KEGG   Rhinopithecus bieti (black snub-nosed monkey): 108527540
Entry
108527540         CDS       T04641                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
rbb  Rhinopithecus bieti (black snub-nosed monkey)
Pathway
rbb00562  Inositol phosphate metabolism
rbb01100  Metabolic pathways
rbb01521  EGFR tyrosine kinase inhibitor resistance
rbb04068  FoxO signaling pathway
rbb04070  Phosphatidylinositol signaling system
rbb04071  Sphingolipid signaling pathway
rbb04115  p53 signaling pathway
rbb04140  Autophagy - animal
rbb04150  mTOR signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04218  Cellular senescence
rbb04510  Focal adhesion
rbb04931  Insulin resistance
rbb05165  Human papillomavirus infection
rbb05166  Human T-cell leukemia virus 1 infection
rbb05200  Pathways in cancer
rbb05206  MicroRNAs in cancer
rbb05208  Chemical carcinogenesis - reactive oxygen species
rbb05213  Endometrial cancer
rbb05214  Glioma
rbb05215  Prostate cancer
rbb05218  Melanoma
rbb05222  Small cell lung cancer
rbb05224  Breast cancer
rbb05225  Hepatocellular carcinoma
rbb05230  Central carbon metabolism in cancer
rbb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rbb05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rbb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108527540 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    108527540 (PTEN)
   04070 Phosphatidylinositol signaling system
    108527540 (PTEN)
   04071 Sphingolipid signaling pathway
    108527540 (PTEN)
   04151 PI3K-Akt signaling pathway
    108527540 (PTEN)
   04150 mTOR signaling pathway
    108527540 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108527540 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    108527540 (PTEN)
   04218 Cellular senescence
    108527540 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108527540 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108527540 (PTEN)
   05206 MicroRNAs in cancer
    108527540 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    108527540 (PTEN)
   05230 Central carbon metabolism in cancer
    108527540 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108527540 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    108527540 (PTEN)
   05214 Glioma
    108527540 (PTEN)
   05218 Melanoma
    108527540 (PTEN)
   05215 Prostate cancer
    108527540 (PTEN)
   05213 Endometrial cancer
    108527540 (PTEN)
   05224 Breast cancer
    108527540 (PTEN)
   05222 Small cell lung cancer
    108527540 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108527540 (PTEN)
   05165 Human papillomavirus infection
    108527540 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    108527540 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    108527540 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108527540 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rbb01009]
    108527540 (PTEN)
Enzymes [BR:rbb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     108527540 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     108527540 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     108527540 (PTEN)
Protein phosphatases and associated proteins [BR:rbb01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    108527540 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 108527540
NCBI-ProteinID: XP_017724346
LinkDB
Position
Unknown
AA seq 388 aa
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVSCAERH
YDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMI
CAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLF
HKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKV
EFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEY
LVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPD
HYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1167 nt   +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaagttgtgctgaaagacat
tatgacaccgccaaatttaattgcagagttgcacaatatccttttgaagaccataaccca
ccacagctagaactgatcaaacccttttgtgaagatcttgaccaatggctaagtgaagat
gacaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggtgtaatgatt
tgtgcatatttattacatcggggcaaatttttaaaggcacaagaggccctagatttctat
ggggaagtaaggaccagagacaaaaagggagtaactattcccagtcagaggcgctatgtg
tattattatagctacctgttaaagaatcacctggattatagaccagtggcactgttgttt
cacaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaatcctcagttt
gtggtctgccagctaaaggtgaagatatattcctccaattcaggccccacacgacgggaa
gacaagttcatgtactttgagttccctcagccattacctgtgtgtggtgatatcaaagta
gaattcttccacaaacagaacaagatgctaaaaaaggacaaaatgtttcacttttgggta
aatacattcttcataccaggaccagaggaaacctcagaaaaagtagaaaatggaagtcta
tgtgatcaagaaattgatagcatttgcagtatagagcgtgcagataatgacaaggaatat
ctagtacttactttaacaaaaaatgatcttgacaaagcaaataaagacaaagccaaccga
tacttttctccaaattttaaggtgaagctgtacttcacaaaaacagtagaggagccgtca
aatccagaggctagcagttcaacttctgtaacaccagatgttagtgacaatgaacctgat
cattatagatactctgacaccactgactctgatccagagaatgaaccttttgatgaagat
cagcatacacaaattacaaaagtctga

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