KEGG   Sorex araneus (European shrew): 101540938
Entry
101540938         CDS       T07854                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
sara  Sorex araneus (European shrew)
Pathway
sara01521  EGFR tyrosine kinase inhibitor resistance
sara01522  Endocrine resistance
sara01524  Platinum drug resistance
sara04012  ErbB signaling pathway
sara04014  Ras signaling pathway
sara04015  Rap1 signaling pathway
sara04024  cAMP signaling pathway
sara04062  Chemokine signaling pathway
sara04066  HIF-1 signaling pathway
sara04068  FoxO signaling pathway
sara04070  Phosphatidylinositol signaling system
sara04071  Sphingolipid signaling pathway
sara04072  Phospholipase D signaling pathway
sara04081  Hormone signaling
sara04140  Autophagy - animal
sara04150  mTOR signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04152  AMPK signaling pathway
sara04210  Apoptosis
sara04211  Longevity regulating pathway
sara04213  Longevity regulating pathway - multiple species
sara04218  Cellular senescence
sara04360  Axon guidance
sara04370  VEGF signaling pathway
sara04380  Osteoclast differentiation
sara04510  Focal adhesion
sara04550  Signaling pathways regulating pluripotency of stem cells
sara04611  Platelet activation
sara04613  Neutrophil extracellular trap formation
sara04620  Toll-like receptor signaling pathway
sara04625  C-type lectin receptor signaling pathway
sara04630  JAK-STAT signaling pathway
sara04650  Natural killer cell mediated cytotoxicity
sara04660  T cell receptor signaling pathway
sara04662  B cell receptor signaling pathway
sara04664  Fc epsilon RI signaling pathway
sara04666  Fc gamma R-mediated phagocytosis
sara04668  TNF signaling pathway
sara04670  Leukocyte transendothelial migration
sara04722  Neurotrophin signaling pathway
sara04725  Cholinergic synapse
sara04750  Inflammatory mediator regulation of TRP channels
sara04810  Regulation of actin cytoskeleton
sara04910  Insulin signaling pathway
sara04914  Progesterone-mediated oocyte maturation
sara04915  Estrogen signaling pathway
sara04917  Prolactin signaling pathway
sara04919  Thyroid hormone signaling pathway
sara04923  Regulation of lipolysis in adipocytes
sara04926  Relaxin signaling pathway
sara04929  GnRH secretion
sara04930  Type II diabetes mellitus
sara04931  Insulin resistance
sara04932  Non-alcoholic fatty liver disease
sara04933  AGE-RAGE signaling pathway in diabetic complications
sara04935  Growth hormone synthesis, secretion and action
sara04960  Aldosterone-regulated sodium reabsorption
sara04973  Carbohydrate digestion and absorption
sara05010  Alzheimer disease
sara05017  Spinocerebellar ataxia
sara05020  Prion disease
sara05100  Bacterial invasion of epithelial cells
sara05135  Yersinia infection
sara05142  Chagas disease
sara05146  Amoebiasis
sara05160  Hepatitis C
sara05161  Hepatitis B
sara05162  Measles
sara05163  Human cytomegalovirus infection
sara05164  Influenza A
sara05165  Human papillomavirus infection
sara05166  Human T-cell leukemia virus 1 infection
sara05167  Kaposi sarcoma-associated herpesvirus infection
sara05168  Herpes simplex virus 1 infection
sara05169  Epstein-Barr virus infection
sara05170  Human immunodeficiency virus 1 infection
sara05171  Coronavirus disease - COVID-19
sara05200  Pathways in cancer
sara05203  Viral carcinogenesis
sara05205  Proteoglycans in cancer
sara05206  MicroRNAs in cancer
sara05207  Chemical carcinogenesis - receptor activation
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05210  Colorectal cancer
sara05211  Renal cell carcinoma
sara05212  Pancreatic cancer
sara05213  Endometrial cancer
sara05214  Glioma
sara05215  Prostate cancer
sara05218  Melanoma
sara05220  Chronic myeloid leukemia
sara05221  Acute myeloid leukemia
sara05222  Small cell lung cancer
sara05223  Non-small cell lung cancer
sara05224  Breast cancer
sara05225  Hepatocellular carcinoma
sara05226  Gastric cancer
sara05230  Central carbon metabolism in cancer
sara05231  Choline metabolism in cancer
sara05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sara05415  Diabetic cardiomyopathy
sara05417  Lipid and atherosclerosis
sara05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sara00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101540938 (PIK3R2)
   04014 Ras signaling pathway
    101540938 (PIK3R2)
   04015 Rap1 signaling pathway
    101540938 (PIK3R2)
   04370 VEGF signaling pathway
    101540938 (PIK3R2)
