVQIIAELEGQERMNTQPGNQEKIETKTVKKTSVSFRPQDSIIEL
IPVDDNSSEIIDNSEVHQNDVPNLENGEGFVLPLGMFDSLLLEQNNEHRSVPAPAELHYM
AATKRKAAEIQDASTNTDPGSGLKSNHEYLPSTVPQLLPPDLYQNLRFLNGLEEQIVPSK
TSDPETVPPKHQYINVIDIEASDFLKDLPTRESPEEELTRDRADHASAPSSAQLHHMAAS
VTNVIPPDEFESTDYLLQLPVSQSQNLNEKPGVAGDVVTWNLLQDDLDIVKPSERSVKTF
SAKPMSKVHMDSKLHEMEAQLSALQNMAEYMERDFANSELLVNTIENLGSAMDSVHEEIP
YSSTGIQDTTKELFFNPVRLEDLIEEEEEDSKSELIANNASAWQTPAYSAVSAANPASTT
EASAAERGDVRHQCIDSRLKKPFSVSDFPRVEEVRESFSDAPLEMTGLSDIADIIGDLVR
HGGVAASELGLTEAQARIFSRASNDKANSTRLTKKMESKRQEIRDWMKLKQKERLAEHCK
KREELREREYDPFRPQKDLQRTFNSSDLRKIQKAKEEKDKTLLSEHHSHRVAQAFTLMNN
ILSATSQAPATNPYHPPNSPLRLKSPQSIQGQPLTRQRVYSLKRSLSANPAEKRRAIPRT
GSSQARSLSTPSYGSAHSRGPWTLPKKIPDSRAQSATSYSLKAKIETSLPRDRMSQITRR
GILVNRSTKKGHAHVEGREKPGFDAKRPVSANPGLAFDRSGKEIFRKPTKQAAECQTNET
GLENEDSDSLSHWEVPDEINRILNSSQDAWSLLQEEEHFPQSFNDIDNMSESTGSILSKL
DWNMIEDMVASVEEKSN
NT seq
9954 nt
NT seq
+upstream
nt +downstream
nt
atggaagtaaaattagaggtcctaatctctagaagcatcaggagaaaaaaaccatgttct
cgattttgctggctggggcaggaaaaggaatcggtttttctgttagatgataatagcttc
agcgaaatcaacctggtgtctgggaggattaagaagaaagttgcccgacttcagccttta
ctaaaaaataaaaatgtggcagtgctgggaacatccagaaatggtgcttggctggcagga
gtccttacgtcaggagaaatatttatttggaacaaagatcaagatgttgtgaaaacaata
cccttaacagaagaacttagtaatgaacttgcagcatcggaagagagatgcaggagatta
tacctctttgtgtccgaggatgggagaagactacttcttgcaacaacactaggtagtgtg
tttgtatgggagagcatagacatcaaaaattttccatcatcatggaaaggtcctttgtca
tctgggagatggtcaagaatcgatcctgatgcatctacagtattacctgatactgacaat
aaagagacagcagtccatgcaattttcataaggaaccagacactgggcgattgctgttta
tgctcatttgcattttatattgaggaccgtttaatgctggtatttctattgttacgttgg
catgaaaatgcataccagtacatcagttctctgccgtatgatgtccattggtcccaccaa
gaatgttctttgtctagcctggttccgtcatgtactcctgtaaagtcaaaaggagctttg
attactgcttttgctggtgatggactggtgctggcagcaactattaatcagaaagaccct
gaggcaactcaggttttgtttgtaaacatcgtaaattttgtcaccatttctggtagcctg
aagggatgcagcagcaagaatcatatgattccaactaaattcatcaggtcctactgggtg
ggtgatatgagctggactcatgattcacttttccttgcgtgcatcttgaagcgtggggcc
cttgtcctgttgactcgtctaggggatttgttgagcctagtgacaactggctgttctgtg
gaatttggaccagcagaattcatccctcttcatcccttaataacataccgatcatctgat
gctgcattgcaaactgcagatggaaatagttctcttgggtcaacagcgtctgagaaagat
atgttgagacagaggttttctgttacgacacacccacgatcaccctatctgattgtctct
gatggttacatggttactgctcttagattcataaataactattctccatcttcctttatg
aagtcacttcttctagattcagcccagagtctggaagcaatgcgccaattgcatcttccc
tcaaagcaccacaaagggaaacggccaaagttgcgatccttatcatcattaaaagctagc
atattaaaagcccatggaagtcaaaattcgactttttccatgattccaagatttttgcaa
ggcgaggaagagatgctggagttgcgattagcagacttgcaggtttgcgaagaagattct
gaggatgaagttctgccaaaggatggattcacctcactcagttttaaacatgattcctct
ggcaagagtgttgatcatggtaggttggagtttgcatccatgtttgacacaattcatgct
acagatgctacggatgaaatggatgatgagggtaatgttttttccaagctgaactgtatt
cagaaaaatctcatgactgcttggagtttaggaatatcatttggaaccattgaagaaaaa
gatgtactattgaattctactattggttttttaactcacctaatcaatgtgcttcagttt
