KEGG   Rattus norvegicus (rat): 25513
Entry
25513             CDS       T01003                                 
Symbol
Pik3r1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno01524  Platinum drug resistance
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04081  Hormone signaling
rno04140  Autophagy - animal
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04152  AMPK signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04218  Cellular senescence
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04611  Platelet activation
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04926  Relaxin signaling pathway
rno04929  GnRH secretion
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno04960  Aldosterone-regulated sodium reabsorption
rno04973  Carbohydrate digestion and absorption
rno05010  Alzheimer disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05100  Bacterial invasion of epithelial cells
rno05135  Yersinia infection
rno05142  Chagas disease
rno05146  Amoebiasis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25513 (Pik3r1)
   04014 Ras signaling pathway
    25513 (Pik3r1)
   04015 Rap1 signaling pathway
    25513 (Pik3r1)
   04370 VEGF signaling pathway
    25513 (Pik3r1)
   04630 JAK-STAT signaling pathway
    25513 (Pik3r1)
   04668 TNF signaling pathway
    25513 (Pik3r1)
   04066 HIF-1 signaling pathway
    25513 (Pik3r1)
   04068 FoxO signaling pathway
    25513 (Pik3r1)
   04070 Phosphatidylinositol signaling system
    25513 (Pik3r1)
   04072 Phospholipase D signaling pathway
    25513 (Pik3r1)
   04071 Sphingolipid signaling pathway
    25513 (Pik3r1)
   04024 cAMP signaling pathway
    25513 (Pik3r1)
   04151 PI3K-Akt signaling pathway
    25513 (Pik3r1)
   04152 AMPK signaling pathway
    25513 (Pik3r1)
   04150 mTOR signaling pathway
    25513 (Pik3r1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    25513 (Pik3r1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    25513 (Pik3r1)
  09143 Cell growth and death
   04210 Apoptosis
    25513 (Pik3r1)
   04218 Cellular senescence
    25513 (Pik3r1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    25513 (Pik3r1)
   04550 Signaling pathways regulating pluripotency of stem cells
    25513 (Pik3r1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    25513 (Pik3r1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    25513 (Pik3r1)
   04613 Neutrophil extracellular trap formation
    25513 (Pik3r1)
   04620 Toll-like receptor signaling pathway
    25513 (Pik3r1)
   04625 C-type lectin receptor signaling pathway
    25513 (Pik3r1)
   04650 Natural killer cell mediated cytotoxicity
    25513 (Pik3r1)
   04660 T cell receptor signaling pathway
    25513 (Pik3r1)
   04662 B cell receptor signaling pathway
    25513 (Pik3r1)
   04664 Fc epsilon RI signaling pathway
    25513 (Pik3r1)
   04666 Fc gamma R-mediated phagocytosis
    25513 (Pik3r1)
   04670 Leukocyte transendothelial migration
    25513 (Pik3r1)
   04062 Chemokine signaling pathway
    25513 (Pik3r1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    25513 (Pik3r1)
   04923 Regulation of lipolysis in adipocytes
    25513 (Pik3r1)
   04929 GnRH secretion
    25513 (Pik3r1)
   04915 Estrogen signaling pathway
    25513 (Pik3r1)
   04914 Progesterone-mediated oocyte maturation
    25513 (Pik3r1)
   04917 Prolactin signaling pathway
    25513 (Pik3r1)
   04926 Relaxin signaling pathway
    25513 (Pik3r1)
   04935 Growth hormone synthesis, secretion and action
    25513 (Pik3r1)
   04919 Thyroid hormone signaling pathway
    25513 (Pik3r1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    25513 (Pik3r1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    25513 (Pik3r1)
  09156 Nervous system
   04725 Cholinergic synapse
    25513 (Pik3r1)
   04722 Neurotrophin signaling pathway
    25513 (Pik3r1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25513 (Pik3r1)
  09158 Development and regeneration
   04360 Axon guidance
    25513 (Pik3r1)
   04380 Osteoclast differentiation
    25513 (Pik3r1)
  09149 Aging
   04211 Longevity regulating pathway
    25513 (Pik3r1)
   04213 Longevity regulating pathway - multiple species
    25513 (Pik3r1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25513 (Pik3r1)
   05206 MicroRNAs in cancer
    25513 (Pik3r1)
   05205 Proteoglycans in cancer
    25513 (Pik3r1)
   05207 Chemical carcinogenesis - receptor activation
    25513 (Pik3r1)
   05208 Chemical carcinogenesis - reactive oxygen species
    25513 (Pik3r1)
   05203 Viral carcinogenesis
    25513 (Pik3r1)
   05230 Central carbon metabolism in cancer
    25513 (Pik3r1)
   05231 Choline metabolism in cancer
    25513 (Pik3r1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    25513 (Pik3r1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    25513 (Pik3r1)
   05212 Pancreatic cancer
    25513 (Pik3r1)
   05225 Hepatocellular carcinoma
    25513 (Pik3r1)
   05226 Gastric cancer
    25513 (Pik3r1)
   05214 Glioma
    25513 (Pik3r1)
