KEGG   Rattus norvegicus (rat): 360348
Entry
360348            CDS       T01003                                 
Symbol
Hsd3b1
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno01100  Metabolic pathways
rno04913  Ovarian steroidogenesis
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04934  Cushing syndrome
Module
rno_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rno_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rno_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    360348 (Hsd3b1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    360348 (Hsd3b1)
   04925 Aldosterone synthesis and secretion
    360348 (Hsd3b1)
   04927 Cortisol synthesis and secretion
    360348 (Hsd3b1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    360348 (Hsd3b1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     360348 (Hsd3b1)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     360348 (Hsd3b1)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 NAD_binding_10 GDP_Man_Dehyd NmrA RmlD_sub_bind KR Ldh_1_N Sacchrp_dh_NADP DapB_N Semialdhyde_dh
Other DBs
NCBI-GeneID: 360348
NCBI-ProteinID: NP_001007720
RGD: 1308676
Ensembl: ENSRNOG00000070622
UniProt: P22071 A6K3E2
LinkDB
Position
2:complement(188858574..188864694)
AA seq 373 aa
MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLE
GDILDAQYLRRACQGISVVIHTAAVIDVSHVLPRQTILDVNLKGTQNILEACVEASVPAF
IYCSTVDVAGPNSYKKIILNGHEEEHHESTWSDAYPYSKRMAEKAVLAANGSILKNGGTL
HTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKFSIANPVYVGNVAWAHILAARGL
RDPKKSQNVQGQFYYISDDTPHQSYDDLNCTLSKEWGLRLDSSWSLPLPLLYWLAFLLET
VSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKAQRDLGYVPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctggatggagctgcctggtgacaggagcaggagggtttgtgggccagaggatcatc
cggatgttggtgcaggagaaagaactgcaggaggtcagggctctggacaaagtcttcaga
ccagaaaccaaggaggaattctctaagctgcagacaaaggccaaggtgacaatgttagaa
ggagatattctggatgcccagtacctgaggagagcgtgccagggcatctctgttgtcatc
cacaccgctgctgtcattgatgtctcacatgtcctacccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacatattggaggcctgcgtcgaagccagtgtgccagccttc
atctactgcagcacagttgacgttgcagggcccaactcctacaagaagatcatcctgaat
ggccatgaggaagagcatcatgaaagcacatggtcagatgcatacccatacagcaaaagg
atggccgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcacactg
catacttgtgccttaaggcccatgtacatttatggggagagaagtccattcctttctgtc
atgatacttgcggccctcaaaaataagggtattctgaatgttactggcaaattctccata
gccaatccagtgtatgtaggcaatgtggcctgggcacatattctggctgccaggggcctt
cgagaccccaagaagtcacaaaatgtccaaggacagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattgcaccctgagcaaggaatggggcctccgcctt
gattccagctggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgcgtccattttacaactataggccaccctttaactgccacttggtc
acactgtcaaatagcaagttcactttctcctacaagaaagctcagagagatctgggctat
gtgccacttgtcagctgggaggaagccaagcagaaaacctcggagtggatcgggacacta
gtggagcagcacagggagacactggacacaaagtctcagtga

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