KEGG   PATHWAY: rhi02030
Entry
rhi02030                    Pathway                                
Name
Bacterial chemotaxis - Sinorhizobium fredii NGR234
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
rhi02030  Bacterial chemotaxis
rhi02030

Other DBs
GO: 0006935
Organism
Sinorhizobium fredii NGR234 [GN:rhi]
Gene
NGR_a01640  [KO:K03406]
NGR_a02500  [KO:K10439]
NGR_a03800  [KO:K03406]
NGR_b01060  rbsB; periplasmic ribose-binding protein [KO:K10439]
NGR_b02560  [KO:K10439]
NGR_b03760  cheB1; CheB, chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
NGR_b03770  cheA1; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
NGR_b03780  [KO:K03406]
NGR_b03790  [KO:K03408]
NGR_b03800  [KO:K00575] [EC:2.1.1.80]
NGR_b04230  [KO:K10439]
NGR_b04250  [KO:K10439]
NGR_b04270  [KO:K10439]
NGR_b04390  [KO:K10439]
NGR_b07480  [KO:K10439]
NGR_b15010  [KO:K10439]
NGR_b15680  [KO:K10439]
NGR_b18110  [KO:K03406]
NGR_b18470  [KO:K03406]
NGR_b19010  [KO:K03406]
NGR_b21720  [KO:K10439]
NGR_b22390  [KO:K10439]
NGR_b22620  [KO:K03406]
NGR_c00530  [KO:K03406]
NGR_c00850  [KO:K03406]
NGR_c02510  [KO:K03406]
NGR_c02530  [KO:K03413]
NGR_c02540  cheA2; Chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
NGR_c02550  cheW1; putative CheW family chemotaxis protein [KO:K03408]
NGR_c02560  cheR; Chemotaxis protein methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
NGR_c02570  cheB2; Chemotaxis response regulator protein-glutamate methylesterase CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
NGR_c02580  [KO:K03413]
NGR_c02590  cheD; predicted chemotaxis protein CheD [KO:K03411] [EC:3.5.1.44]
NGR_c02660  fliG; flagellar motor switch protein FliG [KO:K02410]
NGR_c02670  fliN; predicted flagellar motor switch protein FliN [KO:K02417]
NGR_c02680  fliM; Flagellar motor switch protein FliM [KO:K02416]
NGR_c02690  motA; chemotaxis protein motility protein A [KO:K02556]
NGR_c02890  motB; chemotaxis protein motility protein B [KO:K02557]
NGR_c03230  [KO:K03406]
NGR_c03460  dppA; periplasmic dipeptide ABC transport protein precursor DppA [KO:K12368]
NGR_c04920  [KO:K03406]
NGR_c06210  [KO:K10439]
NGR_c06270  [KO:K10439]
NGR_c06650  [KO:K03406]
NGR_c10410  [KO:K03406]
NGR_c17120  [KO:K03406]
NGR_c17380  [KO:K10439]
NGR_c17460  [KO:K03406]
NGR_c20840  [KO:K03408]
NGR_c20850  [KO:K03406]
NGR_c27590  [KO:K03413]
NGR_c30840  cheW2; chemotaxis protein, CheW family [KO:K03408]
NGR_c30850  [KO:K03406]
NGR_c33680  [KO:K10439]
NGR_c35160  cheB3; chemotaxis protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
NGR_c35170  [KO:K03412] [EC:3.1.1.61 3.5.1.44]
NGR_c35180  [KO:K13924] [EC:2.1.1.80 3.1.1.61]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
PMID:12011078
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
PMID:11722727
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
PMID:12920116
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
PMID:14749334
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
PMID:11158445
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
PMID:15187186
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
PMID:18774298
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
PMID:18990184
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
rhi02040  Flagellar assembly
KO pathway
ko02030   

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