Sorex araneus (European shrew): 101553455 Help Entry 101553455         CDS       T07854                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism sara  Sorex araneus (European shrew) Pathway sara04062   Chemokine signaling pathway sara04151   PI3K-Akt signaling pathway sara04217   Necroptosis sara04550   Signaling pathways regulating pluripotency of stem cells sara04630   JAK-STAT signaling pathway sara04658   Th1 and Th2 cell differentiation sara04659   Th17 cell differentiation sara05161   Hepatitis B sara05162   Measles sara05166   Human T-cell leukemia virus 1 infection sara05169   Epstein-Barr virus infection sara05200   Pathways in cancer sara05203   Viral carcinogenesis sara05223   Non-small cell lung cancer sara05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101553455 (JAK3)    04151 PI3K-Akt signaling pathway     101553455 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101553455 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101553455 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101553455 (JAK3)    04659 Th17 cell differentiation     101553455 (JAK3)    04062 Chemokine signaling pathway     101553455 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101553455 (JAK3)    05203 Viral carcinogenesis     101553455 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     101553455 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101553455 (JAK3)    05161 Hepatitis B     101553455 (JAK3)    05162 Measles     101553455 (JAK3)    05169 Epstein-Barr virus infection     101553455 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     101553455 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sara01001]     101553455 (JAK3) Enzymes [BR:sara01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101553455 (JAK3) Protein kinases [BR:sara01001]  Non-receptor tyrosine kinases   JAK family [OT]    101553455 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl ABC1 Kdo FERM_C_FAK1 Kinase-like APH Haspin_kinase Motif Other DBs NCBI-GeneID:  101553455 NCBI-ProteinID:  XP_004616913 LinkDB All DBs Position Unknown AA seq 1103 aa AA seqDB search MAPPSEETPLLPQRSCSLSSSEAGALQVLLPPRGPGPPRRLSFSFGEHSAEELCVIAAEA SGILPVYHPLFALATEDLSLWFPPSHIFSVDDAGTQVLLYRLRFYFPNWYGLDKCHRFGL RKELASGVLDLAVLEHIFAQHRADLVSGRLPVGISLKEQGECLSLAVLDLAQMACERAQQ PQDLLKTVSYKACLPPGLRELIQSLSFVTRKRIRRTMRQALRRVVACRADKHSLMAKYIM DLERLELARVSETFCVGLPGVTGDQVAKGLLQVAGASGIAWSLGGQEALQPFCDFPEIVD ISIKQASRAGQAGEQRLVTVTRTDSQTLEAEFPGLPEALSFLSLVDGYFRLTTDSRHYFC KEVAPPRLLDDIAEQCHGPITLDFAINKLKAEGSLPGSYVLRRSPQDFNSFLLTVCVQTP LGPDYKGCLIRYDPKGSFSLAGLGRPHSSLRVLLAACRESGLHADGVALSLTSCCVPRSK ERTNLIVVRSDCSLSASPPIHPQVQCQLSQMTFHTIPAQSLEWHENLGHGSFTKIYRGHR HEVVDGEARDTEVLLKVMDAKHKSCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ EFVRPGALDTYLQKCGPLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGS DGSPPFIKLSDPGVSPAVLNLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVLS GITMPVSALDPAQKLQFYQRRQQLPTPKWTELAVLIQQCMAYEPHLRPSFRAIIRDLNNL ITSDYELLSDPSPDALTPRDTLWSGAQLCQDPTIFQERHLKYISQLGKGNFGSVELCRYD PLGDNTGALVAVKQLLQHSEPEQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLV MEYMPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGARRCVHRDLAARNILVESET HVKIADFGLAKLLPLDKDYYVVQEPGQSPIFWYAPESLSDNVFSRQSDVWSFGVVLYELF TYGDKSCSPSAEFLRMTGCERDVPALCRLLELLAEGQRLPAPPACPVEVHELMKGCWADS PQDRPSFSALGPQLEALRSGAPG NT seq 3312 nt NT seq  +upstreamnt  +downstreamnt