Rattus norvegicus (rat): 29241 Help Entry 29241             CDS       T01003                                  Symbol Adcy8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00230   Purine metabolism rno01100   Metabolic pathways rno01522   Endocrine resistance rno04015   Rap1 signaling pathway rno04020   Calcium signaling pathway rno04022   cGMP-PKG signaling pathway rno04024   cAMP signaling pathway rno04062   Chemokine signaling pathway rno04072   Phospholipase D signaling pathway rno04081   Hormone signaling rno04082   Neuroactive ligand signaling rno04114   Oocyte meiosis rno04211   Longevity regulating pathway rno04213   Longevity regulating pathway - multiple species rno04261   Adrenergic signaling in cardiomyocytes rno04270   Vascular smooth muscle contraction rno04371   Apelin signaling pathway rno04540   Gap junction rno04611   Platelet activation rno04713   Circadian entrainment rno04714   Thermogenesis rno04720   Long-term potentiation rno04723   Retrograde endocannabinoid signaling rno04724   Glutamatergic synapse rno04725   Cholinergic synapse rno04727   GABAergic synapse rno04742   Taste transduction rno04750   Inflammatory mediator regulation of TRP channels rno04911   Insulin secretion rno04912   GnRH signaling pathway rno04913   Ovarian steroidogenesis rno04914   Progesterone-mediated oocyte maturation rno04915   Estrogen signaling pathway rno04916   Melanogenesis rno04918   Thyroid hormone synthesis rno04921   Oxytocin signaling pathway rno04923   Regulation of lipolysis in adipocytes rno04925   Aldosterone synthesis and secretion rno04926   Relaxin signaling pathway rno04927   Cortisol synthesis and secretion rno04928   Parathyroid hormone synthesis, secretion and action rno04934   Cushing syndrome rno04935   Growth hormone synthesis, secretion and action rno04970   Salivary secretion rno04971   Gastric acid secretion rno04972   Pancreatic secretion rno04976   Bile secretion rno05032   Morphine addiction rno05163   Human cytomegalovirus infection rno05166   Human T-cell leukemia virus 1 infection rno05200   Pathways in cancer rno05207   Chemical carcinogenesis - receptor activation rno05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     29241 (Adcy8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     29241 (Adcy8)    04371 Apelin signaling pathway     29241 (Adcy8)    04020 Calcium signaling pathway     29241 (Adcy8)    04072 Phospholipase D signaling pathway     29241 (Adcy8)    04024 cAMP signaling pathway     29241 (Adcy8)    04022 cGMP-PKG signaling pathway     29241 (Adcy8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     29241 (Adcy8)    04081 Hormone signaling     29241 (Adcy8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     29241 (Adcy8)   09144 Cellular community - eukaryotes    04540 Gap junction     29241 (Adcy8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     29241 (Adcy8)    04062 Chemokine signaling pathway     29241 (Adcy8)   09152 Endocrine system    04911 Insulin secretion     29241 (Adcy8)    04923 Regulation of lipolysis in adipocytes     29241 (Adcy8)    04912 GnRH signaling pathway     29241 (Adcy8)    04913 Ovarian steroidogenesis     29241 (Adcy8)    04915 Estrogen signaling pathway     29241 (Adcy8)    04914 Progesterone-mediated oocyte maturation     29241 (Adcy8)    04921 Oxytocin signaling pathway     29241 (Adcy8)    04926 Relaxin signaling pathway     29241 (Adcy8)    04935 Growth hormone synthesis, secretion and action     29241 (Adcy8)    04918 Thyroid hormone synthesis     29241 (Adcy8)    04928 Parathyroid hormone synthesis, secretion and action     29241 (Adcy8)    04916 Melanogenesis     