Rhinopithecus roxellana (golden snub-nosed monkey): 104654605
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Entry
104654605 CDS
T03989
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
rro
Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00140
Steroid hormone biosynthesis
rro01100
Metabolic pathways
rro04913
Ovarian steroidogenesis
rro04925
Aldosterone synthesis and secretion
rro04927
Cortisol synthesis and secretion
rro04934
Cushing syndrome
Module
rro_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rro_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rro_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rro_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
rro00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
104654605
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
104654605
04925 Aldosterone synthesis and secretion
104654605
04927 Cortisol synthesis and secretion
104654605
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
104654605
Enzymes [BR:
rro01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
104654605
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
104654605
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Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
KR
RmlD_sub_bind
NmrA
Ldh_1_N
Sacchrp_dh_NADP
Semialdhyde_dh
Motif
Other DBs
NCBI-GeneID:
104654605
NCBI-ProteinID:
XP_010352116
UniProt:
A0A2K6RWX3
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All DBs
Position
8:complement(51142458..51150489)
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AA seq
373 aa
AA seq
DB search
MTGWSCLVTGAGGFLGQRIVRLLVEEKELKEIRVLDKAFRPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDISVVIHTACIIDVSGVIHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEPLENTWSAPYPYSKKLAEKAVLAADGWTLKNGGTL
YTCALRPMYIYGEGSQFLSAGINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
RDPKKAPSVRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSLPLSLMYWIGFLLEI
VSFLLRPIYTYQPPFNRHMVTLSNSVFTFSYKKAQRDLAYEPLYSWEEAKQKTVEWVGSL
VDRHKDTLKSKTQ
NT seq
1122 nt
NT seq
+upstream
nt +downstream
nt
atgacgggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcgtc
cgcctcttggtggaggagaaggagctgaaggagatcagagtcttggacaaggccttcaga
ccagaactgagggaggaattttccaagctccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacatctcagttgtcatc
cacactgcctgtatcattgatgtctccggtgtcattcacagagagtccatcatgaatgtc
aatgtgaaaggtacgcagctcctgttagaggcctgtgtccaagctagtgtgccagtcttc
atctataccagtagcatagaggtagccggacccaactcgtacaaggaaatcatccagaac
ggccacgaagaagagcctctggaaaacacatggtctgctccatacccatacagcaaaaag
cttgctgagaaggcagtgctggcagctgatggatggactctgaaaaacggtggtaccttg
tacacttgtgccttaagacccatgtatatctatggggaaggaagccaattcctttctgct
ggtataaatgaagccctgaacaacaatgggatcctgtcaagtgttggcaagttctccact
gtcaacccagtctatgttggcaacgtggcctgggctcacattctggccttgagggccctg
cgggaccccaagaaggccccaagtgtccgaggacagttctactatatctcagacgacacg
cctcaccaaagctatgataaccttaattacaccctgagcaaagagttcggcctccgcctt
gattccagatggagccttcctttatccctgatgtactggattggcttcctgctggaaata
gtgagcttccttctcaggccaatttacacctatcaaccaccctttaaccgccacatggtg
acattgtcaaatagcgtgttcaccttctcttacaagaaggctcagcgagatctggcgtat
gagccgctctacagctgggaggaagccaagcagaaaaccgtggagtgggttggttccctt
gtggaccggcacaaggacaccctgaagtccaagactcagtga
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