Rattus norvegicus (rat): 25116
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Entry
25116 CDS
T01003
Symbol
Hsd11b1
Name
(RefSeq) 11-beta-hydroxysteroid dehydrogenase 1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00140
Steroid hormone biosynthesis
rno00980
Metabolism of xenobiotics by cytochrome P450
rno01100
Metabolic pathways
rno05204
Chemical carcinogenesis - DNA adducts
Module
rno_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
25116 (Hsd11b1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
25116 (Hsd11b1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
25116 (Hsd11b1)
Enzymes [BR:
rno01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
25116 (Hsd11b1)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
THF_DHG_CYH_C
FMO-like
DUF1776
Pyr_redox_2
2-Hacid_dh_C
T3S_SPI-1_N0
Shikimate_DH
Motif
Other DBs
NCBI-GeneID:
25116
NCBI-ProteinID:
NP_058776
RGD:
2834
Ensembl:
ENSRNOG00000005861
UniProt:
P16232
A6JH26
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All DBs
Position
13:complement(107277526..107327462)
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AA seq
288 aa
AA seq
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MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
NT seq
867 nt
NT seq
+upstream
nt +downstream
nt
atgaaaaaatacctcctccccgtcctggtgctctgcctgggttactactattctacaaat
gaagagttcagaccagaaatgctccaggggaagaaagtgattgtcactggggccagcaaa
gggatcggaagagaaatggcatatcatctgtcaaaaatgggagcccatgtggtattgact
gcaaggtcggaggaagggctccagaaggtggtgtctcgctgccttgaactcggagcagcc
tctgctcactatattgccggcactatggaagacatggcttttgcagagcgatttgttgtt
gaggcaggaaagctcttgggtggactggacatgctcattctcaatcacatcacacagacc
actatgtctctcttccacgatgatatccactctgtgcgaagaagcatggaggtcaacttc
ctcagctatgtggtcctgagcacagcagccttgcccatgctgaaacagagcaatggcagc
attgccatcatctcctccatggctgggaaaatgacccaacctctgattgcttcctactct
gcaagcaagtttgctctggatgggttcttttccaccattagaaaagaacacttgatgacc
aaggtcaacgtgtccatcactctctgtgtcctcggcttcatagacacagaaacagctttg
aaagaaacctctgggataatcttgagtcaagctgctcccaaggaggaatgcgccctggag
atcatcaaaggcacagttctgcgcaaagatgaggtatactatgacaaatcatcttggact
ccacttctgcttgggaatccaggaaggaggatcatggaatttctttcattacggtcatat
aacagggacctatttgtaagcaactag
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