KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117038261
Entry
117038261         CDS       T07722                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq01521  EGFR tyrosine kinase inhibitor resistance
rfq01522  Endocrine resistance
rfq01524  Platinum drug resistance
rfq04012  ErbB signaling pathway
rfq04014  Ras signaling pathway
rfq04015  Rap1 signaling pathway
rfq04024  cAMP signaling pathway
rfq04062  Chemokine signaling pathway
rfq04066  HIF-1 signaling pathway
rfq04068  FoxO signaling pathway
rfq04070  Phosphatidylinositol signaling system
rfq04071  Sphingolipid signaling pathway
rfq04072  Phospholipase D signaling pathway
rfq04081  Hormone signaling
rfq04140  Autophagy - animal
rfq04145  Phagocytosis
rfq04150  mTOR signaling pathway
rfq04151  PI3K-Akt signaling pathway
rfq04152  AMPK signaling pathway
rfq04210  Apoptosis
rfq04211  Longevity regulating pathway
rfq04213  Longevity regulating pathway - multiple species
rfq04218  Cellular senescence
rfq04360  Axon guidance
rfq04370  VEGF signaling pathway
rfq04380  Osteoclast differentiation
rfq04510  Focal adhesion
rfq04517  IgSF CAM signaling
rfq04518  Integrin signaling
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04611  Platelet activation
rfq04613  Neutrophil extracellular trap formation
rfq04620  Toll-like receptor signaling pathway
rfq04625  C-type lectin receptor signaling pathway
rfq04630  JAK-STAT signaling pathway
rfq04650  Natural killer cell mediated cytotoxicity
rfq04660  T cell receptor signaling pathway
rfq04662  B cell receptor signaling pathway
rfq04664  Fc epsilon RI signaling pathway
rfq04666  Fc gamma R-mediated phagosome formation
rfq04668  TNF signaling pathway
rfq04670  Leukocyte transendothelial migration
rfq04722  Neurotrophin signaling pathway
rfq04725  Cholinergic synapse
rfq04750  Inflammatory mediator regulation of TRP channels
rfq04810  Regulation of actin cytoskeleton
rfq04910  Insulin signaling pathway
rfq04914  Progesterone-mediated oocyte maturation
rfq04915  Estrogen signaling pathway
rfq04917  Prolactin signaling pathway
rfq04919  Thyroid hormone signaling pathway
rfq04923  Regulation of lipolysis in adipocytes
rfq04926  Relaxin signaling pathway
rfq04929  GnRH secretion
rfq04930  Type II diabetes mellitus
rfq04931  Insulin resistance
rfq04932  Non-alcoholic fatty liver disease
rfq04933  AGE-RAGE signaling pathway in diabetic complications
rfq04935  Growth hormone synthesis, secretion and action
rfq04960  Aldosterone-regulated sodium reabsorption
rfq04973  Carbohydrate digestion and absorption
rfq05010  Alzheimer disease
rfq05017  Spinocerebellar ataxia
rfq05020  Prion disease
rfq05100  Bacterial invasion of epithelial cells
rfq05135  Yersinia infection
rfq05142  Chagas disease
rfq05146  Amoebiasis
rfq05160  Hepatitis C
rfq05161  Hepatitis B
rfq05162  Measles
rfq05163  Human cytomegalovirus infection
rfq05164  Influenza A
rfq05165  Human papillomavirus infection
rfq05166  Human T-cell leukemia virus 1 infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05168  Herpes simplex virus 1 infection
rfq05169  Epstein-Barr virus infection
rfq05170  Human immunodeficiency virus 1 infection
rfq05171  Coronavirus disease
rfq05200  Pathways in cancer
rfq05203  Viral carcinogenesis
rfq05205  Proteoglycans in cancer
rfq05206  MicroRNAs in cancer
rfq05207  Chemical carcinogenesis - receptor activation
rfq05208  Chemical carcinogenesis - reactive oxygen species
rfq05210  Colorectal cancer
rfq05211  Renal cell carcinoma
rfq05212  Pancreatic cancer
rfq05213  Endometrial cancer
rfq05214  Glioma
rfq05215  Prostate cancer
rfq05218  Melanoma
rfq05220  Chronic myeloid leukemia
rfq05221  Acute myeloid leukemia
rfq05222  Small cell lung cancer
rfq05223  Non-small cell lung cancer
rfq05224  Breast cancer
rfq05225  Hepatocellular carcinoma
rfq05226  Gastric cancer
rfq05230  Central carbon metabolism in cancer
rfq05231  Choline metabolism in cancer
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rfq05415  Diabetic cardiomyopathy
rfq05417  Lipid and atherosclerosis
rfq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    117038261 (PIK3R2)
   04014 Ras signaling pathway
    117038261 (PIK3R2)
   04015 Rap1 signaling pathway
    117038261 (PIK3R2)
   04370 VEGF signaling pathway
    117038261 (PIK3R2)
   04630 JAK-STAT signaling pathway
    117038261 (PIK3R2)
   04668 TNF signaling pathway
    117038261 (PIK3R2)
   04066 HIF-1 signaling pathway
    117038261 (PIK3R2)
   04068 FoxO signaling pathway
    117038261 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    117038261 (PIK3R2)
   04072 Phospholipase D signaling pathway
