KEGG   Puma yagouaroundi (jaguarundi): 121011002
Entry
121011002         CDS       T07555                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pyu  Puma yagouaroundi (jaguarundi)
Pathway
pyu01521  EGFR tyrosine kinase inhibitor resistance
pyu01522  Endocrine resistance
pyu01524  Platinum drug resistance
pyu04012  ErbB signaling pathway
pyu04014  Ras signaling pathway
pyu04015  Rap1 signaling pathway
pyu04024  cAMP signaling pathway
pyu04062  Chemokine signaling pathway
pyu04066  HIF-1 signaling pathway
pyu04068  FoxO signaling pathway
pyu04070  Phosphatidylinositol signaling system
pyu04071  Sphingolipid signaling pathway
pyu04072  Phospholipase D signaling pathway
pyu04081  Hormone signaling
pyu04140  Autophagy - animal
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04152  AMPK signaling pathway
pyu04210  Apoptosis
pyu04211  Longevity regulating pathway
pyu04213  Longevity regulating pathway - multiple species
pyu04218  Cellular senescence
pyu04360  Axon guidance
pyu04370  VEGF signaling pathway
pyu04380  Osteoclast differentiation
pyu04510  Focal adhesion
pyu04550  Signaling pathways regulating pluripotency of stem cells
pyu04611  Platelet activation
pyu04613  Neutrophil extracellular trap formation
pyu04620  Toll-like receptor signaling pathway
pyu04625  C-type lectin receptor signaling pathway
pyu04630  JAK-STAT signaling pathway
pyu04650  Natural killer cell mediated cytotoxicity
pyu04660  T cell receptor signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04664  Fc epsilon RI signaling pathway
pyu04666  Fc gamma R-mediated phagocytosis
pyu04668  TNF signaling pathway
pyu04670  Leukocyte transendothelial migration
pyu04722  Neurotrophin signaling pathway
pyu04725  Cholinergic synapse
pyu04750  Inflammatory mediator regulation of TRP channels
pyu04810  Regulation of actin cytoskeleton
pyu04910  Insulin signaling pathway
pyu04914  Progesterone-mediated oocyte maturation
pyu04915  Estrogen signaling pathway
pyu04917  Prolactin signaling pathway
pyu04919  Thyroid hormone signaling pathway
pyu04923  Regulation of lipolysis in adipocytes
pyu04926  Relaxin signaling pathway
pyu04929  GnRH secretion
pyu04930  Type II diabetes mellitus
pyu04931  Insulin resistance
pyu04932  Non-alcoholic fatty liver disease
pyu04933  AGE-RAGE signaling pathway in diabetic complications
pyu04935  Growth hormone synthesis, secretion and action
pyu04960  Aldosterone-regulated sodium reabsorption
pyu04973  Carbohydrate digestion and absorption
pyu05010  Alzheimer disease
pyu05017  Spinocerebellar ataxia
pyu05020  Prion disease
pyu05100  Bacterial invasion of epithelial cells
pyu05135  Yersinia infection
pyu05142  Chagas disease
pyu05146  Amoebiasis
pyu05160  Hepatitis C
pyu05161  Hepatitis B
pyu05162  Measles
pyu05163  Human cytomegalovirus infection
pyu05164  Influenza A
pyu05165  Human papillomavirus infection
pyu05166  Human T-cell leukemia virus 1 infection
pyu05167  Kaposi sarcoma-associated herpesvirus infection
pyu05168  Herpes simplex virus 1 infection
pyu05169  Epstein-Barr virus infection
pyu05170  Human immunodeficiency virus 1 infection
pyu05171  Coronavirus disease - COVID-19
pyu05200  Pathways in cancer
pyu05203  Viral carcinogenesis
pyu05205  Proteoglycans in cancer
pyu05206  MicroRNAs in cancer
pyu05207  Chemical carcinogenesis - receptor activation
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05210  Colorectal cancer
pyu05211  Renal cell carcinoma
pyu05212  Pancreatic cancer
pyu05213  Endometrial cancer
pyu05214  Glioma
pyu05215  Prostate cancer
pyu05218  Melanoma
pyu05220  Chronic myeloid leukemia
pyu05221  Acute myeloid leukemia
pyu05222  Small cell lung cancer
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
pyu05226  Gastric cancer
pyu05230  Central carbon metabolism in cancer
pyu05231  Choline metabolism in cancer
pyu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pyu05415  Diabetic cardiomyopathy
pyu05417  Lipid and atherosclerosis
pyu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pyu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    121011002 (PIK3R2)
   04015 Rap1 signaling pathway
    121011002 (PIK3R2)
   04630 JAK-STAT signaling pathway
    121011002 (PIK3R2)
   04668 TNF signaling pathway
    121011002 (PIK3R2)
   04066 HIF-1 signaling pathway
    121011002 (PIK3R2)
   04068 FoxO signaling pathway
    121011002 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    121011002 (PIK3R2)
   04072 Phospholipase D signaling pathway
    121011002 (PIK3R2)
   04071 Sphingolipid signaling pathway
    121011002 (PIK3R2)
   04024 cAMP signaling pathway
    121011002 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    121011002 (PIK3R2)
   04152 AMPK signaling pathway
    121011002 (PIK3R2)
   04150 mTOR signaling pathway
    121011002 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121011002 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121011002 (PIK3R2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    121011002 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121011002 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    121011002 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    121011002 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    121011002 (PIK3R2)
   04660 T cell receptor signaling pathway
    121011002 (PIK3R2)
   04662 B cell receptor signaling pathway
    121011002 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    121011002 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    121011002 (PIK3R2)
   04670 Leukocyte transendothelial migration
    121011002 (PIK3R2)
   04062 Chemokine signaling pathway
    121011002 (PIK3R2)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    121011002 (PIK3R2)
   04929 GnRH secretion
    121011002 (PIK3R2)
   04915 Estrogen signaling pathway
    121011002 (PIK3R2)
   04917 Prolactin signaling pathway
    121011002 (PIK3R2)
   04926 Relaxin signaling pathway
