KEGG   Rhinopithecus roxellana (golden snub-nosed monkey): 104675620
Entry
104675620         CDS       T03989                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
rro  Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro01521  EGFR tyrosine kinase inhibitor resistance
rro01522  Endocrine resistance
rro01524  Platinum drug resistance
rro04012  ErbB signaling pathway
rro04014  Ras signaling pathway
rro04015  Rap1 signaling pathway
rro04024  cAMP signaling pathway
rro04062  Chemokine signaling pathway
rro04066  HIF-1 signaling pathway
rro04068  FoxO signaling pathway
rro04070  Phosphatidylinositol signaling system
rro04071  Sphingolipid signaling pathway
rro04072  Phospholipase D signaling pathway
rro04081  Hormone signaling
rro04140  Autophagy - animal
rro04150  mTOR signaling pathway
rro04151  PI3K-Akt signaling pathway
rro04152  AMPK signaling pathway
rro04210  Apoptosis
rro04211  Longevity regulating pathway
rro04213  Longevity regulating pathway - multiple species
rro04218  Cellular senescence
rro04360  Axon guidance
rro04370  VEGF signaling pathway
rro04380  Osteoclast differentiation
rro04510  Focal adhesion
rro04550  Signaling pathways regulating pluripotency of stem cells
rro04611  Platelet activation
rro04613  Neutrophil extracellular trap formation
rro04620  Toll-like receptor signaling pathway
rro04625  C-type lectin receptor signaling pathway
rro04630  JAK-STAT signaling pathway
rro04650  Natural killer cell mediated cytotoxicity
rro04660  T cell receptor signaling pathway
rro04662  B cell receptor signaling pathway
rro04664  Fc epsilon RI signaling pathway
rro04666  Fc gamma R-mediated phagocytosis
rro04668  TNF signaling pathway
rro04670  Leukocyte transendothelial migration
rro04722  Neurotrophin signaling pathway
rro04725  Cholinergic synapse
rro04750  Inflammatory mediator regulation of TRP channels
rro04810  Regulation of actin cytoskeleton
rro04910  Insulin signaling pathway
rro04914  Progesterone-mediated oocyte maturation
rro04915  Estrogen signaling pathway
rro04917  Prolactin signaling pathway
rro04919  Thyroid hormone signaling pathway
rro04923  Regulation of lipolysis in adipocytes
rro04926  Relaxin signaling pathway
rro04929  GnRH secretion
rro04930  Type II diabetes mellitus
rro04931  Insulin resistance
rro04932  Non-alcoholic fatty liver disease
rro04933  AGE-RAGE signaling pathway in diabetic complications
rro04935  Growth hormone synthesis, secretion and action
rro04960  Aldosterone-regulated sodium reabsorption
rro04973  Carbohydrate digestion and absorption
rro05010  Alzheimer disease
rro05017  Spinocerebellar ataxia
rro05020  Prion disease
rro05100  Bacterial invasion of epithelial cells
rro05135  Yersinia infection
rro05142  Chagas disease
rro05146  Amoebiasis
rro05160  Hepatitis C
rro05161  Hepatitis B
rro05162  Measles
rro05163  Human cytomegalovirus infection
rro05164  Influenza A
rro05165  Human papillomavirus infection
rro05166  Human T-cell leukemia virus 1 infection
rro05167  Kaposi sarcoma-associated herpesvirus infection
rro05168  Herpes simplex virus 1 infection
rro05169  Epstein-Barr virus infection
rro05170  Human immunodeficiency virus 1 infection
rro05171  Coronavirus disease - COVID-19
rro05200  Pathways in cancer
rro05203  Viral carcinogenesis
rro05205  Proteoglycans in cancer
rro05206  MicroRNAs in cancer
rro05207  Chemical carcinogenesis - receptor activation
rro05208  Chemical carcinogenesis - reactive oxygen species
rro05210  Colorectal cancer
rro05211  Renal cell carcinoma
rro05212  Pancreatic cancer
rro05213  Endometrial cancer
rro05214  Glioma
rro05215  Prostate cancer
rro05218  Melanoma
rro05220  Chronic myeloid leukemia
rro05221  Acute myeloid leukemia
rro05222  Small cell lung cancer
rro05223  Non-small cell lung cancer
rro05224  Breast cancer
rro05225  Hepatocellular carcinoma
rro05226  Gastric cancer
rro05230  Central carbon metabolism in cancer
rro05231  Choline metabolism in cancer
rro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rro05415  Diabetic cardiomyopathy
rro05417  Lipid and atherosclerosis
rro05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    104675620 (PIK3R1)
   04014 Ras signaling pathway
    104675620 (PIK3R1)
   04015 Rap1 signaling pathway
    104675620 (PIK3R1)
   04370 VEGF signaling pathway
    104675620 (PIK3R1)
   04630 JAK-STAT signaling pathway
    104675620 (PIK3R1)
   04668 TNF signaling pathway
    104675620 (PIK3R1)
   04066 HIF-1 signaling pathway
    104675620 (PIK3R1)
   04068 FoxO signaling pathway
    104675620 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    104675620 (PIK3R1)
   04072 Phospholipase D signaling pathway
    104675620 (PIK3R1)
   04071 Sphingolipid signaling pathway
    104675620 (PIK3R1)
   04024 cAMP signaling pathway
    104675620 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    104675620 (PIK3R1)
   04152 AMPK signaling pathway
    104675620 (PIK3R1)
   04150 mTOR signaling pathway
    104675620 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    104675620 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    104675620 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    104675620 (PIK3R1)
   04218 Cellular senescence
    104675620 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    104675620 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    104675620 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104675620 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104675620 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    104675620 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    104675620 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    104675620 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    104675620 (PIK3R1)
   04660 T cell receptor signaling pathway