    117038261 (PIK3R2)
   04071 Sphingolipid signaling pathway
    117038261 (PIK3R2)
   04024 cAMP signaling pathway
    117038261 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    117038261 (PIK3R2)
   04152 AMPK signaling pathway
    117038261 (PIK3R2)
   04150 mTOR signaling pathway
    117038261 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    117038261 (PIK3R2)
   04517 IgSF CAM signaling
    117038261 (PIK3R2)
   04518 Integrin signaling
    117038261 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    117038261 (PIK3R2)
   04140 Autophagy - animal
    117038261 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    117038261 (PIK3R2)
   04218 Cellular senescence
    117038261 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    117038261 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    117038261 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117038261 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    117038261 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    117038261 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    117038261 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    117038261 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    117038261 (PIK3R2)
   04660 T cell receptor signaling pathway
    117038261 (PIK3R2)
   04662 B cell receptor signaling pathway
    117038261 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    117038261 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    117038261 (PIK3R2)
   04670 Leukocyte transendothelial migration
    117038261 (PIK3R2)
   04062 Chemokine signaling pathway
    117038261 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117038261 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    117038261 (PIK3R2)
   04929 GnRH secretion
    117038261 (PIK3R2)
   04915 Estrogen signaling pathway
    117038261 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    117038261 (PIK3R2)
   04917 Prolactin signaling pathway
    117038261 (PIK3R2)
   04926 Relaxin signaling pathway
    117038261 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    117038261 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    117038261 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    117038261 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    117038261 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    117038261 (PIK3R2)
   04722 Neurotrophin signaling pathway
    117038261 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    117038261 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    117038261 (PIK3R2)
   04380 Osteoclast differentiation
    117038261 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    117038261 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    117038261 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117038261 (PIK3R2)
   05206 MicroRNAs in cancer
    117038261 (PIK3R2)
   05205 Proteoglycans in cancer
    117038261 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    117038261 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    117038261 (PIK3R2)
   05203 Viral carcinogenesis
    117038261 (PIK3R2)
   05230 Central carbon metabolism in cancer
    117038261 (PIK3R2)
   05231 Choline metabolism in cancer
    117038261 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117038261 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117038261 (PIK3R2)
   05212 Pancreatic cancer
    117038261 (PIK3R2)
   05225 Hepatocellular carcinoma
    117038261 (PIK3R2)
   05226 Gastric cancer
    117038261 (PIK3R2)
   05214 Glioma
    117038261 (PIK3R2)
   05221 Acute myeloid leukemia
    117038261 (PIK3R2)
   05220 Chronic myeloid leukemia
    117038261 (PIK3R2)
   05218 Melanoma
    117038261 (PIK3R2)
   05211 Renal cell carcinoma
    117038261 (PIK3R2)
   05215 Prostate cancer
    117038261 (PIK3R2)
   05213 Endometrial cancer
    117038261 (PIK3R2)
   05224 Breast cancer
    117038261 (PIK3R2)
   05222 Small cell lung cancer
    117038261 (PIK3R2)
   05223 Non-small cell lung cancer
    117038261 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117038261 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    117038261 (PIK3R2)
   05161 Hepatitis B
    117038261 (PIK3R2)
   05160 Hepatitis C
    117038261 (PIK3R2)
   05171 Coronavirus disease
    117038261 (PIK3R2)
   05164 Influenza A
    117038261 (PIK3R2)
   05162 Measles
    117038261 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    117038261 (PIK3R2)
   05163 Human cytomegalovirus infection
    117038261 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117038261 (PIK3R2)