   05221 Acute myeloid leukemia
    25513 (Pik3r1)
   05220 Chronic myeloid leukemia
    25513 (Pik3r1)
   05218 Melanoma
    25513 (Pik3r1)
   05211 Renal cell carcinoma
    25513 (Pik3r1)
   05215 Prostate cancer
    25513 (Pik3r1)
   05213 Endometrial cancer
    25513 (Pik3r1)
   05224 Breast cancer
    25513 (Pik3r1)
   05222 Small cell lung cancer
    25513 (Pik3r1)
   05223 Non-small cell lung cancer
    25513 (Pik3r1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    25513 (Pik3r1)
   05170 Human immunodeficiency virus 1 infection
    25513 (Pik3r1)
   05161 Hepatitis B
    25513 (Pik3r1)
   05160 Hepatitis C
    25513 (Pik3r1)
   05171 Coronavirus disease - COVID-19
    25513 (Pik3r1)
   05164 Influenza A
    25513 (Pik3r1)
   05162 Measles
    25513 (Pik3r1)
   05168 Herpes simplex virus 1 infection
    25513 (Pik3r1)
   05163 Human cytomegalovirus infection
    25513 (Pik3r1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    25513 (Pik3r1)
   05169 Epstein-Barr virus infection
    25513 (Pik3r1)
   05165 Human papillomavirus infection
    25513 (Pik3r1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    25513 (Pik3r1)
   05100 Bacterial invasion of epithelial cells
    25513 (Pik3r1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    25513 (Pik3r1)
   05142 Chagas disease
    25513 (Pik3r1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    25513 (Pik3r1)
   05017 Spinocerebellar ataxia
    25513 (Pik3r1)
   05020 Prion disease
    25513 (Pik3r1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    25513 (Pik3r1)
   05418 Fluid shear stress and atherosclerosis
    25513 (Pik3r1)
   05415 Diabetic cardiomyopathy
    25513 (Pik3r1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    25513 (Pik3r1)
   04932 Non-alcoholic fatty liver disease
    25513 (Pik3r1)
   04931 Insulin resistance
    25513 (Pik3r1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    25513 (Pik3r1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    25513 (Pik3r1)
   01524 Platinum drug resistance
    25513 (Pik3r1)
   01522 Endocrine resistance
    25513 (Pik3r1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    25513 (Pik3r1)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    25513 (Pik3r1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 Bap31_Bap29_C
Other DBs
NCBI-GeneID: 25513
NCBI-ProteinID: NP_037137
RGD: 3329
Ensembl: ENSRNOG00000018903
UniProt: Q63787 A6I5C4 F1LNG5
Structure
LinkDB
Position
2:complement(34612946..34697660)
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAE
QFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLDVFDVH
VLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISTEWSE
RQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagcgcagaggggtaccagtacagagcgctgtatgactacaaaaaggaacgagaggaa
gacatcgacctacacttgggggacatcctgactgtgaataaaggctccttagtggcactt
ggattcagtgatggccaggaagcccggccagaagatattggctggttaaatggttacaat
gaaactactggggagaggggagactttccaggaacttatgttgagtacattggaaggaaa
agaatttcaccccccactcctaagccacggccccctcgacctcttcctgtagcacccggt
tcttcaaaaactgaagcagacactgagcaaccagtgttgacccttcctgatctggccgag
cagtttgcccctcctgatgttgccccgcctctccttataaagctcctggaagccattgag
aagaaaggactggaatgttcaactctatacagaacacagagctccagcaaccctgcagag
ttacgacagcttcttgattgtgatgccgcctcagtggacttggatgtgttcgatgtacac
gttttagcagatgctttcaaacgctatctcgccgacttaccaaatcctgtcattccagta
gctgtttacaatgagatgatgtctttagcccaagaagtaccaagctccgaagactacatc
cagctgttgaagaagctcattaggtcgcctaatatacctcatcagtattggcttacgctc
cagtatttgctcaagcacttcttcaagctctctcaagcctccagcaagaaccttctgaat
gcaagagccctctctgaaattttcagccacgtgcttttcagattcccagcagccagctct
gataatactgaacacctcataaaagcggtagagcttttaatctcaacggagtggagtgag
cgacagccagcaccagcactgccccctaaaccacccaagcccacttctatagccaacaac
agcatgaacaacaatatgtccttacaggatgctgaatggtactggggagatatctcaagg
gaagaagtaaatgaaaaactccgagacactgctgatgggacctttctggtacgagatgca
tccactaaaatgcacggcgactacactctcacactaaggaaaggaggaaataacaaatta
atcaaaatctttcaccgagatgggaaatacggcttctctgatccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgagtccttagctcagtacaatcccaagctg
gatgtgaagttactctacccagtgtctaaataccagcaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataatactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggaatacactcgtacttcccaggaaatacagatgaaa
agaacagctatcgaagcatttaatgaaaccataaaaatattcgaagagcagtgccaaacc
caggagcggtacagcaaagaatacatagagaagtttaaacgcgaaggcaacgagaaggaa
attcaaaggataatgcataatcacgataagctgaagtctcggatcagcgagatcatcgac
agcaggaggagactggaggaagacttgaagaagcaggcagccgagtatcgcgagatcgac
aagcgcatgaatagcattaagccggacctcattcagctgagaaagacaagagatcaatac
ttgatgtggctgacgcagaaaggggtccggcagaagaagctgaacgaatggttgggaaac
gaaaacacagaagaccaatactcactggtagaagatgacgaggatttgccccaccatgat
gagaagacgtggaatgtggggagcagcaaccgaaacaaagccgagaacctattgcgaggg
aaacgagatggcactttcctggtccgggagagcagtaagcagggctgctatgcctgctct
gtagtggtagatggcgaagtcaaacattgcgtcatcaacaagactgccaccggctatggc
ttcgccgagccctacaacctgtacagctccctgaaagagctggtgctacattaccaacac
acctccctggtgcagcacaatgactccctcaatgtcacactagcatacccagtatatgca
caacagaggcgatga

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