29241 (Adcy8)    04925 Aldosterone synthesis and secretion     29241 (Adcy8)    04927 Cortisol synthesis and secretion     29241 (Adcy8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     29241 (Adcy8)    04270 Vascular smooth muscle contraction     29241 (Adcy8)   09154 Digestive system    04970 Salivary secretion     29241 (Adcy8)    04971 Gastric acid secretion     29241 (Adcy8)    04972 Pancreatic secretion     29241 (Adcy8)    04976 Bile secretion     29241 (Adcy8)   09156 Nervous system    04724 Glutamatergic synapse     29241 (Adcy8)    04727 GABAergic synapse     29241 (Adcy8)    04725 Cholinergic synapse     29241 (Adcy8)    04720 Long-term potentiation     29241 (Adcy8)    04723 Retrograde endocannabinoid signaling     29241 (Adcy8)   09157 Sensory system    04742 Taste transduction     29241 (Adcy8)    04750 Inflammatory mediator regulation of TRP channels     29241 (Adcy8)   09149 Aging    04211 Longevity regulating pathway     29241 (Adcy8)    04213 Longevity regulating pathway - multiple species     29241 (Adcy8)   09159 Environmental adaptation    04713 Circadian entrainment     29241 (Adcy8)    04714 Thermogenesis     29241 (Adcy8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     29241 (Adcy8)    05207 Chemical carcinogenesis - receptor activation     29241 (Adcy8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     29241 (Adcy8)    05163 Human cytomegalovirus infection     29241 (Adcy8)   09165 Substance dependence    05032 Morphine addiction     29241 (Adcy8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     29241 (Adcy8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     29241 (Adcy8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     29241 (Adcy8) Enzymes [BR:rno01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      29241 (Adcy8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  29241 NCBI-ProteinID:  NP_058838 RGD:  2036 Ensembl:  ENSRNOG00000004890 UniProt:  P40146 LinkDB All DBs Position 7:complement(98306434..98555687) Genome browser AA seq 1248 aa AA seqDB search MELSDVHCLSGSEELYTIHPTPPAADGGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGG GSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGSGERAHNTGGTKVFPERSGSGSASGSGG GGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEV VMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQ YSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQ VTLQVLIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRL ETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGF TNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCV EMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESG GIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVK ESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSG PEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVL LFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYL ARNVIIFASILINFLGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLA MVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLL LMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHF LEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLG EDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFN NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQ GFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSL NRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEGTDKSDLP NT seq 3747 nt NT seq  +upstreamnt  +downstreamnt atggaactctcggatgtgcactgccttagcggcagcgaggaactctataccattcacccg acgcccccggccgcggacggcgggagcggctctcggccgcagcggctgctgtggcagacg gcggtgcggcacatcaccgagcagcgcttcatccacggccaccgaggcggcggcggcggg ggctcccgcaaagcctcgaaccctgcgggcagcggaccaaaccaccacgcgccgcagctg