atggccccgcccagcgaggagacgcccctgctcccacagcgctcctgtagcctgtcttcc tcagaggccggtgccctgcaggtgctgctgcccccgcggggacctgggcctcccaggcgt ctgtccttctcctttggggagcactcagcggaggagctgtgtgtgattgcagccgaggct agcggcatcctgcccgtgtaccaccccctctttgctctggccacggaggacctgtcctta tggttccctcccagccacatcttctcggtggatgacgccggcacccaagtcctgctctac aggctgcgattttacttccccaactggtatggactggataaatgccaccgcttcgggctg cggaaggagctggccagcggcgtgctggacctggcagtgctggagcacatctttgcccag caccgcgcagacctggtgagtggccgcctccccgtgggcatcagcctcaaggagcagggc gagtgcctcagcttggcggtgctggacctcgcccagatggcatgcgagcgggcccagcag ccccaggacttgctgaagacagtcagctacaaggcctgcctgccccccgggctgcgggag ctgatccagagcctgagctttgtgacgcgcaagcgcatccgcaggactatgcgccaagcc ctgcgccgtgtggtggcctgccgggccgacaaacactcactcatggccaagtacatcatg gacctggagcggctggaactggcccgggtttcagagaccttctgcgtgggcctccctggg gtcactggggaccaggttgccaaggggctgctccaggtggctggggccagcggcattgcc tggagccttggagggcaagaggcgctccagcccttctgtgactttccagaaatcgtggac attagtatcaagcaggcctctcgcgcgggccaggccggggaacagcgcctggtcacagtc accaggacggacagccagaccctggaggctgagttcccggggctgcccgaggccttgtcc ttcctctcactggtggatggctacttccggctgaccaccgactctcgtcactacttctgc aaggaggtggcaccgccacggctgctggacgacatagcagagcagtgccatgggcccatc accctggactttgccatcaacaagctcaaggctgagggctccctccctggctcctatgtt ctgcgccgaagccctcaggatttcaacagcttcctcctcacagtctgtgtccagaccccg ttgggccccgattacaaggggtgcctcatccggtacgaccccaaaggcagcttctccctg gctggccttggccgcccccacagcagtctccgcgtgctcctggcagcctgcagggagagt ggtctgcacgcggatggtgtggcattgagccttacctcctgctgcgtccccagatccaaa gaaaggacgaacctgatcgtggtgcgaagcgactgcagtctgtctgcatcgccccccatc cacccccaagtccagtgccagctgagtcagatgaccttccacacgatccctgcccagagc ctggagtggcacgagaacctgggtcacgggtccttcaccaagatttaccggggccatcgg cacgaggtggtggatggggaggcccgggacaccgaggtgctactgaaagtgatggacgcc aagcacaagagctgcatggagtcgttcctggaagctgcgagcctcatgagccaagtgtcc taccagcatctggtgctactccacggcgtgtgcatggctggagacagtatcatggtgcag gaattcgtacgtcccggggcactggacacctatctgcagaagtgtgggcccctggtgccg gccagctggaagctccaggtgatcaagcagctggcctacgccctcaactatctggaagat aaaggcctcccccatggcaatgtctcagcccggaaggtgctgctggctcgagaggggtct gatgggagtcccccattcatcaaactgagcgaccctggcgtcagccctgctgtgctgaac ctggagatgctcacagacaggatcccctgggtagctcccgagtgtctccaggaggcccga accctcggcttggaagcagacaagtggggcttcggggccactgtctgggaggtgctgagt ggaatcacaatgcctgtcagtgccctggatcctgcccagaaactccagttttaccaacga cggcagcagctgcccacgcccaagtggacggagctggccgtgctcatccagcagtgcatg gcctacgagccccacctcaggccctccttccgcgccatcatccgggacctcaacaacctc atcacctcagattatgagcttctctcagaccccagccccgatgccctgacacctcgggat acactgtggagcggcgcccagctctgccaggaccccaccatcttccaggagagacacctc aagtacatttctcagctgggcaagggcaacttcggtagtgtagagctgtgccgttacgac ccgctgggtgacaacacgggtgcactggtggcggtgaagcagctgctgcagcacagcgag cccgagcagcagcgtgatttccagcgggagatccagatcctcaaagccctgcacagcgac ttcatcgtcaagtaccgcggagtcagttacggcccaggccgtcagagcctgcggctggtt atggagtacatgcccagcggctgcctgcgagactttctccagcgccaccgtgcgcgtctg gacgccagccgtctcctgctctacgcctcgcagatctgcaagggcatggagtacctgggc gcccgtcgctgcgtgcaccgggacctggccgccaggaacatcctggtggagagtgagacg catgtcaagatcgcagacttcggcctcgctaaactgttgccgctggacaaggactactac gtggtccaggagcccggccagagccccatcttctggtacgcccctgagtccctgtcagac aacgtcttctcgcgccagtcggacgtgtggagcttcggggtggtcctgtatgagctcttt acctatggcgacaagagctgcagcccctcggctgagttcctgcggatgacagggtgtgag cgagacgtccccgccctctgccggctcctggagctcctggctgaaggccagcggcttcct gcacctcctgcctgcccagtagaggttcacgagctcatgaaggggtgctgggcggacagc ccacaggaccggccgtccttcagtgccttgggcccccagctggaggcgctgcgaagcggg gccccaggctag

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