ttaaaacggccaccatctacaaaagacaaattttcaagaacgactgctaggaacagttca
tgggtgcactttgtcttcaaacttttccagcagtgtttaattgtcctgcagtgggatgtg
ccacatagacaagggtttcgacatataataaagctaacatctgaagtagttaaactgatg
actgtttgtccgcaagatcagcccttttccaggactctgttggaagctttcagcttactg
aaaatggtctcatactacctcaatattatctacacacctcagtgtaaccgtatttctgca
tccgttggcaaagatttgtctgtggagcttgattcactttttctacccctttgccaaaat
ctttctgagagcaaagttaaggatttttttttcatggatgttctatgcagtctccctcca
agaacgtcaacctttgaacacagcccagataaaaggctgacgttcctttggcggttgctg
taccagcacgcactgcgatttcaagcacagctctgcctgcacgtgtcaagaaacgacagc
caactaaaagagaaaataaatgacgaagaatcaattattgcggtcgtattatgtcatatt
caggcgacactacagtcttctggtgatactctggagaaagcagtgcgtcttgaacctgtg
accggtgaggagcactttctcctaggctcatacaaagaatctgtacagatctggaagagg
gctctgcaagaaaacaccgctccagaagggaagagaacatgtttccttcagatgcggtat
ttcctggctatgttatattgtcatttatattacaacaatttaagtgaagcccagggtctg
tgtgatcatctaacaagagagttgctgagtcgatcccggttacctttcgatcaactggaa
tgcaattctgaatctcctcgtgctgatgaccttggtctgctgagaggtgttcatgtgaag
gctgctttgacagtggtacagtccatggcacgtttcatggcatcatatttcacaaaccaa
ccattgtatgtgcttccaccgcataatgtgaatatcctacctccacttcacataaggcaa
gaaaaatgtccacgagttgttcccctgcagcactgtactgttgctaatgcagttcgagat
cagaacctttccagcgtgtggactgttgaatatgctcttgatttgttgctcattggtggg
ctgattccagaagcagcttggtttgcactccagctcggagactggaagatgtcagtctcc
ataggtttggcctataatctgtcctgtcaaattacagaggaccgtacatggttaaacagt
gtagaaatgcagttaccgccaaagctgacacccgcacatacttttcaggagaaattgcaa
tctttcttgggacgcccaggtagctcagaaataataaaggcagaaggcagaggctacaaa
cagtttacggatccaattgaagacgaggatacagatgccctctttagttctgttcaagaa
atgctgaaggctgcagtgatggctgaggccgatattctgtcggaaacatttttacttttg
attgaagcagccaaagatcttagcaaaggtttgagtggcctagtgcctgaaaagctttat
cttccagcgccgccgttatactgccctcaaccagcctctgttagcgagggtgactatggt
gaccaggttttagcatctgagaaagattatcgtcaaaagttgtctggtgtccttcaaaga
atccttcttctcctgcgtgcagctcgttgctcaattccttcagcccagtggtacattaag
aaactgaaatgggccagaaaagttatgcaaaagattagagcaaaaagcttccttcctcca
ttgagtcagcttcctgaatcactgctaaactattcgcgcaccaattcaaccttctttaag
acaggacctgatggagacaaacttgatgatgtatcctgtaaaataattggttccttcaga
gagctctgtgcattgtgttggatgcttcatgttcgtgaaaaattgtctgatggttgtaga
cgttaccaaatttcacgggacaatatggaaaagcagcaggactttgagaagactgtcccc
tttgattcttcagttgtagaacagtgcctgaatgctttggaatgggcttatcgaatgtta
cctttttctgcttttttaaatattgaagaacttgttcaagacataattctcagcctcatt
ggagagctccctccagtgcaaaaggtcgcagaaattttggtgaaggcatttcccagctca
gaagctgtccgagtgtctttgagagacaaataccattctcttcaacagcgattaagacac
tgtatggtcaaaggccctaaaggagaggaaatgatgtctcttgtaatgcacaattttcac
aaagtgagaattaaaaccttgaaacgtgtagtaaggaacattgggcccatcgagatgaat
atttgggaaccagaagaagagaatccagataatgaggtacaattatatgaccgattttcc
atggggacaagcctgagcagaagcactcttacagaatttggtaaaccacaggtttatagt
gatgcagacaccggagatacactttctgaagctttgatgactgaagagcctattccaagg
atggaaatgtcagttacagaggatctacgttacaacaatgacactctatataggaaaaaa