   05169 Epstein-Barr virus infection
    117038261 (PIK3R2)
   05165 Human papillomavirus infection
    117038261 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    117038261 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    117038261 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    117038261 (PIK3R2)
   05142 Chagas disease
    117038261 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117038261 (PIK3R2)
   05017 Spinocerebellar ataxia
    117038261 (PIK3R2)
   05020 Prion disease
    117038261 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117038261 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    117038261 (PIK3R2)
   05415 Diabetic cardiomyopathy
    117038261 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    117038261 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    117038261 (PIK3R2)
   04931 Insulin resistance
    117038261 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    117038261 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117038261 (PIK3R2)
   01524 Platinum drug resistance
    117038261 (PIK3R2)
   01522 Endocrine resistance
    117038261 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rfq04131]
    117038261 (PIK3R2)
Membrane trafficking [BR:rfq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    117038261 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 Ribosomal_L22e ODF2_C Laminin_I
Other DBs
NCBI-GeneID: 117038261
NCBI-ProteinID: XP_032990973
Ensembl: ENSRFEG00010019200
UniProt: A0A671FTJ9
LinkDB
Position
18:51010835..51022463
AA seq 742 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDILVVSRAALQVLGVAEGSERCPQNVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPREGPPEPGLTLPDLPDQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPAQRTDWSLSDVEQWDAAALADGIKGFLLA
LPAPLVTPEAAAEARRALHEAVGPVGPALEPPTLPLHRALTLRFLLQHLGRMARRAPAPG
PAVRALGTAFGPLLLLHAPPPSPPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPAPTGLANEGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQELRAQALDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYSLMDDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTVTGLGFAEPYNLYGSLKELVLHYQHTSLVQHNDALTVTLAHPVRAPG
PGPPPARCPQTGTEQSYLGPSN
NT seq 2229 nt   +upstreamnt  +downstreamnt
atggctggcgctgagggcttccagtaccgtgcactgtacccgttccgccgggagcggcca
gaagacctggagctactaccaggtgatatactggtggtaagccgggcagccctgcaggtg
ctgggtgtggccgagggcagtgagcgctgcccacagaacgtgggttggatgcctggcctc
aacgagcgcacgaggcagcgtggcgattttccgggcacctacgttgagttcttggggcct
gtggccctggctcggcctggccctcgcccccgcggccctcgcccactgccagccaggccc
cgagaagggcccccggagccaggtctcaccctccccgacctgcctgatcagttctcccca
cctgacgtggctccccctctcctggtgaagcttgtggaagccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgccagcccagcgcacagactggtccctcagt
gatgtggagcagtgggatgctgcagccctggcggatggcatcaagggcttcctactggct
cttcccgcgcccctcgtgacgccggaggccgcggccgaggctcgccgggccctgcacgag
gccgtgggacctgttgggccggcactggagcccccgacgctgccgctgcaccgcgcactc
acactgcgcttcctgctccagcacctgggccggatggcccggcgtgccccagccccgggc
cccgcggtgcgagccctgggcactgccttcgggccactgctgctgctacacgcaccgcct
ccctcgccgccaccgccagggggcgcacccgacgggtctgagccctccccggatttccca
gctctgttggtggagaagttgcttcaggagcacctggaggaacaggaggtcgcaccccca
gctctgccgcccaaaccacctaaggcaaaaccggctcctacagggctggccaatgagggg
agcccaccctccctgcaggatgctgagtggtactggggtgacatctccagggaggaggtg
aatgagaaactccgggacacacctgatggcaccttcctggttcgagatgcctccagcaag
atccagggggagtacaccctgactctcaggaaaggcgggaacaacaaattgatcaaagtc
ttccaccgtgatgggcactatggcttctcagaacccctcaccttctgctctgtcgtggac
ctcatcacccactaccgccatgagtctctggcccagtacaatgccaaactggacacacgg
ctcctataccccgtgtccaagtaccagcaggaccagatcgtcaaggaggacagtgtggag
gcagtgggtgcccagctcaaagtctaccaccagcaataccaggacaagagccgcgagtat
gaccaactctacgaggagtacacacgtacctctcaggaactgcagatgaagcgcaccgcc
attgaggccttcaatgaaaccatcaagatctttgaagaacagggccagacgcaagagaag
tgcagcaaggaatatctagagcgcttccgacgtgagggcaatgagaaagagatgcagagg
atcctcctgaactccgagcggctcaagtctcgcatcgccgagatccatgagagccgcaca
aagctggagcaggagctgcgggcacaggccttggacaacagggagattgacaagcgcatg
aacagcctgaagccagacctcatgcagctgcgcaagatccgagaccagtacctggtgtgg
ctcacccagaaaggtgcccggcagaagaaaatcaacgagtggctggggatcaaaaatgag
actgaggatcagtactcactgatggatgacgaggacgacctacctcaccatgaggaacgc
acttggtatgtgggcaagatcaaccgcacgcaggccgaggaaatgctgagtggcaagcgg
gatggcaccttcctcatccgtgagagcagtcagcggggctgctatgcctgctctgtggtg
gtggacggcgacactaagcactgcgtcatctaccgcacggtcaccggcttgggctttgcg
gagccctacaacctgtacgggtccctgaaggagctggtgctgcactaccaacacacctcc
ctcgtgcaacacaatgacgcgctcaccgtcacgctggcccaccccgtgcgcgcccctggc
cctggccccccgcccgcccgctgcccacagacagggacggagcagagctacctgggcccc
agcaactga

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