KEGG   Rattus norvegicus (rat): 81522
Entry
81522             CDS       T01003                                 
Symbol
Mtr
Name
(RefSeq) methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00270  Cysteine and methionine metabolism
rno00450  Selenocompound metabolism
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01230  Biosynthesis of amino acids
rno01523  Antifolate resistance
rno04980  Cobalamin transport and metabolism
rno04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    81522 (Mtr)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    81522 (Mtr)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    81522 (Mtr)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    81522 (Mtr)
   04980 Cobalamin transport and metabolism
    81522 (Mtr)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    81522 (Mtr)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     81522 (Mtr)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding CdhD
Other DBs
NCBI-GeneID: 81522
NCBI-ProteinID: NP_110491
RGD: 621283
Ensembl: ENSRNOG00000017593
UniProt: Q9Z2Q4 G3V8A4 A6KN29
LinkDB
Position
17:62911705..62996544
AA seq 1253 aa
MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHSRPLKGNNDILSIT
QPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEIT
LQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLI
ETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSD
PLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPAMMAMHLKDFA
VDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVPPDSVFEGHMLLSGLEPFRIGPYTNFV
NIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDINMDDGMLDGPSAMTKFC
NFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEDFLEKARKIKKFG
AAVVVMAFDEEGQATETDVKVSVCTRAYHLLVEKVGFNPNDIIFDPNILTIGTGMEEHNL
YAINFIHATRVIKETLPGVRISGGLSNLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIV
NAGSLPVYDDIHKDLLQLCEDLIWNRDAEATEKLLRYAQTHGKGGKKVIQTDEWRNGSIE
ERLEYALVKGIEKHIVEDTEEARLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQ
VIKSARVMKKAVGHLIPFMEKEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIV
GVVLGCNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAI
KIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDDYFEEILEE
YEDIRQDHYESLKERKYLPLSQARKHSFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDY
IDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYEDAQNMLNILISRKKLRARGVV
GFWPAQSVQDDIHLYAEGAVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFVAPLHSG
VRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAY
CGSEQLGVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIEQATGIRLTESLAMAPA
SAVSGLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWLGPILGYDTD
NT seq 3762 nt   +upstreamnt  +downstreamnt
atgaagaaaaccctgcaggatgagattgaagccattcttcggaagaggattatggtgcta
gatggcgggatggggaccatgatccagcggtacaaactaagcgaagaaaatttccaaggt
caagagtttaaagaccacagcaggccactgaaaggcaacaatgacatcttgagtataact
cagcctgatgttatttaccagattcataaggaatacttgctggccggagcagacatcatt
gaaacaaacactttcagcagcactagtatcgcccaggctgactatggcctcgaacacttg
gcctaccggatgaacaaatgctccgcagacgtggccagaaaagccgccgaggagataact
ctgcagacaggagtcaagaggtttgtggctggatctctgggtccgactaacaagacactt
tcagtttccccatctgtggaaaggccagattacaggaacatcacatttgatgagcttgtt
gaagcataccaggagcaggccaagggactgctggatggtggggttgacatcttactcatt
gagacgatttttgatacagccaatgccaaagcagccttgtttgcgctccagaaactcttt