tctagcgactcggtgctgcctctctattctctgggctccggagagcgagcgcacaacacc ggtggcaccaaagtctttccggaacgcagcgggagcggcagtgccagtggcagcgggggt gggggcgacttgggcttcctgcaccttgactgtgccccaagtaactcggatttcttcctc aatgggggatacagctaccgtggggtcattttcccaaccctacgcaactccttcaagtct cgggatctggagcgcctctatcaacgctatttcctgggccagaggcgcaaatcggaggta gtgatgaacgtgctggatgtactaaccaaactcacccttctagtccttcacttgagccta gcctcggctcccatggaccctctcaagggcatcctgctaggctttttcactggcatcgag gtggtgatctgcgccctcgtggtggtcaggaaggacaccacctcccacacttacctgcaa tacagcggcgtggtcacttgggtggctatgaccacccagattctggcagcaggcctgggc tatgggcttctgggcgacggcataggctacgtgctttttacactcttcgccacctacagc atgcttccgctgcctctcacctgggccatcttggccggcctgggcacatccttgctgcaa gtcacacttcaagtgctcatacccagactagcggtcttttccatcaaccaggtcctggcc caggtggtgctcttcatgtgcatgaatacagcaggcatcttcatcagttacctttcagac cgcgcccagcggcaggccttcctggagacccggaggtgtgtggaggccaggctccgcctg gagacagagaaccaaagacaggagcggcttgtgctctctgtgctccccaggtttgtcgtc ctagaaatgatcaatgacatgaccaatgtggaggacgagcacctgcagcatcagttccac cgcatctacatccatcgctacgagaacgtcagtattctttttgcagatgtcaaaggattt accaacctctctacgaccttgtctgctcaggagcttgtcaggatgctcaacgagctcttt gccagatttgatcggctggcccatgagcatcactgtcttcgcattaaaatcctgggggac tgctactactgtgtgtcaggactgcctgagccccgccaggaccatgctcattgctgtgtt gaaatgggcctcagcatgatcaaaactatcaggtttgtgaggtccagaacgaagcatgat gttgacatgcgaattggaatccattcaggctctgtgctgtgtggtgtgttgggcctgaga aaatggcagtttgatgtctggtcttgggatgtggacatcgcaaacaaacttgaatctgga ggaatccctgggagaattcacatttccaaagccacactggattgcctcagtggtgactat aatgtggaagagggccacggtaaggagaggaatgaattcttgaggaagcataatatagag acctatttgattaagcagcccgaggagagtttgctatccttgcctgaagatatagttaag gagtcggtgagctgctcggacaggagaaacagtggggcaacgttcacagaaggatcctgg agcccagaactgccattcgacaacatcgtgggcaaacagaatactctggctgccctaaca agaaattcaataaatctgcttccaaaccatctcgcacaagctttgcatgtccagtctggg cctgaggaaattaacaagagaatagagcataccatcgacttgcggagtggcgataagttg agaagagagcatatcaagccattctcactgatgtttaaagactccagcctggagcacaag tattctcaaatgcgggatgaagtattcaagtcaaacttggtctgtgcatttatcgttctt ctgtttatcactgcgattcaaagtttgcttccttcttcgaggctgatgcctatgaccatc cagttctccatcctgatcatgctgcactccgccctggtcctcatcaccacggcagaagac tataagtgtctgcctctcattctccgcaaaacctgttgttggattaacgagacctatttg gcccgcaacgtcatcatctttgcttccatcttgattaatttcctgggagccgtcataaat attctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaattcctca gctgtgtttacagatatctgctcctacccagagtactttgtcttcactggggtgttggcc atggtgacgtgtgcagtatttctccggcttaactctgtcctgaagctggctgtgctgctc attatgatcgccatctacgccctgctgacagagaccatctatgcaggtctctttctgagt tatgacaacctgaaccacagtggagaagattttctggggaccaaggaggcatcactgcta ctgatggccatgttccttcttgctgtattctaccatggacagcagctggagtacacagcc cgcctagatttcctgtggcgagtacaggccaaagaggagatcaacgagatgaaggacttg agggaacacaatgagaacatgcttcgcaatatcttacccggccacgtggcccgccacttc ctggagaaagacagagacaatgaggagctgtattctcaatcctatgatgccgttggggta atgtttgcctccattcctggatttgcagacttttactctcagacagaaatgaacaaccag ggagtggaatgtctgcgcttgctgaatgagatcattgctgactttgatgagttacttgga gaggaccgctttcaggacatagagaagattaagaccattggtagtacatacatggctgtc tcaggactgtcaccagagaaacagcaatgtgaagataaatggggacatttgtgtgccctg gctgacttctctcttgccctgactgaaagcatacaagagatcaacaagcattcgttcaac aattttgaactccgtattggcatcagccatggctcagtggtagcaggtgtaattggcgct aagaaaccacagtatgacatttggggtaaaactgtgaacttggcaagccgaatggacagc acaggagtgagtggccggatccaagttcctgaggagacctatctcatcctgaaggatcag ggctttgccttcgactaccggggagagatatatgtgaagggcatcagcgaacaagaaggg aaaatcaaaacatattttctcctgggacgagtccaacccaacccattcatcttaccccca agaagacttcctgggcagtactctctggctgcagttgtccttgggcttgtccagtctctc aacaggcaaaggcagaagcaactactcaatgagaacagcaactctggcatcatcaagagc cattacaaccggcggactttgctaacgccaagtgggccagagcctggagcacaggctgaa ggcactgacaaatccgatttgccataa

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