    121011002 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    121011002 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    121011002 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121011002 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121011002 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    121011002 (PIK3R2)
   04722 Neurotrophin signaling pathway
    121011002 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121011002 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    121011002 (PIK3R2)
   04380 Osteoclast differentiation
    121011002 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    121011002 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    121011002 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121011002 (PIK3R2)
   05206 MicroRNAs in cancer
    121011002 (PIK3R2)
   05205 Proteoglycans in cancer
    121011002 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    121011002 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    121011002 (PIK3R2)
   05203 Viral carcinogenesis
    121011002 (PIK3R2)
   05230 Central carbon metabolism in cancer
    121011002 (PIK3R2)
   05231 Choline metabolism in cancer
    121011002 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121011002 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121011002 (PIK3R2)
   05212 Pancreatic cancer
    121011002 (PIK3R2)
   05225 Hepatocellular carcinoma
    121011002 (PIK3R2)
   05226 Gastric cancer
    121011002 (PIK3R2)
   05214 Glioma
    121011002 (PIK3R2)
   05221 Acute myeloid leukemia
    121011002 (PIK3R2)
   05220 Chronic myeloid leukemia
    121011002 (PIK3R2)
   05218 Melanoma
    121011002 (PIK3R2)
   05211 Renal cell carcinoma
    121011002 (PIK3R2)
   05215 Prostate cancer
    121011002 (PIK3R2)
   05213 Endometrial cancer
    121011002 (PIK3R2)
   05224 Breast cancer
    121011002 (PIK3R2)
   05222 Small cell lung cancer
    121011002 (PIK3R2)
   05223 Non-small cell lung cancer
    121011002 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121011002 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    121011002 (PIK3R2)
   05161 Hepatitis B
    121011002 (PIK3R2)
   05160 Hepatitis C
    121011002 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    121011002 (PIK3R2)
   05164 Influenza A
    121011002 (PIK3R2)
   05162 Measles
    121011002 (PIK3R2)
   05163 Human cytomegalovirus infection
    121011002 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121011002 (PIK3R2)
   05169 Epstein-Barr virus infection
    121011002 (PIK3R2)
   05165 Human papillomavirus infection
    121011002 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    121011002 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    121011002 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121011002 (PIK3R2)
   05142 Chagas disease
    121011002 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121011002 (PIK3R2)
   05017 Spinocerebellar ataxia
    121011002 (PIK3R2)
   05020 Prion disease
    121011002 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121011002 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    121011002 (PIK3R2)
   05415 Diabetic cardiomyopathy
    121011002 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121011002 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    121011002 (PIK3R2)
   04931 Insulin resistance
    121011002 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121011002 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121011002 (PIK3R2)
   01524 Platinum drug resistance
    121011002 (PIK3R2)
   01522 Endocrine resistance
    121011002 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pyu04131]
    121011002 (PIK3R2)
Membrane trafficking [BR:pyu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121011002 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 121011002
NCBI-ProteinID: XP_040300854
LinkDB
Position
Unknown
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEEFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPAPRTDWSLSDVEQWDATALADGVKGFLLA
LPAPLVTPEAAAEARRALREATGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPAAR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggggacgtgctggtggtgagccgagcagccctgcaggtg
ctgggcgtggccgagggcaacgaacgctgcccacagagtgtgggctggatgccgggcctc
aatgagcgcacgcggcagcgaggtgacttccccggcacctacgtcgagttcctgggtcct
gtagccctggcccggcccggccctcgtccgcgtggcccccgcccactgcccgccaggccc
cgggacgggccccctgagccaggcctcacgctccctgacctgccagaggagttctcccca
cctgatgtggctcccccgctcctggtgaagctcgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgccacagccctggcagatggcgtcaagggcttcctgctggcg
ctgcccgcccccctcgtgacgcccgaggctgcggccgaagcgcgccgggccctgcgggag
gccacggggcccgtggggccggcgctggagcccccgacgctgccactgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccgacgtgccccggctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgcgcgccgcccccc
tcgccgccgccagggggcgcgcccgacgggactgagcccagccctgacttcccggcgttg
ctggtggagaagttgcttcaggaacatctggaagagcaggaggtcgcacccccagcgctg
ccgcccaaaccccccaaggccaagccagcacccgcaggcctagccaatggggggagcccg
ccctccctgcaggatgccgagtggtactggggtgacatctccagggaggaagtgaatgag
aaactccgggacacacccgacggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacactgaccctcaggaaaggcgggaacaacaagctgattaaggtcttccat
cgtgacgggcactatggcttctcagagccgctcaccttctgctccgttgtggacctcatc
acccactaccgtcacgagtcgctggcccagtacaatgccaaactggacacacggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggcgcccagctcaaagtctatcaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggaactgcagatgaagcgcacagcaattgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacacaagagaagtgtagc
aaggagtatctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacgaagctg
gagcaggagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctccgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggtgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaagacgaggatgacctcccccaccacgaggaacgcacgtgg
tacgtgggcaagatcaaccgcacgcaagctgaggaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctctgtggtggtggac
ggcgacaccaagcactgtgtcatctaccgcacggccaccggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcattaccagcacgcctcgctggtg
cagcacaacgacgcgctcaccgtcactctcgcgcaccccgtgcgggcccccgggcccggg
cccccgccggccgcccgctga

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