   04630 JAK-STAT signaling pathway
    101540938 (PIK3R2)
   04668 TNF signaling pathway
    101540938 (PIK3R2)
   04066 HIF-1 signaling pathway
    101540938 (PIK3R2)
   04068 FoxO signaling pathway
    101540938 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    101540938 (PIK3R2)
   04072 Phospholipase D signaling pathway
    101540938 (PIK3R2)
   04071 Sphingolipid signaling pathway
    101540938 (PIK3R2)
   04024 cAMP signaling pathway
    101540938 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    101540938 (PIK3R2)
   04152 AMPK signaling pathway
    101540938 (PIK3R2)
   04150 mTOR signaling pathway
    101540938 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101540938 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101540938 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    101540938 (PIK3R2)
   04218 Cellular senescence
    101540938 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101540938 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101540938 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101540938 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101540938 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    101540938 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    101540938 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    101540938 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    101540938 (PIK3R2)
   04660 T cell receptor signaling pathway
    101540938 (PIK3R2)
   04662 B cell receptor signaling pathway
    101540938 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    101540938 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    101540938 (PIK3R2)
   04670 Leukocyte transendothelial migration
    101540938 (PIK3R2)
   04062 Chemokine signaling pathway
    101540938 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101540938 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    101540938 (PIK3R2)
   04929 GnRH secretion
    101540938 (PIK3R2)
   04915 Estrogen signaling pathway
    101540938 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    101540938 (PIK3R2)
   04917 Prolactin signaling pathway
    101540938 (PIK3R2)
   04926 Relaxin signaling pathway
    101540938 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    101540938 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    101540938 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101540938 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101540938 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    101540938 (PIK3R2)
   04722 Neurotrophin signaling pathway
    101540938 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101540938 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    101540938 (PIK3R2)
   04380 Osteoclast differentiation
    101540938 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    101540938 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    101540938 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101540938 (PIK3R2)
   05206 MicroRNAs in cancer
    101540938 (PIK3R2)
   05205 Proteoglycans in cancer
    101540938 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    101540938 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101540938 (PIK3R2)
   05203 Viral carcinogenesis
    101540938 (PIK3R2)
   05230 Central carbon metabolism in cancer
    101540938 (PIK3R2)
   05231 Choline metabolism in cancer
    101540938 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101540938 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101540938 (PIK3R2)
   05212 Pancreatic cancer
    101540938 (PIK3R2)
   05225 Hepatocellular carcinoma
    101540938 (PIK3R2)
   05226 Gastric cancer
    101540938 (PIK3R2)
   05214 Glioma
    101540938 (PIK3R2)
   05221 Acute myeloid leukemia
    101540938 (PIK3R2)
   05220 Chronic myeloid leukemia
    101540938 (PIK3R2)
   05218 Melanoma
    101540938 (PIK3R2)
   05211 Renal cell carcinoma
    101540938 (PIK3R2)
   05215 Prostate cancer
    101540938 (PIK3R2)
   05213 Endometrial cancer
    101540938 (PIK3R2)
   05224 Breast cancer
    101540938 (PIK3R2)
   05222 Small cell lung cancer
    101540938 (PIK3R2)
   05223 Non-small cell lung cancer
    101540938 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101540938 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    101540938 (PIK3R2)
   05161 Hepatitis B
    101540938 (PIK3R2)
   05160 Hepatitis C