gatatttctgccaaaagtaagactgatcagaaagaaccaaaagagactacactgctgcct
tctgtgggaacgtgggaattcgaacgagatgacgatgaatatattgcttttctagatctc
tttatgagttacctgctagaaagagatctgattaattacactgatccctgcattccattc
ttaacaagtttttcagaacacttacgtgaattcgagctgaactctctgctttttgatgtg
cacacaacactgaaacgccgccagggtaggagtaaacattgcaatgtttttcgagccggt
tatagctacactgcctctgcagaggctggcgcacaaccagtgaactcagtccaaccatgt
gacgaaaaggaaaatgctttacgtaggctaccttctaatcccacttcattaatatttcta
ccagcttcaaagccctctctaattcaatattttaatgaaggtaataacgctacgttggga
aaaaaaggtttgtttggtttaaatctccggactgctctccaagaggaccatcaagaagaa
tcatctgcttgtccaaaggaaccccatcaaagtactgaaactcctgtagttgtgaacact
ttcaaaataattcactttgaatccgtattgccaagtgaagagctcctgacggaattgaaa
actaaatttgggggtgtttcaagattgttggaatggatgatcaggtggtcagagaagcaa
ctcctgtgtggctccagcaaggaagagttgatccgtgagaacagtacgataatcagggtc
aagacgtctgcagccgccatccttacttctctctggctgttagaggagcggcactgtgct
ggatgccgagacaaaaataccaacttcaggattccagatgctgaaaatataaaagccccg
gtgtttcaatctatggaacggcaaaccatgcagagggagtcaagtgtggatactggttat
cgtgggtcaacaggaacaccaatagatgccctggaagaaaatctttatgaagatgtttgt
gagagtgatcctgagtcatcttctattcatgatcataaggatgagctggaagaagttcag
gatattcaacaaaaggttctagatatcccatctacatccgaagatgactttgaggacgat
tttgaccctgtaagtccaagtatttctgtcaacatcaggccggttcaaaggctaacagaa
aatagtgtggaaacatacgaaattccctacagagaatcagaaagtgaaaagttagaagaa
aaaaagactcaccacgattccacctgtgccagtgaacaacccggcggccctcccttagtc
tgtgcagacatgaaagtttctactcctagtgacagagggtctcctgcgcctgcttcatct
tacggaccatccttcccaactttgccagacttgcatgcagaaaatgtgcaatcacatgct
gctatttacacaagcccactagatacccataatagtgaccacagaactcagccacaaaat
acctccgaagcagtcagacaaatgttccaagatgaaatgttccggttgctgcagctccag
caaatcaatttcatgagtttaatgcaaattgtggggtcttcatttgcaagccttccgcaa
gtgcagcagctgcttcaacaatcacaaccaataaaccttcaagaaggacagacatcagcc
aacgttagaggccttgtcactgaaggattactcaccactcctgctgaagatagacatcat
atgatttctgttccacctgtgcaacagccacatacaatgaaaagtggtggtgaaagggcc
accaattcaagcaactctttgccttcgcctgatgaaagcagtaaagaaaatcaacaggat
catacagagttgaaacgagaagagagtcggccttcaaaaagcagaatgcttctagcaact
tgtaacatgcttgactcagtcaatggaaaggcttcaatagatacccagaatgtcattccg
ttagttactactccccagaatttgagtgcagcaaagagttttccattgcttcatctttca
cctgagcgcagttttaagcctgaagaaaatgatacatttcagtcttttgctagaccgcca
caaaacccgagagaggcatgggttacaattgagactataaagaacagaaaagattccgaa
acgccagagtacagttctggtgtggtgcaaccacatgtaaatcaacaggtcaaacatttt
aaacagaaagaaaaacagaagaaaaaatcagcagtgtgtgtaaagacagaaacccctaaa
aatgtacatgttaatccttatatgttgaattctaaccgtgcaactctgccgcagaatttg
aaacatgctgtagcaccatcactagagtcaaaggtttctagtcaaggcgcattccggaac
caagctggatttcccttgctacacatgcaggtcaacccagtgccgctttttccccatatt
atcaggccaaataatgctggattgataataccacctcacgatatatcaagaaaagatatt
caagtaccacagcagattccgaaactgacgttgcttcatgccagcatccctctggagaac
aaggttatatctcaagttctgccttttcaaccaccaagactcatcccacttcaacatatt
attgcttataaacaaagcattcagaataagtctgagcagttgtttgaagagcatgttgct
