Rattus norvegicus (rat): 29376 Help Entry 29376             CDS       T01003                                  Symbol Irs2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism rno  Rattus norvegicus (rat) Pathway rno04022   cGMP-PKG signaling pathway rno04068   FoxO signaling pathway rno04081   Hormone signaling rno04140   Autophagy - animal rno04152   AMPK signaling pathway rno04211   Longevity regulating pathway rno04213   Longevity regulating pathway - multiple species rno04910   Insulin signaling pathway rno04920   Adipocytokine signaling pathway rno04923   Regulation of lipolysis in adipocytes rno04930   Type II diabetes mellitus rno04931   Insulin resistance rno04932   Non-alcoholic fatty liver disease rno04935   Growth hormone synthesis, secretion and action rno05010   Alzheimer disease rno05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     29376 (Irs2)    04022 cGMP-PKG signaling pathway     29376 (Irs2)    04152 AMPK signaling pathway     29376 (Irs2)   09133 Signaling molecules and interaction    04081 Hormone signaling     29376 (Irs2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     29376 (Irs2)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     29376 (Irs2)    04935 Growth hormone synthesis, secretion and action     29376 (Irs2)   09149 Aging    04211 Longevity regulating pathway     29376 (Irs2)    04213 Longevity regulating pathway - multiple species     29376 (Irs2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     29376 (Irs2)   09164 Neurodegenerative disease    05010 Alzheimer disease     29376 (Irs2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     29376 (Irs2)    04932 Non-alcoholic fatty liver disease     29376 (Irs2)    04931 Insulin resistance     29376 (Irs2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Mcp5_PH Motif Other DBs NCBI-GeneID:  29376 NCBI-ProteinID:  NP_001162104 RGD:  69316 Ensembl:  ENSRNOG00000023509 UniProt:  A6IWQ8 F1MAL5 LinkDB All DBs Position 16:85190310..85214543 Genome browser AA seq 1327 aa AA seqDB search MASAPLPGPPASAGGDGPNLNNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGEE AAAAGGSPPQPPRLEYYESEKKWKSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKD EYFAVAAENEQEQEGWYRALTDLVSEGRSGDGGSGTTGGSCSASLPGALGGSAGAAGCDD NYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQL MNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRP RSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVR TASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVALAPAG GALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQCQRPS SGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYM SMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRA TFSGSSGRLCPSLPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALR SGGPNSCKSDDYMPMSPTSVSAPKQILQPRSAAALPPSGAAVPAPPSGAGRTFPVNGGGY KASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFFSAA LRPGGEALKGVPGHCYSSLPRSYKAPCTCGGGDNDQYVLMSSPVGRILEEERLEPQATPG AGTFGAAGGSHTQPHHSAVPSSMRPSGIVGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQ EYPLPTEPKSPGEYINIDFGEGGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGT SSDSRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSIDGLLSPEASSPYPPLPPRPSASP SSLQQPLPPAPGDLYRLPPATAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIA APPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHS SETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGNSILGGSDEPSTSPGQAQPS AGVPPAPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQS QPQHPQPGDKNSWGRTRSLGGLLGTVGGSGTSGVCGGPGTGALPSASTYASIDFLSHHLK EATVVKE NT seq 3984 nt NT seq  +upstreamnt  +downstreamnt atggctagcgcgcccctgcctgggccccccgcgtcggcgggcggggacggcccgaacctc aataacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaag cagaagcacggccacaagcgcttcttcgtgctgcgcggcccgggcaccggcggcgaggag gcagccgcggctggggggtcgccgccgcagcctccgcggctggagtactatgagagcgag aagaagtggaagagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgtctg aacatcaacaagcgcgcggacgccaagcacaagtacctgatcgccctctacaccaaggac gagtacttcgccgtagcggcggagaacgagcaggagcaggagggctggtaccgcgcactc accgacttggtcagcgaaggccgctctggcgatgggggctccggcaccacgggcggctct tgcagcgcctctctcccgggggccctgggcggctcggcgggcgccgctggctgcgatgac aactacgggctcgtgacgcccgccacggcagtctaccgcgaggtgtggcaggtgaacctg aagcctaagggactgggccagagcaagaacctgaccggtgtataccgcctatgcctgtct gcgcgcaccatcggcttcgtgaagctcaattgcgaacagccgtcggtgacgctgcagctt atgaacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgttca gccgtcaccggtcccggcgagctgtggatgcaagccgatgactcggtggtggcgcagaac atccatgagaccatcctggaggccatgaaggcactcaaggagctcttcgagttccggcct cgcagcaagagtcagtcgtctgggtcgtctgccacgcaccccatcagcgtaccgggcgcg cgccgccaccaccacctagtcaacctaccccctagccagacgggcctggtgcgccgctct cgcactgatagcctggcggccaccccgccagcagccaagtgcacttcgtgccgggttcgt acagccagcgagggtgacggcggcgcggcaggcggagccgggacggcaggaggcaggccg atgtcggtggcagggagccccctgagtcccgggccggtgcgcgcgccccttagccgctcg cacaccctgagcgccggctgcggaggccgcccgagcaaagtggctctggcgccggcaggg ggagccctacaacacagccgctccatgtccatgcccgtggcgcactcgccgcctgcagcc accagcccaggcagcctgtcctccagcagtgggcatggctcaggctcctacccgctgcct cctggttcccacccgcacctgcctcatccgctccatcacccccaatgccaacgtccgtcc agcggaagtgcctccgcctcgggctcccccagcgacccgggtttcatgtcccttgacgag tatggctccagccctggtgacctgagagccttcagtagccacaggagcaacacacctgag tccatcgcggagaccccgccagccagggacggcagtgggggcgagctctatgggtatatg agcatggataggcccctgagccactgtggccgcccttaccgtagggtctctggggatggg gcccaggatctggacagaggactgaggaagaggacttactccctaaccacgcctgcccgg cagcggcaggttcctcagccttcctctgcctctctagacgaatacactctcatgcgggcc accttctctggcagttcaggtcgcctctgcccatccctccctgcgtcctctcccaaagtg gcctacaacccttacccagaggactatggagacattgagattggttctcacaagagttcc agcagtaacctgggggcagatgatggctacatgcccatgacccctggggcagccctcagg agtggtggccccaatagctgcaagagcgatgactacatgcccatgagccccaccagcgtg tctgcccctaagcagatcctgcaaccacgttcggcagcggccttgcccccctctggagca gccgtgccagcacccccttcaggggcgggcaggactttcccagtgaacggaggcggctac aaagccagctccccagcggagagctccccagaagatagcgggtacatgcgaatgtggtgt ggctccaagctgtccatggagaacccagaccctaagctgctccccaatggggactacctc aacatgtcccccagtgaggcaggcaccgcagggaccccacctgacttcttctcagcagct ttgcgtccaggcggtgaggccctcaaaggcgtccctggccactgctacagctctttgccc cgctcttacaaggctccctgtacttgcggtggtggagacaacgaccagtacgtgctcatg agctcccctgtgggtcggattttggaagaggagagactggagccccaggccaccccaggg gctggcacatttggggcagctggtggtagtcatacccagcctcatcactcagcagtgcct tcctccatgagaccaagtggcatcgttggccgacctgagggcttcctgggccagcgctgt cgggcagtgcggcccacacgcctttcgctagagggactgcagacccttcccagcatgcaa gagtaccctctacccactgagcccaagagccctggcgagtacatcaacattgactttggt gaagggggtacccgtctgtctccgcctgctcccccactactggcatcagcggcctcctcc tcttcactgctctcagccagtagtcctgcttcatccctgggttcaggtaccccaggcacc agcagtgacagccggcagcgctctccgctctctgactatatgaacctggacttcagttct cccaagtcccctaagcctagcacccgcagtggggacacagtgggctccatcgatggcctt ctctctccagaagcctcatccccatacccaccgctgcccccgcgtccttctgcttcccct tcctccttacagcagcctctgccacctgccccaggagacctataccgcctgcctccagca acagctgccacatcccagggtcccactgctggctcctcaatgtcctctgagcctggggat aatggtgactataccgagatggcctttggtgtggctgctaccccgccacaacctattgcg gcacccccgaagccagaaggtgcccgagtgaccagtcccacatcaggcttgaagcggcta agtctcatggatcaggtatctggggtagaggccttccttcaagtcagccagccccctgat ccccaccggggcgctaaggtcatccgtgcagacccgcaggggggacgtcgtcgccacagt tcagagaccttctcctctaccaccactgtcaccccagtgtccccatcctttgctcacaat tccaagcgccacaattcggcctctgtggaaaacgtctctctcaggaaaagcagtgaaggc aacagcatcctgggaggaagtgatgagccatccacatccccaggacaggcacagccctcg gcaggtgtgcccccagcgccacaggctaggccatggaaccccggtcagcctggagctttg attggctgtcctggaggcagcagttctcccatgcgcagagagacctccgtgggtttccag aacggcctcaactatatcgccatcgatgtgagaggtgagcaggggtccttggcgcagtct cagcctcagcatccacagccaggagacaagaactcctggggccggacccgtagccttggg gggctcctcggtaccgttggaggctctggcaccagtggagtgtgtgggggtccaggcact ggagccttaccctctgccagcacctacgcaagcatcgacttcttgtcccatcacttgaaa gaagccaccgtggtgaaagagtaa

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