Sorex araneus (European shrew): 101557843 Help Entry 101557843         CDS       T07854                                  Symbol ADCY1 Name (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism sara  Sorex araneus (European shrew) Pathway sara00230   Purine metabolism sara01100   Metabolic pathways sara01522   Endocrine resistance sara04015   Rap1 signaling pathway sara04020   Calcium signaling pathway sara04022   cGMP-PKG signaling pathway sara04024   cAMP signaling pathway sara04062   Chemokine signaling pathway sara04072   Phospholipase D signaling pathway sara04081   Hormone signaling sara04082   Neuroactive ligand signaling sara04114   Oocyte meiosis sara04211   Longevity regulating pathway sara04213   Longevity regulating pathway - multiple species sara04261   Adrenergic signaling in cardiomyocytes sara04270   Vascular smooth muscle contraction sara04371   Apelin signaling pathway sara04540   Gap junction sara04611   Platelet activation sara04713   Circadian entrainment sara04714   Thermogenesis sara04720   Long-term potentiation sara04723   Retrograde endocannabinoid signaling sara04724   Glutamatergic synapse sara04725   Cholinergic synapse sara04727   GABAergic synapse sara04750   Inflammatory mediator regulation of TRP channels sara04911   Insulin secretion sara04912   GnRH signaling pathway sara04913   Ovarian steroidogenesis sara04914   Progesterone-mediated oocyte maturation sara04915   Estrogen signaling pathway sara04916   Melanogenesis sara04918   Thyroid hormone synthesis sara04921   Oxytocin signaling pathway sara04923   Regulation of lipolysis in adipocytes sara04925   Aldosterone synthesis and secretion sara04926   Relaxin signaling pathway sara04927   Cortisol synthesis and secretion sara04928   Parathyroid hormone synthesis, secretion and action sara04934   Cushing syndrome sara04935   Growth hormone synthesis, secretion and action sara04970   Salivary secretion sara04971   Gastric acid secretion sara04972   Pancreatic secretion sara04976   Bile secretion sara05032   Morphine addiction sara05142   Chagas disease sara05146   Amoebiasis sara05163   Human cytomegalovirus infection sara05166   Human T-cell leukemia virus 1 infection sara05200   Pathways in cancer sara05207   Chemical carcinogenesis - receptor activation sara05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:sara00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101557843 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101557843 (ADCY1)    04371 Apelin signaling pathway     101557843 (ADCY1)    04020 Calcium signaling pathway     101557843 (ADCY1)    04072 Phospholipase D signaling pathway     101557843 (ADCY1)    04024 cAMP signaling pathway     101557843 (ADCY1)    04022 cGMP-PKG signaling pathway     101557843 (ADCY1)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101557843 (ADCY1)    04081 Hormone signaling     101557843 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101557843 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     101557843 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101557843 (ADCY1)    04062 Chemokine signaling pathway     101557843 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     101557843 (ADCY1)    04923 Regulation of lipolysis in adipocytes     101557843 (ADCY1)    04912 GnRH signaling pathway     101557843 (ADCY1)    04913 Ovarian steroidogenesis     101557843 (ADCY1)    04915 Estrogen signaling pathway     101557843 (ADCY1)    04914 Progesterone-mediated oocyte maturation     101557843 (ADCY1)    04921 Oxytocin signaling pathway     101557843 (ADCY1)    04926 Relaxin signaling pathway     101557843 (ADCY1)    04935 Growth hormone synthesis, secretion and action     101557843 (ADCY1)    04918 Thyroid hormone synthesis     101557843 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     101557843 (ADCY1)    04916 Melanogenesis     101557843 (ADCY1)    04925 Aldosterone synthesis and secretion     101557843 (ADCY1)    04927 Cortisol synthesis and secretion     101557843 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101557843 (ADCY1)    04270 Vascular smooth muscle contraction     101557843 (ADCY1)   09154 Digestive system    04970 Salivary secretion     101557843 (ADCY1)    04971 Gastric acid secretion     101557843 (ADCY1)    04972 Pancreatic secretion     101557843 (ADCY1)    04976 Bile secretion     101557843 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     101557843 (ADCY1)    04727 GABAergic synapse     101557843 (ADCY1)    04725 Cholinergic synapse     101557843 (ADCY1)    04720 Long-term potentiation     101557843 (ADCY1)    04723 Retrograde endocannabinoid signaling     101557843 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101557843 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     101557843 (ADCY1)    04213 Longevity regulating pathway - multiple species     101557843 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     101557843 (ADCY1)    04714 Thermogenesis     101557843 