ggatccattaagttgctgaaagcgaacattgaaccttttgagggaagagatgtacaaaaa
gagagaaaaggacgggtaaggcgacgtttggagaaacagcacaagcaagagcatgttgag
agaccgccatacaaacaagataacacggagacaaagctggagaagcaagtgcaaatcatt
gcagagttggaggggcaagagcgaatgaatacacagccaggcaaccaagagaaaattgaa
actaagacagtgaaaaaaacaagtgtgtcattccgccctcaggattccataattgaatta
attccagtcgatgacaacagctctgaaattattgataactcagaggtacatcagaatgac
gtgccaaacttggagaatggagaaggatttgttctacctcttgggatgtttgattctctc
cttttggagcaaaacaatgaacacagatcggttcctgcaccagcagaattgcattatatg
gcagcaacaaagagaaaagctgctgaaattcaagatgcaagcacaaatacagatcctggt
agtggactaaaatcaaatcatgaatatctgccttcaacagtcccacagctgctgccacca
gatttgtaccaaaacctgagattcttgaatgggttggaagaacaaattgtaccatccaaa
acctctgatcctgaaactgttccgcctaaacatcagtatatcaatgtaattgacattgag
gcatcggatttcctgaaagacttgccaaccagagaatctccagaagaggagttgaccaga
gatcgagctgatcatgcctcggctccatcctcggcacagcttcatcacatggcagcttcg
gttacaaatgttattccaccagatgagtttgaaagcacggattatttgcttcagttacca
gtatcccagagccaaaatctgaatgagaaacctggtgttgctggagatgttgttacctgg
aatttgttgcaagatgatcttgatattgtgaagccctcagaacgatccgtgaagactttt
tcagcaaaacccatgagcaaagtacatatggactcaaaactgcatgaaatggaggcccag
ctgtctgctcttcaaaacatggcggaatacatggaacgtgactttgctaacagtgaactg
ttggttaatacaatagaaaacttaggatcagctatggattcagttcatgaagaaatacct
tactcttccacgggcatccaagatactacaaaagaattattttttaatcccgtccgacta
gaagatctaattgaagaagaggaagaagattcaaaatcagaattaattgccaataatgct
tctgcatggcagactcctgcttattctgcagtgtcagctgctaatcctgcctccacaact
gaagcttctgctgcagagaggggagatgttcgccaccaatgcattgactcgagactcaag
aagcccttttctgtttcagactttcccagagtggaggaagtgcgcgagagtttttcagat
gctcccttagagatgacaggcctgagtgacattgcggacattattggcgaccttgtaaga
catggtggtgttgcagcaagtgaacttggcttaacagaggctcaagctaggatattttca
agagcgagtaatgacaaggctaattctactagacttactaagaaaatggagagtaagagg
caagagattcgggactggatgaagttaaaacaaaaggaaagactggcagaacactgtaaa
aagcgagaagaactgcgagagcgagagtatgacccttttcggcctcaaaaagatttgcaa
cgtaccttcaattcaagcgacttaaggaaaatccaaaaagcgaaagaggagaaagacaaa
acactgctgtctgaacaccacagtcatcgtgtagcacaggcatttactttgatgaacaat
attctttctgcaacaagtcaagcacctgcaactaacccttatcaccctcctaactctcca
ttaaggttgaaatcacctcagagcattcaaggacaacctttaactcgtcaaagggtttac
tctttaaaacgcagtctgtcagcaaatcctgctgagaaaagaagagcaattcccagaact
ggctctagtcaggcaaggtctctttctactccatcatatgggtcagctcattctcgagga
ccttggacattaccaaagaaaattcctgattccagagctcaaagtgcaacaagctactct
ctaaaagctaaaattgaaacctccttgccacgggatcgaatgtctcagatcacacgaaga
ggaattctagttaatcggagcacaaaaaaaggacatgctcacgtcgagggaagggagaag
ccaggcttcgatgcaaaaaggcctgtctcagccaatccaggcttagcatttgatagatca
ggaaaagaaattttcagaaaaccaacaaaacaagcagcagaatgccaaacaaacgaaact
ggactagagaatgaagacagtgactctctaagtcattgggaagtacctgatgaaatcaac
agaattctcaacagcagtcaagatgcatggtctttgcttcaggaggaagaacattttcct
caaagctttaatgatatcgacaatatgtctgaaagcaccggcagtattttaagcaaattg
gactggaatatgatcgaggacatggttgcaagcgttgaagaaaagagtaattga
DBGET
integrated database retrieval system