Sorex araneus (European shrew): 101540332 Help Entry 101540332         CDS       T07854                                  Symbol PTK2 Name (RefSeq) focal adhesion kinase 1   KO K05725   focal adhesion kinase 1 [EC:2.7.10.2] Organism sara  Sorex araneus (European shrew) Pathway sara01522   Endocrine resistance sara04012   ErbB signaling pathway sara04062   Chemokine signaling pathway sara04148   Efferocytosis sara04151   PI3K-Akt signaling pathway sara04360   Axon guidance sara04370   VEGF signaling pathway sara04510   Focal adhesion sara04670   Leukocyte transendothelial migration sara04810   Regulation of actin cytoskeleton sara04935   Growth hormone synthesis, secretion and action sara05100   Bacterial invasion of epithelial cells sara05135   Yersinia infection sara05146   Amoebiasis sara05163   Human cytomegalovirus infection sara05165   Human papillomavirus infection sara05170   Human immunodeficiency virus 1 infection sara05200   Pathways in cancer sara05202   Transcriptional misregulation in cancer sara05205   Proteoglycans in cancer sara05208   Chemical carcinogenesis - reactive oxygen species sara05222   Small cell lung cancer sara05417   Lipid and atherosclerosis sara05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     101540332 (PTK2)    04370 VEGF signaling pathway     101540332 (PTK2)    04151 PI3K-Akt signaling pathway     101540332 (PTK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     101540332 (PTK2)   09144 Cellular community - eukaryotes    04510 Focal adhesion     101540332 (PTK2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     101540332 (PTK2)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     101540332 (PTK2)    04062 Chemokine signaling pathway     101540332 (PTK2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     101540332 (PTK2)   09158 Development and regeneration    04360 Axon guidance     101540332 (PTK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101540332 (PTK2)    05202 Transcriptional misregulation in cancer     101540332 (PTK2)    05205 Proteoglycans in cancer     101540332 (PTK2)    05208 Chemical carcinogenesis - reactive oxygen species     101540332 (PTK2)   09162 Cancer: specific types    05222 Small cell lung cancer     101540332 (PTK2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101540332 (PTK2)    05163 Human cytomegalovirus infection     101540332 (PTK2)    05165 Human papillomavirus infection     101540332 (PTK2)   09171 Infectious disease: bacterial    05135 Yersinia infection     101540332 (PTK2)    05100 Bacterial invasion of epithelial cells     101540332 (PTK2)   09174 Infectious disease: parasitic    05146 Amoebiasis     101540332 (PTK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101540332 (PTK2)    05418 Fluid shear stress and atherosclerosis     101540332 (PTK2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101540332 (PTK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sara01001]     101540332 (PTK2)    01009 Protein phosphatases and associated proteins [BR:sara01009]     101540332 (PTK2) Enzymes [BR:sara01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101540332 (PTK2) Protein kinases [BR:sara01001]  Non-receptor tyrosine kinases   FAK family    101540332 (PTK2) Protein phosphatases and associated proteins [BR:sara01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      101540332 (PTK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Focal_AT Pkinase FERM_C_FAK1 FERM_N_2 FERM_M Kinase-like FERM_F2 Haspin_kinase ABC1 Motif Other DBs NCBI-GeneID:  101540332 NCBI-ProteinID:  XP_004618731 LinkDB All DBs Position Unknown AA seq 1068 aa AA seqDB search MAAAYLDPNLNHTPSSGTKVPLNTGAERSPGAMERLLKVFHYFESNSEPTTWASIIRHGD ATDVRGIIQKIVDSHKVKHVACYGFRLSHLHSEEVHWLHLDMGVSSVREKYELAHPPEEW KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMSEVADQVDQEIALKLGCLEIRRSY WEMRGNALEKKSNYEVLEKDVGLKRFFPRSLLDSVKAKTLRKLIQQTFRQFANLNREESI LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQ TIQYSHSEDKDRKGTLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVSGASQSFIV RPQKEGERALPSIPKLANSEKQGVRAHAVSVSDEISGDETDDYAEIIDEEETYTMPSKSY