    101540938 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    101540938 (PIK3R2)
   05164 Influenza A
    101540938 (PIK3R2)
   05162 Measles
    101540938 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    101540938 (PIK3R2)
   05163 Human cytomegalovirus infection
    101540938 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101540938 (PIK3R2)
   05169 Epstein-Barr virus infection
    101540938 (PIK3R2)
   05165 Human papillomavirus infection
    101540938 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101540938 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    101540938 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101540938 (PIK3R2)
   05142 Chagas disease
    101540938 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101540938 (PIK3R2)
   05017 Spinocerebellar ataxia
    101540938 (PIK3R2)
   05020 Prion disease
    101540938 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101540938 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    101540938 (PIK3R2)
   05415 Diabetic cardiomyopathy
    101540938 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101540938 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    101540938 (PIK3R2)
   04931 Insulin resistance
    101540938 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101540938 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101540938 (PIK3R2)
   01524 Platinum drug resistance
    101540938 (PIK3R2)
   01522 Endocrine resistance
    101540938 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:sara04131]
    101540938 (PIK3R2)
Membrane trafficking [BR:sara04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101540938 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 TACC_C Mod_r
Other DBs
NCBI-GeneID: 101540938
NCBI-ProteinID: XP_012790015
LinkDB
Position
Unknown
AA seq 599 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDLLVVSRAALQALGVAEGAERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGLRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAVERTGLDSEALYRPESPAPRTDWTLSDVEQWDAAALADGVKSFLLA
LPAPLVTPEAAAEAHQALREATGPVAPTLEPPTLPLHRALTLRFLLQHLGRLARRAPTPG
LAARALGATFGPLLLPPPSLPPGGAPEGTEPSPDFPVLLLEKLLQEQLEEQEVAPPALPP
KPPKAKPAPTSLTNGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGE
YTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFGSVVELITHYRHESLAQYNAKLDTRLLYP
VSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAF
NETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRSKLQQ
ELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEE
NT seq 1800 nt   +upstreamnt  +downstreamnt
atggccggtgccgagggcttccagtaccgggcgctctaccccttccgccgggagcggccg
gaggaccttgagctgctgcccggggacctgctggtggtgagccgggccgccctgcaggct
ctgggggtggccgagggtgccgagcgctgcccgcagagcgtgggctggatgcccggcctc
aacgagcgcactcggcaacgcggggacttcccgggcacctacgtggagttcctggggccg
gtggccctggccaggcctggcctgcggccccgcggccctcgacccctgcctgcccggccc
cgcgatggaccgcctgagccaggcctcacactcccggacctccccgagcagttttcccct
cccgacgtggccccccccatcttggtgaagctggtggaggctgtggagcgcacaggactg
gacagcgaggctctgtaccggccagagtcgcctgccccgcgcacagactggaccctgagt
gatgtggagcagtgggacgcggcagcgttggctgatggcgtcaagagcttcctgttagcg
ctgcccgctcccctggtgactcccgaggccgcggctgaggcgcaccaggccctgcgggag
gccacggggccggtggcgcccacgttggagcccccgacgctgccgctgcaccgcgcactc
actctgcgcttcctactccagcatctggggcgcctggcccggcgggccccaacccctggc
ctcgctgcacgggccctgggtgccaccttcgggccgctgctgctgccgccgccctcgctg
ccgccagggggcgcgcccgaggggaccgagcccagccctgacttccccgtgctgctgctt
gagaagctgctccaggaacagctggaggaacaggaagttgcccccccagcactgcctccc
aaacctcccaaggccaagccggcccccacaagcctcaccaatggggggagcccaccttcc
ctgcaggacgctgagtggtactggggcgacatctccagggaggaggtgaatgagaaactc
cgcgacacacctgacggcaccttcctggtccgagatgcttccagcaagatccagggggag
tatacactgacgctcaggaaaggcgggaacaacaagctgatcaaagtcttccaccgggat
ggccactatggcttctctgagccgctgaccttcggctcggtggtggagctcatcacccac
taccgccatgagtcgctggcccagtacaatgccaagctcgacacgcggctgctgtaccct
gtgtccaagtaccagcaggaccagattgttaaggaggacagcgtggaggcggtgggggcc
cagctgaaggtgtaccatcaacagtaccaggataagagccgcgagtacgaccagctgtac
gaggaatacacgcgcacctcgcaggagctgcagatgaagcgcacagccatcgaggccttc
aacgagaccatcaagatctttgaagagcaaggccagacgcaggagaagtgcagcaaggag
tatctggagcgcttccggcgcgaggggaatgagaaagagatgcagaggatcctgctgaac
tcggagcggctcaagtcccgcatcgctgagatccacgagagccggagcaagctgcagcag
gagctgcgggcacaggcctccgacaaccgggagatcgacaagcgcatgaacagcctcaag
cctgatctcatgcagctccgcaagatccgggaccagtacctagtgtggctcacacagaag
ggcgcccggcagaagaaaatcaacgagtggttagggatcaaaaacgagactgaagagtga

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