    104675620 (PIK3R1)
   04662 B cell receptor signaling pathway
    104675620 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    104675620 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    104675620 (PIK3R1)
   04670 Leukocyte transendothelial migration
    104675620 (PIK3R1)
   04062 Chemokine signaling pathway
    104675620 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    104675620 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    104675620 (PIK3R1)
   04929 GnRH secretion
    104675620 (PIK3R1)
   04915 Estrogen signaling pathway
    104675620 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    104675620 (PIK3R1)
   04917 Prolactin signaling pathway
    104675620 (PIK3R1)
   04926 Relaxin signaling pathway
    104675620 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    104675620 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    104675620 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    104675620 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    104675620 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    104675620 (PIK3R1)
   04722 Neurotrophin signaling pathway
    104675620 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    104675620 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    104675620 (PIK3R1)
   04380 Osteoclast differentiation
    104675620 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    104675620 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    104675620 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104675620 (PIK3R1)
   05206 MicroRNAs in cancer
    104675620 (PIK3R1)
   05205 Proteoglycans in cancer
    104675620 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    104675620 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    104675620 (PIK3R1)
   05203 Viral carcinogenesis
    104675620 (PIK3R1)
   05230 Central carbon metabolism in cancer
    104675620 (PIK3R1)
   05231 Choline metabolism in cancer
    104675620 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104675620 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    104675620 (PIK3R1)
   05212 Pancreatic cancer
    104675620 (PIK3R1)
   05225 Hepatocellular carcinoma
    104675620 (PIK3R1)
   05226 Gastric cancer
    104675620 (PIK3R1)
   05214 Glioma
    104675620 (PIK3R1)
   05221 Acute myeloid leukemia
    104675620 (PIK3R1)
   05220 Chronic myeloid leukemia
    104675620 (PIK3R1)
   05218 Melanoma
    104675620 (PIK3R1)
   05211 Renal cell carcinoma
    104675620 (PIK3R1)
   05215 Prostate cancer
    104675620 (PIK3R1)
   05213 Endometrial cancer
    104675620 (PIK3R1)
   05224 Breast cancer
    104675620 (PIK3R1)
   05222 Small cell lung cancer
    104675620 (PIK3R1)
   05223 Non-small cell lung cancer
    104675620 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104675620 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    104675620 (PIK3R1)
   05161 Hepatitis B
    104675620 (PIK3R1)
   05160 Hepatitis C
    104675620 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    104675620 (PIK3R1)
   05164 Influenza A
    104675620 (PIK3R1)
   05162 Measles
    104675620 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    104675620 (PIK3R1)
   05163 Human cytomegalovirus infection
    104675620 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104675620 (PIK3R1)
   05169 Epstein-Barr virus infection
    104675620 (PIK3R1)
   05165 Human papillomavirus infection
    104675620 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    104675620 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    104675620 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    104675620 (PIK3R1)
   05142 Chagas disease
    104675620 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104675620 (PIK3R1)
   05017 Spinocerebellar ataxia
    104675620 (PIK3R1)
   05020 Prion disease
    104675620 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104675620 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    104675620 (PIK3R1)
   05415 Diabetic cardiomyopathy
    104675620 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    104675620 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    104675620 (PIK3R1)
   04931 Insulin resistance
    104675620 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    104675620 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104675620 (PIK3R1)
   01524 Platinum drug resistance
    104675620 (PIK3R1)
   01522 Endocrine resistance
    104675620 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rro04131]
    104675620 (PIK3R1)
Membrane trafficking [BR:rro04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    104675620 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 FANCI_S2 FWWh Exonuc_VII_L
Other DBs
NCBI-GeneID: 104675620
NCBI-ProteinID: XP_010378506
UniProt: A0A2K6PY64
LinkDB
Position
3:61480858..61564841
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTASVDLEMIDVH
ILADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaagaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtaaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacgccaaagccccggccgcctcggcctcttcctgttgcaccaggt
tcttcaaaaactgaagcagatgttgaacaacaagctttgactctcccggaccttgcagag
cagtttgcccctcctgacgttgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgatcgatgtgcac
attttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcaagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
agagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccatcaaaatatttgaagaacagtgccagacc
caggagcgctacagcaaagaatacatagaaaagtttaaacgtgagggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtaggagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaagatttaccccatcatgat
gagaagacgtggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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