GIDEARDYEIQRERIELGRCIGEGQFGDVHQGVYMSPENPALAVAIKTCKNCTSDSVREK FLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKHSLALASLILYA YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIK WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC PPTLYSLMTKCWAYDPSRRPRFTELKAQLSAILEEEKVQQEERLRMESRRQVTVSWDSAG PDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQANHYQVSAYPGPHGVTATAGSIYPGQASL LDQTDTWNHRAQEVSMWRPTVEDSAALDLRGIGQVLPAHLMEERLIRQQQEMEEDQRWLE KEERSLKPDVRLSRGSMDREDGGLQGSTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGS LASLSSPGDSYNEGVKPWRLQPQEISPPPTANLDRSSDKVYENVTGLVKAVIEMSSRIQP APPEEYVPMVKEVGLALRTLLATVDETIPALPASTHREIEMAQKLLNSDLGELINKMKLA QQYVLTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQPRPR NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt atggcagccgcttacctcgacccgaacctgaaccacacacccagctctggcaccaaagtc ccactgaacacgggtgcagaacgctcccctggggccatggagcggctcttgaaggtcttc cattatttcgagagcaatagtgagccgaccacgtgggccagtatcatcaggcatggagac gccacagatgtcaggggcatcatccagaagatagtggacagtcacaaggtcaagcatgtg gcttgctacggattccgcctgagtcacctgcactcagaggaggttcactggctgcatctg gatatgggcgtctccagtgtgcgggagaagtacgagctggcacacccgcctgaggagtgg aagtatgaattgagaattcgttatttgccaaaaggatttctaaaccagtttactgaagac aagccaactctgaatttcttctatcaacaggtgaagagtgactacatgtcagaggttgct gaccaagtggaccaggaaatcgccctgaagctgggttgcctcgagattcggcgatcctac tgggagatgcggggcaacgcgctggagaagaagtccaactacgaggtgttagagaaagac gttgggttgaagcggtttttccctcggagcttactggattctgtcaaggccaaaacacta aggaagctcatccagcagacgttccgccagtttgccaacctgaaccgggaagaaagtatc ctcaagttcttcgagatcctctccccggtgtacagatttgacaaggaatgcttcaagtgt gccctggggtcaagctggattatttcggtggaactggccatcggtcctgaagaaggcatc agttacctcacggacaagggctgcaaccccacacacctggccgacttcaaccaagtgcag accattcagtattcgcacagcgaggacaaggaccgaaaaggaacgctgcagctgaaaata gcgggcgcccctgagcccctcacagtgaccgcaccgtccctcaccatcgcagagaatatg gctgacctgatcgacggctactgccggctggtgagtggggcctcgcagtccttcatcgtc cggcctcagaaggaaggtgaacgggctttgccatccataccaaagttggccaacagcgag aagcagggtgtgcgggcacacgccgtctccgtgtcagatgaaattagtggggacgaaacg gacgattatgccgagatcatagacgaagaggagacatacaccatgccctcaaaaagctat ggaatagatgaagccagggattatgagattcagagagaaagaatagaacttggacggtgt attggagaaggccagtttggagatgtccaccaaggcgtttatatgagtccagagaaccca gcgctcgcggtcgctataaagacatgtaaaaactgtacttcggacagcgtcagagagaag ttcctgcaggaagccttgaccatgcggcagttcgaccaccctcacatcgtgaagctgatc ggcgttatcactgagaaccctgtgtggatcatcatggagctctgcacgcttggagagctg aggtcattcctgcaagtgaggaagcacagcctggccctggcctctctgatcctgtatgcc taccagctgagcacagctctcgcctacttggagagcaagagattcgtgcacagggacatt gctgctcggaatgttctggtgtcctccaatgactgtgtgaaattaggagactttggcttg tcccgctacatggaagacagcacgtactacaaagcttccaaggggaaactgcctattaaa tggatggctcccgagtccatcaacttccggcgcttcacctcggccagtgatgtgtggatg tttggtgtgtgtatgtgggagattctcatgcatggtgtgaagccttttcaaggagtgaag aacaatgatgtgatcgggcggattgagaatggggaaagattaccaatgcctccaaattgc cctcccaccctctacagccttatgacgaaatgctgggcctatgaccccagcaggcggccc cggttcactgagctcaaagctcagctcagtgccatcctggaggaggagaaggtgcagcag gaggagcggctgaggatggagtcccggcggcaagtcacggtgtcctgggactcggcgggc cccgatgaagcgccacccaagcccagcagacccggctaccccagtccccggtccagcgag ggcttttaccccagcccgcagcacatggtccaggccaatcactaccaggtgtccgcctac cctggcccccacggggtcacagccacagctggcagcatctacccaggccaggcttcactc ctggaccagacagacacttggaatcacagagctcaggaggtgtccatgtggcggcccact gtggaggactctgccgccctggacctgcgcgggattgggcaggtgctgcccgcgcacctc atggaggagcggctgatccggcagcagcaggagatggaggaagaccagcgctggctggag aaggaggagcgctccctgaaaccagatgtgaggctctcgagaggcagcatggacagggag gacggcggtctgcagggctcgaccgggaaccagcacatctaccagcccgtcgggaagccg gatcctgcagctccaccaaagaagccaccgcgccctggtgcccctggccacctgggcagc ctcgccagcctcagcagccctggggacagctacaacgagggcgtcaagccatggcggctg cagccccaggagatcagcccccctcccactgccaacctggaccggtccagcgacaaggta tatgagaacgtgactgggctggtgaaagcggtcattgagatgtccagcaggatccagcct gcgccgcccgaggagtatgtacctatggtgaaggaggtgggcctggccctgcggacgctg ttggcgacggtggatgagaccatccctgcactgcccgccagcactcatcgagagattgag atggcccagaaactgctgaactcggacctgggtgagctcatcaacaagatgaaactggcc cagcagtatgtcctgaccagcctccagcaggagtacaagaagcagatgctgaccgcggct catgccttggccgtggatgccaagaacttgctcgatgtcattgaccaggcgagactgaag atgcttggacagcctcggccacgctga

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