gaagagaattatgcttctcccaggcctatctttatttctgggaccattgttgataaaagt
ggacggactctttctggccagacaggagaggcttttgtcaccagcgtgtctcattcagac
cccctgtgcattggattaaattgtgctctgggtgcagctgaaatgaggcctttcattgaa
acaattggaaaatgtacaacagcttatgtcctctgttacccaaatgcaggtcttcccaat
acctttggtgattatgatgaaacaccagccatgatggccatgcacctgaaggactttgcc
gtggacggcttggtgaatgtagttggtggatgctgtggttcaacgcctgatcacatcagg
gaaattgcagaagctgtgaaaaattgtaagccaagagttccccctgatagtgtttttgaa
ggacatatgttactgtctggtctagagcccttcaggattggaccatacactaactttgtt
aacattggagagcgctgtaacgtggcaggatccaagaaatttgctaagctcatcatggca
ggaaactatgaggaagccctgagcgttgccaaagtgcaggtggaaatgggagctcaggtg
ctggatatcaacatggatgacggcatgctggatggtcccagtgcgatgaccaaattttgc
aacttcattgcttcggagcctgacattgccaaggtgcccctgtgcattgactcttccaat
tttgctgtgatcgaggcggggttgaagtgctgccaagggaagtgcatagtcaacagcatc
agcctgaaggagggggaggaggacttcctggagaaggccaggaagattaagaagtttgga
gctgctgtggtggttatggcttttgatgaggaaggacaggcaacagaaacagatgttaaa
gtcagtgtgtgcactagagcctaccatctacttgtggaaaaagtgggcttcaatccaaat
gatatcatctttgaccccaacatccttaccattggaactggaatggaagaacataacttg
tatgctatcaattttattcatgcaacgagagtcattaaggaaacattaccaggagtcaga
ataagtggaggtctctccaacctatccttcgccttccgagggatggacgccattcgagaa
gcaatgcacggtgttttcctttatcatgcaatcaagttcggtatggacatggggatagtc
aatgccggcagtctccccgtgtacgatgatatccataaggaccttcttcagctctgtgaa
gacctcatctggaacagagacgctgaggctactgagaaactcttacgatatgcccagact
catggcaaaggagggaagaaagtcatccagacagatgagtggaggaatggctcgattgaa
gagcgcctggagtatgctcttgtgaagggcattgaaaagcacattgttgaagacactgaa
gaagccaggttaaaccgggaaaaatacccccggcctctgaatataattgaagggcccctg
atgaatggcatgaaagtggttggtgatctttttggagctggaaaaatgtttctacctcag
gttataaagtcagcccgtgtcatgaagaaggctgttggccaccttatccctttcatggaa
aaagaaagagaagaagccagggtgcttaatggttcggttgaagaagaggacccttaccaa
ggcaccattgtgctggccactgttaaaggtgatgtgcatgacattggcaagaacattgtt
ggtgtggtgctgggctgtaataatttcagagttattgatttaggagtcatgactccctgt
gataagatacttcaagctgctctggaccacaaagcagatataattggcttgtcaggactc
atcacgccatccttggatgaaatgatttttgttgccaaggaaatggagaggttggctata
aagattccattgttgataggaggagcaaccacttcaagaacccacacagcagttaaaata
gcaccacggtacagtgcgcctgtaatccatgttctagatgcatccaagagtgtggtggtg
tgttctcagctgttagatgaaaatctgaaagatgactactttgaagaaatactggaagag
tatgaagatattagacaggaccactacgagtctctcaaagagagaaaatacttaccccta
agtcaagccagaaaacacagtttccacattgattggctgtctgaacctcacccagtgaag
cccacgtttattgggacccaggtctttgaagactacaacctgcaaaagctggtggactac
attgactggaagcctttctttgatgtctggcagctccgcggcaagtacccgaaccgagga
tttcccaagatattcaatgacaaagcagtaggtgaagaagccagaaaggtatatgaggat
gctcagaacatgctgaacatactgatcagtcgaaagaaactccgggccaggggtgtggtt
ggattctggccagcacagagcgtccaagatgacatccacctgtatgcagagggggcggtg
ccccaggccgccgagcccatagccaccttctatggactgaggcagcaggctgagaaggac
tcctccagtacagacccctaccactgcctctcagacttcgttgctcctctgcattctggt
gtccgtgactacttgggtctgtttgctgtggcctgctttggggttgaagagctgagtaag
gcctatgaggatgatggcgatgactacagcagcatcatggtgaaggccctgggggacagg
ctggcggaggcctttgcagaggagctccacgagagagtgcgcagagaactctgggcttac
tgtgggagtgagcagttgggtgtcacagacttgcgcaaactccgctatgagggcatccgg
ccagctcctggttaccccagccagcctgaccataccgagaagctcaccatgtggaggctg
gccaacatcgagcaggccacaggcatcaggttgacagaatccttggcaatggcacctgct
tcagcagtgtcgggtctctacttctccaatgtaaagtccaaatattttgctgtggggaaa
atttccaaagatcagattgaggattatgccttgaggaagaacatgtcagtggccgaggtg
gaaaaatggcttggccccattctgggatatgatacagactga

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