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101557843 (ADCY1)    05207 Chemical carcinogenesis - receptor activation     101557843 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101557843 (ADCY1)    05163 Human cytomegalovirus infection     101557843 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     101557843 (ADCY1)    05142 Chagas disease     101557843 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     101557843 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101557843 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101557843 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101557843 (ADCY1) Enzymes [BR:sara01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101557843 (ADCY1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom DUF6594 Motif Other DBs NCBI-GeneID:  101557843 NCBI-ProteinID:  XP_012790931 LinkDB All DBs Position Unknown AA seq 985 aa AA seqDB search MLGRLALLFCLTFALLCCPLALGGPAGAHAGVAAGPGAAERGVWQLLLVTFVSYALLPVR SLLAVGFGLVVAAAHLVLTATSFPAKRPRLWRTLGANALLFVGVNMYGVFLRVLAERCQR RAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL TQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNSFLKAHNIETFFIVPSH RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSSATCGDDKRRALRTT SEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEIADLNFFTLKYKQAERERKYH QLQDEYFTSAVALALILAALFGLIYLLVIPQNLALLLLLVFCICFLLACVLYLQVTQVQC FPGCLTIQIRTVLCIFIVVLVYAVAQGCVVGCLPWAWSIRPNASLVVLTPGAPSGDAVPH ALLCGQVGTLPLAVFLRVSSLPKVILLAVLTASYILVLELSGYAEAVGGTVSGHSSEPIM AILLFSCALALHARQVDIKLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHF LLSNPRNMDLYYQSYAQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMD KDFYKDLEKIKTIGSTYMAAVGLAPTAGVKVKKCISAHLSTLADFAIEMFDVLDEINYQS YNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLR QGVYHFVCRGKVSVKGKGEMLTYFLEGRTDGGPRARTQALGRKLCPYRRAGLPGRLAALG SLQGAGLTSGPPTQHLPPGAAGKEA NT seq 2958 nt NT seq  +upstreamnt  +downstreamnt atgctcggccgcctggcgctgctcttctgcctcaccttcgcgctgctctgctgccccttg gcgctgggcgggcccgcgggggcgcacgccggggtggccgcgggcccgggggccgccgag cggggcgtctggcagctgctgctggtcaccttcgtgtcctatgcgctgctcccggtgcgc agcctgctggccgtcggcttcgggctcgtggtggccgccgcgcacttggtgctcacggcc acttcgttccctgccaagcgcccacgtctctggaggacgctgggcgccaacgccctcctc ttcgtgggcgtgaacatgtacggggtgtttctgcgggtcctggccgagcgctgccagcgg agagcattcctgcaggcgcggaactgcatcgaagaccggctgcggctggaggacgagaac gagaagcaggagcggctgctcatgagcctcctgccccggaatgtcgccatggagatgaag gaggacttcctgaagccccccgagaggatcttccacaagatctacatccagaggcatgac aatgtgagcatcctcttcgccgacatcgtgggcttcacaggcttggcctcgcagtgcacg gcccaggagctggtgaagctgctcaacgagctcttcggcaagtttgacgagctggccacg gagaaccactgccgccgcatcaagatcctgggcgactgctactactgtgtgtctggcctc acgcagcccaaggccgaccatgcccactgctgcgtggagatgggcctggacatgatcgac accatcacgtctgtggctgaggccactgaggtggacctgaacatgcgtgtgggcctgcac acgggccgcgtgctctgtggggtcctgggcctgcgcaagtggcagtatgacgtgtggtcc aacgacgtcaccctggccaatgtcatggaagctgccggcctccccgggaaggtccacatc accaagaccaccctggcgtgcttgaacggcgactatgaggtggagccaggccacgggcac gagcggaacagcttcctgaaagcccacaacatcgagaccttcttcattgtgccctcacac cggagaaagatatttccagggctgatcctctccgacatcaagcctgccaagaggatgaag ttcaagactgtctgctacctgctggtgcagctcatgcactgccggaagatgttcaaagcc gagatccccttctccagcgccacctgtggggacgacaagcgcagggcattgagaacaact tcagagaaactcagaaaccgctcatccttctctaccaatgttgtctacaccaccccgggc acccgtgtcaatcggtacatcagccgcctcctggaagcccgccagacggagctggagata gctgacctgaacttcttcaccctcaagtacaagcaggctgagcgtgagcggaagtaccac cagctccaggacgagtacttcaccagcgcggtcgcgctcgccctgattctcgctgcattg ttcggcctcatctaccttcttgtgatcccgcagaacctggccctcctgctccttctggtg ttctgcatctgcttcctgctggcctgtgtcttgtacctgcaggtcacccaggtccagtgt tttccaggctgcctgaccatccagatccgcaccgtcctgtgcatcttcatagtagtcctg gtctacgccgtggcccaaggctgtgtggtgggctgcctgccctgggcctggagcatccgc cccaacgcgtccctggtggtcctgacgcctggcgccccctctggcgacgctgtgccccac gctctgctctgcggccaggtgggcactctgcccctggccgtgtttctgcgtgtgtcctcc ctgccgaaagtgatcctgctggccgtgctcacggcgtcctacatcctggttctggagctc agcggctacgcggaggccgtcggcggcactgtgtctgggcacagctcggagcccatcatg gccatcctgctgttctcctgcgccctggccctccatgcccggcaggtggacatcaagctc cggctggactacctctgggctgcgcaggcggaggaggagcgagacgacatggagcgggtg aagctggacaacaagcggatcctcttcaacctcctgcccgcccacgtggcccagcacttc ctcctgtccaacccccggaacatggatctctactaccagtcgtacgcacaggtgggcgtc atgttcgcctccatccccaacttcaacgacttctacatcgagctggatggcaacaacatg ggggtggagtgcctgcggctcctcaacgagatcatcgccgactttgacgagctcatggac aaagatttctacaaggacctggagaagatcaagaccatcggcagcacctacatggctgca gtggggctggcacccacggcaggggtcaaggtgaagaagtgcatctccgcccacctcagc accctggccgacttcgccatcgagatgttcgacgtgttggatgagatcaactatcagtcc tacaacgacttcgtgctgcgtgtcggcatcaatgtgggccctgtggtggctggagtgatc ggtgctcggagaccccagtatgatatttgggggaacacggtcaacgtggccagtcggatg gacagtaccggggtccagggcagaatccaggtgacggaggaggtccaccggctgctgcgc cagggcgtgtaccactttgtgtgccgaggcaaggtcagcgtcaagggcaagggcgagatg ctgacctacttcctggaaggcaggaccgatggtggcccccgggcccgtacccaggccctg ggccggaagctgtgtccctaccgcagagccggcctcccgggcagactggccgcgctgggg tctctgcagggcgcaggactgacctccgggccccccacccagcacctgccccctggagca gcggggaaggaggcttag

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