Rhinopithecus roxellana (golden snub-nosed monkey): 104654602
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Entry
104654602 CDS
T03989
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
rro
Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00140
Steroid hormone biosynthesis
rro01100
Metabolic pathways
rro04913
Ovarian steroidogenesis
rro04925
Aldosterone synthesis and secretion
rro04927
Cortisol synthesis and secretion
rro04934
Cushing syndrome
Module
rro_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rro_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rro_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rro_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
rro00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
104654602
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
104654602
04925 Aldosterone synthesis and secretion
104654602
04927 Cortisol synthesis and secretion
104654602
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
104654602
Enzymes [BR:
rro01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
104654602
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
104654602
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Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
Polysacc_synt_2
GDP_Man_Dehyd
NAD_binding_10
RmlD_sub_bind
NmrA
KR
Ldh_1_N
Sacchrp_dh_NADP
Motif
Other DBs
NCBI-GeneID:
104654602
NCBI-ProteinID:
XP_030792323
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All DBs
Position
8:complement(51202782..51220814)
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AA seq
295 aa
AA seq
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MMGWSCLVTGAGGFLGQRIICLLVEETELKEIRALDKAFRPRLREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVVIHTACIIDVFGVIHRESIMNVNVNGTQLLLEACVQDSVPVF
IYPSALEVAGPNSYKEIIENAHERDCLENTWSAPYPHSKKLAEKAVLAANGRTLKNGDTF
YTCALRPMYIYGEGSPFLTANINEALNNNGILSSVGKFSAVNPVYIGNVAWAHILALRAL
RDPKKALSVPGQFYYISDDTSHQRYDNLNYILSKEFGLRLDSRWNQGTGLVSCWK
NT seq
888 nt
NT seq
+upstream
nt +downstream
nt
atgatgggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcttgttggtggaggagacagagctgaaggagatcagggccttggacaaggccttcaga
ccaagactgagggaggaattttctaagctccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccatttctgaagagagcctgccaggacgtctcggtcgtcatc
cacaccgcctgtatcattgatgtcttcggtgtcattcacagagagtccatcatgaatgtc
aatgtgaacggtactcagctcctgttggaggcctgtgtccaagatagtgtgccagtcttc
atctaccccagtgccctagaggtagctgggcccaactcctacaaggaaatcatcgagaat
gcccatgaacgagactgtctggaaaacacatggtctgctccatatccacacagcaaaaag
ctcgctgagaaggctgtgctggcagctaatggaaggactctgaaaaatggtgataccttt
tacacttgtgccttaagacccatgtatatctatggagaaggaagcccatttcttactgcc
aatataaatgaggccctgaacaacaatgggatcctgtcaagtgttggcaaattctccgca
gtcaacccagtctatattggcaacgtggcctgggctcacattctggccttgagggccctg
cgggaccccaagaaggccctaagtgtcccagggcagttctactacatctcagatgacaca
tctcaccaaagatatgataaccttaattacatcctgagcaaagagttcggcctccgcctt
gattccagatggaatcaaggtactggattggtttcctgctggaaatag
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