Rattus norvegicus (rat): 81636 Help Entry 81636             CDS       T01003                                  Symbol Adcy2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00230   Purine metabolism rno01100   Metabolic pathways rno01522   Endocrine resistance rno04015   Rap1 signaling pathway rno04020   Calcium signaling pathway rno04022   cGMP-PKG signaling pathway rno04024   cAMP signaling pathway rno04062   Chemokine signaling pathway rno04072   Phospholipase D signaling pathway rno04081   Hormone signaling rno04082   Neuroactive ligand signaling rno04114   Oocyte meiosis rno04211   Longevity regulating pathway rno04213   Longevity regulating pathway - multiple species rno04261   Adrenergic signaling in cardiomyocytes rno04270   Vascular smooth muscle contraction rno04371   Apelin signaling pathway rno04540   Gap junction rno04611   Platelet activation rno04713   Circadian entrainment rno04714   Thermogenesis rno04723   Retrograde endocannabinoid signaling rno04724   Glutamatergic synapse rno04725   Cholinergic synapse rno04727   GABAergic synapse rno04750   Inflammatory mediator regulation of TRP channels rno04911   Insulin secretion rno04912   GnRH signaling pathway rno04913   Ovarian steroidogenesis rno04914   Progesterone-mediated oocyte maturation rno04915   Estrogen signaling pathway rno04916   Melanogenesis rno04918   Thyroid hormone synthesis rno04921   Oxytocin signaling pathway rno04922   Glucagon signaling pathway rno04923   Regulation of lipolysis in adipocytes rno04925   Aldosterone synthesis and secretion rno04926   Relaxin signaling pathway rno04927   Cortisol synthesis and secretion rno04928   Parathyroid hormone synthesis, secretion and action rno04934   Cushing syndrome rno04935   Growth hormone synthesis, secretion and action rno04970   Salivary secretion rno04971   Gastric acid secretion rno04972   Pancreatic secretion rno04976   Bile secretion rno05032   Morphine addiction rno05163   Human cytomegalovirus infection rno05166   Human T-cell leukemia virus 1 infection rno05200   Pathways in cancer rno05207   Chemical carcinogenesis - receptor activation rno05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     81636 (Adcy2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     81636 (Adcy2)    04371 Apelin signaling pathway     81636 (Adcy2)    04020 Calcium signaling pathway     81636 (Adcy2)    04072 Phospholipase D signaling pathway     81636 (Adcy2)    04024 cAMP signaling pathway     81636 (Adcy2)    04022 cGMP-PKG signaling pathway     81636 (Adcy2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     81636 (Adcy2)    04081 Hormone signaling     81636 (Adcy2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     81636 (Adcy2)   09144 Cellular community - eukaryotes    04540 Gap junction     81636 (Adcy2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     81636 (Adcy2)    04062 Chemokine signaling pathway     81636 (Adcy2)   09152 Endocrine system    04911 Insulin secretion     81636 (Adcy2)    04922 Glucagon signaling pathway     81636 (Adcy2)    04923 Regulation of lipolysis in adipocytes     81636 (Adcy2)    04912 GnRH signaling pathway     81636 (Adcy2)    04913 Ovarian steroidogenesis     81636 (Adcy2)    04915 Estrogen signaling pathway     81636 (Adcy2)    04914 Progesterone-mediated oocyte maturation     81636 (Adcy2)    04921 Oxytocin signaling pathway     81636 (Adcy2)    04926 Relaxin signaling pathway     81636 (Adcy2)    04935 Growth hormone synthesis, secretion and action     81636 (Adcy2)    04918 Thyroid hormone synthesis     81636 (Adcy2)    04928 Parathyroid hormone synthesis, secretion and action     81636 (Adcy2)    04916 Melanogenesis     81636 (Adcy2)    04925 Aldosterone synthesis and secretion     81636 (Adcy2)    04927 Cortisol synthesis and secretion     81636 (Adcy2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     81636 (Adcy2)    04270 Vascular smooth muscle contraction     81636 (Adcy2)   09154 Digestive system    04970 Salivary secretion     81636 (Adcy2)    04971 Gastric acid secretion     81636 (Adcy2)    04972 Pancreatic secretion     81636 (Adcy2)    04976 Bile secretion     81636 (Adcy2)   09156 Nervous system    04724 Glutamatergic synapse     81636 (Adcy2)    04727 GABAergic synapse     81636 (Adcy2)    04725 Cholinergic synapse     81636 (Adcy2)    04723 Retrograde endocannabinoid signaling     81636 (Adcy2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     81636 (Adcy2)   09149 Aging    04211 Longevity regulating pathway     81636 (Adcy2)    04213 Longevity regulating pathway - multiple species     81636 (Adcy2)   09159 Environmental adaptation    04713 Circadian entrainment     81636 (Adcy2)    04714 Thermogenesis     81636 (Adcy2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     81636 (Adcy2)    05207 Chemical carcinogenesis - receptor activation     81636 (Adcy2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     81636 (Adcy2)    05163 Human cytomegalovirus infection     81636 (Adcy2)   09165 Substance dependence    05032 Morphine addiction     81636 (Adcy2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     81636 (Adcy2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     81636 (Adcy2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     81636 (Adcy2) Enzymes [BR:rno01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      81636 (Adcy2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  81636 NCBI-ProteinID:  NP_112269 RGD:  619965 Ensembl:  ENSRNOG00000032150 UniProt:  P26769 F1LV12 A6JV23 Structure PDBPDBj LinkDB All DBs Position 1:36204054..36650645 Genome browser AA seq 1095 aa AA seqDB search MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMG ACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWIC LVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVY LSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFE KRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADI VGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAK NCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHM EAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHL FRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQ NRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRATA LPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSK KASTSLMWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSN ANVSVPDNQASILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTI LLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKN KFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDF KEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPS QEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKP QYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFV NTEMSRSLSQSNLAS NT seq 3288 nt NT seq  +upstreamnt  +downstreamnt atgtggcaggaggcgatgcggcggcgccgctacctgcgggaccgcgccgaggcggcggcg gcagcggcggcgggaggcggagaggggctgcagcggtcccgggactggctctacgagtcc tactactgcatgagccagcagcacccgctcatcgtcttcctgctgctcatcgtcatgggc gcctgcctcgccctgctagccgtcttcttcgcgctcgggctggaggtggaagaccatgtg gcatttttaataacggttcccactgccctggccattttctttgccatattcattcttgtc tgcatagagtctgtgttcaagaagctactccgtgtgttttcgctggtgatttggatatgt ctggttgccatgggatacctgttcatgtgcttcggagggactgtgtctgcctgggaccag gtgtcattcttcctcttcatcatctttgtggtatataccatgcttcccttcaacatgcga gatgccatcattgccagcatcctcacatcttcatctcatacgatagtgctgagcgtctac ctgtctgcaacaccaggggccaaggagcacctgttctggcagatactggccaatgtgatc attttcatttgtgggaacttggcgggagcctaccacaagcacctcatggagcttgccttg cagcaaacctatcgggacacgtgtaattgcatcaagtcccggatcaagctggaatttgaa aaacggcagcaggaacggctcctgctctccttgctgccagctcacatcgccatggagatg aaagctgaaatcattcagaggctgcagggccccaaagcaggacagatggaaaacacaaac aacttccacaatctgtatgtcaaacgacacaccaacgtgagcatattatacgctgacatt gttggcttcacccgccttgcaagcgattgctcccctggcgaactggtccacatgctgaat gaactctttgggaagtttgatcaaatagcaaaggagaatgaatgcatgagaattaaaatt ttaggagactgctattactgtgtttccgggctccctatatcactccctaaccatgccaag aactgtgtgaaaatgggattggatatgtgcgaagccataaagaaagtgagggatgctacc ggagttgatatcaacatgcgtgtaggagtgcattctgggaacgttctctgtggtgtgatt ggtctccagaagtggcagtatgatgtgtggtctcatgatgttactctggcaaaccacatg gaagctggaggagtccctgggcgtgttcacatttcttcagtcactctggagcacttgaat ggggcttataaagtggaggaaggagatggtgagataagagacccatatttaaagcagcac ttggtgaaaacctactttgtaatcaatcccaagggagagcgacggagtcctcagcatctc ttcagacctcgacacactctggacggagccaagatgagagcatctgtccgcatgacccgg tacttggagtcctggggagcagccaagccattcgcacatctgcaccacagagatagcatg accacagagaatgggaagattagtaccacggatgtgccaatgggtcaacataattttcaa aatcgcaccttaagaactaagtcacagaagaagagatttgaagaagaactgaatgaaagg atgatccaagcaattgatgggatcaatgcacagaagcaatggctcaagtcagaagacatt caaagaatctccctgcttttctataacaagaatatagagaaagaataccgagctactgca ctgccagcattcaagtactacgtgacctgtgcctgcctcatctttctctgcatcttcatt gtacagatacttgtattgccaaaaacgtccatccttggcttctcctttggagctgcattt ctctccctcatcttcatcctctttgtctgcttcgctggacagcttttgcaatgcagcaaa aaggcctccacctctctcatgtggcttttgaaatcatcaggcatcatcgccaaccgccca tggccacggatctccctcacaatcgtcaccacggctatcatactaaccatggctgtgttc aacatgtttttcctgagcaactctgaggagacaacccttcccactgccaatacatcaaat gcaaacgtttctgtcccggataaccaggcgtcgattcttcatgctcgaaacttgtttttc ctcccgtacttcatatacagctgcatcctgggcttgatctcctgctccgttttcctgagg gtgaactatgagttaaaaatgttaatcatgatggtggcactcgtgggctacaacaccatt ctactccacacccatgcccatgttctggatgcgtacagccaggtcctgtttcagagacca ggcatttggaaagacctgaagaccatgggctccgtgtcactctccatattcttcatcacg ctgctggttctgggcagacagagtgaatattactgtaggttagacttcttgtggaagaac aagttcaaaaaagagcgggaggagatagaaaccatggagaacctaaatcgagtgctgctg gagaacgtgcttcctgcacacgtggctgaacacttcctggccaggagcctgaaaaatgag gagctgtaccaccagtcctacgactgtgtctgtgtcatgtttgcctccattccggacttc aaggagttctacacagagtcagatgtgaacaaggaaggcttggaatgcctgcggctcctg aatgagatcattgctgactttgatgatctgctttctaagccaaagttcagtggtgttgaa aagatcaagaccattgggagcacatacatggcagccacgggactgagtgccatacccagc caggagcacgcccaggaacctgagcgtcagtacatgcacataggcaccatggtggagttt gcatatgccctggtgggaaaactggatgccatcaataagcactccttcaacgacttcaaa ctgcgagtgggtatcaaccatgggcctgtaatagctggcgtcataggggctcaaaagcca cagtatgacatctggggcaacactgtcaacgtggccagcagaatggacagcaccggggtc ctggacaaaatacaggtgactgaggagacaagcctcatcttgcagacgcttggctacacg tgtacatgtcgaggtatcatcaatgtgaaggggaaaggggacctgaagacatattttgta aacacagagatgtcaaggtccctttctcagagcaacttggcatcctga

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