Rattus norvegicus (rat): 64044 Help Entry 64044             CDS       T01003                                  Symbol Casp8 Name (RefSeq) caspase-8   KO K04398   caspase 8 [EC:3.4.22.61] Organism rno  Rattus norvegicus (rat) Pathway rno01524   Platinum drug resistance rno04115   p53 signaling pathway rno04210   Apoptosis rno04215   Apoptosis - multiple species rno04217   Necroptosis rno04620   Toll-like receptor signaling pathway rno04621   NOD-like receptor signaling pathway rno04622   RIG-I-like receptor signaling pathway rno04623   Cytosolic DNA-sensing pathway rno04625   C-type lectin receptor signaling pathway rno04657   IL-17 signaling pathway rno04668   TNF signaling pathway rno04932   Non-alcoholic fatty liver disease rno04936   Alcoholic liver disease rno05010   Alzheimer disease rno05016   Huntington disease rno05022   Pathways of neurodegeneration - multiple diseases rno05132   Salmonella infection rno05134   Legionellosis rno05142   Chagas disease rno05145   Toxoplasmosis rno05152   Tuberculosis rno05160   Hepatitis C rno05161   Hepatitis B rno05162   Measles rno05163   Human cytomegalovirus infection rno05164   Influenza A rno05165   Human papillomavirus infection rno05167   Kaposi sarcoma-associated herpesvirus infection rno05168   Herpes simplex virus 1 infection rno05169   Epstein-Barr virus infection rno05170   Human immunodeficiency virus 1 infection rno05200   Pathways in cancer rno05203   Viral carcinogenesis rno05416   Viral myocarditis rno05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     64044 (Casp8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     64044 (Casp8)    04215 Apoptosis - multiple species     64044 (Casp8)    04217 Necroptosis     64044 (Casp8)    04115 p53 signaling pathway     64044 (Casp8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     64044 (Casp8)    04621 NOD-like receptor signaling pathway     64044 (Casp8)    04622 RIG-I-like receptor signaling pathway     64044 (Casp8)    04623 Cytosolic DNA-sensing pathway     64044 (Casp8)    04625 C-type lectin receptor signaling pathway     64044 (Casp8)    04657 IL-17 signaling pathway     64044 (Casp8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     64044 (Casp8)    05203 Viral carcinogenesis     64044 (Casp8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     64044 (Casp8)    05161 Hepatitis B     64044 (Casp8)    05160 Hepatitis C     64044 (Casp8)    05164 Influenza A     64044 (Casp8)    05162 Measles     64044 (Casp8)    05168 Herpes simplex virus 1 infection     64044 (Casp8)    05163 Human cytomegalovirus infection     64044 (Casp8)    05167 Kaposi sarcoma-associated herpesvirus infection     64044 (Casp8)    05169 Epstein-Barr virus infection     64044 (Casp8)    05165 Human papillomavirus infection     64044 (Casp8)   09171 Infectious disease: bacterial    05132 Salmonella infection     64044 (Casp8)    05134 Legionellosis     64044 (Casp8)    05152 Tuberculosis     64044 (Casp8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     64044 (Casp8)    05142 Chagas disease     64044 (Casp8)   09164 Neurodegenerative disease    05010 Alzheimer disease     64044 (Casp8)    05016 Huntington disease     64044 (Casp8)    05022 Pathways of neurodegeneration - multiple diseases     64044 (Casp8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     64044 (Casp8)    05416 Viral myocarditis     64044 (Casp8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     64044 (Casp8)    04932 Non-alcoholic fatty liver disease     64044 (Casp8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     64044 (Casp8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:rno01002]     64044 (Casp8) Enzymes [BR:rno01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      64044 (Casp8) Peptidases and inhibitors [BR:rno01002]  Cysteine peptidases   Family C14: caspase family    64044 (Casp8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DED Peptidase_C14 PYRIN MukF_C Motif Other DBs NCBI-GeneID:  64044 NCBI-ProteinID:  NP_071613 RGD:  620945 Ensembl:  ENSRNOG00000012331 UniProt:  Q9JHX4 LinkDB All DBs Position 9:60263863..60312542 Genome browser AA seq 482 aa AA seqDB search MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLS FLKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYRVMLFKLSEDMDKEDLKSF KFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTLKSICFRVNRSLLGRIDDYER SSTERRMSTEGGEELPVSVLDEVTIKMQDMWDSPGEQESESLNSDNVYQMKSKPRGYCLI FNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFSDCTASQIHEVLVS YQSKDHKGKDCFICCILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQ ACQGNNFQKAVPVPDETGLEQEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSYRDPTR GTWYIQSLCQSLRERCPRGEDILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFFP PN NT seq 1449 nt NT seq  +upstreamnt  +downstreamnt atggatttccacagttgtctttacgatattgctgaacgtctgggcaacgaagaactggct gccctcaagttcctgtgcttggaccacatcccgcagaagaagcaggagtccatcaatgat gtcctggtgctatttcagaggctgcaggaagaggggatgttggaggaagacaatttgtcc ttcctgaaggagctgcttttccatatcagtcggcgggatctgctgagcagagtcctaaaa agcagcccagaggaaatggtgagggagctgcaggttctgggcaaagcccaggtttctgcc tacagggttatgctctttaagctctcagaagacatggacaaggaggatttgaaatctttt aagttccttttgatcactgagatccctaaatgtaaactgcaagacaactcgagcctgctt gatattttcgtagagatggagaagaggactatcctggcagaaaacaacttggttacccta aaatcaatctgtttccgggtcaacaggagcttgctgggaaggatcgacgattacgaacga tcaagcacagagagaagaatgagcactgaaggaggggaagagctgccagtttctgttttg gatgaggtgaccatcaaaatgcaggacatgtgggactcgccaggagagcaagagagtgag tcactaaattcagacaacgtttaccaaatgaagagcaaacctcgggggtactgtctgatc ttcaacaataataatttcagcaaagcacgggaggacatacccaaactcagcaacatgcgg gacagaaaaggaaccaactatgatgaagaggctctgagtaagacctttaaggagcttcat tttgagatcgtgtccttcagtgattgcacagcaagtcaaatccatgaggttctagtatcc tatcaaagcaaggaccacaagggcaaagactgcttcatctgctgcatcctatcacatggg gacaagggcatcgtctacggaacggatgggaaggaagcctctatctatgagctgacatct tacttcactggctcaaagtgcccttccctggctggaaaacccaaaatcttttttattcaa gcttgtcaaggaaataacttccagaaagcggtgcctgtgcctgatgagacaggcttagaa caggagcacgttttagaagaggattcatcatcttacaagaactatatcccagatgaggca gactttctgctggggatggctactgtgaaaaactgtgtttcctaccgagatcccacgcgt gggacctggtatatccagtcactttgccagagcctgagggaaagatgtcctcgaggtgag gatattctcagcatcctgactggcgtgaactatgatgtgagcaataaagacaacccgagg aacatgggaaagcagatgccacagcccatcttcacactacggaagaagctcttcttccct cctaactga

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