KEGG   Rattus norvegicus (rat): 682974
Entry
682974            CDS       T01003                                 
Symbol
Hsd3b3
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno01100  Metabolic pathways
rno04913  Ovarian steroidogenesis
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04934  Cushing syndrome
Module
rno_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rno_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rno_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    682974 (Hsd3b3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    682974 (Hsd3b3)
   04925 Aldosterone synthesis and secretion
    682974 (Hsd3b3)
   04927 Cortisol synthesis and secretion
    682974 (Hsd3b3)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    682974 (Hsd3b3)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     682974 (Hsd3b3)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     682974 (Hsd3b3)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Sacchrp_dh_NADP Ldh_1_N Semialdhyde_dh DapB_N
Other DBs
NCBI-GeneID: 682974
NCBI-ProteinID: NP_001036084
RGD: 1592771
Ensembl: ENSRNOG00000063905
UniProt: P22072 A6K3E1
LinkDB
Position
2:complement(188826756..188832734)
AA seq 373 aa
MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLE
GDILDAQYLRRACQGISVVIHTASVMDFSRVLPRQTILDVNLKGTQNLLEAGIHASVPAF
IYCSTVDVAGPNSYKKTILNGREEEHHESTWSNPYPYSKKMAEKAVLAANGSILKNGGTL
HTCALRPMYIYGERGQFLSRIIIMALKNKGVLNVTGKFSIVNPVYVGNVAWAHILAARGL
RDPKKSQNIQGQFYYISDDTPHQSYDDLNCTLSKEWGLRLDSSWSLPLPLLYWLAFLLET
VSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctggatggagctgcctggtgacaggagcaggagggtttgtgggccagaggatcatc
cggatgttggtgcaggagaaagaactgcaggaggtcagggctctggacaaagtcttcaga
ccagaaaccaaggaggaattctctaagctgcagacaaaggccaaggtgacaatgttagaa
ggagatattctggatgcccagtacctgaggagagcgtgccagggcatctctgttgtcatc
cacacggcttctgtcatggatttctcacgtgtcctacccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacctattggaggccggtatccacgctagtgtgccagccttc
atctactgcagcacagttgacgttgcagggcccaactcctacaagaagaccatcctgaat
ggccgtgaggaagagcatcatgaaagcacatggtcaaatccatacccatacagcaaaaag
atggccgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcacactg
catacttgtgccttaaggcccatgtacatttatggggagagaggtcaattcctttctaga
ataataattatggccctcaaaaataagggtgttctgaacgttactggcaaattctccata
gtcaatccagtgtatgtaggcaatgtggcctgggcacatattctggctgccaggggcctt
cgagaccccaagaagtcacaaaatatccaaggacagttctactatatctcagatgacacc
cctcaccaaagctatgatgatttaaattgcaccctgagcaaggaatggggcctccgcctt
gattccagctggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgcgtccattttacaactataggccaccctttaactgccacttggtc
acactgtcaaatagcaagttcactttctcctacaagaaagctcagagagatctgggctat
gagccacttgtcagctgggaggaagccaagcagaaaacctcggagtggatcgggacacta
gtggagcagcacagggagacactggacacaaagtctcagtga

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